The importance of a critical protonation state and the fate of the catalytic steps in class A β-lactamases and penicillin-binding proteins

Journal of Biological Chemistry

Volumn 279, Issue 33, 2004, Pages 34665-34673

  Golemi Kotra, Dasantila ^a   Meroueh, Samy O ^a   Kim, Choonkeun ^a   Vakulenko, Sergei B ^a   Bulychev, Alexey ^a   Stemmler, Ann J ^a   Stemmler, Timothy L ^b   Mobashery, Shahriar ^a  

^a UNIVERSITY OF NOTRE DAME   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLATION; ANTIBIOTICS; BIOSYNTHESIS; CELL MEMBRANES; ENZYME KINETICS; NUCLEAR MAGNETIC RESONANCE; PROTEINS; THERMODYNAMICS;

CELL WALLS; CRITICAL PROTONATION STATES; PROTONATION; THERMODYNAMIC INTEGRATION METHODS;

CATALYST ACTIVITY;

BETA LACTAMASE; GLUTAMIC ACID; LYSINE; PENICILLIN BINDING PROTEIN; THIAMINE DERIVATIVE; BACTERIAL PROTEIN; CARBOXYPEPTIDASE TRANSPEPTIDASE; CARRIER PROTEIN; CYSTEINE; DRUG DERIVATIVE; GLYCOSYLTRANSFERASE; ION; PEPTIDYLTRANSFERASE; PROTON; S (2 AMINOETHYL)CYSTEINE; S-2-AMINOETHYL CYSTEINE; SERINE;

ARTICLE; CATALYSIS; ESCHERICHIA COLI; GENE EXPRESSION; KINETICS; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTON TRANSPORT; THERMODYNAMICS; TITRIMETRY; BINDING SITE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; GENE VECTOR; MOLECULAR CLONING; MUTATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH; PROTEIN BINDING; PROTEIN MOTIF;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

AMINO ACID MOTIFS; BACTERIAL PROTEINS; BETA-LACTAMASES; BINDING SITES; CARRIER PROTEINS; CATALYSIS; CLONING, MOLECULAR; CYSTEINE; ESCHERICHIA COLI; GENETIC VECTORS; GLUTAMIC ACID; HEXOSYLTRANSFERASES; HYDROGEN-ION CONCENTRATION; IONS; KINETICS; LYSINE; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; MODELS, MOLECULAR; MURAMOYLPENTAPEPTIDE CARBOXYPEPTIDASE; MUTATION; PENICILLIN-BINDING PROTEINS; PEPTIDYL TRANSFERASES; PROTEIN BINDING; PROTONS; SERINE; THERMODYNAMICS;

EID: 4544384195     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M313143200     Document Type: Article

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