Design, synthesis, and SAR of tachykinin antagonists: Modulation of balance in NK1/NK2 receptor antagonist activity

Journal of Medicinal Chemistry

Volumn 45, Issue 18, 2002, Pages 3972-3983

  Albert, Jeffrey S ^a   Andisik, Donald ^a   Barthlow, Herbert ^a   Bernstein, Peter R ^a   Bialecki, Russell A ^a   Dedinas, Robert ^a   Dembofsky, Bruce T ^a   Hill, Daniel ^a   Kirkland, Karin ^a   Koether, Gerard M ^a   Kosmider, Benedict J ^a   Ohnmacht, Cyrus ^a   Palmer, William ^a   Potts, William ^a   Rumsey, William ^a   Shen, Lihong ^a   Shenvi, Ashok ^a   Sherwood, Scott ^a   Aharony, David ^a   Warwick, Paul J ^a   Russell, Keith ^a   more..

^a ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROKININ 1 RECEPTOR ANTAGONIST; NEUROKININ 2 RECEPTOR ANTAGONIST; PIPERIDINE; SULFOXIDE; TACHYKININ RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG; ZD 6021;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NEUROMODULATION; NONHUMAN; RAT; REACTION ANALYSIS; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; BIOLOGICAL AVAILABILITY; DOGS; PIPERIDINES; RATS; RECEPTORS, NEUROKININ-1; RECEPTORS, NEUROKININ-2; STRUCTURE-ACTIVITY RELATIONSHIP; SULFOXIDES; TACHYKININS;

EID: 0037194617     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020094i     Document Type: Article

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