Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice

Nature Genetics

Volumn 15, Issue 2, 1997, Pages 146-156

  Mendez, Michael J ^b   Green, Larry L ^a   Corvalan, Jose R F ^a   Jia, Xiao Chi ^a   Yang, Xiao Dong ^a   Gallo, Michael L ^a   Louie, Donna M ^a   Lee, Doris V ^a   Erickson, Karen L ^a   Luna, Jac ^b   Roy, Catherine M N ^a   Abderrahim, Hadi ^b   Kirschenbaum, Ford ^b   Noguchi, Masato ^b   Smith, Douglas H ^b   Fukushima, Atsushi ^b   Hales, Joanna F ^a   Finer, Mitchell H ^b   Geoffrey Davis, C ^a   Zsebo, Krisztina M ^b   Jakobovits, Aya ^a   more..

^a Abgcnix Inc   (United States)

^b CELL GENESYS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN KAPPA CHAIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; GENE MUTATION; GENE REARRANGEMENT; GERM LINE; HUMORAL IMMUNITY; IMMUNOGLOBULIN GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; YEAST ARTIFICIAL CHROMOSOME;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY AFFINITY; ANTIBODY DIVERSITY; ANTIBODY FORMATION; B-LYMPHOCYTES; CHROMOSOMES, ARTIFICIAL, YEAST; GENE REARRANGEMENT, B-LYMPHOCYTE; GENES, IMMUNOGLOBULIN; HUMANS; HYBRIDOMAS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN KAPPA-CHAINS; INTERLEUKIN-8; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; RECEPTOR, EPIDERMAL GROWTH FACTOR; SPECIES SPECIFICITY; TRANSGENES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0031039315     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng0297-146     Document Type: Article

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