Identification of Glu166 as the general base in the acylation reaction of class A, β-lactamases through QM/MM modeling

Journal of the American Chemical Society

Volumn 125, Issue 32, 2003, Pages 9590-9591

  Hermann, Johannes C ^a   Ridder, Lars ^b   Mulholland, Adrian J ^b   Höltje, Hans Dieter ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAMASE; GLUTAMIC ACID;

ACYLATION; AMINO ACID SUBSTITUTION; ARTICLE; CHEMICAL REACTION; ENZYME MECHANISM; MOLECULAR DYNAMICS; QUANTUM MECHANICS; REACTION ANALYSIS;

ACYLATION; BETA-LACTAMASES; BINDING SITES; COMPUTER SIMULATION; ESCHERICHIA COLI; GLUTAMIC ACID; QUANTUM THEORY; THERMODYNAMICS;

EID: 0042125389     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja034434g     Document Type: Article

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