SAR of 2-benzyl-4-aminopiperidines: CGP 49823, an orally and centrally active non-peptide NK1 antagonist

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 14, 1996, Pages 1623-1628

  Ofner, Silvio ^a   Hauser, Kathleen ^a   Schilling, Walter ^a   Vassout, Annick ^a   Veenstra, Siem J ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

2 BENZHYDRYL 3 (2 METHOXYBENZYLAMINO) 1 AZABICYCLO[2.2.2]OCTANE; 2 BENZYL 1 (3,5 DIMETHYLBENZOYL) 4 (4 QUINOLINYLMETHYLAMINO)PIPERIDINE; NEUROKININ 1 RECEPTOR; PIPERIDINE DERIVATIVE; TACHYKININ RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CATTLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG DESIGN; DRUG RECEPTOR BINDING; GERBIL; HUMAN; HUMAN CELL; INTRAPERITONEAL DRUG ADMINISTRATION; METABOLISM; NONHUMAN; ORAL DRUG ADMINISTRATION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RETINA; STEREOCHEMISTRY;

ANIMALIA; BOS TAURUS; GERBILLINAE;

EID: 0030598679     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00287-9     Document Type: Article

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