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Volumn 106, Issue 37, 2002, Pages 9687-9695

Catalytic mechanism of class A β-lactamase: Role of lysine 73 and C3-carboxyl group of the substrate pen G in the deacylation step

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[No Author keywords available]

Indexed keywords

PROTON TRANSFER;

EID: 0037136776     PISSN: 10895647     EISSN: None     Source Type: Journal    
DOI: 10.1021/jp021414c     Document Type: Article
Times cited : (18)

References (73)
  • 60
    • 0011758390 scopus 로고    scopus 로고
    • note
    • The structure of A3′ did not completely correspond to that of A3″. However, the strucutral difference between A3′ and A3 was only a conformation of carboxyl group of Glu166. Further, Glu166 did not participiate in the 3rd elementary reaction. It should be also noted that the potential energy of A3′ was almost same as that of A3 (the energy difference was only 0.3 kcal/mol). Therefore, we assumed that A3 and A3′ were indentical in the terms of reaction mechanism.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.