2-Aryl indole NK1 antagonists: Optimisation of the amide substituent

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 23, 2001, Pages 3031-3034

  Shaw, Duncan ^a   Chicchi, Gary G ^b   Elliott, Jason M ^a   Kurtz, Marc ^b   Morrison, Denise ^a   Ridgill, Mark P ^a   Szeto, Nicola ^a   Watt, Alan P ^a   Williams, Angela R ^a   Swain, Christopher J ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 METHOXYPHENYL)PIPERAZINE AMIDE; 2 INDOLE; 4 BENZYL 4 HYDROXYPIPERIDINE; 4 BENZYL 4 HYDROXYPIPERIDINOL; AMIDE; INDOLE DERIVATIVE; NEUROKININ 1 RECEPTOR ANTAGONIST; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG MECHANISM; DRUG METABOLISM; DRUG STRUCTURE; GERBIL; MEAN RESIDENCE TIME; NONHUMAN; RAT; REACTION ANALYSIS;

ADMINISTRATION, ORAL; AMIDES; ANIMALS; BIOLOGICAL AVAILABILITY; CRICETINAE; DRUG EVALUATION, PRECLINICAL; INDOLES; INHIBITORY CONCENTRATION 50; METABOLIC CLEARANCE RATE; NEUROKININ A; PIPERAZINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035802986     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00616-3     Document Type: Article

References (9)