2-Aryl indole NK1 receptor antagonists: Optimisation of the 2-aryl ring and the indole nitrogen substituent

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 9, 2001, Pages 1237-1240

  Dinnell, Kevin ^a   Chicchi, Gary G ^b   Dhar, Madhumeeta J ^b   Elliott, Jason M ^a   Hollingworth, Gregory J ^a   Kurtz, Marc M ^b   Ridgill, Mark P ^a   Rycroft, Wayne ^a   Tsao, Kwei Lan ^b   Williams, Angela R ^a   Swain, Christopher J ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 METHOXYPHENYL)PIPERAZINE; 5 AMINOVALERYLSUBSTANCE P [7-11][9 PROLINE 10 (N METHYLLEUCINE)]; INDOLE DERIVATIVE; NEUROKININ 1 RECEPTOR; NEUROKININ 1 RECEPTOR ANTAGONIST;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BRAIN MEMBRANE; CONTROLLED STUDY; DRUG PENETRATION; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; NONHUMAN; REACTION ANALYSIS; RECEPTOR BINDING; STOICHIOMETRY;

ANIMALS; BEHAVIOR, ANIMAL; BINDING, COMPETITIVE; CHO CELLS; CRICETINAE; ELECTRONS; GERBILLINAE; INDOLES; MOLECULAR CONFORMATION; NITROGEN; RECEPTORS, NEUROKININ-1; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTANCE P;

EID: 0035821416     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00183-4     Document Type: Article

References (13)