Protonation of the β-lactam nitrogen is the trigger event in the catalytic action of class A β-lactamases

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 7, 2000, Pages 3160-3165

  Atanasov, Boris P ^a,b   Mustafi, Devkumar ^b   Makinen, Marvin W ^b  

^a INSTITUTE OF ORGANIC CHEMISTRY   (Bulgaria)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 N (2,2,5,5 TETRAMETHYL 1 OXYPYRROLINYL 3 CARBOXYL)PENICILLANIC ACID; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE; NITROGEN; PENICILLIN G DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONTROLLED STUDY; ELECTRIC POTENTIAL; ENZYME ACTIVE SITE; ENZYME MECHANISM; ESCHERICHIA COLI; HYDROGEN BOND; NONHUMAN; PH; PKA; PRIORITY JOURNAL; PROTON TRANSPORT; X RAY CRYSTALLOGRAPHY;

BETA-LACTAMASES; BETA-LACTAMS; CATALYSIS; ELECTROSTATICS; ESCHERICHIA COLI; NITROGEN; PROTEIN CONFORMATION; PROTONS;

ESCHERICHIA COLI;

EID: 0034724334     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.060027897     Document Type: Article

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