An orally active, water-soluble neurokinin-1 receptor antagonist suitable for both intravenous and oral clinical administration

Journal of Medicinal Chemistry

Volumn 44, Issue 24, 2001, Pages 4296-4299

  Harrison, T ^a   Owens, A P ^a   Williams, B J ^a   Swain, C J ^a   Williams, A ^a   Carlson, E J ^a   Rycroft, W ^a   Tattersall, F D ^a   Cascieri, M A ^b   Chicchi, G G ^b   Sadowski, S ^b   Rupniak, N M J ^a   Hargreaves, R J ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [5 [[2 [[1 [3,5 BIS(TRIFLUOROMETHYL)PHENYL]ETHYL]OXY] 3 (4 FLUOROPHENYL)MORPHOLIN 4 YL]METHYL] 2H 1,2,3 TRIAZOL 4 YL] N,N DIMETHYLMETHANAMINE; 3 (2 METHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; 5 AMINOVALERYLSUBSTANCE P [7-11][9 PROLINE 10 (N METHYLLEUCINE)]; APREPITANT; AZIDE; DIMETHYLAMINE; NEUROKININ 1 RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DEPRESSION; DRUG ACTIVITY; DRUG EFFICACY; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SOLUBILITY; DRUG STRUCTURE; HYDROPHILICITY; NONHUMAN; RECEPTOR BLOCKING; STRUCTURE ACTIVITY RELATION; THERMAL ANALYSIS; VOMITING;

ADMINISTRATION, ORAL; AMINES; ANIMALS; ANIMALS, NEWBORN; ANTIDEPRESSIVE AGENTS; ANTIEMETICS; BRAIN; DOGS; FERRETS; GERBILLINAE; GUINEA PIGS; INJECTIONS, INTRAVENOUS; MACACA MULATTA; MORPHOLINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, NEUROKININ-1; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES; VOCALIZATION, ANIMAL;

EID: 0035935713     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0109558     Document Type: Article

References (17)

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5. The tachykinin NK-1 receptor antagonist CP-99,994 attenuates cisplatin-induced emesis in the ferret
6. Anti-emetic profile of a non-peptide neurokinin-1 receptor antagonist, CP-99,994, in ferrets
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