Theoretical studies on the ring opening of β-lactams: Processes in solution and in enzymatic media

Current Organic Chemistry

Volumn 10, Issue 7, 2006, Pages 805-821

  Lopez R ^a   Menendez M I ^a   Diaz N ^a   Suarez D ^a   Campomanes, P ^a   Ardura, D ^a   Sordo, T L ^a  

^a UNIVERSITY OF OVIEDO   (Spain)

Author keywords

2 Azetidinone; Acidic hydrolysis; Alcoholysis; Ozonolysis; Penicillin binding proteins; Zwitterionic Intermediates

Indexed keywords

ALKALINITY; AMIDES; AMINO ACIDS; BINDING ENERGY; BINDING SITES; CATALYSIS; COMPUTATIONAL CHEMISTRY; CONTINUUM MECHANICS; COPPER COMPOUNDS; DENSITY FUNCTIONAL THEORY; ENZYMES; HYDROLYSIS; OZONE; PHYSICAL CHEMISTRY; QUANTUM CHEMISTRY; TRANSITION METALS; ZINC COMPOUNDS;

2-AZETIDINONE; ACIDIC HYDROLYSIS; ALCOHOLYSIS; AZETIDINONES; OZONOLYSIS; PENICILLIN- BINDING PROTEINS; RING OPENING; SERINE PROTEASE; THEORETICAL STUDY; ZWITTERIONIC INTERMEDIATE;

SOLVENTS;

AMPHOLYTE; AZETIDINONE DERIVATIVE; BACTERIAL ENZYME; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE; BETA LACTAMASE INHIBITOR; CARBAPENEM; CEPHALOSPORIN; CEPHEM DERIVATIVE; CLAVULANIC ACID; COPPER COMPLEX; DRUG SOLVENT; HUMAN SERUM ALBUMIN; LATAMOXEF; LYSINE; MONOBACTAM; PENAM DERIVATIVE; PENICILLIN BINDING PROTEIN; PENICILLIN G; PENICILLIN RECOGNIZIG PROTEIN; PROTEINASE; SERINE PROTEINASE; TRANSITION ELEMENT; UNCLASSIFIED DRUG; ZINC COMPLEX; ZINC PROTEINASE;

AB INITIO CALCULATION; ALCOHOLYSIS; AMINOLYSIS; AMMONOLYSIS; ANTIBIOTIC THERAPY; AQUEOUS SOLUTION; CATALYSIS; CHEMICAL BOND; CLUSTER ANALYSIS; DENSITY FUNCTIONAL THEORY; DRUG DEGRADATION; DRUG DESIGN; DRUG HYDROLYSIS; DRUG HYPERSENSITIVITY; DRUG MECHANISM; DRUG STABILITY; DRUG STRUCTURE; EMPIRICISM; ENZYME ACTIVE SITE; ENZYME CHEMISTRY; ENZYME MECHANISM; HUMAN; MATHEMATICAL COMPUTING; MOLECULAR DYNAMICS; NONHUMAN; OZONOLYSIS; PENICILLIN ALLERGY; PROCESS OPTIMIZATION; QUANTUM CHEMISTRY; REVIEW; RING OPENING; THEORETICAL STUDY;

EID: 33646570484     PISSN: 13852728     EISSN: None     Source Type: Journal    
DOI: 10.2174/138527206776818883     Document Type: Review

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