2-Aryl indole NK1 receptor antagonists: Optimisation of indole substitution

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 9, 2001, Pages 1233-1236

  Cooper, Laura C ^a   Chicchi, Gary G ^b   Dinnell, Kevin ^a   Elliott, Jason M ^a   Hollingworth, Gregory J ^a   Kurtz, Marc M ^b   Locker, Karen L ^a   Morrison, Denise ^a   Shaw, Duncan E ^a   Tsao, Kwei Lan ^b   Watt, Alan P ^a   Williams, Angela R ^a   Swain, Christopher J ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (2 METHOXYPHENYL)PIPERAZINE; ACETIC ACID DERIVATIVE; BROMIDE; CHLORIDE; INDOLE DERIVATIVE; NEUROKININ 1 RECEPTOR; NEUROKININ 1 RECEPTOR ANTAGONIST; PIPERAZINE DERIVATIVE; REAGENT; UNCLASSIFIED DRUG; VINYL DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CHO CELL; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; NONHUMAN; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; BEHAVIOR, ANIMAL; BINDING, COMPETITIVE; BRAIN CHEMISTRY; CHO CELLS; CRICETINAE; GERBILLINAE; INDICATORS AND REAGENTS; INDOLES; RATS; RECEPTORS, NEUROKININ-1; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTANCE P;

EID: 0035821395     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00182-2     Document Type: Article

References (19)