SSR240600 [(R)-2-(1-{2-[4-{2-[3,5-bis(trifluoromethyl)- phenyl]acetyl}-2-(3,4-dichlorophenyl)-2-morpholinyl]ethyl}- 4-piperidinyl)-2-methylpropanamide], a centrally active non-peptide antagonist of the tachykinin neurokinin-1 receptor: I. Biochemical and pharmacological characterization

Journal of Pharmacology and Experimental Therapeutics

Volumn 303, Issue 3, 2002, Pages 1171-1179

  Emonds Alt, Xavier ^a   Proietto, Vincenzo ^a   Steinberg, Régis ^a   Oury Donat, Florence ^a   Vigé, Xavier ^a   Vilain, Pol ^a   Naline, Emmanuel ^b   Daoui, Samira ^b   Advenier, Charles ^b   Le Fur, Gérard ^a   Maffrand, Jean Pierre ^a   Soubrie, Philippe ^a   Pascal, Marc ^a  

^a SANOFI   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 [1 [2 [4 [2 [3,5 BIS(TRIFLUOROMETHYL)PHENYL]ACETYL] 2 (3,4 DICHLOROPHENYL) 2 MORPHOLINYL]ETHYL] 4 PIPERIDINYL] 2 METHYLPROPANAMIDE; 5 AMINOVALERYLSUBSTANCE P [7-11][9 PROLINE 10 (N METHYLLEUCINE)]; CITRIC ACID; INOSITOL PHOSPHATE; NEUROKININ 1 RECEPTOR; NEUROKININ 1 RECEPTOR ANTAGONIST; NEUROKININ 2 RECEPTOR; NEUROKININ 3 RECEPTOR; NEUROKININ A; NEUROKININ B; NORADRENALIN; PROPIONAMIDE DERIVATIVE; SEPTIDE; SSR 240600; SUBSTANCE P; SUBSTANCE P DERIVATIVE; TACHYKININ; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOMA CELL; BINDING AFFINITY; BINDING ASSAY; BINDING COMPETITION; BRAIN CORTEX; BRONCHOSPASM; BRONCHUS; CELL LINE; CENTRAL NERVOUS SYSTEM; CLINICAL ARTICLE; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; COUGHING; DISEASE MODEL; DOG; DRUG EFFECT; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; FEMALE; GERBIL; GUINEA PIG; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTENSION; IC 50; IN VITRO STUDY; LYMPHOBLAST; MALE; MICROVASCULATURE; NONHUMAN; PRIORITY JOURNAL; RABBIT; RAT; SPECIES COMPARISON; VASCULAR DISEASE;

ANIMALS; BINDING, COMPETITIVE; BRONCHI; CEREBRAL CORTEX; CHO CELLS; CRICETINAE; DOGS; ENDOTHELIUM, VASCULAR; FEMALE; GERBILLINAE; GUINEA PIGS; HUMANS; MALE; MIDDLE AGED; MORPHOLINES; PIPERIDINES; QUINUCLIDINES; RABBITS; RATS; RECEPTORS, NEUROKININ-1; TUMOR CELLS, CULTURED;

EID: 0036897244     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.040162     Document Type: Article

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