Identification of a novel 1′-[5-((3,5-Dichlorobenzoyl)methylamino)-3-(3,4-dichlorophenyl)-4- (methoxyimino)pentyl]-2-oxo-(1,4′-bipiperidine) as a Dual NK1/NK2 antagonist

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 16, 2002, Pages 2125-2128

  Ting, Pauline C ^a   Lee, Joe F ^a   Shih, Neng Yang ^a   Piwinski, John J ^a   Anthes, John C ^a   Chapman, Richard W ^a   Rizzo, Charles A ^a   Hey, John A ^a   Ng, Kwokei ^a   Nomeir, Amin A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1' [5 [(3,5 DICHLOROBENZOYL)METHYLAMINO] 3 (3,4 DICHLOROPHENYL) 4 (METHOXYIMINO)PENTYL] 2 OXO (1,4' DIPIPERIDINE); NEUROKININ 1 RECEPTOR ANTAGONIST; NEUROKININ 2 RECEPTOR ANTAGONIST; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG; NEUROKININ 1 RECEPTOR; NEUROKININ 2 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOG; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG POTENCY; GUINEA PIG; IN VIVO STUDY; NONHUMAN; ANIMAL; AREA UNDER THE CURVE; BLOOD; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG SCREENING; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

CANIS FAMILIARIS;

ANIMALS; AREA UNDER CURVE; DOGS; DRUG EVALUATION, PRECLINICAL; GUINEA PIGS; MOLECULAR STRUCTURE; PIPERIDINES; RECEPTORS, NEUROKININ-1; RECEPTORS, NEUROKININ-2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037136002     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00340-2     Document Type: Article

References (15)