Gut hormones as peripheral anti obesity targets

Current Drug Targets: CNS and Neurological Disorders

Volumn 3, Issue 5, 2004, Pages 379-388

  Small, Caroline J ^a   Bloom, Stephen R ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Appetite; Gut hormones; Obesity; Peptide YY

Indexed keywords

AGOUTI RELATED PROTEIN; ANTIOBESITY AGENT; CHOLECYSTOKININ; COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PEPTIDE; EXENDIN 4; G PROTEIN COUPLED RECEPTOR; GASTROINTESTINAL HORMONE; GHRELIN; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 2; GROWTH HORMONE SECRETAGOGUE RECEPTOR; LEPTIN; LIRAGLUTIDE; MELANIN CONCENTRATING HORMONE; NEUROPEPTIDE Y RECEPTOR AGONIST; NEUROPEPTIDE Y1 RECEPTOR; NEUROPEPTIDE Y2 RECEPTOR AGONIST; NEW DRUG; OXYNTOMODULIN; PANCREAS POLYPEPTIDE; PEPTIDE HORMONE; PEPTIDE YY; PEPTIDE YY 3 36; PLACEBO; PREPROGLUCAGON; PROOPIOMELANOCORTIN; SIBUTRAMINE; TETRAHYDROLIPSTATIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ALPHA TOCOPHEROL DEFICIENCY; APPETITE; BYPASS SURGERY; CLINICAL TRIAL; DEATH; DOSE RESPONSE; DRUG ADMINISTRATION ROUTE; DRUG MECHANISM; DRUG RECEPTOR BINDING; FEEDING BEHAVIOR; FOOD INTAKE; GASTROINTESTINAL TRACT FUNCTION; HORMONE RELEASE; HORMONE SYNTHESIS; HUMAN; HYPERTENSION; INTESTINE CELL; L CELL; LEAN BODY WEIGHT; META ANALYSIS; MOUSE; NONHUMAN; OBESITY; POSTPRANDIAL STATE; PREVALENCE; RAT; RETINOL DEFICIENCY; REVIEW; TACHYCARDIA; UNITED KINGDOM; WEIGHT REDUCTION;

ANIMALS; ANTI-OBESITY AGENTS; APPETITE REGULATION; DRUG DESIGN; GASTROINTESTINAL HORMONES; GLUCAGON; GLUCAGON-LIKE PEPTIDE 1; GLUCAGON-LIKE PEPTIDES; HUMANS; MICE; OBESITY; OXYNTOMODULIN; PANCREATIC POLYPEPTIDE; PEPTIDE FRAGMENTS; PEPTIDE HORMONES; PEPTIDE YY; PROTEIN PRECURSORS; RATS; RECEPTORS, G-PROTEIN-COUPLED;

EID: 9144257374     PISSN: 1568007X     EISSN: None     Source Type: Journal    
DOI: 10.2174/1568007043336950     Document Type: Review

References (94)

1. Foxcroft, D.R., Milne, R. Obes.Rev., 2000, 1 121-126.
2. Stock, M.J., Int. J. Obes. Relat. Metab. Disord., 1997, 21 Suppl. 1, S25-S29
3. Finer, N. Int. J. Obes. Relat. Metab. Disord., 2002 26 Suppl. 4, S29-S33
4. Finer, N. Best Pract. Res. Clin. Endocrinol. Metab., 2002, 16, 717-742
5. Mitchell, J.E., Lancaster, K.L., Burgard, M.A., Howell, L.M., Krahn, D.D., Crosby, R.D., Wonderlich, S.A., Gosnell, B.A. Obes. Surg. 2001, 11, 464-468
6. Sarson, D.L., Scopinaro, N., Bloom, S.R. Int. J. Obes., 1981, 5, 471-480
7. Cummings, D.E., Shannon, M.H. J. Clin. Endocrinol. Metab. 2003, 88, 2999-3002
8. Cummings, D.E., Weigle, D.S., Frayo, R.S., Breen, P.A., Ma, M.K., Dellinger, E.P., Purnell, J.Q. N. Engl. J. Med., 2002, 346, 1623-1630
9. Cummings, D.E., Shannon, M.H. Arch. Surg., 2003, 138, 389-396
10. Kojima, M., Kangawa, K. Curr. Opin. Pharmacol., 2002 2, 665-668
11. Moran, T.H., Schwartz, G.J. Crit. Rev. Neurobiol., 1994, 9, 1-28
12. Batterham, R.L., Cowley, M.A., Small, C.J., Herzog, H., Cohen, M.A., Dakin, C.L., Wren, A.M., Brynes, A.E., Low, M.J., Ghatei, M.A., Cone, R.D., Bloom, S.R. Nature, 2002, 418, 650-654
13. Batterham, R.L., Cohen, M.A., Ellis, S.M., Le R.oux, C.W., Withers, D.J., Frost, G.S., Ghatei, M.A., Bloom, S.R. N. Engl. J. Med. 2003, 349, 941-948
14. Cohen, M.A., Ellis, S.M., Le Roux, C.W., Batterham, R.L., Park. A., Patterson, M., Frost, G.S., Ghatei, M.A., Bloom, S.R. J. Clin. Endocrinol. Metab., 2003, 88, 4696-4701
15. Dakin, C.L., Small, C.J., Batterham, R.L., Neary, N.M., Cohen, M.A., Patterson, M., Ghatei, M.A., Bloom, S.R. Endocrinology 2004, 145, 2687-2695
16. Batterham, R.L., Le Roux, C.W., Cohen, M.A., Park, A.J., Ellis, S.M., Patterson ,M., Frost, G.S., Ghatei, M.A., Bloom, S.R. J. Clin. Endocrinol. Metab., 2003, 88, 3989-3992
17. Wren, A.M., Small, C.J., Abbott, C.R., Dhillo, W.S., Seal, L.J., Cohen, M.A., Batterham, R.L., Taheri, S., Stanley, S.A., Ghatei, M.A., Bloom, S.R. Diabetes, 2001, 50, 2540-2547
18. Wren, A.M., Seal, L.J., Cohen, M.A., Brynes, A.E., Frost, G.S., Murphy, K.G., Dhillo, W.S., Ghatei, M.A., Bloom, S.R. J. Clin. Endocrinol. Metab., 2001, 86, 5992
19. Schwartz, M.W., Woods, S.C., Porte, D. Jr., Seeley, R.J., Baskin, D.G. Nature, 2000, 404, 661-671
20. Kalra, S.P., Dube, M.G., Pu, S., Xu, B., Horvath, T.L., Kalra, P.S. Endocr. Rev., 1999, 20, 68-100
21. Cone, R.D., Cowley, M.A., Butler, A.A., Fan, W., Marks, D.L., Low, M.J. Int. J. Obes. Relat. Metab. Disord., 2001, 25 Suppl. 5, S63-S67
22. Cowley, M.A., Cone, R.D., Enriori, P., Louiselle, I., Williams, S.M., Evans, A.E. Ann. N. Y. Acad. Sci., 2003, 994, 175-186
23. Barsh, G.S., Farooqi, I.S., O'Rahilly, S. Nature, 2000, 404, 644-651
24. O'Rahilly, S. Nature, 1998, 392, 330-331
25. Tatemoto, K., Mutt, V. Nature, 1980, 285, 417-418
26. Larhammar, D. Regul. Pept., 1996, 65, 165-174
27. Claustre, J., Brechet, S., Plaisancie, P., Chayvialle, J.A., Cuber, J.C. J. Endocrinol., 1999, 162, 271-278
28. Adrian, T.E., Ferri, G.L., Bacarese-Hamilton, A.J., Fuessl, H.S., Polak, J.M., Bloom, S.R. Gastroenterology, 1985, 89 1070-1077
29. Ekblad, E., Sundler, F. Peptides, 2002, 23, 251-261
30. Okada, S., Ohshima, K., Mori, M., Tatemoto, K. Endocrinlogy, 1993, Suppl. 180
31. Batterham, R.L., Bloom, S.R. Ann. N. Y. Acad. Sci., 2003, 994, 162-168
32. Halatchev, I.G., Ellacott, K.L., Fan, W., Cone, R.D. Endocrinology, 2004, 145, 2585-2590
33. Challis, B.G., Pinnock, S.B., Coll, A.P., Carter, R.N., Dickson, S.L., O'Rahilly, S. Biochem. Biophys. Res. Commun., 2003, 311, 915-919
34. Thone-Reineke, C. The Endocrine society's 85th Annual Meeting 2003, 1-253. 2004.
35. Challis, B.G., Coll, A.P., Yeo, G.S., Pinnock, S.B., Dickson, S.L., Thresher, R.R., Dixon, J., Zahn, D., Rochford, J.J., White, A., Oliver, R.L., Millington, G., Aparicio, S.A., Colledge, W.H., Russ, A.P., Carlton, M.B., O'Rahilly, S. Proc. Natl. Acad. Sci. USA, 2004 101, 4695-4700
36. Onaga, T., Zabielski, R., Kato, S. Peptides, 2002 23, 279-290
37. Kimmel, J.R., Hayden, L.J., Pollock, H.G. J. Biol. Chem. 1975, 250, 9369-9376
38. Ekblad, E., Sundler, F. Peptides, 2002, 23, 251-261
39. Malaisse-Lagae, F., Carpentier, J.L., Patel, Y.C., Malaisse, W.J., Orci, L. Experientia, 1977, 33, 915-917
40. Asakawa, A., Inui, A., Yuzuriha, H., Ueno, N., Katsuura, G., Fujimiya, M., Fujino, M.A., Niijima, A., Meguid, M.M., Kasuga, M. Gastroenterology, 2003, 124, 1325-1336
41. Asakawa, A., Inui, A., Ueno, N., Fujimiya, M., Fujino, M.A., Kasuga, M. Peptides, 1999, 20, 1445-1448
42. Ueno, N., Inui, A., Asakawa, A., Yuzuriha, H., Kasuga, M., Fujimiya, M. Diabetologia, 2002, 45, 1048-1049
43. Ueno, N., Inui, A., Iwamoto, M., Kaga, T., Asakawa, A., Okita, M., Fujimiya, M., Nakajima, Y., Ohmoto, Y., Ohnaka, M., Nakaya, Y., Miyazaki, J.I., Kasuga, M. Gastroenterology, 1999, 117 1427-1432
44. Berntson, G.G., Zipf, W.B., O'Dorisio, T.M., Hoffman, J.A., Chance, R.E. Peptides, 1993, 14, 497-503
45. Katsuura, G., Asakawa, A., Inui, A. Peptides, 2002 23, 323-329
46. Turton, M.D., O'Shea. D., Gunn, I., Beak, S.A., Edwards, C.M., Meeran, K., Choi, S.J., Taylor, G.M., Heath, M.M., Lambert, P.D., Wilding, J.P., Smith, D.M., Ghatei, M.A., Herbert, J., Bloom, S.R. Nature, 1996, 379, 69-72
47. Meeran, K., O'Shea, D., Edwards, C.M., Turton, M.D., Heath, M.M., Gunn, I., Abusnana, S., Rossi, M., Small, C.J., Goldstone, A.P., Taylor, G.M., Sunter, D., Steere, J., Choi, S.J., Ghatei, M.A., Bloom, S.R. Endocrinology, 1999, 140, 244-250
48. Dakin, C.L., Gunn, I., Small, C.J., Edwards, C.M., Hay, D.L., Smith, D.M., Ghatei, M.A., Bloom, S.R. Endocrinology, 2001, 142, 4244-4250
49. Gutzwiller, J.P., Drewe, J., Goke, B., Schmidt, H., Rohrer, B., Lareida, J., Beglinger, C. Am. J. Physiol., 1999, 276 R1541-R1544
50. Gutzwiller, J.P., Goke, B., Drewe, J., Hildebrand, P., Ketterer, S., Handschin, D., Winterhalder, R., Conen, D., Beglinger, C. Gut, 1999, 44, 81-86
51. Toft-Nielsen, M.B., Madsbad, S., Holst, J.J. Diabetes Care 1999, 22, 1137-1143
52. Schirra, J., Katschinski, M., Weidmann, C., Schafer, T., Wank, U., Arnold, R., Goke, B. J. Clin. Invest., 1996, 97 92-103
53. Willms, B., Werner, J., Holst, J.J., Orskov, C., Creutzfeldt, W., Nauck, M.A. J. Clin. Endocrinol. Metab., 1996, 81, 327-332
54. Naslund, E., Barkeling, B., King, N., Gutniak, M., Blundell, J.E., Holst, J.J., Rossner, S., Hellstrom, P.M. Int. J. Obes. Relat. Metab. Disord., 1999, 23, 304-311
55. Verdich, C., Flint, A., Gutzwiller, J.P., Naslund, E., Beglinger, C., Hellstrom, P.M., Long, S.J., Morgan, L.M., Holst, J.J., Astrup, A. J. Clin. Endocrinol. Metab., 2001, 86, 4382-4389
56. Tang-Christensen, M., Vrang, N., Larsen, P.J. Int. J. Obes. Relat. Metab. Disord., 2001, 25 Suppl. 5, 42-S47
57. Zander, M., Madsbad, S., Madsen, J.L., Holst, J.J. Lancet 2002, 359, 824-830
58. Verdich, C., Toubro, S., Buemann, B., Lysgard, M.J., Juul, H.J., Astrup, A. Int. J. Obes. Relat. Metab. Disord., 2001, 25, 1206-1214
59. Vilsboll, T., Krarup, T., Sonne, J., Madsbad, S., Volund, A., Juul, A.G., Holst, J.J. J. Clin. Endocrinol. Metab., 2003, 88, 2706-2713
60. Vilsboll, T., Agerso, H., Krarup, T., Holst, J.J. J. Clin. Endocrinol. Metab., 2003, 88, 220-224
61. Velasquez-Mieyer, P.A., Cowan, P.A., Umpierrez, G.E., Lustig, R.H., Cashion, A.K., Burghen, G.A. Int. J. Obes. Relat. Metab. Disord. 2003, 27, 1359-1364
62. Feinle, C., Chapman, I.M., Wishart, J., Horowitz, M. Peptides, 2002, 23, 1491-1495
63. Naslund, E. Br. J. Nutr., In Press. 2003.
64. Meier, J.J., Gallwitz, B., Schmidt, W.E., Nauck, M.A Eur. J. Pharmacol., 2002, 440, 269-279
65. Egan, J.M., Meneilly, G.S., Elahi, D. Am. J. Physiol. Endocrinol. Metab., 2003, 284, E1072-E1079
66. Chang, A.M., Jakobsen, G., Sturis, J., Smith, M.J., Bloem, C.J., An, B., Galecki, A., Halter, J.B. Diabetes, 2003, 52 1786-1791
67. Juhl, C.B., Hollingdal, M., Sturis, J., Jakobsen, G., Agerso, H., Veldhuis, J., Porksen, N., Schmitz, O. Diabetes, 2002, 51, 424-429
68. Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., Kangawa, K. Nature, 1999, 402, 656-660
69. Asakawa, A., Inui, A., Kaga, T., Yuzuriha, H., Nagata, T., Ueno, N., Makino, S., Fujimiya, M., Niijima, A., Fujino, M.A., Kasuga, M. Gastroenterology, 2001, 120, 337-345
70. Bednarek, M.A., Feighner, S.D., Pong, S.S., Mckee, K.K., Hreniuk, D.L., Silva, M.V., Warren, V.A., Howard, A.D, Van der Ploeg, L.H., Heck, J.V. J. Med. Chem., 2000, 43, 4370-4376
71. Kojima, M., Hosoda, H., Matsuo, H., Kangawa, K. Trends Endocrinol. Metab., 2001, 12, 118-122
72. Guan, X.M., Yu, H., Palyha, O.C., Mckee, K.K., Feighner, S.D., Sirinathsinghji, D.J., Smith, R.G., Van der Ploeg, L.H., Howard, A.D. Brain Res. Mol. Brain Res., 1997, 48, 23-29
73. Wren, A.M., Small, C.J., Ward, H.L., Murphy, K.G., Dakin, C.L., Taheri, S., Kennedy, A.R., Roberts, G.H., Morgan, D.G., Ghatei, M.A., Bloom, S.R. Endocrinology, 2000, 141, 4325-4328
74. Tschop, M., Smiley, D.L., Heiman, M.L. Nature, 2000 407, 908-913
75. Masuda, Y., Tanaka, T., Inomata, N., Ohnuma, N., Tanaka, S., Itoh, Z., Hosoda, H., Kojima, M., Kangawa, K. Biochem. Biophys. Res. Commun., 2000, 276, 905-908
76. Trudel, L., Tomasetto, C., Rio, M.C., Bouin, M., Plourde, V., Eberling, P., Poitras, P. Am. J. Physiol. Gastrointest. Liver Physiol. 2002, 282, G948-G952
77. Ariyasu, H., Takaya, K., Tagami, T., Ogawa, Y., Hosoda, K., Akamizu, T., Suda, M., Koh, T., Natsui, K., Toyooka, S., Shirakami, G., Usui, T., Shimatsu, A., Doi, K., Hosoda, H., Kojima, M., Kangawa, K., Nakao, K. J. Clin. Endocrinol. Metab., 2001, 86, 4753-4758
78. Shiiya, T., Nakazato, M., Mizuta, M., Date, Y., Mondal, M.S., Tanaka, M, Nozoe, S., Hosoda, H., Kangawa, K., Matsukura, S. J. Clin. Endocrinol. Metab., 2002, 87, 240-244
79. Hansen, T.K., Dall, R., Hosoda, H., Kojima, M., Kangawa, K., Christiansen, J.S., Jorgensen, J.O. Clin. Endocrinol. (Oxf), 2002, 56, 203-206
80. English, P.J., Ghatei, M.A., Malik, I.A., Bloom, S.R., Wilding, J.P. J. Clin. Endocrinol. Metab., 2002, 87, 2984
81. Cummings, D.E., Clement, K., Purnell, J.Q., Vaisse, C., Foster, K.E., Frayo, R.S., Schwartz, M.W., Basdevant, A., Weigle, D.S. Nat. Med., 2002, 8, 643-644
82. Wang, H.J., Geller, F., Dempfle, A., Schauble, N., Friedel, S., Lichtner, P., Fontenla-Horro, F., Wudy, S., Hagemann, S., Gortner, L., Huse, K., Remschmidt, H., Bettecken, T., Meitinger, T., Schafer, H., Hebebrand, J., Hinney, A. J. Clin. Endocrinol. Metab., 2004, 89, 157-162
83. Hinney, A., Hoch, A., Geller, F., Schafer, H., Siegfried, W., Goldschmidt, H., Remschmidt, H., Hebebrand, J. J. Clin. Endocrinol. Metab., 2002,87, 2716
84. Korbonits, M., Gueorguiev, M., O'Grady, E., Lecoeur, C., Swan, D.C., Mein, C.A., Weill, J., Grossman, A.B., Froguel, P. J. Clin. Endocrinol. Metab., 2002, 87, 4005-4008
85. Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., Friedman, J.M. Nature, 1994, 372, 425-432
86. Friedman, J.M., Halaas, J.L. Nature, 1998, 395 763-770
87. Cowley, M.A., Smart, J.L., Rubinstein, M., Cerdan, M.G., Diano, S., Horvath, T.L., Cone, R.D., Low, M.J. Nature, 2001, 411, 480-484
88. Ahima, R.S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos, F.E., Flier, J.S. Nature, 1996, 382, 250-252
89. Bado, A., Levasseur, S., Attoub, S., Kermorgant, S., Laigneau, J.P., Bortoluzzi. M.N., Moizo, L., Lehy, T., Guerre-Millo, M., Marchand-Brustel, Y., Lewin, M.J. Nature, 1998, 394, 790-793
90. Mix, H., Widjaja, A., Jandl, O., Cornberg, M., Kaul, A., Goke, M., Beil, W., Kuske, M., Brabant, G., Manns, M.P., Wagner, S. Gut, 47, 2000, 481-486
91. Woods, S.C., Porte, D., Jr. Adv. Metab. Disord., 1983, 10, 457-468
92. Tschop, M., Weyer, C., Tataranni, P.A., Devanarayan, V., Ravussin, E., Heiman, M.L. Diabetes, 2001, 50, 707-709
93. Naslund, E., Gryback, P., Hellstrom, P.M., Jacobsson, H., Holst, J.J., Theodorsson, E., Backman, L. Int. J. Obes. Relat. Metab. Disord., 1997, 21, 387-392
94. Le Roux, C.W., Shurey, S., Ghatei, M.A., Bloom, S.R. Endocrine Abstracts, British Endocrine Society, Glasgow 2003.