Selective and Combined Neurokinin Receptor Antagonists

Progress in Medicinal Chemistry

Volumn 43, Issue C, 2005, Pages 49-103

  Gerspacher, Marc ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROKININ A; NEUROKININ B; SUBSTANCE P; TACHYKININ RECEPTOR;

ANIMAL; CENTRAL NERVOUS SYSTEM DISEASE; DRUG ANTAGONISM; DRUG COMBINATION; GASTROINTESTINAL DISEASE; HUMAN; LUNG DISEASE; METABOLISM; PAIN; REVIEW; URINARY TRACT DISEASE; VOMITING;

ANIMALS; CENTRAL NERVOUS SYSTEM DISEASES; DRUG COMBINATIONS; GASTROINTESTINAL DISEASES; HUMANS; LUNG DISEASES; NEUROKININ A; NEUROKININ B; PAIN; RECEPTORS, TACHYKININ; SUBSTANCE P; UROLOGIC DISEASES; VOMITING;

EID: 27744568987     PISSN: 00796468     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0079-6468(05)43003-9     Document Type: Review

References (155)

1. Maggio J.E., and Mantyh P.W. History of tachykinin peptides. In: Buck S.H. (Ed). The Tachykinin Receptors (1994), Humana, Totowa 1-21
2. Regoli D., Boudon A., and Fauchére J.-L. Pharmacol. Rev. 46 (1994) 551-599
3. Maggi C.A., Patacchini R., Rovero P., and Giachetti A. J. Auton. Pharmacol. 13 (1993) 23-93
4. Maggi C.A. Gen. Pharmacol. 26 (1995) 911-944
5. Zhang Y., Lu L., Furlonger C., Wu G.E., and Paige C.J. Nat. Immunol. 1 (2000) 392-397
6. Morteau O., Lu B., Gerard C., and Gerard N.P. Nat. Immunol. 2 (2001) 1088
7. Bellucci F., Carini F., Catalani C., Cucchi P., Lecci A., Meini S., Patacchini R., Quartara L., Ricci R., Tramontana M., Giuliani S., and Maggi C.A. Brit. J. Pharmacol. 135 (2002) 266-274
8. Page N.M., Bell N.J., Gardiner S.M., Manyonda I.T., Brayley K.J., Strange P.G., and Lowry P.J. Proc. Nat. Acad. Sci. USA 100 (2003) 6245-6250
9. Burcher E., Mussap C.J., and Stephenson J.A. Autoradiographic localization of receptors in peripheral tissues. In: Buck S.H. (Ed). The Tachykinin Receptors (1994), Humana, Totowa 125-163
10. Nakanishi S. Ann. Rev. Neurosci. 14 (1991) 123-136
11. Krause J.E., Blount P., and Sachais B.S. Molecular biology of receptors. In: Buck S.H. (Ed). The Tachykinin Receptors (1994), Humana, Totowa 165-218
12. Giardina G.A.M., Raveglia L.F., and Grugni M. Drugs Fut. 22 (1997) 1235-1257
13. Sarau H.M., Mooney J.L., Schmidt D.B., Foley J.J., Buckley P.T., Giardina G.A., Wang D.Y., Lee J.A., and Hay D.W. Mol. Pharmacol. 58 (2000) 552-559
14. Page N.M., and Bell N.J. Eur. J. Pharmacol. 437 (2002) 27-30
15. Pennefather J.N., Lecci A., Candenas M.L., Patak E., Pinto F.M., and Maggi C.A. Life Sci. 74 (2004) 1445-1463
16. Lecci A., and Maggi C.A. Exp. Opin. Ther. Targets 7 (2003) 343-362
17. Saito R., Takano R., and Kamiya H. J. Pharmacol. Sci. 91 (2003) 87-94
18. Stout S.C., Owens M.J., and Nemeroff C.B. Annu. Rev. Pharmacol. Toxicol. 41 (2001) 877-906
19. May A., and Goadsby P.J. Exp. Opin. Invest. Drugs 10 (2001) 673-678
20. Rogers D.F. Exp. Opin Ther. Pat. 11 (2001) 1097-1121
21. Baker K.G., Halliday G.M., Hornung J.P., Geffen L.B., Cotton R.G., and Törk I. Neuroscience 42 (1991) 757-775
22. Kramer M.S., Cutler N., Feighner J., Shrivastava R., Carman J., Sramek J.J., Reines S.A., Liu G., Snavely D., Wyatt-Knowles E., Hale J.J., Mills S.G., MacCoss M., Swain C.J., Harrison T., Hill R.G., Hefti F., Scolnick E.M., Cascieri M.A., Chicchi G.G., Sadowski S., Williams A.R., Hewson L., Smith D., Carlson E.J., Hargreaves R.J., and Rupniak N.M.J. Science 281 (1998) 1640-1645 Washington DC
23. Kramer M.S., Alexander R., Ball W.A., Shedden A., and Reines S.A. Neuropsychopharmacology 23 Suppl. 2 (2000) S22
24. Editorial (1999) Scrip 2406, 20
25. Watson J.W., Gonsalves S.F., Fossa A.A., McLean S., Seeger T., Obach S., and Andrews P.L. Brit. J. Pharmacol. 115 (1995) 84-95
26. Hesketh P.J., Gralla R.J., Webb R.T., Ueno W., DelPrete S., Bachinsky M.E., Dirlam N.L., Stack C.B., and Silberman S.L. J. Clin. Onc. 17 (1999) 338-343
27. Sorbera L.A., Castañer J., Bayés M., and Silvestre J. Drugs Fut. 27 (2002) 211-222
28. Campos D., Rodrigues J.R., Reinhardt R.R., Carracedo C., Poli S., Vogel C., Martinez-Cedillo J., Erazo A., Wittreich J., Eriksson L.-O., Carides A.D., and Gertz B.J. J. Clin. Onc. 19 (2001) 1759-1767
29. Holzer P., and Holzer-Petsche U. Curr. Opin. Pharmacol. 1 (2001) 583-590
30. Patachini R., and Maggi C.A. Eur. J. Pharmacol. 429 (2001) 13-21
31. Lecci A., and Maggi C.A. Expert Opin. Ther. Targets 7 (2003) 343-362
32. Furness J.B. Curr. Opin. Invest. Drugs 2 (2001) 1437-1440
33. Kamo I., and Doi T. Japn. J. Pharm. 86 (2001) 165-169
34. Venkova K., Sutkowski-Markmann D.M., and Greenwood-Van Meerveld B. J. Pharmacol. Exp. Ther. 300 (2002) 1046-1052
35. Patak E., Candenas M.L., Pennefather J.N., Ziccone S., Lilley A., Martin J.D., Flores C., Mantecon A.G., Story M.E., and Pinto F.M. Brit. J. Pharmacol. 139 (2003) 523-532
36. Goldstein D., Wang O., Saper J., Stoltz R., Silberstein S., and Mathew N. Cephalalgia 17 (1996) 785-790
37. Goldstein D.J., Offen W.W., Klein E.G., Phebus L.A., Hipskind P., Johnson K.W., and Re Jr. R. Cephalalgia 21 (2001) 102-106
38. Norman, B., Panebianco, D. and Block, G. (1998) 12th Migraine Trust Int. Symp. (September 1-4 London), Abst. 42.
39. Jasmin L., Tien D., Weinshenker D., Palmiter R.D., Green P.G., Janni G., and Ohara P.T. Proc. Natl Acad. Sci. USA 99 (2002) 1029-1034
40. Advenier C., Lagente V., and Boichot E. Eur. Respir., J. 10 (1997) 1892-1906
41. Chapman R.W., Hey J.A., McLeod R., Minnicozzi M., and Rizzo C. Drug News Perspect. 11 (1998) 480-489
42. Barnes P.J., Baraniuk J.M., and Belvisi M.G. Am. Rev. Respir. Dis. 144 (1991) 1187-1198
43. Martling C.R., Theodorsson-Norheim E., and Lundberg J.M. Life Sci. 40 (1987) 1633-1643
44. Holgate S.T., Djukanovic R., Wilson J., Roche W., and Howarth P.H. Clin. Exp. Allergy 21 Suppl. 1 (1991) 30-36
45. Lei Y., Barnes P.J., and Rogers D.F. Brit. J. Pharmacol. 105 (1992) 261-262
46. Turner C.R., Andresen C.J., Pattersen D.K., Keir R.F., Obach S., Lee P., and Watson J.W. Am. J. Respir. Crit. Care Med. 153 (1996) A160
47. Amann R., Schuligoi R., Holzer P., and Donnerer J. Arch. Pharmacol. 352 (1995) 201-205
48. Emonds-Alt X., Advenier C., Soubrié P., Le Fur G., and Breliere J.-C. Drugs Fut. 20 (1995) 701-707
49. Maggi C.A., Astolfi M., Giuliani S., Goso C., Manzini S., Meini S., Patacchini R., Pavone V., Pedone C., and Quartara L. J. Pharmacol. Exp. Ther. 271 (1994) 1489-1500
50. Cooper A.W.J., Adams H.S., Bell R., Gore P.M., McElroy A.B., Pritchard J.M., Smith P.W., and Ward P. Bioorg. Med. Chem. Lett. 4 (1994) 1951-1956
51. Kudlacz E.M., Scott A., Shatzer S.A., Knippenberg R.W., Logan D.E., Poirot M., van Giersbergen P.L.M., and Burkholder T.P. J. Pharmacol. Exp. Ther. 277 (1996) 840-851
52. Kraan J., Vink-Klooster H., and Postma D.S. Clin. Exp. Allergy 31 (2001) 274-278
53. Joos G.F., Van Schoor J., Kips J.C., and Pauwels R.A. Am. J. Respir. Crit. Care 153 (1996) 1781-1784
54. Joos, G.F., Vincken, W., Louis, R., Wang, J., Shaw, M. and Pauwels, R. (2001) Am. Thoracic Soc. Meeting (San Francisco, May, 18-23), Poster: F45.
55. Hey J.A., and Shih N.-Y. Annu. Rep. Med. Chem. 36 (2000) 53-62
56. Joss G.F., and Pauwels R.A. Curr. Opin. Pharmacol. 1 (2001) 235-241
57. Giardina G.A., Raveglia L.F., Grugni M., Sarau H.M., Farina C., Medhurst A.D., Graziani D., Schmidt D.B., Rigolio R., Luttmann M., Cavagnera S., Foley J.J., Vecchietti V., and Hay D.W. J. Med. Chem. 42 (1999) 1053-1065
58. Emonds-Alt X., Bichon D., Ducoux J.P., Heaulme M., Miloux B., Poncelet M., Proietto V., van Broeck D., Vilain P., Neilat G., Soubrié P., Le Fur G., and Brelière J.C. Life Sci. 56 (1995) PL27, PL32
59. Advenier C., Daoui S., Cui Y.Y., Lagente V., and Emonds-Alt X. Am. J. Respir. Crit. Care 153 (1996) A163
60. Swain C. In: King F.D. (Ed). Medicinal Chemistry. 2nd ed. (2002), Royal Society of Chemistry, Cambridge, UK 415-427
61. Humphrey J.M. Curr. Topics Med. Chem. 3 (2003) 1423-1435
62. Johansson A. Curr. Topics Med. Chem. 3 (2003) 1436-1445
63. Giardina G.A.M., Grugni M., and Raveglia L.F. Exp. Opin. Ther. Pat. 10 (2000) 939-960
64. Giardina G.A.M., Gagliardi S., and Martinelli M. IDrugs 6 (2003) 758-772
65. Ofner S., Hauser K., Schilling W., Vassout A., and Veenstra S.J. Bioorg. Med. Chem. Lett. 6 (1996) 1623-1628
66. Vassout A., Veenstra S., Hauser K., Ofner S., Brugger F., Schilling W., and Gentsch C. Regul. Peptides 96 (2000) 7-16
67. Gentsch C., Cutler M., Vassout A., Veenstra S., and Brugger F. Behav. Brain Res. 133 (2002) 363-368
68. Arnold, E.P., Chappie, T.A., Huang, J., Humphrey, J.M., Nagel, A.A., O'Neill, B.T., Sobolov-Jaynes, S.B. and Vincent, L.A. (2001) PCT Int. Appl., WO2001077100, CA 135:331346.
69. Chappel P.B., O'Neill B.T., and Saltarelli M.D. Eur. Pat. Appl. (2002) 102294 EP1172106, CA 136:
70. Harrison T., Owens A.P., Williams B.J., Swain C.J., Williams A., Carlson E.J., Rycroft W., Tattersall F.D., Cascieri M.A., Chicchi G.G., Sadowski S., Rupniak N.M.J., and Hargreaves R.J. J. Med. Chem. 44 (2001) 4296-4299
71. Seward E.M., Carlson E., Harrison T., Haworth K.E., Herbert R., Kelleher F.J., Kurtz M.M., Moseley J., Owen S.N., Owens A.P., Sadowski S.J., Swain C.J., and Williams B.J. Bioorg. Med. Chem. Lett. 12 (2002) 2515-2518
72. Williams B.J., Cascieri M.A., Chicchi G.G., Harrison T., Owens A.P., Owen S.N., Rupniak N.M.J., Tattersall D.F., Williams A., and Swain C.J. Bioorg. Med. Chem. Lett. 12 (2002) 2719-2722
73. Cooper L.C., Chicchi G.G., Dinnell K., Elliott J.M., Hollingworth G.J., Kurtz M.M., Locker K.L., Morrison D., Shaw D.E., Tsao K.L., Watt A.P., Williams A.R., and Swain C.J. Bioorg. Med. Chem. Lett. 11 (2001) 1233-1236
74. Dinnell K., Chicchi G.G., Dhar M.J., Elliott J.M., Hollingworth G.J., Kurtz M.M., Ridgill M.P., Rycroft W., Tsao K.L., Williams A.R., and Swain C.J. Bioorg. Med. Chem. Lett. 11 (2001) 1237-1240
75. Shaw D., Chicchi G.G., Elliott J.M., Kurtz M., Morrison D., Ridgill M.P., Szeto N., Watt A.P., Williams A.R., and Swain C.J. Bioorg. Med. Chem. Lett. 11 (2001) 3031-3034
76. Hoffmann, T., Poli, S.M., Schnider, P. and Sleight, A. (2003) PCT Int. Appl., WO2003011860, CA 138:1700243.
77. Godel, T., Hoffmann, T., Schnider, P. and Stadler, H. (2002) PCT Int. Appl., WO2002016324, CA 136:216651.
78. Boes, M., Galley, G., Godel, T., Hoffmann, T., Hunkeler, W., Schnider, P. and Stadler, H. (2000) PCT Int. Appl., WO2000073279, CA 134:29425.
79. Galley, G., Godel, T., Goergler, A., Hoffmann, T., Kolczewski, S. and Roever, S. (2001) PCT Int. Appl., WO2001094346, CA 136:37519.
80. Cai, H-Y., Dillon, M.P., Galley, G., Goergler, A., Kolczewski, S. and Muszynski-Barsy, D.M. (2002) PCT Int. Appl., WO 2002092604, CA 137:384847.
81. Kolczewski, S., Roever, S. and Schnider, P. (2002) PCT Int. Appl. WO 2002062784, CA 137:169546.
82. Alvaro, G., Di Fabio, R., Giovanni, R., Guercio, G., St. Denis, Y. and Ursini, A. (2001) PCT Int. Appl., WO200125219, CA 134:295839.
83. Alvaro, G., Di Fabio. R., Maragni, P., Tampieri, M. and Tranquillini, M.E. (2002) PCT Int. Appl., WO2002032867, CA 136:325568.
84. Natsugari H., Ikeura Y., Kamo I., Ishimaru T., Ishichi Y., Fujishima A., Tanaka T., Kasahara F., Kawada M., and Doi T. J. Med. Chem. 42 (1999) 3982-3993
85. Doi T., Kamo I., Imai S., Okanishi S., Ishimaru T., Ikeura Y., and Natsugari H. Eur. J. Pharmacol. 383 (1999) 297-303
86. Furness J.B. Curr. Opin. Invest. Drugs 2 (2001) 1437-1440
87. Emonds-Alt X., Proietto V., Steinberg R., Oury-Donat F., Vige X., Vilain P., Naline E., Daoui S., Advenier C., Le Fur G., Maffrand J.-P., Soubrie P., and Pascal M. J. Pharmacol. Exp. Ther. 303 (2002) 1171-1179
88. Steinberg R., Alonso R., Rouquier L., Desvignes C., Michaud J.-C., Cudennec A., Jung M., Simiand J., Griebel G., Emonds-Alt X., Le Fur G., and Soubrie P. J. Pharmacol. Exp. Ther. 303 (2002) 1180-1188
89. Fritz J.E., Hipskind P.A., Lobb K.L., Nixon J.A., Threlkeld P.G., Gitter B.D., McMillan C.L., and Kaldor S.W. Bioorg. Med. Chem. Lett. 11 (2001) 1643-1646
90. MacKenzie A.R., Marchington A.P., Middleton D.S., Newman S.D., and Jones B.C. J. Med. Chem. 45 (2002) 5365-5377
91. Middleton, D.S. (2002). Abstracts of Papers, 223rd ACS National Meeting, Orlando, FL, United States, April 7-11, MEDI 137.
92. MacKenzie A.R., Marchington A.P., Middleton D.S., Newman S.D., Selway C.N., and Terrett N.K. Bioorg. Med. Chem. Lett. 13 (2003) 2211-2215
93. Emonds-Alt X., Advenier C., Cognon C., Croci T., Daoui S., Ducoux J.P., Landi M., Naline E., Neliat G., Poncelet M., Proietto V., Van Broeck D., Vilain P., Soubrie P., Le Fur G., Maffrand J.P., and Breliere J.C. Neuropeptides 31 (1997) 449-458
94. Shenvi, A.B., Aharony, D., Brown, F.J., Buckner, C.K., Campbell, J.B., Dedinas, R.F., Gero, T.W., Green, R.C., Jacobs, R.T., Kusner, E.J., Miller, S.C., Ohnmacht, C.J., Palmer, W.E., Smith, R.W., Steelman, G.B., Ulatowski, T.G., Veale, C.A. and Walsh, S.A. (1997). Book of Abstracts, 214th ACS National Meeting, Las Vegas, NV, United States, September 7-11, MEDI 264.
95. Harrison T., Korsgaard M.P.G., Swain C.J., Cascieri M.A., Sadowski S., and Seabrook G.R. Bioorg. Med. Chem. Lett. 8 (1998) 1343-1348
96. Giannotti D., Perrotta E., Di Bugno C., Nannicini R., Harmat N.J.S., Giolitti A., Patacchini R., Renzetti A.R., Rotondaro L., Giuliani S., Altamura M., and Maggi C.A. J. Med. Chem. 43 (2000) 4041-4044
97. Harmat N.J.S., Giannotti D., Nannicini R., Perrotta E., Criscuoli M., Patacchini R., Renzetti A.R., Giuliani S., Altamura M., and Maggi C.A. Bioorg. Med. Chem. Lett. 12 (2002) 693-696
98. Emonds-Alt X., Proietto V., Steinberg R., Advenier C., Daoui S., Naline E., Gueudet C., Michaud J.-C., Oury-Donat F., Poncelet M., Vilain P., Le Fur G., Maffrand J.-P., Soubrie P., and Pascal M. Can. J. Physiol. Pharmacol. 80 (2002) 482-488
99. Gerspacher M., and von Sprecher A. Drugs Fut. 24 (1999) 883-892
100. Rizzo C.A., Anthes J.C., Corboz M.R., Chapman R.W., Shih N.-Y., Reichard G.A., Ng K.J., and Hey J.A. Curr. Topics Med. Chem. 3 (2003) 1410-1422
101. Fujii T. Folia Pharmacol. Jpn. 106 (1995) 193-204
102. Hirayama Y., Lei Y.-H., Barnes P.J., and Rogers D.F. Br. J. Pharmacol. 108 (1993) 844-851
103. Robineau P., Lonchampt M., Kucharczyk N., Krause J.E., Regoli D., Fauchère J.L., Prost J.F., and Canet E. Eur. J. Pharmacol. 294 (1995) 677-684
104. Burkholder T.P., Kudlacz E.M., Le T.-B., Knippenberg R.W., Shatzer S.A., Maynard G.D., Webster M.E., and Horgan S.W. Bioorg. Med. Chem. Lett. 6 (1996) 951-956
105. Kudlacz E.M., Knippenberg R.W., Shatzer S.A., Kehne J.H., McCloskey T.C., and Burkholder T.P. J. Auton. Pharmacol. 17 (1997) 109-119
106. Burkholder, T.P., Maynard, G.D. and Kudlacz, E.M., WO9827085, CA 129:95498.
107. Burkholder, T.P., Maynard, G.D. and Kudlacz, E.M., WO9827086, CA 129:95499.
108. Kubota, H., Kakefuda, A., Nagaoka, H., Yamamoto, O., Ikeda, K. and Shibanuma, T. (1995) AFMC Int. Med. Chem. Symp/AIMECS 95 (September 3-8, Tokyo Japan), 1995, P6M139; (Derwent Conf Fast Track 3 (14) 96, 1995).
109. Kubota H., Kakefuda A., Okamoto Y., Fujii M., Yamamoto O., Yamagiwa Y., Orita M., Ikeda K., Takeuchi M., Shibanuma T., and Isomura Y. Chem. Pharm. Bull. 46 (1998) 1538-1544
110. Shah, S.K., Hale, J.J., Qi, H., Miller, D.J., Dorn, Jr. C.P. and Mills, S.G. (1996) Book of Abstracts, 212th ACS National Meeting, (August 25-29, Orlando, Florida, USA), 1996 MEDI 136.
111. Mills, S.G. (1996) William Harvey Res. Inst. Conf. Tachykinins and their antagonists (October 10-11, 1996), London, UK P5.
112. Chiang, Y-C.P., Finke, P.E., MacCoss, M., Meurer, L.C., Miller, D.J., Mills, S.G., Robichaud, A.J. and Shah, S.K., WO9610568, CA 125:114694.
113. Hongbo, O., Shah, S.K., Sadowski, S.J., Cascieri, M.A. and MacCoss, M. (1996) 25th National Medicinal Chemistry Symposium, University of Michigan (June 18-22 Ann Arbor, Michigan, USA), 1996, Poster 94.
114. Hipskind, P.A. and Lobb, K.L., US 5891875, CA 130:267442.
115. Cho, S-S.Y., Hipskind, P.A., Howbert, J.J., Muehl, B.S. and Nixon, J.A., WO9631214, CA 125:301600.
116. Hipskind, P.A., EP714891, CA 125:142523.
117. Gitter, B.D. and Iyengar, S., WO9731635, CA 127:262677.
118. Monaghan, S.M., Alker, D. and Burns, C.J., WO9807722, CA 128:205021.
119. Natsugari, H., Ishimaru, T., Doi, T., Ikeura, Y. and Kimura, C., EP733632, CA 126:8145.
120. Gerspacher, M., von Sprecher, A., Mah, R., Roggo, S., Ofner, S., Auberson, Y., Betschart, C., Schilling, W., Anderson, G.P., Ball, H., Bertrand, C., Subramanian, N. and Hauser, K. (1998) Abstracts of Papers, 212th ACS National Meeting, Boston, MA, United States, August 23-27, 1998.
121. Gerspacher M., Von Sprecher A., Mah R., Anderson G.P., Bertrand C., Subramanian N., Hauser K., and Ball H.A. Bioorg. Med. Chem. Lett. 10 (2000) 1467-1470
122. Gerspacher M., La Vecchia L., Mah R., von Sprecher A., Anderson G.P., Subramanian N., Hauser K., Bammerlin H., Kimmel S., Pawelzik V., Ryffel K., and Ball H.A. Bioorg. Med. Chem. Lett. 11 (2001) 3081-3084
123. Gerspacher, M. (2002) Abstracts of Papers, 223rd ACS National Meeting, Orlando, FL, United States, April 7-11, 2002 MEDI 139.
124. Gerspacher M., Lewis C., Ball H.A., Howes C., Subramanian N., Ryffel K., and Fozard J.R. J. Med. Chem. 46 (2003) 3508-3513
125. Joos G.F., Vincken W., Louis R., Schelfhout V.J., Wang J.H., Shaw M.J., Cioppa G.D., and Pauwels R.A. Eur. Respir. J. 23 (2004) 76-81
126. Harrison T., Williams B.J., Swain C.J., and Ball R.G. Bioorg. Med. Chem. Lett. 4 (1994) 2545-2550
127. Desai M.C., Lefkowitz S.L., Thadeio P.F., Longo K.P., and Snider R.M. J. Med. Chem. 35 (1992) 4911-4913
128. Mah R., Gerspacher M., von Sprecher A., Stutz S., Tschinke V., Anderson G.P., Bertrand C., Subramanian N., and Ball H.A. Bioorg. Med. Chem. Lett. 12 (2002) 2065-2068
129. Nishi T., Fukazawa T., Ishibashi K., Nakajima K., Sugioka Y., Iio Y., Kurata H., Itoh K., Mukaiyama O., Satoh Y., and Yamaguchi T. Bioorg. Med. Chem. Lett. 9 (1999) 875-880
130. Nishi T. Yuki Gosei Kagaku Kyokaishi 60 (2002) 657-667
131. Nishi T., Ishibashi K., Takemoto T., Nakajima K., Fukazawa T., Iio Y., Itoh K., Mukaiyama O., and Yamaguchi T. Bioorg. Med. Chem. Lett. 10 (2000) 1665-1668
132. Blythin D.J., Xiao C., Piwinski J.J., Shih N.-Y., Shue H.-J., Anthes J.C., and McPhail A.T. Bioorg. Med. Chem. Lett. 12 (2002) 3161-3165
133. Williams B.J., Teall M., Kenna J., Harrison T., Swain C.J., Cascieri M.A., Sadowski S., Strader C., and Baker R. Bioorg. Med. Chem. Lett. 16 (1994) 1903-1908
134. Reichard G.A., Ball Z.T., Aslanian R., Anthes J.C., Shih N.-Y., and Piwinski J.J. Bioorg. Med. Chem. Lett. 10 (2000) 2329-2332
135. Ting P.C., Lee J.F., Anthes J.C., Shih N.-Y., and Piwinski J.J. Bioorg. Med. Chem. Lett. 10 (2000) 2333-2335
136. Ting P.C., Lee J.F., Anthes J.C., Shih N.-Y., and Piwinski J.J. Bioorg. Med. Chem. Lett. 11 (2001) 491-494
137. Shih N.-Y., Albanese M., Anthes J.C., Carruthers N.I., Grice C.A., Lin L., Mangiaracina P., Reichard G.A., Schwerdt J., Seidl V., Wong S.-C., and Piwinski J.J. Bioorg. Med. Chem. Lett. 12 (2002) 141-145
138. Reichard G.A., Grice C.A., Shih N.-Y., Spitler J., Majmundar S., Wang S.D., Paliwal S., Anthes J.C., and Piwinski J.J. Bioorg. Med. Chem. Lett. 12 (2002) 2355-2358
139. Ting P.C., Lee J.F., Shih N.-Y., Piwinski J.J., Anthes J.C., Chapman R.W., Rizzo C.A., Hey J.A., Ng K., and Nomeir A.A. Bioorg. Med. Chem. Lett. 12 (2002) 2125-2128
140. Anthes J.C., Chapman R.W., Richard C., Eckel S., Corboz M., Hey J.A., Fernandez X., Greenfeder S., McLeod R., Sehring S., Rizzo C., Crawley Y., Shih N.-Y., Piwinski J., Reichard G., Ting P., Carruthers N., Cuss F.M., Billah M., Kreutner W., and Egan R.W. Eur. J. Pharmacol. 450 (2002) 191-202
141. Reichard G.A., Spitler J., Aslanian R., Mutahi M.W., Shih N.-Y., Lin L., Ting P.C., Anthes J.C., and Piwinski J.J. Bioorg. Med. Chem. Lett. 12 (2002) 833-836
142. Hale J.J., Mills S.G., MacCoss M., Finke P.E., Cascieri M.A., Sadowski S., Ber E., Chicchi G.G., Kurtz M., Metzger J., Eiermann G., Tsou N.N., Tattersall F.D., Rupniak N.M.J., Williams A.R., Rycroft W., Hargreaves R., and MacIntyre D.E. J. Med. Chem. 41 (1998) 4607-4614
143. Bernstein P.R., Aharony D., Albert J.S., Andisik D., Barthlow H.G., Bialecki R., Davenport T., Dedinas R.F., Dembofsky B.T., Koether G., Kosmider B.J., Kirkland K., Ohnmacht C.J., Potts W., Rumsey W.L., Shen L., Shenvi A., Sherwood S., Stollman D., and Russell K. Bioorg. Med. Chem. Lett. 11 (2001) 2769-2773
144. Rumsey W.L., Aharony D., Bialecki R.A., Abbott B.M., Barthlow H.G., Caccese R., Ghanekar S., Lengel D., Mccarthy M., Wenrich B., Undem B., Ohnmacht C., Shenvi A., Albert J.S., Brown F., Bernstein P.R., and Russell K. J. Pharmacol. Exp.Ther. 298 (2001) 307-315
145. Albert J.S., Aharony D., Andisik D., Barthlow H., Bernstein P.R., Bialecki R.A., Dedinas R., Dembofsky B.T., Hill D., Kirkland K., Koether G.M., Kosmider B.J., Ohnmacht C., Palmer W., Potts W., Rumsey W., Shen L., Shenvi A., Sherwood S., Warwick P.J., and Russell K. J. Med. Chem. 45 (2002) 3972-3983
146. Shenvi, A.B. (2002) PCT Int. Appl., WO 2002051807, CA 137:78859.
147. Bernstein, P. (2002) PCT Int. Appl., WO 2002012168, CA 136:167183.
148. Bernstein, P. (2001) PCT Int. Appl., WO 2001077069, CA 135:303688.
149. Bernstein, P. (2002) PCT Int. Appl., WO 2002026724, CA 136:294860.
150. Take, K., Kasahara, C., Shigenaga, S., Azami, H., Eikyu, Y., Nakai, K. and Morita, M. (2002) PCT Int. Appl., WO 2002000631, CA 136:85824.
151. Take, K., Kasahara, C., Shigenaga, S., Azami, H., Eikyu, Y., Nakai, K. and Morita, M. (2002) PCT Int. Appl., WO 2002055518, CA 137:109295.
152. Take, K., Kasahara, C., Shigenaga, S., Eikyu, Y. and Tojo, T. (2003) PCT Int. Appl., WO 2003053957, CA 139:85380.
153. Kordik, C.P., Reitz, A.B., Coats, S.J., Luo, C., Pan, K. and Parker, M.H. (2002) PCT Int. Appl., WO 2002040466, CA 136:386139.
154. Blaney F.E., Raveglia L.F., Artico M., Cavagnera S., Dartois C., Farina C., Grugni M., Gagliardi S., Luttmann M.A., Martinelli M., Nadler G.M.M.G., Parini C., Petrillo P., Sarau H.M., Scheideler M.A., Hay D.W.P., and Giardina G.A.M. J. Med. Chem. 44 (2001) 1675-1689
155. Emonds-alt, X. and Proietto, V. (2002) PCT Int. Appl., WO 2002094821, CA 137:384848.