Dual neurokinin NK1/NK2 antagonists: N-[(R,R)-(E)-1-arylmethyl-3-(2-oxo-azepan-3-yl)carbamoyl]allyl-N-methyl-3,5- bis(trifluoromethyl)benzamides and 3-[N′-3,5-bis(trifluoromethyl)benzoyl-N-arylmethyl-N′- methylhydrazino]-N-[(R)-2-oxo-azepan-3-yl]propionamides

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 23, 2001, Pages 3081-3084

  Gerspacher, Marc ^a   La Vecchia, Luigi ^a   Mah, Robert ^a   Von Sprecher, Andreas ^a   Anderson, Gary P ^b   Subramanian, Natarajan ^a   Hauser, Kathleen ^a   Bammerlin, Heinrich ^a   Kimmel, Sabine ^a   Pawelzik, Viviane ^a   Ryffel, Karin ^a   Ball, Howard A ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

3 [N' 3,5 BIS(TRIFLUOROMETHYL)BENZOYL N (3,4 DICHLOROBENZYL) N' METHYLHYDRAZINO] N (2 OXAZEPAN 3 YL)PROPIONAMIDE; 3 [N' 3,5 BIS(TRIFLUOROMETHYL)BENZOYL N METHYL N' METHYLHYDRAZINO] N [2 OXO AZEPAN 3 YL]PROPIONAMIDE DERIVATIVE; BENZAMIDE DERIVATIVE; DNK 333; N [1 (3,4 DICHLOROBENZYL) 3 (2 OXOAZEPAN 3 YL)CARBAMOYL]ALLYL N METHYL 3,5 BIS(TRIFLUOROMETHYL)BENZAMIDE; N [1 3 (2 OXO AZEPAN 3 YL)CARBAMOYL]ALLYL N METHYL 3,5 BIS(TRIFLUOROMETHYL)BENZAMIDE DERIVATIVE; PROPIONAMIDE DERIVATIVE; TACHYKININ RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; DRUG IDENTIFICATION; DRUG POTENCY; DRUG STRUCTURE; REACTION ANALYSIS; RECEPTOR AFFINITY; RECEPTOR BLOCKING;

ANIMALS; AZA COMPOUNDS; BENZAMIDES; CHO CELLS; CRICETINAE; DRUG EVALUATION, PRECLINICAL; HUMANS; HYDRAZINES; INHIBITORY CONCENTRATION 50; RECEPTORS, NEUROKININ-1; RECEPTORS, NEUROKININ-2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035803010     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00631-X     Document Type: Article

References (22)