Catalytic mechanism of class A β-lactamase. I. The role of Glu166 and Ser130 in the deacylation reaction

Chemical and Pharmaceutical Bulletin

Volumn 48, Issue 4, 2000, Pages 447-453

  Hata, Masayuki ^a   Fujii, Yasuyuki ^a   Ishii, Miho ^a   Hoshino, Tyuji ^a   Tsuda, Minoru ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

ab initio molecular orbital method; Deacylation reaction; Hydrogen bond network; Lys73; Tetrahedral intermediate; lactamase

Indexed keywords

AMINO ACID; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE; GLUTAMINE DERIVATIVE; LYSINE DERIVATIVE; PENICILLIN G; SERINE DERIVATIVE;

ARTICLE; CATALYSIS; DEACYLATION; DRUG STRUCTURE; ENERGY; ENZYME ACTIVE SITE; HYDROGEN BOND; MOLECULAR DYNAMICS; MOLECULAR MODEL;

EID: 0034015916     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.48.447     Document Type: Article

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