Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 2. Identification of (S)-N-(1-phenylpropyl)-3- hydroxy-2-phenylquinoline-4-carboxamide (SB 223412)

Journal of Medicinal Chemistry

Volumn 42, Issue 6, 1999, Pages 1053-1065

  Giardina, Giuseppe A M ^a   Raveglia, Luca F ^a   Grugni, Mario ^a   Sarau, Henry M ^b   Farina, Carlo ^a   Medhurst, Andrew D ^b   Graziani, Davide ^a   Schmidt, Dulcie B ^b   Rigolio, Roberto ^a   Luttmann, Mark ^a   Cavagnera, Stefano ^a   Foley, James J ^b   Vecchietti, Vittorio ^a   Hay, Douglas W P ^b  

^a SmithKline Beecham SpA   (Italy)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROKININ 3 RECEPTOR ANTAGONIST; TALNETANT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHO CELL; DRUG ACTIVITY; DRUG EFFECT; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHUMAN; RABBIT; RECEPTOR AFFINITY;

ANIMALS; CALCIUM; CELL LINE; CHO CELLS; CLONING, MOLECULAR; CRICETINAE; HUMANS; IRIS; MICE; MIOSIS; MOTOR ACTIVITY; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PEPTIDE FRAGMENTS; QUINOLINES; RABBITS; RADIOLIGAND ASSAY; RECEPTORS, NEUROKININ-3; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTANCE P;

EID: 0033602522     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980633c     Document Type: Article

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