Peripheral Activity of a New NK1 receptor antagonist TAK-637 in the gastrointestinal tract

Journal of Pharmacology and Experimental Therapeutics

Volumn 300, Issue 3, 2002, Pages 1046-1052

  Venkova, Kalina ^a,b   Sutkowski Markmann, D M ^a,b   Greenwood Van Meerveld, Beverley ^a,b,c  

^a Oklahoma Foundation for Digestive Research   (United States)

^b TAP PHARMACEUTICAL PRODUCTS INC   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINOVALERYLSUBSTANCE P [7-11][9 PROLINE 10 (N METHYLLEUCINE)]; 7 [3,5 BIS(TRIFLUOROMETHYL)BENZYL] 8,9,10,11 TETRAHYDRO 9 METHYL 5 [4 METHYL 5 (4 METHYLPHENYL) 7H [1,4]DIAZOCINO[2,1 G][1,7]NAPHTHYRIDINE 6,13 DIONE]; ATROPINE; CAPSAICIN; NAPHTHYRIDINE DERIVATIVE; NEUROKININ 1 RECEPTOR AGONIST; NEUROKININ 1 RECEPTOR ANTAGONIST; NEUROKININ 3 RECEPTOR AGONIST; NEUROKININ A [3-10][3 LYSINE 8 GLYCINE GAMMA LACTAM 9 LEUCINE]; SENKTIDE; SUBSTANCE P; SUBSTANCE P DERIVATIVE; TAK 637; TETRODOTOXIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CHOLINERGIC ACTIVITY; COLON MUCOSA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; GASTROINTESTINAL TRACT; GUINEA PIG; INTESTINE CONTRACTION; MALE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; CAPSAICIN; DIGESTIVE SYSTEM; ELECTRIC STIMULATION; GUINEA PIGS; ISOMETRIC CONTRACTION; MALE; MUSCLE, SMOOTH; NAPHTHYRIDINES; PEPTIDE FRAGMENTS; RECEPTORS, NEUROKININ-1; SUBSTANCE P;

EID: 0036182104     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.300.3.1046     Document Type: Article

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