The catalytic mechanism of β-lactamases: NMR titration of an active-site lysine residue of the TEM-1 enzyme

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 5, 1996, Pages 1747-1752

  Damblon, Christian ^a   Raquet, Xavier ^a   Lian, Lu Yun ^b   Lamotte Brasseur, Josette ^a   Fonze, Eveline ^a   Charlier, Paulette ^a   Roberts, Gordon C K ^b   Frère, Jean Marie ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

antibiotics; heteronuclear NMR; lysine pK; protein NMR

Indexed keywords

BETA LACTAMASE; CEFALOTIN; CEFOXITIN; CEPHALOSPORIN DERIVATIVE; GLUTAMIC ACID; IMIPENEM; LYSINE; PENICILLIN DERIVATIVE; TEMOCILLIN; TRINITROBENZENESULFONIC ACID;

ANTIBIOTIC RESISTANCE; ARTICLE; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME MODIFICATION; ENZYME SPECIFICITY; MATHEMATICAL ANALYSIS; NUCLEAR MAGNETIC RESONANCE; PH MEASUREMENT; PKA; PRIORITY JOURNAL;

BETA-LACTAMASES; BINDING SITES; KINETICS; LYSINE; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR;

EID: 0029944652     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.5.1747     Document Type: Article

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