Factors governing intrinsic chemical reactivity differences between clavulanic and penicillanic acids

Journal of the American Chemical Society

Volumn 124, Issue 40, 2002, Pages 12042-12053

  Lin, Yen Lin ^a   Chang, Nai Yuan ^b,c   Lim, Carmay ^a,c  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSITION STATES;

ANTIBIOTICS; BACTERIA; ELECTROSTATICS; ENZYMES; FREE ENERGY; HYDROLYSIS; PROTONS; REACTION KINETICS;

BIOCHEMISTRY;

BETA LACTAM; BETA LACTAMASE; CLAVULANIC ACID; HYDROLASE; HYDROXIDE; OXAZOLIDINE DERIVATIVE; PENICILLANIC ACID; PENICILLIN G; SOLVENT; THIAZOLIDINE DERIVATIVE;

AB INITIO CALCULATION; ANTIMICROBIAL ACTIVITY; ARTICLE; CHEMICAL REACTION; ENERGY; ENZYME INHIBITION; HYDROLYSIS; MOLECULAR INTERACTION; MOLECULAR STABILITY; TECHNIQUE;

ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; CLAVULANIC ACID; ENZYME INHIBITORS; PENICILLANIC ACID; SOLUTIONS; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 0037048611     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja020788g     Document Type: Article

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