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of outstanding interest. This paper provides the first molecular evidence that very little B-lymphopoiesis is occurring in the adult rabbit. The authors showed that in eight week old rabbits, essentially all V(D)J genes in both peripheral B cells and bone marrow cells are highly somatically diversified. Further, by searching for V-D and D-J recombination circles, the authors found little evidence for ongoing V-D and D-J recombination in the bone marrow of adult rabbits, indicating little if any B lymphopoiesis occurs in adult rabbit.
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of outstanding interest Crane MA, Kingzette M, Knight KL. Evidence for limited B-lymphopoiesis in adult rabbits. J Exp Med. 183:1996;2119-2127 This paper provides the first molecular evidence that very little B-lymphopoiesis is occurring in the adult rabbit. The authors showed that in eight week old rabbits, essentially all V(D)J genes in both peripheral B cells and bone marrow cells are highly somatically diversified. Further, by searching for V-D and D-J recombination circles, the authors found little evidence for ongoing V-D and D-J recombination in the bone marrow of adult rabbits, indicating little if any B lymphopoiesis occurs in adult rabbit.
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H allotype were proliferating more than those which did not express this allotype, whereas allotype-negative B cells were undergoing more apoptosis, suggesting that selection based on allotypic differences was occurring in the young rabbit appendix.
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