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Volumn 162, Issue , 1998, Pages 67-76

Recombination-based mechanisms for somatic hypermutation

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

EID: 0031944788     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-065X.1998.tb01430.x     Document Type: Review
Times cited : (15)

References (107)
  • 1
    • 0024844388 scopus 로고
    • Conformations of immunoglobulin variable regions
    • Chothia C, et al. Conformations of immunoglobulin variable regions. Nature 1989;342:877-883.
    • (1989) Nature , vol.342 , pp. 877-883
    • Chothia, C.1
  • 2
    • 0025119206 scopus 로고
    • Three-dimensional structure determination of an anti-2-phenyloxazolone antibody: The role of somatic mutation and heavy/light chain pairing in the maturation of an immune response
    • Alzari PM, et al. Three-dimensional structure determination of an anti-2-phenyloxazolone antibody: the role of somatic mutation and heavy/light chain pairing in the maturation of an immune response. EMBO J 1990;9:3807-3814.
    • (1990) EMBO J , vol.9 , pp. 3807-3814
    • Alzari, P.M.1
  • 3
    • 0030932541 scopus 로고    scopus 로고
    • Generation of antibody diversity in rabbits
    • Knight KL, Winstead CR. Generation of antibody diversity in rabbits. Curr Opin Immunol 1997;9:228-232.
    • (1997) Curr Opin Immunol , vol.9 , pp. 228-232
    • Knight, K.L.1    Winstead, C.R.2
  • 4
    • 0030052281 scopus 로고    scopus 로고
    • Rearrangement/hypermutation/gene conversion: When, where and why?
    • Weill J-C, Reynaud C-A. Rearrangement/hypermutation/gene conversion: when, where and why? Immunol Today 1996;17:92-97.
    • (1996) Immunol Today , vol.17 , pp. 92-97
    • Weill, J.-C.1    Reynaud, C.-A.2
  • 5
    • 0028818503 scopus 로고
    • Somatic hypermutation: How many mechanisms diversify V region sequences?
    • Maizels N. Somatic hypermutation: how many mechanisms diversify V region sequences? Cell 1995;83:9-12.
    • (1995) Cell , vol.83 , pp. 9-12
    • Maizels, N.1
  • 6
    • 0026060620 scopus 로고
    • Intraclonal generation of antibody mutants in germinal centres
    • Jacob J, Kelsoe G, Rajewsky K, Weiss U. Intraclonal generation of antibody mutants in germinal centres. Nature 1991;354:389-392.
    • (1991) Nature , vol.354 , pp. 389-392
    • Jacob, J.1    Kelsoe, G.2    Rajewsky, K.3    Weiss, U.4
  • 7
    • 0028005612 scopus 로고
    • From the dark zone to the light
    • MacLennan ICM. From the dark zone to the light. Curr Biol 1994;4:70-73.
    • (1994) Curr Biol , vol.4 , pp. 70-73
    • MacLennan, I.C.M.1
  • 8
    • 0028588941 scopus 로고
    • The appendix functions as a mammalian bursal equivalent in the developing rabbit
    • Weinstein PD, Mage RG, Anderson AO. The appendix functions as a mammalian bursal equivalent in the developing rabbit. Adv Exp Med Biol 1994;355:249-253.
    • (1994) Adv Exp Med Biol , vol.355 , pp. 249-253
    • Weinstein, P.D.1    Mage, R.G.2    Anderson, A.O.3
  • 9
    • 0029895262 scopus 로고    scopus 로고
    • The germinal center: A crucible for lymphocyte selection
    • Kelsoe G. The germinal center: a crucible for lymphocyte selection. Semin Immunol 1996;8:179-184.
    • (1996) Semin Immunol , vol.8 , pp. 179-184
    • Kelsoe, G.1
  • 10
    • 0019794854 scopus 로고
    • Differences between germ-line and rearranged immunoglobulin Vκ coding sequences suggest a localized mutation mechanism
    • Pech M, Hochtl J, Schnell H, Zachau HG. Differences between germ-line and rearranged immunoglobulin Vκ coding sequences suggest a localized mutation mechanism. Nature 1981;291:668-670.
    • (1981) Nature , vol.291 , pp. 668-670
    • Pech, M.1    Hochtl, J.2    Schnell, H.3    Zachau, H.G.4
  • 11
    • 0020569881 scopus 로고
    • Somatic mutations of immunoglobulin variable genes are restricted to the rearranged V gene
    • Gorski J, Rollini P, Mach B. Somatic mutations of immunoglobulin variable genes are restricted to the rearranged V gene. Science 1983;220:1179-1181.
    • (1983) Science , vol.220 , pp. 1179-1181
    • Gorski, J.1    Rollini, P.2    Mach, B.3
  • 12
    • 0020503988 scopus 로고
    • Clusters of point mutations are found exclusively around rearranged antibody variable genes
    • Gearhart PJ, Bogenhangen DF. Clusters of point mutations are found exclusively around rearranged antibody variable genes. Proc Natl Acad Sci USA 1983;80:3439-3443.
    • (1983) Proc Natl Acad Sci USA , vol.80 , pp. 3439-3443
    • Gearhart, P.J.1    Bogenhangen, D.F.2
  • 13
    • 0028270307 scopus 로고
    • Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region
    • Betz AG, Milstein C, González-Fernández A, Pannel R, Larson T, Neuberger MS. Elements regulating somatic hypermutation of an immunoglobulin κ gene: critical role for the intron enhancer/matrix attachment region. Cell 1994;77:239-248.
    • (1994) Cell , vol.77 , pp. 239-248
    • Betz, A.G.1    Milstein, C.2    González-Fernández, A.3    Pannel, R.4    Larson, T.5    Neuberger, M.S.6
  • 14
    • 0030588542 scopus 로고    scopus 로고
    • Somatic hypermutation of a λ2 transgene under control of the λ enhancer or the heavy chain intron enhancer
    • Klotz EL, Storb U. Somatic hypermutation of a λ2 transgene under control of the λ enhancer or the heavy chain intron enhancer. J Immunol 1996;157:4458-4463.
    • (1996) J Immunol , vol.157 , pp. 4458-4463
    • Klotz, E.L.1    Storb, U.2
  • 15
    • 0019847882 scopus 로고
    • Antibody diversity: Somatic hypermutation of rearranged VH genes
    • Kim S, Davis M, Sinn E, Patten P, Hood L. Antibody diversity: somatic hypermutation of rearranged VH genes. Cell 1981;17:573-581.
    • (1981) Cell , vol.17 , pp. 573-581
    • Kim, S.1    Davis, M.2    Sinn, E.3    Patten, P.4    Hood, L.5
  • 16
    • 0023161406 scopus 로고
    • Mutation drift and repertoire shift in the maturation of the immune response
    • Berek C, Milstein C. Mutation drift and repertoire shift in the maturation of the immune response. Immunol Rev 1987;96:23-41.
    • (1987) Immunol Rev , vol.96 , pp. 23-41
    • Berek, C.1    Milstein, C.2
  • 17
    • 0025148941 scopus 로고
    • Distribution of mutations around rearranged heavy-chain antibody variable-region genes
    • Both GW, Taylor L, Pollard JW, Steele EJ. Distribution of mutations around rearranged heavy-chain antibody variable-region genes. Mol Cell Biol 1990;10:5187-5196.
    • (1990) Mol Cell Biol , vol.10 , pp. 5187-5196
    • Both, G.W.1    Taylor, L.2    Pollard, J.W.3    Steele, E.J.4
  • 18
    • 0025630537 scopus 로고
    • Boundaries of somatic mutation in rearranged immunoglobulin genes: 5′ boundary is near the promoter, and 3′ boundary is approximately 1 kb from V(D)J gene
    • Lebecque SG, Gearhart PJ. Boundaries of somatic mutation in rearranged immunoglobulin genes: 5′ boundary is near the promoter, and 3′ boundary is approximately 1 kb from V(D)J gene. J Exp Med 1990;172:1717-1727.
    • (1990) J Exp Med , vol.172 , pp. 1717-1727
    • Lebecque, S.G.1    Gearhart, P.J.2
  • 19
    • 0025188821 scopus 로고
    • The BALB/c secondary response to the Sb site of influenza virus hemagglutinin
    • Clarke S, Rickert R, Wloch MK, Staudt L, Gerhard W, Weigert M. The BALB/c secondary response to the Sb site of influenza virus hemagglutinin. J Immunol 1990;145:2286-2296.
    • (1990) J Immunol , vol.145 , pp. 2286-2296
    • Clarke, S.1    Rickert, R.2    Wloch, M.K.3    Staudt, L.4    Gerhard, W.5    Weigert, M.6
  • 20
    • 0027194781 scopus 로고
    • Somatic hypermutation in 5′ flanking regions of heavy chain antibody variable regions
    • Rothenfluh HS, Taylor L, Bothwell ALM, Both GW, Steele EJ. Somatic hypermutation in 5′ flanking regions of heavy chain antibody variable regions. Eur J Immunol 1993;23:2152-2159.
    • (1993) Eur J Immunol , vol.23 , pp. 2152-2159
    • Rothenfluh, H.S.1    Taylor, L.2    Bothwell, A.L.M.3    Both, G.W.4    Steele, E.J.5
  • 21
    • 0028063853 scopus 로고
    • Comparison of somatic mutation frequency among immunoglobulin genes
    • Motoyama N, Miwa T, Suzuki Y, Okada H, Azuma T. Comparison of somatic mutation frequency among immunoglobulin genes. J Exp Med 1994;179:395-403.
    • (1994) J Exp Med , vol.179 , pp. 395-403
    • Motoyama, N.1    Miwa, T.2    Suzuki, Y.3    Okada, H.4    Azuma, T.5
  • 22
    • 0028577994 scopus 로고
    • Somatic mutation of immunoglobulin lambda chains: A segment of the major intron hypermutates as much as the complementarity-determining regions
    • Gonzalez-Fernández A, Gupta SK, Pannell R, Neuberger MS, Milstein C. Somatic mutation of immunoglobulin lambda chains: a segment of the major intron hypermutates as much as the complementarity-determining regions. Proc Natl Acad Sci USA 1994;91:12614-12618.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 12614-12618
    • Gonzalez-Fernández, A.1    Gupta, S.K.2    Pannell, R.3    Neuberger, M.S.4    Milstein, C.5
  • 23
    • 0028243803 scopus 로고
    • The 5′ boundary of somatic hypermutation in a V kappa gene is in the leader intron
    • Rada C, González-Fernández A, Jarvis JM, Milstein C. The 5′ boundary of somatic hypermutation in a V kappa gene is in the leader intron. Eur J Immunol 1994;24:1453-1457.
    • (1994) Eur J Immunol , vol.24 , pp. 1453-1457
    • Rada, C.1    González-Fernández, A.2    Jarvis, J.M.3    Milstein, C.4
  • 24
    • 0028125606 scopus 로고
    • Mapping the upstream boundary of somatic mutations in rearranged immunoglobulin transgenes and endogenous genes
    • Rogerson B. Mapping the upstream boundary of somatic mutations in rearranged immunoglobulin transgenes and endogenous genes. Mol Immunol 1994;31:83-98.
    • (1994) Mol Immunol , vol.31 , pp. 83-98
    • Rogerson, B.1
  • 25
    • 0028128577 scopus 로고
    • Development of antibody diversity in single germinal centers: Selective expansion of high-affinity variants
    • Ziegner M, Steinhauser G, Berek C. Development of antibody diversity in single germinal centers: selective expansion of high-affinity variants. Eur J Immunol 1994;24:2393-2400.
    • (1994) Eur J Immunol , vol.24 , pp. 2393-2400
    • Ziegner, M.1    Steinhauser, G.2    Berek, C.3
  • 26
    • 0028177913 scopus 로고
    • A λ1 transgene under the control of the heavy chain promoter and enhancer does not undergo somatic hypermutation
    • Hengstschläger M, Williams M, Maizels N. A λ1 transgene under the control of the heavy chain promoter and enhancer does not undergo somatic hypermutation. Eur J Immunol 1994;24:1649-1656.
    • (1994) Eur J Immunol , vol.24 , pp. 1649-1656
    • Hengstschläger, M.1    Williams, M.2    Maizels, N.3
  • 27
    • 0029067875 scopus 로고
    • Targeting of non-Ig sequences in place of the V segment by somatic hypermutation
    • Yelamos J, et al. Targeting of non-Ig sequences in place of the V segment by somatic hypermutation. Nature 1995;376:225-229.
    • (1995) Nature , vol.376 , pp. 225-229
    • Yelamos, J.1
  • 28
    • 0027499308 scopus 로고
    • Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: Clustering, polarity, and specific hot spots
    • Betz AG, Rada C, Pannell R, Milstein C, Neuberger MS. Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots. Proc Natl Acad Sci USA 1993;90:2385-2388.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 2385-2388
    • Betz, A.G.1    Rada, C.2    Pannell, R.3    Milstein, C.4    Neuberger, M.S.5
  • 29
    • 0027227311 scopus 로고
    • Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes
    • Betz AG, Neuberger MS, Milstein C. Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes. Immunol Today 1993;14:405-411.
    • (1993) Immunol Today , vol.14 , pp. 405-411
    • Betz, A.G.1    Neuberger, M.S.2    Milstein, C.3
  • 30
    • 0029872907 scopus 로고    scopus 로고
    • Somatic hypermutation of immunoglobulin genes
    • Wagner SD, Neuberger MS. Somatic hypermutation of immunoglobulin genes. Annu Rev Immunol 1996;14:441-457.
    • (1996) Annu Rev Immunol , vol.14 , pp. 441-457
    • Wagner, S.D.1    Neuberger, M.S.2
  • 31
    • 0000590741 scopus 로고
    • Genes and antibodies
    • Lederberg J. Genes and antibodies. Science 1959;129:1649-1653.
    • (1959) Science , vol.129 , pp. 1649-1653
    • Lederberg, J.1
  • 32
    • 0014019617 scopus 로고
    • Origin of antibody variation
    • Brenner S, Milstein C. Origin of antibody variation. Nature 1966;211:242-243.
    • (1966) Nature , vol.211 , pp. 242-243
    • Brenner, S.1    Milstein, C.2
  • 33
    • 0019391404 scopus 로고
    • H gene product encodes the immune response to phosphorylcholine: Somatic mutation is correlated with the class of the antibody
    • H gene product encodes the immune response to phosphorylcholine: somatic mutation is correlated with the class of the antibody. Cell 1981;25:59-66.
    • (1981) Cell , vol.25 , pp. 59-66
    • Crews, S.1    Griffin, J.2    Huang, H.3    Calame, K.4    Hood, L.5
  • 35
    • 0024320369 scopus 로고
    • Analysis of fidelity mechanisms with eukaryotic DNA replication and repair proteins
    • Kunkel TA, Bebenek K, Roberts JD, Fitzgerald MP, Thomas DC. Analysis of fidelity mechanisms with eukaryotic DNA replication and repair proteins. Genome 1989;31:100-103.
    • (1989) Genome , vol.31 , pp. 100-103
    • Kunkel, T.A.1    Bebenek, K.2    Roberts, J.D.3    Fitzgerald, M.P.4    Thomas, D.C.5
  • 36
    • 0001078874 scopus 로고    scopus 로고
    • The SOS response in Escherichia coli
    • Neidhardt FC, Curtiss III R, Ingraham JL, eds. Washington (DC): American Society for Microbiology Press
    • Walker GC. The SOS response in Escherichia coli. In: Neidhardt FC, Curtiss III R, Ingraham JL, eds. Escherichia coli and Salmonella: cellular and molecular biology. 2nd ed. Washington (DC): American Society for Microbiology Press; 1996. p. 1400-1416.
    • (1996) Escherichia Coli and Salmonella: Cellular and Molecular Biology. 2nd Ed. , pp. 1400-1416
    • Walker, G.C.1
  • 37
    • 0029916565 scopus 로고    scopus 로고
    • Substitution of mucAB or rumAB for umuDC alters the relative frequencies of the two classes of mutations induced by a site-specific T-T cyclobutane dimer and the efficiency of translesion DNA synthesis
    • Szekeres ES, Woodgate R, Lawrence CW. Substitution of mucAB or rumAB for umuDC alters the relative frequencies of the two classes of mutations induced by a site-specific T-T cyclobutane dimer and the efficiency of translesion DNA synthesis. J Bacteriol 1996;178:2559-2563.
    • (1996) J Bacteriol , vol.178 , pp. 2559-2563
    • Szekeres, E.S.1    Woodgate, R.2    Lawrence, C.W.3
  • 38
    • 0030018123 scopus 로고    scopus 로고
    • Analysis of the mutagenic properties of the UmuDC, MucAB and RumAB proteins, using a site specific abasic lesion
    • Lawrence CW, Borden A, Woodgate R. Analysis of the mutagenic properties of the UmuDC, MucAB and RumAB proteins, using a site specific abasic lesion. Mol Gen Genet 1996;251:493-498.
    • (1996) Mol Gen Genet , vol.251 , pp. 493-498
    • Lawrence, C.W.1    Borden, A.2    Woodgate, R.3
  • 39
    • 0024437947 scopus 로고
    • The extreme mutator effect of Escherichia coli mutD5 results from saturation of mismatch repair by excessive DNA replication errors
    • Schaaper RM, Radman M. The extreme mutator effect of Escherichia coli mutD5 results from saturation of mismatch repair by excessive DNA replication errors. EMBO J 1989;8:3511-3516.
    • (1989) EMBO J , vol.8 , pp. 3511-3516
    • Schaaper, R.M.1    Radman, M.2
  • 41
    • 0026060520 scopus 로고
    • Mutation pattern of immunoglobulin transgenes is compatible with a model of somatic hypermutation in which targeting of the mutator is linked to the direction of DNA replication
    • Rogerson B, Hackett JJ, Peters A, Haasch D, Storb U. Mutation pattern of immunoglobulin transgenes is compatible with a model of somatic hypermutation in which targeting of the mutator is linked to the direction of DNA replication. EMBO J 1991;10:4331-4341.
    • (1991) EMBO J , vol.10 , pp. 4331-4341
    • Rogerson, B.1    Hackett, J.J.2    Peters, A.3    Haasch, D.4    Storb, U.5
  • 42
    • 0029996999 scopus 로고    scopus 로고
    • Characterization of the cis-acting elements required for somatic hypermutation of murine antibody V genes using conventional transgenic and transgene homologous recombination approaches
    • Tumas-Brundage K, Vora KA, Giusti AM, Manser T. Characterization of the cis-acting elements required for somatic hypermutation of murine antibody V genes using conventional transgenic and transgene homologous recombination approaches. Semin Immunol 1996;8:141-150.
    • (1996) Semin Immunol , vol.8 , pp. 141-150
    • Tumas-Brundage, K.1    Vora, K.A.2    Giusti, A.M.3    Manser, T.4
  • 44
    • 0030863389 scopus 로고    scopus 로고
    • Evaluation of the role of the 3′ alpha heavy chain enhancer
    • Tumas-Brundage KM, Vora KA, Manser T. Evaluation of the role of the 3′ alpha heavy chain enhancer. Mol Immunol 1997;34:367-378.
    • (1997) Mol Immunol , vol.34 , pp. 367-378
    • Tumas-Brundage, K.M.1    Vora, K.A.2    Manser, T.3
  • 45
    • 0030063726 scopus 로고    scopus 로고
    • Somatic hypermutation of immunoglobulin genes is linked to transcription initiation
    • Peters A, Storb U. Somatic hypermutation of immunoglobulin genes is linked to transcription initiation. Immunity 1996;4:57-65.
    • (1996) Immunity , vol.4 , pp. 57-65
    • Peters, A.1    Storb, U.2
  • 46
    • 0030450401 scopus 로고    scopus 로고
    • Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation
    • Goyenechea B, Milstein C. Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation. Proc Natl Acad Sci USA 1997;93:13979-13984.
    • (1997) Proc Natl Acad Sci USA , vol.93 , pp. 13979-13984
    • Goyenechea, B.1    Milstein, C.2
  • 47
    • 0029927054 scopus 로고    scopus 로고
    • The mechanism of somatic hypermutation studied with transgenic and transfected target genes
    • Storb U, Peters A, Klotz E, Rogerson B, Hackett J. The mechanism of somatic hypermutation studied with transgenic and transfected target genes. Semin Immunol 1996;8:131-140.
    • (1996) Semin Immunol , vol.8 , pp. 131-140
    • Storb, U.1    Peters, A.2    Klotz, E.3    Rogerson, B.4    Hackett, J.5
  • 48
    • 0028282580 scopus 로고
    • Where transcription meets repair
    • Drapkin R, Sancar A, Reinberg D. Where transcription meets repair. Cell 1994;77:9-12.
    • (1994) Cell , vol.77 , pp. 9-12
    • Drapkin, R.1    Sancar, A.2    Reinberg, D.3
  • 49
    • 0030013201 scopus 로고    scopus 로고
    • Relationships between DNA repair and transcription
    • Friedberg EC. Relationships between DNA repair and transcription. Annu Rev Biochem 1996;65:15-42.
    • (1996) Annu Rev Biochem , vol.65 , pp. 15-42
    • Friedberg, E.C.1
  • 50
    • 0030761761 scopus 로고    scopus 로고
    • B lymphocytes of xeroderma pigmentosum or Cockayne syndrome patients with inherited defects in nucleotide excision repair are fully capable of somatic hypermutation of immunoglobulin genes
    • Kim N, Kage K, Matsuda F, Lefranc MP, Storb U. B lymphocytes of xeroderma pigmentosum or Cockayne syndrome patients with inherited defects in nucleotide excision repair are fully capable of somatic hypermutation of immunoglobulin genes. J Exp Med 1997;186:413-419.
    • (1997) J Exp Med , vol.186 , pp. 413-419
    • Kim, N.1    Kage, K.2    Matsuda, F.3    Lefranc, M.P.4    Storb, U.5
  • 51
    • 0000542120 scopus 로고    scopus 로고
    • The inactivation of the XP-C gene does not affect somatic hypermutation or class switch recombination of immunoglobulin genes
    • Shen HM, Cheo DL, Friedberg E, Storb U. The inactivation of the XP-C gene does not affect somatic hypermutation or class switch recombination of immunoglobulin genes. Mol Immunol 1997;34:527-533.
    • (1997) Mol Immunol , vol.34 , pp. 527-533
    • Shen, H.M.1    Cheo, D.L.2    Friedberg, E.3    Storb, U.4
  • 52
    • 0031047442 scopus 로고    scopus 로고
    • Mechanism of antigen-driven somatic hypermutation of rearranged immunoglobulin V(D)J genes in the mouse
    • Steele EJ, Rothenfluh HS, Blanden RV. Mechanism of antigen-driven somatic hypermutation of rearranged immunoglobulin V(D)J genes in the mouse. Immunol Cell Biol 1997;75:82-95.
    • (1997) Immunol Cell Biol , vol.75 , pp. 82-95
    • Steele, E.J.1    Rothenfluh, H.S.2    Blanden, R.V.3
  • 53
    • 0023267995 scopus 로고
    • Hypothesis: Somatic hypermutation by gene conversion via the error prone DNA - RNA - DNA information loop
    • Steele EJ, Pollard JW. Hypothesis: somatic hypermutation by gene conversion via the error prone DNA - RNA - DNA information loop. Mol Immunol 1987;24:667-673.
    • (1987) Mol Immunol , vol.24 , pp. 667-673
    • Steele, E.J.1    Pollard, J.W.2
  • 54
    • 0012595279 scopus 로고
    • Somatic recombination of duplicated genes: An hypothesis on the origin of antibody diversity
    • Edelman GM, Gally JA. Somatic recombination of duplicated genes: an hypothesis on the origin of antibody diversity. Proc Natl Acad Sci USA 1967;57:353-358.
    • (1967) Proc Natl Acad Sci USA , vol.57 , pp. 353-358
    • Edelman, G.M.1    Gally, J.A.2
  • 55
    • 0042719601 scopus 로고
    • The genetic basis of antibody variability
    • Smithies O. The genetic basis of antibody variability. Cold Spring Harb Symp Quant Biol 1967;32:161-168.
    • (1967) Cold Spring Harb Symp Quant Biol , vol.32 , pp. 161-168
    • Smithies, O.1
  • 56
    • 0014213154 scopus 로고
    • Antibody variability
    • Smithies O. Antibody variability. Science 1967;157:267-273.
    • (1967) Science , vol.157 , pp. 267-273
    • Smithies, O.1
  • 58
    • 0019830478 scopus 로고
    • Gene conversion: Some implications for immunoglobulin genes
    • Baltimore D. Gene conversion: some implications for immunoglobulin genes. Cell 1981;24:592-594.
    • (1981) Cell , vol.24 , pp. 592-594
    • Baltimore, D.1
  • 59
    • 0018251442 scopus 로고
    • Sequences of mouse immunoglobulin light chain genes before and after somatic changes
    • Bernard O, Hozumi N, Tonegawa S. Sequences of mouse immunoglobulin light chain genes before and after somatic changes. Cell 1978;15:1133-1144.
    • (1978) Cell , vol.15 , pp. 1133-1144
    • Bernard, O.1    Hozumi, N.2    Tonegawa, S.3
  • 60
    • 0023899334 scopus 로고
    • Point mutations cause the somatic diversification of IgM and IgG2a antiphosphorylcholine antibodies
    • Chien NC, Pollock RR, Desaymard C, Scharff MD. Point mutations cause the somatic diversification of IgM and IgG2a antiphosphorylcholine antibodies. J Exp Med 1988;167:954-973.
    • (1988) J Exp Med , vol.167 , pp. 954-973
    • Chien, N.C.1    Pollock, R.R.2    Desaymard, C.3    Scharff, M.D.4
  • 61
    • 0024315266 scopus 로고
    • Gene conversion and the generation of antibody diversity
    • Wysocki LJ, Gefter ML. Gene conversion and the generation of antibody diversity. Annu Rev Biochem 1989;58:509-531.
    • (1989) Annu Rev Biochem , vol.58 , pp. 509-531
    • Wysocki, L.J.1    Gefter, M.L.2
  • 62
    • 0024551797 scopus 로고
    • Might gene conversion be the mechanism of somatic hypermutation of mammalian immunoglobulin genes?
    • Maizels N. Might gene conversion be the mechanism of somatic hypermutation of mammalian immunoglobulin genes? Trends Genet 1989;5:4-8.
    • (1989) Trends Genet , vol.5 , pp. 4-8
    • Maizels, N.1
  • 63
    • 0023043553 scopus 로고
    • Introduction of homologous DNA sequences into mammalian cells induces mutations in the cognate gene
    • Thomas KR, Capecchi MR. Introduction of homologous DNA sequences into mammalian cells induces mutations in the cognate gene. Nature 1986;324:34-38.
    • (1986) Nature , vol.324 , pp. 34-38
    • Thomas, K.R.1    Capecchi, M.R.2
  • 64
    • 0023652339 scopus 로고
    • A hyperconversion mechanism generates the chicken light chain preimmune repertoire
    • Reynaud C-A, Anquez V, Grimal H, Weill J-C. A hyperconversion mechanism generates the chicken light chain preimmune repertoire. Cell 1987;48:379-388.
    • (1987) Cell , vol.48 , pp. 379-388
    • Reynaud, C.-A.1    Anquez, V.2    Grimal, H.3    Weill, J.-C.4
  • 66
    • 0026712363 scopus 로고
    • Germ line variable regions that match hypermutated sequences in genes encoding murine anti-hapten antibodies
    • David V, Folk NL, Maizels N. Germ line variable regions that match hypermutated sequences in genes encoding murine anti-hapten antibodies. Genetics 1992;132:799-811.
    • (1992) Genetics , vol.132 , pp. 799-811
    • David, V.1    Folk, N.L.2    Maizels, N.3
  • 67
    • 0027358578 scopus 로고
    • Preimmune diversification creates a repertoire while somatic hypermutation fine-tunes affinity - Implications for the processes of mutation
    • Maizels N. Preimmune diversification creates a repertoire while somatic hypermutation fine-tunes affinity - implications for the processes of mutation. Res Immunol 1993;144:459-463.
    • (1993) Res Immunol , vol.144 , pp. 459-463
    • Maizels, N.1
  • 68
    • 0028025489 scopus 로고
    • Analysis of sequence transfers resembling gene conversion in a mouse antibody transgene
    • Xu B, Selsing E. Analysis of sequence transfers resembling gene conversion in a mouse antibody transgene. Science 1994;265:1590-1593.
    • (1994) Science , vol.265 , pp. 1590-1593
    • Xu, B.1    Selsing, E.2
  • 69
    • 0029938761 scopus 로고    scopus 로고
    • Gene conversion and homologous recombination in murine B cells
    • Selsing E, Xu B. Sigurdardottir D. Gene conversion and homologous recombination in murine B cells. Semin Immunol 1996;8:151-158.
    • (1996) Semin Immunol , vol.8 , pp. 151-158
    • Selsing, E.1    Xu, B.2    Sigurdardottir, D.3
  • 70
    • 0020213475 scopus 로고
    • Homothallic switching of yeast mating type cassettes is initiated by a double-stranded cut in the MAT locus
    • Strathern JN, et al. Homothallic switching of yeast mating type cassettes is initiated by a double-stranded cut in the MAT locus. Cell 1982;31:183-192.
    • (1982) Cell , vol.31 , pp. 183-192
    • Strathern, J.N.1
  • 71
    • 0019136287 scopus 로고
    • Evidence for a physical interaction between the transposed and the substituted sequences during mating type gene transposition in yeast
    • Klar AJS, McIndoo J, Strathern HN, Hicks JB. Evidence for a physical interaction between the transposed and the substituted sequences during mating type gene transposition in yeast. Cell 1980;22:291-298.
    • (1980) Cell , vol.22 , pp. 291-298
    • Klar, A.J.S.1    McIndoo, J.2    Strathern, H.N.3    Hicks, J.B.4
  • 72
    • 0017642791 scopus 로고
    • Idiotypic analysis of the response of C57BL/6 mice to the (4-hydroxy-5-bromo-3-nitrophenyl) acetyl group
    • Jack RS, Imanishi-Kari T, Rajewsky K. Idiotypic analysis of the response of C57BL/6 mice to the (4-hydroxy-5-bromo-3-nitrophenyl) acetyl group. Eur J Immunol 1977;7:559-565.
    • (1977) Eur J Immunol , vol.7 , pp. 559-565
    • Jack, R.S.1    Imanishi-Kari, T.2    Rajewsky, K.3
  • 73
    • 0018179467 scopus 로고
    • Analysis of the repertoire of anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibodies in C57BL/6 mice by cell fusion. I. Characterization of antibody families in the primary and hyperimmune response
    • Reth M, Hammerling GJ, Rajewsky K. Analysis of the repertoire of anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibodies in C57BL/6 mice by cell fusion. I. Characterization of antibody families in the primary and hyperimmune response. Eur J Immunol 1978;8:393-400.
    • (1978) Eur J Immunol , vol.8 , pp. 393-400
    • Reth, M.1    Hammerling, G.J.2    Rajewsky, K.3
  • 74
    • 0019442186 scopus 로고
    • Heavy chain variable region contribution to the NPb family of antibodies: Somatic mutation evident in a γ2a variable region
    • Bothwell ALM, Paskind M, Reth M, Imanishi-Kari T, Rajewsky K, Baltimore D. Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a γ2a variable region. Cell 1981;24:625-637.
    • (1981) Cell , vol.24 , pp. 625-637
    • Bothwell, A.L.M.1    Paskind, M.2    Reth, M.3    Imanishi-Kari, T.4    Rajewsky, K.5    Baltimore, D.6
  • 75
    • 0029833006 scopus 로고    scopus 로고
    • Rad51 expression and localization in B cells carrying out heavy chain class switch recombination
    • Li M-J, et al. Rad51 expression and localization in B cells carrying out heavy chain class switch recombination. Proc Natl Acad Sci USA 1996;93:10222-10227.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 10222-10227
    • Li, M.-J.1
  • 76
    • 0031586614 scopus 로고    scopus 로고
    • Nuclear Rad51 foci induced by DNA damage are distinct from Rad51 foci associated with B cell activation and recombination
    • Li MJ, Maizels N. Nuclear Rad51 foci induced by DNA damage are distinct from Rad51 foci associated with B cell activation and recombination. Exp Cell Res 1997;237:93-100.
    • (1997) Exp Cell Res , vol.237 , pp. 93-100
    • Li, M.J.1    Maizels, N.2
  • 77
    • 0029987450 scopus 로고    scopus 로고
    • Targeted disruption of the Rad51 gene leads to lethality in embryonic mice
    • Tsuzuki T, et al. Targeted disruption of the Rad51 gene leads to lethality in embryonic mice. Proc Natl Acad Sci USA 1996;93:6236-6240.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 6236-6240
    • Tsuzuki, T.1
  • 78
    • 0028879965 scopus 로고
    • Homologous recombination and the roles of double-strand breaks
    • Shinohara A, Ogawa T. Homologous recombination and the roles of double-strand breaks. Trends Biochem Sci 1995;20:387-390.
    • (1995) Trends Biochem Sci , vol.20 , pp. 387-390
    • Shinohara, A.1    Ogawa, T.2
  • 79
    • 0029900078 scopus 로고    scopus 로고
    • Role of recombination enzymes in mammalian cell survival
    • Edelmann W, Kucherlapati R. Role of recombination enzymes in mammalian cell survival. Proc Natl Acad Sci USA 1996;93:6225-6227.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 6225-6227
    • Edelmann, W.1    Kucherlapati, R.2
  • 81
    • 0029943449 scopus 로고    scopus 로고
    • Mismatch repair in replication fidelity, genetic recombination, and cancer biology
    • Modrich P, Lahue R. Mismatch repair in replication fidelity, genetic recombination, and cancer biology. Annu Rev Biochem 1996;65:101-133.
    • (1996) Annu Rev Biochem , vol.65 , pp. 101-133
    • Modrich, P.1    Lahue, R.2
  • 82
    • 0029784320 scopus 로고    scopus 로고
    • Biochemistry and genetics of eukaryotic mismatch repair
    • Kolodner RD. Biochemistry and genetics of eukaryotic mismatch repair. Genes Dev 1996;10:1433-1442.
    • (1996) Genes Dev , vol.10 , pp. 1433-1442
    • Kolodner, R.D.1
  • 83
    • 0031554275 scopus 로고    scopus 로고
    • Hypermutation under stress
    • Bridges BA. Hypermutation under stress. Nature 1997;387:557-558.
    • (1997) Nature , vol.387 , pp. 557-558
    • Bridges, B.A.1
  • 85
    • 0030924613 scopus 로고    scopus 로고
    • Genome-wide hypermutation in a subpopulation of stationary-phase cells underlies recombination-dependent adaptive mutation
    • Torkelson J, Harris RS, Lombardo M-J, Nagendran J, Thulin C, Rosenberg SM. Genome-wide hypermutation in a subpopulation of stationary-phase cells underlies recombination-dependent adaptive mutation. EMBO J 1997;16:3303-3311.
    • (1997) EMBO J , vol.16 , pp. 3303-3311
    • Torkelson, J.1    Harris, R.S.2    Lombardo, M.-J.3    Nagendran, J.4    Thulin, C.5    Rosenberg, S.M.6
  • 86
    • 0031046575 scopus 로고    scopus 로고
    • Nonadaptive mutations occur on the F′ episome during adaptive mutation conditions in Escherichia coli
    • Foster PL. Nonadaptive mutations occur on the F′ episome during adaptive mutation conditions in Escherichia coli. J Bacteriol 1997;179:1550-1554.
    • (1997) J Bacteriol , vol.179 , pp. 1550-1554
    • Foster, P.L.1
  • 87
    • 0026094779 scopus 로고
    • Adaptive reversion of a frameshift mutation in Escherichia coli
    • Cairns J, Foster PL. Adaptive reversion of a frameshift mutation in Escherichia coli. Genetics 1991;128:695-701.
    • (1991) Genetics , vol.128 , pp. 695-701
    • Cairns, J.1    Foster, P.L.2
  • 89
    • 0030000945 scopus 로고    scopus 로고
    • Opposing roles of the Holliday junction processing systems of Escherichia coli in recombination-dependent adaptive mutation
    • Harris RS, Ross KJ, Rosenberg SM. Opposing roles of the Holliday junction processing systems of Escherichia coli in recombination-dependent adaptive mutation. Genetics 1996;142:681-691.
    • (1996) Genetics , vol.142 , pp. 681-691
    • Harris, R.S.1    Ross, K.J.2    Rosenberg, S.M.3
  • 90
    • 0030051842 scopus 로고    scopus 로고
    • Two enzymes, both of which process recombination intermediates, have opposite effects on adaptive mutation in Escherichia coli
    • Foster PL, Trimarchi JM, Maurer RA. Two enzymes, both of which process recombination intermediates, have opposite effects on adaptive mutation in Escherichia coli. Genetics 1996;142:25-37.
    • (1996) Genetics , vol.142 , pp. 25-37
    • Foster, P.L.1    Trimarchi, J.M.2    Maurer, R.A.3
  • 92
    • 0028566106 scopus 로고
    • χ and RecBCD enzyme of Escherichia coli
    • Myers RS, Stahl FW. χ and RecBCD enzyme of Escherichia coli. Annu Rev Genet 1994;28:49-70.
    • (1994) Annu Rev Genet , vol.28 , pp. 49-70
    • Myers, R.S.1    Stahl, F.W.2
  • 93
    • 0025905608 scopus 로고
    • The split-end model for homologous recombination at double-strand breaks and at Chi
    • Rosenberg SM, Hastings PJ. The split-end model for homologous recombination at double-strand breaks and at Chi. Biochimie 1991;73:385-397.
    • (1991) Biochimie , vol.73 , pp. 385-397
    • Rosenberg, S.M.1    Hastings, P.J.2
  • 94
    • 0027938589 scopus 로고
    • Adaptive reversion of a frameshift mutation in Escherichia coli by simple base deletions in homopolymeric runs
    • Foster PL, Trimarchi JM. Adaptive reversion of a frameshift mutation in Escherichia coli by simple base deletions in homopolymeric runs. Science 1994;265:407-409.
    • (1994) Science , vol.265 , pp. 407-409
    • Foster, P.L.1    Trimarchi, J.M.2
  • 95
    • 0027941501 scopus 로고
    • Adaptive mutation by deletions in small mononucleotide repeats
    • Rosenberg SM, Longerich S, Gee P, Harris RS. Adaptive mutation by deletions in small mononucleotide repeats. Science 1994;265:405-407.
    • (1994) Science , vol.265 , pp. 405-407
    • Rosenberg, S.M.1    Longerich, S.2    Gee, P.3    Harris, R.S.4
  • 96
    • 0025630591 scopus 로고
    • Frameshift mutation: Determinants of specificity
    • Ripley LS. Frameshift mutation: determinants of specificity. Annu Rev Genet 1990;24:189-213.
    • (1990) Annu Rev Genet , vol.24 , pp. 189-213
    • Ripley, L.S.1
  • 97
    • 0030988977 scopus 로고    scopus 로고
    • A direct role for DNA polymerase III in adaptive reversion of a frameshift mutation in Escherichia coli
    • Harris RS, Bull HJ, Rosenberg SM. A direct role for DNA polymerase III in adaptive reversion of a frameshift mutation in Escherichia coli. Mutat Res 1997;375:19-24.
    • (1997) Mutat Res , vol.375 , pp. 19-24
    • Harris, R.S.1    Bull, H.J.2    Rosenberg, S.M.3
  • 99
    • 0030987686 scopus 로고    scopus 로고
    • Mismatch repair protein MutL becomes limiting during stationary-phase mutation
    • Harris RS, et al. Mismatch repair protein MutL becomes limiting during stationary-phase mutation. Genes Dev 1997;11:2426-2437.
    • (1997) Genes Dev , vol.11 , pp. 2426-2437
    • Harris, R.S.1
  • 100
    • 0030582673 scopus 로고    scopus 로고
    • Meiotic recombination in yeast: Coronation of the double-strand break repair model
    • Stahl R. Meiotic recombination in yeast: coronation of the double-strand break repair model. Cell 1996;87:965-968.
    • (1996) Cell , vol.87 , pp. 965-968
    • Stahl, R.1
  • 101
    • 0029024834 scopus 로고
    • DNA synthesis errors associated with double-strand-break repair
    • Strathern JN, Shafer BK, McGill CB. DNA synthesis errors associated with double-strand-break repair. Genetics 1995;140:965-972.
    • (1995) Genetics , vol.140 , pp. 965-972
    • Strathern, J.N.1    Shafer, B.K.2    McGill, C.B.3
  • 102
    • 0030700468 scopus 로고    scopus 로고
    • A role for REV3 in mutagenesis during double-strand break repair in Saccharomyces cerevisiae
    • Holbeck SL, Strathern JN. A role for REV3 in mutagenesis during double-strand break repair in Saccharomyces cerevisiae. Genetics 1997;147:1017-1024.
    • (1997) Genetics , vol.147 , pp. 1017-1024
    • Holbeck, S.L.1    Strathern, J.N.2
  • 104
    • 0024469392 scopus 로고
    • The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatch repair mutants
    • Rayssiguier C, Thaler DS, Radman M. The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatch repair mutants. Nature 1989;342:396-401.
    • (1989) Nature , vol.342 , pp. 396-401
    • Rayssiguier, C.1    Thaler, D.S.2    Radman, M.3
  • 105
    • 0040746316 scopus 로고
    • Gene conversion
    • Roitt IM, Delves PJ, eds. San Diego (CA): Academic Press
    • Hastings PJ, Rosenberg SM. Gene conversion. In: Roitt IM, Delves PJ, eds. Encyclopedia of immunology. San Diego (CA): Academic Press; 1992. p. 602-605.
    • (1992) Encyclopedia of Immunology , pp. 602-605
    • Hastings, P.J.1    Rosenberg, S.M.2
  • 106
    • 8944232867 scopus 로고    scopus 로고
    • Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over
    • Baker SM, et al. Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over. Nat Genet 1996;13:336-342.
    • (1996) Nat Genet , vol.13 , pp. 336-342
    • Baker, S.M.1
  • 107
    • 0030965212 scopus 로고    scopus 로고
    • Elevated levels of mutation in multiple tissues of mice deficient in the DNA mismatch repair gene Pms2
    • Narayanan L, Fritzell JA, Baker SM, Liskay RM, Glazer PM. Elevated levels of mutation in multiple tissues of mice deficient in the DNA mismatch repair gene Pms2. Proc Natl Acad Sci USA 1997;294:3122-3127.
    • (1997) Proc Natl Acad Sci USA , vol.294 , pp. 3122-3127
    • Narayanan, L.1    Fritzell, J.A.2    Baker, S.M.3    Liskay, R.M.4    Glazer, P.M.5


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