Discovery of novel, orally active dual NK1/NK2 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 20, 2001, Pages 2769-2773

  Bernstein, Peter R ^a   Aharony, David ^a   Albert, Jeffrey S ^a   Andisik, Donald ^a   Barthlow, Herbert G ^a   Bialecki, Russell ^a   Davenport, Timothy ^a   Dedinas, Robert F ^a   Dembofsky, Bruce T ^a   Koether, Gerard ^a   Kosmider, Benedict J ^a   Kirkland, Karin ^a   Ohnmacht, Cyrus J ^a   Potts, William ^a   Rumsey, William L ^a   Shen, Lihong ^a   Shenvi, Ashok ^a   Sherwood, Scott ^a   Stollman, David ^a   Russell, Keith ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG ANALOG; MDL 105212; NEUROKININ 1 RECEPTOR; NEUROKININ 1 RECEPTOR AGONIST; NEUROKININ 1 RECEPTOR ANTAGONIST; NEUROKININ 2 RECEPTOR; NEUROKININ 2 RECEPTOR ANTAGONIST; NEUROKININ A; PLASMA PROTEIN; SAREDUTANT; SUBSTANCE P; TRITIUM; UNCLASSIFIED DRUG; ZD 6021; ZD 7944;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BRONCHOSPASM; BRONCHUS; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; EXTRAVASATION; GUINEA PIG; NONHUMAN; PROTEIN BINDING; PULMONARY ARTERY; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; BENZAMIDES; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; MODELS, ANIMAL; PIPERIDINES; RATS; RECEPTORS, NEUROKININ-1; RECEPTORS, NEUROKININ-2; STRUCTURE-ACTIVITY RELATIONSHIP; SULFOXIDES;

EID: 0035935196     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00572-8     Document Type: Article

References (19)