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Volumn 41, Issue 2, 2004, Pages 207-231

Jak2 tyrosine kinase: A true jak of all trades?

Author keywords

Disease; Gene transcription; Jak2; Signal transduction; Tyrosine kinase

Indexed keywords

CYTOKINE; JANUS KINASE 2; LIGAND;

EID: 23744492766     PISSN: 10859195     EISSN: None     Source Type: Journal    
DOI: 10.1385/CBB:41:2:207     Document Type: Review
Times cited : (47)

References (165)
  • 1
  • 2
    • 0026081302 scopus 로고
    • Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase
    • Wilks, A. F., Harpur, A. G., Kurban, R. R., Ralph, S. J., Zurcher, G., and Ziemiecki, A. (1991) Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase. Mol. Cell. Biol. 11, 2057-2065.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 2057-2065
    • Wilks, A.F.1    Harpur, A.G.2    Kurban, R.R.3    Ralph, S.J.4    Zurcher, G.5    Ziemiecki, A.6
  • 3
    • 0026735084 scopus 로고
    • JAK2, a third member of the JAK family of protein tyrosine kinases
    • Harpur, A. G., Andres, A. C., Ziemiecki, A., Aston, R. R., and Wilks, A. F. (1992) JAK2, a third member of the JAK family of protein tyrosine kinases. Oncogene 7, 1347-1353.
    • (1992) Oncogene , vol.7 , pp. 1347-1353
    • Harpur, A.G.1    Andres, A.C.2    Ziemiecki, A.3    Aston, R.R.4    Wilks, A.F.5
  • 4
    • 0029059915 scopus 로고
    • Cloning of the gene encoding rat JAK2, a protein tyrosine kinase
    • Duhe, R. J., Rui, H., Greenwood, J. D., Garvey, K., and Farrar, W. L. (1995) Cloning of the gene encoding rat JAK2, a protein tyrosine kinase. Gene 158, 281-285.
    • (1995) Gene , vol.158 , pp. 281-285
    • Duhe, R.J.1    Rui, H.2    Greenwood, J.D.3    Garvey, K.4    Farrar, W.L.5
  • 5
    • 0028301958 scopus 로고
    • Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes
    • Kawamura, M., McVicar, D. W., Johnston, J. A., Blake, T. B., Chen, Y. Q., Lal, B. K., et al. (1994) Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes. Proc. Natl. Acad. Sci. U. S. A. 91, 6374-6378.
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 6374-6378
    • Kawamura, M.1    McVicar, D.W.2    Johnston, J.A.3    Blake, T.B.4    Chen, Y.Q.5    Lal, B.K.6
  • 6
    • 0028268381 scopus 로고
    • Molecular cloning of rat JAK3, a novel mem-ber of the JAK family of protein tyrosine kinases
    • Takahashi, T. and Shirasawa, T. (1994) Molecular cloning of rat JAK3, a novel mem-ber of the JAK family of protein tyrosine kinases. FEBS Lett. 342, 124-128.
    • (1994) FEBS Lett. , vol.342 , pp. 124-128
    • Takahashi, T.1    Shirasawa, T.2
  • 7
    • 0028206119 scopus 로고
    • JAK3: A novel JAK kinase associated with terminal differentiation of hematopoietic cells
    • Rane, S. G. and Reddy, E. P. (1994) JAK3: a novel JAK kinase associated with terminal differentiation of hematopoietic cells. Oncogene 9, 2415-2423.
    • (1994) Oncogene , vol.9 , pp. 2415-2423
    • Rane, S.G.1    Reddy, E.P.2
  • 8
    • 13044263117 scopus 로고    scopus 로고
    • Gene duplication of zebrafish JAK2 homologs is accompanied by divergent embryonic expression patterns: Only jak2a is expressed during erythropoiesis
    • Oates, A. C., Brownlie, A., Pratt, S. J., Irvine, D. V, Liao, E. C., Paw, B. H., et al. (1999) Gene duplication of zebrafish JAK2 homologs is accompanied by divergent embryonic expression patterns: only jak2a is expressed during erythropoiesis. Blood 94, 2622-2636.
    • (1999) Blood , vol.94 , pp. 2622-2636
    • Oates, A.C.1    Brownlie, A.2    Pratt, S.J.3    Irvine, D.V.4    Liao, E.C.5    Paw, B.H.6
  • 9
    • 0027957316 scopus 로고
    • Stripe-specific regulation of pair-rule genes by hopscotch, a putative Jak family tyrosine kinase in Drosophila
    • Binari, R., and Perrimon, N. (1994) Stripe-specific regulation of pair-rule genes by hopscotch, a putative Jak family tyrosine kinase in Drosophila. Genes Dev. 8, 300-312.
    • (1994) Genes Dev. , vol.8 , pp. 300-312
    • Binari, R.1    Perrimon, N.2
  • 10
    • 0027327484 scopus 로고
    • JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin
    • Witthuhn, B. A., Quelle, F. W., Silvennoinen, O., Yi, T., Tang, B., Miura, O., et al. (1993) JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin. Cell 74, 227-236.
    • (1993) Cell , vol.74 , pp. 227-236
    • Witthuhn, B.A.1    Quelle, F.W.2    Silvennoinen, O.3    Yi, T.4    Tang, B.5    Miura, O.6
  • 11
  • 13
    • 0027941433 scopus 로고
    • Activation of receptor-associated tyrosine kinase JAK2 by prolactin
    • Rui, H., Kirken, R. A., and Farrar, W. L. (1994) Activation of receptor-associated tyrosine kinase JAK2 by prolactin. J. Biol. Chem. 269, 5364-5368.
    • (1994) J. Biol. Chem. , vol.269 , pp. 5364-5368
    • Rui, H.1    Kirken, R.A.2    Farrar, W.L.3
  • 15
    • 0027914818 scopus 로고
    • Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway
    • Watling, D., Guschin, D., Muller, M., Silvennoinen, O., Witthuhn, B. A., Quelle, F. W., et al. (1993) Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway. Nature 366, 166-170.
    • (1993) Nature , vol.366 , pp. 166-170
    • Watling, D.1    Guschin, D.2    Muller, M.3    Silvennoinen, O.4    Witthuhn, B.A.5    Quelle, F.W.6
  • 16
    • 0026770248 scopus 로고
    • Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor
    • Schindler, C., Shuai, K., Prezioso, V. R., and Darnell, J. E., Jr. (1992) Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science 257, 809-813.
    • (1992) Science , vol.257 , pp. 809-813
    • Schindler, C.1    Shuai, K.2    Prezioso, V.R.3    Darnell Jr., J.E.4
  • 17
    • 0027090310 scopus 로고
    • Activation of transcription by IFN-gamma: Tyrosine phosphorylation of a 91-kD DNA binding protein
    • Shuai, K., Schindler, C., Prezioso, V. R., and Darnell, J. E., Jr. (1992) Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein. Science 258, 1808-1812.
    • (1992) Science , vol.258 , pp. 1808-1812
    • Shuai, K.1    Schindler, C.2    Prezioso, V.R.3    Darnell Jr., J.E.4
  • 19
    • 0037138370 scopus 로고    scopus 로고
    • Signaling through the JAK/STAT pathway, recent advances and future challenges
    • Kisseleva, T., Bhattacharya, S., Braunstein, J., and Schindler, C. W. (2002) Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene 285:1-24.
    • (2002) Gene , vol.285 , pp. 1-24
    • Kisseleva, T.1    Bhattacharya, S.2    Braunstein, J.3    Schindler, C.W.4
  • 20
    • 0029851396 scopus 로고    scopus 로고
    • Differential activation of signal transducer and activator of transcription (STAT)-3 and STAT-1 transcription factors and c-fos messenger ribonucleic acid by interleukin-6 and interferon-gamma in Sertoli cells
    • Jenab, S. and Morris, P. L. (1996) Differential activation of signal transducer and activator of transcription (STAT)-3 and STAT-1 transcription factors and c-fos messenger ribonucleic acid by interleukin-6 and interferon-gamma in Sertoli cells. Endocrinology 137, 4738-4743.
    • (1996) Endocrinology , vol.137 , pp. 4738-4743
    • Jenab, S.1    Morris, P.L.2
  • 21
    • 0028242505 scopus 로고
    • Physical association of JAK1 and JAK2 tyrosine kinases with the interleukin 2 receptor beta and gamma chains
    • Tanaka, N., Asao, H., Ohbo, K., Ishii, N., Takeshita, T., Nakamura, M., et al. (1994) Physical association of JAK1 and JAK2 tyrosine kinases with the interleukin 2 receptor beta and gamma chains. Proc. Natl. Acad. Sci. U. S. A. 91, 7271-7275.
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 7271-7275
    • Tanaka, N.1    Asao, H.2    Ohbo, K.3    Ishii, N.4    Takeshita, T.5    Nakamura, M.6
  • 22
    • 0028113506 scopus 로고
    • A critical cytoplasmic domain of the interleukin-5 (IL-5) receptor alpha chain and its function in IL-5-mediated growth signal transduction
    • Takaki, S., Kanazawa, H., Shiiba, M., and Takatsu, K. (1994) A critical cytoplasmic domain of the interleukin-5 (IL-5) receptor alpha chain and its function in IL-5-mediated growth signal transduction. Mol. Cell. Biol. 14, 7404-7413.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 7404-7413
    • Takaki, S.1    Kanazawa, H.2    Shiiba, M.3    Takatsu, K.4
  • 23
    • 0028260344 scopus 로고
    • Identification of a 130-kilodalton tyrosine-phosphorylated protein induced by interleukin-11 as JAK2 tyrosine kinase, which associates with gp130 signal transducer
    • Yin, T., Yasukawa, K., Taga, T., Kishimoto, T., and Yang, Y. C. (1994) Identification of a 130-kilodalton tyrosine-phosphorylated protein induced by interleukin-11 as JAK2 tyrosine kinase, which associates with gp130 signal transducer. Exp. Hematol. 22, 467-472.
    • (1994) Exp. Hematol. , vol.22 , pp. 467-472
    • Yin, T.1    Yasukawa, K.2    Taga, T.3    Kishimoto, T.4    Yang, Y.C.5
  • 24
    • 0028910222 scopus 로고
    • Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: Differential use of Janus family tyrosine kinases by IL-2 and IL-12
    • Bacon, C. M., McVicar, D. W., Ortaldo, J. R., Rees, R. C., O'Shea, J. J., and Johnston, J. A. (1995) Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12. J. Exp. Med. 181, 399-404.
    • (1995) J. Exp. Med. , vol.181 , pp. 399-404
    • Bacon, C.M.1    McVicar, D.W.2    Ortaldo, J.R.3    Rees, R.C.4    O'Shea, J.J.5    Johnston, J.A.6
  • 25
    • 0028180569 scopus 로고
    • JAK2 associates with the beta c chain of the receptor for granulocyte macrophage colony-stimulating factor, and its activation requires the membrane-proximal region
    • Quelle, F. W., Sato, N., Witthuhn, B. A., Inborn, R. C., Eder, M., Miyajima, A., et al. (1994) JAK2 associates with the beta c chain of the receptor for granulocyte macrophage colony-stimulating factor, and its activation requires the membrane-proximal region. Mol. Cell. Biol. 14, 4335-4341.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 4335-4341
    • Quelle, F.W.1    Sato, N.2    Witthuhn, B.A.3    Inborn, R.C.4    Eder, M.5    Miyajima, A.6
  • 26
    • 0029151385 scopus 로고
    • Interleukin-6 and ciliary neurotrophic factor trigger janus kinase activation and early gene response in rat hepatocytes
    • Wang, Y. and Fuller, G. M. (1995) Interleukin-6 and ciliary neurotrophic factor trigger janus kinase activation and early gene response in rat hepatocytes. Gene 162, 285-289.
    • (1995) Gene , vol.162 , pp. 285-289
    • Wang, Y.1    Fuller, G.M.2
  • 27
    • 0027965247 scopus 로고
    • G-CSF induces tyrosine phosphorylation of the JAK2 protein in the human myeloid G-CSF responsive and proliferative cells, but not in mature neutrophils
    • Shimoda, K., Iwasaki, H., Okamura, S., Ohno, Y., Kubota, A., Arima, F., et al. (1994) G-CSF induces tyrosine phosphorylation of the JAK2 protein in the human myeloid G-CSF responsive and proliferative cells, but not in mature neutrophils. Biochem. Biophys. Res. Commun. 203, 922-928.
    • (1994) Biochem. Biophys. Res. Commun. , vol.203 , pp. 922-928
    • Shimoda, K.1    Iwasaki, H.2    Okamura, S.3    Ohno, Y.4    Kubota, A.5    Arima, F.6
  • 28
    • 0028910991 scopus 로고
    • The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl
    • Drachman, J. G., Griffin, J. D., and Kaushansky K. (1995) The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl. J. Biol. Chem. 270, 4979-4982.
    • (1995) J. Biol. Chem. , vol.270 , pp. 4979-4982
    • Drachman, J.G.1    Griffin, J.D.2    Kaushansky, K.3
  • 29
    • 0030956390 scopus 로고    scopus 로고
    • The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line
    • Ghilardi, N. and Skoda, R. C. (1997) The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line. Mol. Endocrinol. 11, 393-399.
    • (1997) Mol. Endocrinol. , vol.11 , pp. 393-399
    • Ghilardi, N.1    Skoda, R.C.2
  • 30
    • 0032076183 scopus 로고    scopus 로고
    • Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses
    • Rodig, S. J., Meraz, M. A., White, J. M., Lampe, P. A., Riley, J. K., Arthur, C. D., et al. (1998) Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses. Cell 93, 373-383.
    • (1998) Cell , vol.93 , pp. 373-383
    • Rodig, S.J.1    Meraz, M.A.2    White, J.M.3    Lampe, P.A.4    Riley, J.K.5    Arthur, C.D.6
  • 31
    • 0032076542 scopus 로고    scopus 로고
    • Jak2 is essential for signaling through a variety of cytokine receptors
    • Parganas, E., Wang, D., Stravopodis, D., Topham, D. J., Marine, J. C., Teglund, S., et al. (1998) Jak2 is essential for signaling through a variety of cytokine receptors. Cell 93, 385-395.
    • (1998) Cell , vol.93 , pp. 385-395
    • Parganas, E.1    Wang, D.2    Stravopodis, D.3    Topham, D.J.4    Marine, J.C.5    Teglund, S.6
  • 32
    • 18244432009 scopus 로고    scopus 로고
    • Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis
    • Neubauer, H., Cumano, A., Muller, M., Wu, H., Huffstadt, U., and Pfeffer, K. (1998) Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell 93, 397-409.
    • (1998) Cell , vol.93 , pp. 397-409
    • Neubauer, H.1    Cumano, A.2    Muller, M.3    Wu, H.4    Huffstadt, U.5    Pfeffer, K.6
  • 33
    • 0028799457 scopus 로고
    • Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3
    • Thomis, D. C., Gurniak, C. B., Tivol, E., Sharpe, A. H., and Berg, L. J. (1995) Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science 270, 794-797.
    • (1995) Science , vol.270 , pp. 794-797
    • Thomis, D.C.1    Gurniak, C.B.2    Tivol, E.3    Sharpe, A.H.4    Berg, L.J.5
  • 34
    • 0033952813 scopus 로고    scopus 로고
    • Janus kinase 3 (Jak3) is essential for common cytokine receptor gamma chain (gamma(c))-dependent signaling: Comparative analysis of gamma(c), Jak3, and gamma(c) and Jak3 double-deficient mice
    • Suzuki, K., Nakajima, H., Saito, Y., Saito, T., Leonard, W. J., and Iwamoto, I. (2000) Janus kinase 3 (Jak3) is essential for common cytokine receptor gamma chain (gamma(c))-dependent signaling: comparative analysis of gamma(c), Jak3, and gamma(c) and Jak3 double-deficient mice. Int. Immunol. 12, 123-132.
    • (2000) Int. Immunol. , vol.12 , pp. 123-132
    • Suzuki, K.1    Nakajima, H.2    Saito, Y.3    Saito, T.4    Leonard, W.J.5    Iwamoto, I.6
  • 36
    • 13344282731 scopus 로고    scopus 로고
    • Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway
    • Meraz, M. A., White, J. M., Sheehan, K. C., Bach, E. A., Rodig, S. J., Dighe, A. S., et al. (1996) Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 84, 431-442.
    • (1996) Cell , vol.84 , pp. 431-442
    • Meraz, M.A.1    White, J.M.2    Sheehan, K.C.3    Bach, E.A.4    Rodig, S.J.5    Dighe, A.S.6
  • 37
    • 0034515268 scopus 로고    scopus 로고
    • Immune response in Stat2 knockout mice
    • Park, C., Li, S., Cha, E., and Schindler, C. (2000) Immune response in Stat2 knockout mice. Immunity 13, 795-804.
    • (2000) Immunity , vol.13 , pp. 795-804
    • Park, C.1    Li, S.2    Cha, E.3    Schindler, C.4
  • 39
    • 0029937270 scopus 로고    scopus 로고
    • IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
    • Kaplan, M. H., Sun, Y. L., Hoey, T., and Grusby, M. J. (1996) IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382, 174-177.
    • (1996) Nature , vol.382 , pp. 174-177
    • Kaplan, M.H.1    Sun, Y.L.2    Hoey, T.3    Grusby, M.J.4
  • 40
    • 0034541139 scopus 로고    scopus 로고
    • IL-12 receptor beta 2 (IL-12R beta 2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites
    • Wu, C., Wang, X., Gadina, M., O'Shea, J. J., Presky, D. H., and Magram, J. (2000) IL-12 receptor beta 2 (IL-12R beta 2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites. J. Immunol. 165, 6221-6228.
    • (2000) J. Immunol. , vol.165 , pp. 6221-6228
    • Wu, C.1    Wang, X.2    Gadina, M.3    O'Shea, J.J.4    Presky, D.H.5    Magram, J.6
  • 42
    • 0030833570 scopus 로고    scopus 로고
    • Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression
    • Udy, G. B., Towers, R. P., Snell, R. G., Wilkins, R. J., Park, S. H., Ram, P. A., et al. (1997) Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression. Proc. Natl. Acad. Sci. U.S.A. 94, 7239-7244.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 7239-7244
    • Udy, G.B.1    Towers, R.P.2    Snell, R.G.3    Wilkins, R.J.4    Park, S.H.5    Ram, P.A.6
  • 43
    • 0000943469 scopus 로고    scopus 로고
    • Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses
    • Teglund, S., McKay, C., Schuetz, E., van Deursen, J. M., Stravopodis, D., Wang, D., et al. (1998) Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell 93, 841-850.
    • (1998) Cell , vol.93 , pp. 841-850
    • Teglund, S.1    McKay, C.2    Schuetz, E.3    Van Deursen, J.M.4    Stravopodis, D.5    Wang, D.6
  • 44
    • 0029876629 scopus 로고    scopus 로고
    • Stat6 is required for mediating responses to IL-4 and for development of Th2 cells
    • Kaplan, M. H., Schindler, U., Smiley, S. T., and Grusby, M. J. (1996) Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 4, 313-319.
    • (1996) Immunity , vol.4 , pp. 313-319
    • Kaplan, M.H.1    Schindler, U.2    Smiley, S.T.3    Grusby, M.J.4
  • 45
    • 15844374279 scopus 로고    scopus 로고
    • Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene
    • Shimoda, K., van Deursen, J., Sangster, M. Y., Sarawar, S. R., Carson, R. T., Tripp, R. A., et al. (1996) Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 380, 630-633.
    • (1996) Nature , vol.380 , pp. 630-633
    • Shimoda, K.1    Van Deursen, J.2    Sangster, M.Y.3    Sarawar, S.R.4    Carson, R.T.5    Tripp, R.A.6
  • 46
    • 0028946158 scopus 로고
    • Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway
    • Heim, M. H., Kerr, I. M., Stark, G. R., and Darnell, J. E. Jr. (1995) Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway. Science 267, 1347-1349.
    • (1995) Science , vol.267 , pp. 1347-1349
    • Heim, M.H.1    Kerr, I.M.2    Stark, G.R.3    Darnell Jr., J.E.4
  • 47
    • 0028931604 scopus 로고
    • Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors
    • Stahl, N., Farruggella, T. J., Boulton, T. G., Zhong, Z., Darnell, J. E. Jr, and Yancopoulos, G. D. (1995) Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science 267, 1349-1353.
    • (1995) Science , vol.267 , pp. 1349-1353
    • Stahl, N.1    Farruggella, T.J.2    Boulton, T.G.3    Zhong, Z.4    Darnell Jr., J.E.5    Yancopoulos, G.D.6
  • 48
    • 0028097219 scopus 로고
    • Interaction of the growth hormone receptor cytoplasmic domain with the JAK2 tyrosine kinase
    • Frank, S. J., Gilliland, G., Kraft, A. S., and Arnold, C. S. (1994) Interaction of the growth hormone receptor cytoplasmic domain with the JAK2 tyrosine kinase. Endocrinology 135, 2228-2239.
    • (1994) Endocrinology , vol.135 , pp. 2228-2239
    • Frank, S.J.1    Gilliland, G.2    Kraft, A.S.3    Arnold, C.S.4
  • 49
    • 0027936422 scopus 로고
    • Domains of the growth hormone receptor required for association and activation of JAK2 tyrosine kinase
    • VanderKuur, J. A., Wang, X., Zhang, L., Campbell, G. S., Allevato, G., Billestrup, N., et al. (1994) Domains of the growth hormone receptor required for association and activation of JAK2 tyrosine kinase. J. Biol. Chem. 269, 21709-21717.
    • (1994) J. Biol. Chem. , vol.269 , pp. 21709-21717
    • VanderKuur, J.A.1    Wang, X.2    Zhang, L.3    Campbell, G.S.4    Allevato, G.5    Billestrup, N.6
  • 50
    • 0029117304 scopus 로고
    • Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
    • Wen, Z., Zhong, Z., and Darnell, J. E., Jr. (1995) Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 82, 241-250.
    • (1995) Cell , vol.82 , pp. 241-250
    • Wen, Z.1    Zhong, Z.2    Darnell Jr., J.E.3
  • 51
    • 0030744123 scopus 로고    scopus 로고
    • Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3
    • Wen, Z. and Darnell, J. E., Jr. (1997) Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3. Nucleic Acids Res. 25, 2062-2067.
    • (1997) Nucleic Acids Res. , vol.25 , pp. 2062-2067
    • Wen, Z.1    Darnell Jr., J.E.2
  • 52
    • 0030613545 scopus 로고    scopus 로고
    • Identification of SH2-Bb as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling
    • Rui, L., Mathews, L. S., Hotta, K., Gustafson, T. A., and Carter-Su, C. (1997) Identification of SH2-Bb as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling. Mol. Cell. Biol. 17, 6633-6644.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 6633-6644
    • Rui, L.1    Mathews, L.S.2    Hotta, K.3    Gustafson, T.A.4    Carter-Su, C.5
  • 53
    • 0032704962 scopus 로고    scopus 로고
    • A catalytically active Jak2 is required for the angiotensin II-dependent activation of Fyn
    • Sayeski, P. P., Ali, M. S., Safavi, A., Lyles, M., Kim, S. O., Frank, S. J., et al. (1999) A catalytically active Jak2 is required for the angiotensin II-dependent activation of Fyn. J. Biol. Chem. 274, 33131-33142.
    • (1999) J. Biol. Chem. , vol.274 , pp. 33131-33142
    • Sayeski, P.P.1    Ali, M.S.2    Safavi, A.3    Lyles, M.4    Kim, S.O.5    Frank, S.J.6
  • 54
    • 0033546367 scopus 로고    scopus 로고
    • The angiotensin II-dependent association of Jak2 and c-Src requires the N-terminus of Jak2 and the SH2 domain of c-Src
    • Sayeski, P. P., Ali, M. S., Hawks, K., Frank, S. J., and Bernstein, K. E. (1999) The angiotensin II-dependent association of Jak2 and c-Src requires the N-terminus of Jak2 and the SH2 domain of c-Src. Circ. Res. 84, 1332-1338.
    • (1999) Circ. Res. , vol.84 , pp. 1332-1338
    • Sayeski, P.P.1    Ali, M.S.2    Hawks, K.3    Frank, S.J.4    Bernstein, K.E.5
  • 55
    • 0028799055 scopus 로고
    • Oncostatin M induces association of Grb2 with Janus kinase JAK2 in multiple myeloma cells
    • Chauhan, D., Kharbanda, S. M., Ogata, A., Urashima, M., Frank, D., Malik, N., et al. (1995) Oncostatin M induces association of Grb2 with Janus kinase JAK2 in multiple myeloma cells. J. Exp. Med. 182, 1801-1806.
    • (1995) J. Exp. Med. , vol.182 , pp. 1801-1806
    • Chauhan, D.1    Kharbanda, S.M.2    Ogata, A.3    Urashima, M.4    Frank, D.5    Malik, N.6
  • 56
    • 0030590102 scopus 로고    scopus 로고
    • Complex formation of JAK2 with PP2A, P13K, and Yes in response to the hematopoietic cytokine interleukin-11
    • Fuhrer, D. K. and Yang, Y. C. (1996) Complex formation of JAK2 with PP2A, P13K, and Yes in response to the hematopoietic cytokine interleukin-11. Biochem. Biophys. Res. Comm. 224, 289-296.
    • (1996) Biochem. Biophys. Res. Comm. , vol.224 , pp. 289-296
    • Fuhrer, D.K.1    Yang, Y.C.2
  • 58
    • 0028944585 scopus 로고
    • Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2
    • VanderKuur, J., Allevato, G., Billestrup, N., Norstedt, G., and Carter-Su, C. (1995) Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2. J. Biol. Chem. 270, 7587-7593.
    • (1995) J. Biol. Chem. , vol.270 , pp. 7587-7593
    • VanderKuur, J.1    Allevato, G.2    Billestrup, N.3    Norstedt, G.4    Carter-Su, C.5
  • 59
    • 0028882694 scopus 로고
    • Syp associates with gp130 and Janus kinase 2 in response to interleukin-11 in 3T3-L1 mouse preadipocytes
    • Fuhrer, D. K., Feng, G. S., and Yang, Y. C. (1995) Syp associates with gp130 and Janus kinase 2 in response to interleukin-11 in 3T3-L1 mouse preadipocytes. J. Biol. Chem. 270, 24826-24830.
    • (1995) J. Biol. Chem. , vol.270 , pp. 24826-24830
    • Fuhrer, D.K.1    Feng, G.S.2    Yang, Y.C.3
  • 60
    • 0032562717 scopus 로고    scopus 로고
    • Growth hormone stimulates the tyrosine phosphorylation and association of p 125 focal adhesion kinase (FAK) with JAK2. Fak is not required for stat-mediated transcription
    • Zhu, T., Goh, E. L., and Lobie, P. E. (1998) Growth hormone stimulates the tyrosine phosphorylation and association of p 125 focal adhesion kinase (FAK) with JAK2. Fak is not required for stat-mediated transcription. J. Biol. Chem. 273, 10682-10689.
    • (1998) J. Biol. Chem. , vol.273 , pp. 10682-10689
    • Zhu, T.1    Goh, E.L.2    Lobie, P.E.3
  • 61
    • 0028135399 scopus 로고
    • Angiotensin II stimulates sis-inducing factor-like DNA binding activity. Evidence that the AT1A receptor activates transcription factor-Stat91 and/or a related protein
    • Bhat, G. J., Thekkumkara, T. J., Thomas, W. G., Conrad, K. M., and Baker, K. M. (1994) Angiotensin II stimulates sis-inducing factor-like DNA binding activity. Evidence that the AT1A receptor activates transcription factor-Stat91 and/or a related protein. J. Biol. Chem. 269, 31443-31449.
    • (1994) J. Biol. Chem. , vol.269 , pp. 31443-31449
    • Bhat, G.J.1    Thekkumkara, T.J.2    Thomas, W.G.3    Conrad, K.M.4    Baker, K.M.5
  • 63
    • 0034306129 scopus 로고    scopus 로고
    • Bradykinin activates the Janus-activated kinase/signal transducers and activators of transcription (JAK/STAT) pathway in vascular endothelial cells: Localization of JAK/STAT signalling proteins in plasmalemmal caveolae
    • Ju, H., Venema, V. J., Liang, H., Harris, M. B., Zou, R., and Venema, R. C. (2000) Bradykinin activates the Janus-activated kinase/signal transducers and activators of transcription (JAK/STAT) pathway in vascular endothelial cells: localization of JAK/STAT signalling proteins in plasmalemmal caveolae. Biochem. J. 351, 257-264.
    • (2000) Biochem. J. , vol.351 , pp. 257-264
    • Ju, H.1    Venema, V.J.2    Liang, H.3    Harris, M.B.4    Zou, R.5    Venema, R.C.6
  • 65
    • 0141920604 scopus 로고    scopus 로고
    • Janus kinase 2 activation by the platelet-activating factor receptor (PAFR): Roles of Tyk2 and PAFR C terminus
    • Lukashova, V., Chen, Z., Duhe, R. J., Rola-Pleszczynski, M., and Stankova, J. (2003) Janus kinase 2 activation by the platelet-activating factor receptor (PAFR): roles of Tyk2 and PAFR C terminus. J. Immunol. 171, 3794-3800.
    • (2003) J. Immunol. , vol.171 , pp. 3794-3800
    • Lukashova, V.1    Chen, Z.2    Duhe, R.J.3    Rola-Pleszczynski, M.4    Stankova, J.5
  • 66
    • 0032055121 scopus 로고    scopus 로고
    • Binding of a-melanocyte-stimulating hormone to its G protein-coupled receptor on B-lymphocytes activates the Jak/Stat pathway
    • Buggy, J. J. (1998) Binding of a-melanocyte-stimulating hormone to its G protein-coupled receptor on B-lymphocytes activates the Jak/Stat pathway. Biochem. J. 331, 211-216.
    • (1998) Biochem. J. , vol.331 , pp. 211-216
    • Buggy, J.J.1
  • 68
    • 0030874924 scopus 로고    scopus 로고
    • Dependence on the motif YIPP for the physical association of Jak2 kinase with the intracellular carboxyl tail of the angiotensin II AT1 receptor
    • Ali, M. S., Sayeski, P. P., Dirksen, L. B., Hayzer, D. J., Marrero, M. B., and Bernstein, K. E. (1997) Dependence on the motif YIPP for the physical association of Jak2 kinase with the intracellular carboxyl tail of the angiotensin II AT1 receptor. J. Biol. Chem. 272, 23382-23388.
    • (1997) J. Biol. Chem. , vol.272 , pp. 23382-23388
    • Ali, M.S.1    Sayeski, P.P.2    Dirksen, L.B.3    Hayzer, D.J.4    Marrero, M.B.5    Bernstein, K.E.6
  • 69
    • 0035971187 scopus 로고    scopus 로고
    • The angiotensin II-dependent nuclear translocation of Stat1 is mediated by the Jak2 protein motif 231YRFRR
    • Sayeski, P. P., Ali, M. S., Frank, S. J., and Bernstein, K. E. (2001) The angiotensin II-dependent nuclear translocation of Stat1 is mediated by the Jak2 protein motif 231YRFRR. J. Biol. Chem. 276, 10556-10563.
    • (2001) J. Biol. Chem. , vol.276 , pp. 10556-10563
    • Sayeski, P.P.1    Ali, M.S.2    Frank, S.J.3    Bernstein, K.E.4
  • 70
    • 0034686082 scopus 로고    scopus 로고
    • Jak2 acts as both a STAT1 kinase and as a molecular bridge linking STAT1 to the angiotensin II ATI receptor
    • Ali, M. S., Sayeski, P. P., and Bernstein, K. E. (2000) Jak2 acts as both a STAT1 kinase and as a molecular bridge linking STAT1 to the angiotensin II ATI receptor. J. Biol. Chem. 275, 15586-15593.
    • (2000) J. Biol. Chem. , vol.275 , pp. 15586-15593
    • Ali, M.S.1    Sayeski, P.P.2    Bernstein, K.E.3
  • 71
    • 0035176107 scopus 로고    scopus 로고
    • Growth hormone signalling and its regulation: Preventing too much of a good thing
    • Frank, S. J. (2001) Growth hormone signalling and its regulation: preventing too much of a good thing. Growth Horm. I. G. F. Res. 11, 201-212.
    • (2001) Growth Horm. I. G. F. Res. , vol.11 , pp. 201-212
    • Frank, S.J.1
  • 72
    • 0030447148 scopus 로고    scopus 로고
    • In vitro activation of Stat3 by epidermal growth factor receptor kinase
    • Park, O. K., Schaefer, T. S., and Nathans, D. (1996) In vitro activation of Stat3 by epidermal growth factor receptor kinase. Proc. Natl. Acad. Sci. U. S. A. 93, 13704-13708.
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 13704-13708
    • Park, O.K.1    Schaefer, T.S.2    Nathans, D.3
  • 73
    • 0030953469 scopus 로고    scopus 로고
    • Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop
    • Feng, J., Witthuhn, B. A., Matsuda, T., Kohlhuber, F., Kerr, I. M., and Ihle, J. N. (1997) Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop. Mol. Cell. Biol. 17, 2497-2501.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 2497-2501
    • Feng, J.1    Witthuhn, B.A.2    Matsuda, T.3    Kohlhuber, F.4    Kerr, I.M.5    Ihle, J.N.6
  • 74
    • 0033594812 scopus 로고    scopus 로고
    • Identification of SH2-Bb as a potent cytoplasmic activator of the tyrosine kinase Janus kinase 2
    • Rui, L. and Carter-Su, C. (1999) Identification of SH2-Bb as a potent cytoplasmic activator of the tyrosine kinase Janus kinase 2. Proc. Natl. Acad. Sci. U. S. A. 96, 7172-7177.
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 7172-7177
    • Rui, L.1    Carter-Su, C.2
  • 75
    • 0030921502 scopus 로고    scopus 로고
    • Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2
    • Saxton, T. M., Henkemeyer, M., Gasca, S., Shen, R., Rossi, D. J., Shalaby, F., et al. (1997) Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2. EMBO J. 16, 2352-2364.
    • (1997) EMBO J. , vol.16 , pp. 2352-2364
    • Saxton, T.M.1    Henkemeyer, M.2    Gasca, S.3    Shen, R.4    Rossi, D.J.5    Shalaby, F.6
  • 76
    • 0031890381 scopus 로고    scopus 로고
    • Involvement of the Src homology 2-containing tyrosine phosphatase SHP-2 in growth hormone signaling
    • Kim, S. O., Jiang, J., Yi, W., Feng, G. S., and Frank, S. J. (1998) Involvement of the Src homology 2-containing tyrosine phosphatase SHP-2 in growth hormone signaling. J. Biol. Chem. 273, 2344-2354.
    • (1998) J. Biol. Chem. , vol.273 , pp. 2344-2354
    • Kim, S.O.1    Jiang, J.2    Yi, W.3    Feng, G.S.4    Frank, S.J.5
  • 77
    • 0032980574 scopus 로고    scopus 로고
    • Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway
    • You, M., Yu, D. H., and Feng, G. S. (1999) Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway. Mol. Cell. Biol. 19, 2416-2424.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 2416-2424
    • You, M.1    Yu, D.H.2    Feng, G.S.3
  • 78
    • 0031033714 scopus 로고    scopus 로고
    • Molecular characterization of specific interactions between SHP-2 phosphatase and JAK tyrosine kinases
    • Yin, T., Shen, R., Feng, G. S., and Yang, Y. C. (1997) Molecular characterization of specific interactions between SHP-2 phosphatase and JAK tyrosine kinases. J. Biol. Chem. 272, 1032-1037.
    • (1997) J. Biol. Chem. , vol.272 , pp. 1032-1037
    • Yin, T.1    Shen, R.2    Feng, G.S.3    Yang, Y.C.4
  • 79
    • 0029086236 scopus 로고
    • Characterization of active and inactive forms of the JAK2 protein-tyrosine kinase produced via the baculovirus expression vector system
    • Duhe, R. J. and Farrar, W. L. (1995) Characterization of active and inactive forms of the JAK2 protein-tyrosine kinase produced via the baculovirus expression vector system. J. Biol. Chem. 270, 23084-23089.
    • (1995) J. Biol. Chem. , vol.270 , pp. 23084-23089
    • Duhe, R.J.1    Farrar, W.L.2
  • 80
    • 0028134741 scopus 로고
    • Dominant negative effects of a carboxy-truncated Jak2 mutant on Epo-induced proliferation and Jak2 activation
    • Zhuang, H., Patel, S. V., He, T. C., Niu, Z., and Wojchowski, D. M. (1994) Dominant negative effects of a carboxy-truncated Jak2 mutant on Epo-induced proliferation and Jak2 activation. Biochem. Biophys. Res. Commun. 204, 278-283.
    • (1994) Biochem. Biophys. Res. Commun. , vol.204 , pp. 278-283
    • Zhuang, H.1    Patel, S.V.2    He, T.C.3    Niu, Z.4    Wojchowski, D.M.5
  • 81
    • 0028074204 scopus 로고
    • Inhibition of erythropoietin-induced mitogenesis by a kinase-deficient form of Jak2
    • Zhuang, H., Patel, S. V., He, T. C., Sonsteby, S. K., Niu, Z., and Wojchowski, D. M. (1994) Inhibition of erythropoietin-induced mitogenesis by a kinase-deficient form of Jak2. J. Biol. Chem. 269, 21411-21414.
    • (1994) J. Biol. Chem. , vol.269 , pp. 21411-21414
    • Zhuang, H.1    Patel, S.V.2    He, T.C.3    Sonsteby, S.K.4    Niu, Z.5    Wojchowski, D.M.6
  • 82
    • 0032810186 scopus 로고    scopus 로고
    • Genomic organization of human JAK2 and mutation analysis of its JH2-domain in leukemia
    • Cools, J., Peeters, P., Voet, T., Aventin, A., Mecucci, C., Grandchamp, B., et al. (1999) Genomic organization of human JAK2 and mutation analysis of its JH2-domain in leukemia. Cytogenet. Cell. Genet. 85, 260-266.
    • (1999) Cytogenet. Cell. Genet. , vol.85 , pp. 260-266
    • Cools, J.1    Peeters, P.2    Voet, T.3    Aventin, A.4    Mecucci, C.5    Grandchamp, B.6
  • 83
    • 0029973560 scopus 로고    scopus 로고
    • Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1
    • Jiao, H., Berrada, K., Yang, W., Tabrizi, M., Platanias, L. C., and Yi, T. (1996) Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1. Mol. Cell. Biol. 16, 6985-6992.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 6985-6992
    • Jiao, H.1    Berrada, K.2    Yang, W.3    Tabrizi, M.4    Platanias, L.C.5    Yi, T.6
  • 84
    • 0027197067 scopus 로고
    • Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene
    • Shultz, L. D., Schweitzer, P. A., Rajan, T. V., Yi, T., Ihle, J. N., Matthews, R. J., et al. (1993) Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene. Cell 73, 1445-1454.
    • (1993) Cell , vol.73 , pp. 1445-1454
    • Shultz, L.D.1    Schweitzer, P.A.2    Rajan, T.V.3    Yi, T.4    Ihle, J.N.5    Matthews, R.J.6
  • 85
    • 0027195626 scopus 로고
    • Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene
    • Tsui, H. W., Siminovitch, K. A., de Souza, L., and Tsui, F. W. (1993) Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene. Nat. Genet. 4, 124-129.
    • (1993) Nat. Genet. , vol.4 , pp. 124-129
    • Tsui, H.W.1    Siminovitch, K.A.2    De Souza, L.3    Tsui, F.W.4
  • 86
    • 0029014206 scopus 로고
    • A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors
    • Yoshimura, A., Ohkubo, T., Kiguchi, T., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., et al. (1995) A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. EMBO J. 14, 2816-2826.
    • (1995) EMBO J. , vol.14 , pp. 2816-2826
    • Yoshimura, A.1    Ohkubo, T.2    Kiguchi, T.3    Jenkins, N.A.4    Gilbert, D.J.5    Copeland, N.G.6
  • 87
    • 20244389693 scopus 로고    scopus 로고
    • The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop
    • Yasukawa, H., Misawa, H., Sakamoto, H., Masuhara, M., Sasaki, A., Wakioka, T., et al. (1999) The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop. EMBO J. 18, 1309-1320.
    • (1999) EMBO J. , vol.18 , pp. 1309-1320
    • Yasukawa, H.1    Misawa, H.2    Sakamoto, H.3    Masuhara, M.4    Sasaki, A.5    Wakioka, T.6
  • 88
    • 0030725378 scopus 로고    scopus 로고
    • Specific inhibition of Stat3 signal transduction by PIAS3
    • Chung, C. D., Liao, J., Liu, B., Rao, X., Jay, P., Berta, P., et al. (1997) Specific inhibition of Stat3 signal transduction by PIAS3. Science 278, 1803-1805.
    • (1997) Science , vol.278 , pp. 1803-1805
    • Chung, C.D.1    Liao, J.2    Liu, B.3    Rao, X.4    Jay, P.5    Berta, P.6
  • 90
    • 0035042611 scopus 로고    scopus 로고
    • SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity
    • Yoshikawa, H., Matsubara, K., Qian, G. S., Jackson, P., Groopman, J. D., Mann, J. E., et al. (2001) SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity. Nat. Genet. 1, 29-35.
    • (2001) Nat. Genet. , vol.1 , pp. 29-35
    • Yoshikawa, H.1    Matsubara, K.2    Qian, G.S.3    Jackson, P.4    Groopman, J.D.5    Mann, J.E.6
  • 91
    • 0037206950 scopus 로고    scopus 로고
    • Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells
    • Real, P. J., Sierra, A., De Juan, A., Segovia, J. C., Lopez-Vega, J. M., and Fernandez-Luna, J. L. (2002) Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells. Oncogene 50, 7611-7618.
    • (2002) Oncogene , vol.50 , pp. 7611-7618
    • Real, P.J.1    Sierra, A.2    De Juan, A.3    Segovia, J.C.4    Lopez-Vega, J.M.5    Fernandez-Luna, J.L.6
  • 92
    • 0037126385 scopus 로고    scopus 로고
    • Jak2 is involved in c-Myc induction by Bcr-Abl
    • Xie, S., Lin, H., Sun, T., and Arlinghaus, R. B. (2002) Jak2 is involved in c-Myc induction by Bcr-Abl. Oncogene 47, 7137-7146.
    • (2002) Oncogene , vol.47 , pp. 7137-7146
    • Xie, S.1    Lin, H.2    Sun, T.3    Arlinghaus, R.B.4
  • 93
    • 13344295097 scopus 로고    scopus 로고
    • Inhibition of acute lymphoblastic leukemia by a Jak-2 inhibitor
    • Meydan, N., Grunberger, T., Dadi, H., Shahar, M., Arpaia, E., Lapidot, Z., et al. (1996) Inhibition of acute lymphoblastic leukemia by a Jak-2 inhibitor. Nature 379, 645-648.
    • (1996) Nature , vol.379 , pp. 645-648
    • Meydan, N.1    Grunberger, T.2    Dadi, H.3    Shahar, M.4    Arpaia, E.5    Lapidot, Z.6
  • 94
    • 0034721797 scopus 로고    scopus 로고
    • Constitutive tyrosine phosphorylation of ErbB-2 via Jak2 autocrine secretion of prolactin in human breast cancer
    • Yamauchi, T., Yamauchi, N., Ueki, K., Sugiyama, T., Waki, H., Miki, H., et al. (2000) Constitutive tyrosine phosphorylation of ErbB-2 via Jak2 autocrine secretion of prolactin in human breast cancer. J. Biol. Chem. 275, 33937-33944.
    • (2000) J. Biol. Chem. , vol.275 , pp. 33937-33944
    • Yamauchi, T.1    Yamauchi, N.2    Ueki, K.3    Sugiyama, T.4    Waki, H.5    Miki, H.6
  • 95
    • 0035157978 scopus 로고    scopus 로고
    • The Jak2 inhibitor AG490 predominantly abrogates the growth of human B-precursor leukemic cells with 11q23 translocation or Philadelphia chromosome
    • Miyamoto, N., Sugita, K., Goi, K., Inukai, T., Lijima, K., Tezuka, T., et al. (2001) The Jak2 inhibitor AG490 predominantly abrogates the growth of human B-precursor leukemic cells with 11q23 translocation or Philadelphia chromosome. Leukemia 11, 1758-1768.
    • (2001) Leukemia , vol.11 , pp. 1758-1768
    • Miyamoto, N.1    Sugita, K.2    Goi, K.3    Inukai, T.4    Lijima, K.5    Tezuka, T.6
  • 96
    • 0034617181 scopus 로고    scopus 로고
    • Role of the JAK/STAT pathway in rat carotid artery remodeling after vascular injury
    • Seki, Y., Kai, H. Shibata, R., Nagata, T., Yasukawa, H., Yosimura, A., et al. (2000) Role of the JAK/STAT pathway in rat carotid artery remodeling after vascular injury. Circ. Res. 87, 12-18.
    • (2000) Circ. Res. , vol.87 , pp. 12-18
    • Seki, Y.1    Kai, H.2    Shibata, R.3    Nagata, T.4    Yasukawa, H.5    Yosimura, A.6
  • 97
    • 0033679851 scopus 로고    scopus 로고
    • Significance of ERK cascade compared with JAK/STAT and PI3-K pathway in gp-130-mediated cardiac hypertrophy
    • Kodama, H., Fukuda, K., Pan, J., Sano, M., Takahashi, T., Kato, T., et al. (2000) Significance of ERK cascade compared with JAK/STAT and PI3-K pathway in gp-130-mediated cardiac hypertrophy. Am. J. Physiol. Heart Circ. Physiol. 279, H1635-644.
    • (2000) Am. J. Physiol. Heart Circ. Physiol. , vol.279
    • Kodama, H.1    Fukuda, K.2    Pan, J.3    Sano, M.4    Takahashi, T.5    Kato, T.6
  • 99
    • 0035902571 scopus 로고    scopus 로고
    • JAK/STAT signaling is associated with cardiac dysfunction during ischemia and reperfusion
    • Mascareno, E., El-Shafei, M., Maulik, N., Sato, M., Guo, Y., Das, D. K., et al. (2001) JAK/STAT signaling is associated with cardiac dysfunction during ischemia and reperfusion. Circulation 104, 325-329.
    • (2001) Circulation , vol.104 , pp. 325-329
    • Mascareno, E.1    El-Shafei, M.2    Maulik, N.3    Sato, M.4    Guo, Y.5    Das, D.K.6
  • 100
    • 0032526999 scopus 로고    scopus 로고
    • Inhibition of Cdk2 activation by selected tyrphostins causes cell cycle arrest at late G1 and S phase
    • Kleinberger-Doron, N., Shelah, N., Capone, R., Gazit, A., and Levitzki, A. (1998) Inhibition of Cdk2 activation by selected tyrphostins causes cell cycle arrest at late G1 and S phase. Exp. Cell Res. 241, 340-351.
    • (1998) Exp. Cell Res. , vol.241 , pp. 340-351
    • Kleinberger-Doron, N.1    Shelah, N.2    Capone, R.3    Gazit, A.4    Levitzki, A.5
  • 102
    • 0027198702 scopus 로고
    • Selective inhibition of the EGF and HER2/Neu receptors by tyrphostins
    • Osherov, N., Gazit, A., Gilon, C., and Levitzki, A. (1993) Selective inhibition of the EGF and HER2/Neu receptors by tyrphostins. J. Biol. Chem. 268, 11134-11142.
    • (1993) J. Biol. Chem. , vol.268 , pp. 11134-11142
    • Osherov, N.1    Gazit, A.2    Gilon, C.3    Levitzki, A.4
  • 103
    • 0034790301 scopus 로고    scopus 로고
    • Growth hormone signalling and apoptosis in neonatal rat cardiomyocytes
    • Gu, Y., Zou, Y., Aikawa, R., Hayashi, D., Kudoh, S., Yamauchi, T., et al. (2001) Growth hormone signalling and apoptosis in neonatal rat cardiomyocytes. Mol. Cell. Biochem. 223, 35-46.
    • (2001) Mol. Cell. Biochem. , vol.223 , pp. 35-46
    • Gu, Y.1    Zou, Y.2    Aikawa, R.3    Hayashi, D.4    Kudoh, S.5    Yamauchi, T.6
  • 105
    • 0029024882 scopus 로고
    • Regions of the Jak2 tyrosine kinase required for coupling to the growth hormone receptor
    • Frank, S. J., Yi, W., Zhao, Y., Goldsmith, J. F., Gilliland, G., Jiang, J., et al. (1995) Regions of the Jak2 tyrosine kinase required for coupling to the growth hormone receptor. J. Biol. Chem. 270, 14776-14785.
    • (1995) J. Biol. Chem. , vol.270 , pp. 14776-14785
    • Frank, S.J.1    Yi, W.2    Zhao, Y.3    Goldsmith, J.F.4    Gilliland, G.5    Jiang, J.6
  • 106
    • 0034012330 scopus 로고    scopus 로고
    • Regulation of the Jak2 tyrosine kinase by its pseudokinase domain
    • Saharinen, P., Takaluoma, K., and Silvennoinen, O. (2000) Regulation of the Jak2 tyrosine kinase by its pseudokinase domain. Mol. Cell. Biol. 20, 3387-3395.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 3387-3395
    • Saharinen, P.1    Takaluoma, K.2    Silvennoinen, O.3
  • 107
    • 0031017533 scopus 로고    scopus 로고
    • Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways
    • Luo, H., Rose, P., Barber, D., Hanratty, W. P., Lee, S., Roberts, T. M., et al. (1997) Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways. Mol. Cell. Biol. 17, 1562-1571.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 1562-1571
    • Luo, H.1    Rose, P.2    Barber, D.3    Hanratty, W.P.4    Lee, S.5    Roberts, T.M.6
  • 108
    • 0035045092 scopus 로고    scopus 로고
    • Prediction of the structure of human Janus kinase 2 (JAK2) comprising the two carboxy-terminal domains reveals a mechanism for autoregulation
    • Lindauer, K., Loerting, T., Liedl, K. R., and Kroemer, R. T. (2001) Prediction of the structure of human Janus kinase 2 (JAK2) comprising the two carboxy-terminal domains reveals a mechanism for autoregulation. Protein Engineering 14, 27-37.
    • (2001) Protein Engineering , vol.14 , pp. 27-37
    • Lindauer, K.1    Loerting, T.2    Liedl, K.R.3    Kroemer, R.T.4
  • 109
    • 0033965488 scopus 로고    scopus 로고
    • Complex effects of naturally occurring mutations in the JAK3 pseudokinase domain: Evidence for interactions between the kinase and pseudokinase domains
    • Chen, M., Cheng, A., Candotti, F., Zhou, Y-J., Hymel, A., Fasth, A., et al. (2000) Complex effects of naturally occurring mutations in the JAK3 pseudokinase domain: evidence for interactions between the kinase and pseudokinase domains. Mol. Cell. Biol. 20, 947-956.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 947-956
    • Chen, M.1    Cheng, A.2    Candotti, F.3    Zhou, Y.-J.4    Hymel, A.5    Fasth, A.6
  • 110
    • 0037033012 scopus 로고    scopus 로고
    • The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction
    • Saharinen, P. and Silvennoinen, O. (2002) The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction. J. Biol. Chem. 277, 47954-47963.
    • (2002) J. Biol. Chem. , vol.277 , pp. 47954-47963
    • Saharinen, P.1    Silvennoinen, O.2
  • 111
    • 0038371050 scopus 로고    scopus 로고
    • Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain
    • Saharinen, P., Vihinen, M., and Silvennoinen, O. (2003) Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain. Mol. Biol. Cell 14, 1448-1459.
    • (2003) Mol. Biol. Cell , vol.14 , pp. 1448-1459
    • Saharinen, P.1    Vihinen, M.2    Silvennoinen, O.3
  • 112
    • 0025838083 scopus 로고
    • Predicted Tyk2 protein contains two tandem protein kinase domains
    • Bernards, A. (1991) Predicted Tyk2 protein contains two tandem protein kinase domains. Oncogene 6, 1185-1187.
    • (1991) Oncogene , vol.6 , pp. 1185-1187
    • Bernards, A.1
  • 113
    • 0029976603 scopus 로고    scopus 로고
    • Using CLUSTAL for multiple sequence alignments
    • Higgins, D. G., Thompson, J. D., and Gibson, T. J. (1996) Using CLUSTAL for multiple sequence alignments. Meth. Enzymol. 266, 383-402.
    • (1996) Meth. Enzymol. , vol.266 , pp. 383-402
    • Higgins, D.G.1    Thompson, J.D.2    Gibson, T.J.3
  • 114
    • 0034638632 scopus 로고    scopus 로고
    • Computational and functional analysis of the putative SH2 domain in Janus kinases
    • Kampa, D. and Burnside, J. (2000) Computational and functional analysis of the putative SH2 domain in Janus kinases. Biochem. Biophys. Res. Comm. 278, 175-182.
    • (2000) Biochem. Biophys. Res. Comm. , vol.278 , pp. 175-182
    • Kampa, D.1    Burnside, J.2
  • 115
    • 0036762867 scopus 로고    scopus 로고
    • Prediction of the structure of human Janus kinase 2 (JAK2) comprising JAK homology domains 1 through 7
    • Giordanetto, F. and Kroemer, R. T. (2002) Prediction of the structure of human Janus kinase 2 (JAK2) comprising JAK homology domains 1 through 7. Protein Engineering 15, 727-737.
    • (2002) Protein Engineering , vol.15 , pp. 727-737
    • Giordanetto, F.1    Kroemer, R.T.2
  • 116
    • 0032425542 scopus 로고    scopus 로고
    • Janus kinases and focal adhesion kinases play in the 4.1 band: A superfamily of band 4.1 domains important for cell structure and signal transduction
    • Girault, J. A., Labesse, G., Mornon, J., and Callebaut, I. (1998) Janus kinases and focal adhesion kinases play in the 4.1 band: a superfamily of band 4.1 domains important for cell structure and signal transduction. Mol. Med. 4, 751-769.
    • (1998) Mol. Med. , vol.4 , pp. 751-769
    • Girault, J.A.1    Labesse, G.2    Mornon, J.3    Callebaut, I.4
  • 117
    • 0021240155 scopus 로고
    • A structural model of human erythrocyte protein 4.1
    • Leto, T. L. and Marchesi, V. T. (1984) A structural model of human erythrocyte protein 4.1. J. Biol. Chem. 259, 4603-4608.
    • (1984) J. Biol. Chem. , vol.259 , pp. 4603-4608
    • Leto, T.L.1    Marchesi, V.T.2
  • 118
    • 0028026907 scopus 로고
    • A novel protein-tyrosine phosphatase with homology to both the cytoskeletal proteins of the band 4.1 family and junction associated guanylate kinases
    • Banville, D., Ahmad, S., Stocco, R., and Shen, S. H. (1994) A novel protein-tyrosine phosphatase with homology to both the cytoskeletal proteins of the band 4.1 family and junction associated guanylate kinases. J. Biol. Chem. 269, 22320-22327.
    • (1994) J. Biol. Chem. , vol.269 , pp. 22320-22327
    • Banville, D.1    Ahmad, S.2    Stocco, R.3    Shen, S.H.4
  • 119
  • 120
    • 0032559637 scopus 로고    scopus 로고
    • Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2
    • Yonemura, S., Hirao, M., Doi, Y., Takahashi, N., Kondo, T., Tsukita, S., et al. (1998) Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2. J. Cell. Biol. 140, 885-895.
    • (1998) J. Cell. Biol. , vol.140 , pp. 885-895
    • Yonemura, S.1    Hirao, M.2    Doi, Y.3    Takahashi, N.4    Kondo, T.5    Tsukita, S.6
  • 121
    • 0028957771 scopus 로고
    • The conserved box 1 motif of cytokine receptors is required for association with JAK kinases
    • Tanner, J. W., Chen, W., Young, R. L., Longmore, G. D., and Shaw, A. S. (1995) The conserved box 1 motif of cytokine receptors is required for association with JAK kinases. J. Biol. Chem. 270, 6523-6530.
    • (1995) J. Biol. Chem. , vol.270 , pp. 6523-6530
    • Tanner, J.W.1    Chen, W.2    Young, R.L.3    Longmore, G.D.4    Shaw, A.S.5
  • 122
    • 0029011115 scopus 로고
    • The amino-terminal portion of the JAK2 protein kinase is necessary for binding and phosphorylation of the granulocyte macrophage colony-stimulating factor receptor beta c chain
    • Zhao, Y. M., Wagner, F., Frank, S. J., and Kraft, A. S. (1995) The amino-terminal portion of the JAK2 protein kinase is necessary for binding and phosphorylation of the granulocyte macrophage colony-stimulating factor receptor beta c chain. J. Biol. Chem. 270, 13814-13818.
    • (1995) J. Biol. Chem. , vol.270 , pp. 13814-13818
    • Zhao, Y.M.1    Wagner, F.2    Frank, S.J.3    Kraft, A.S.4
  • 123
    • 0031009816 scopus 로고    scopus 로고
    • The amino terminus of Jak3 is necessary and sufficient for binding to the common gamma chain and confers the ability to transmit interleukin 2-mediated signals
    • Chen, M., Cheng, A., Chen, Y. Q., Hymel, A. Hanson, E. P., Kimmel, E., et al. (1997) The amino terminus of Jak3 is necessary and sufficient for binding to the common gamma chain and confers the ability to transmit interleukin 2-mediated signals. Proc. Natl. Acad. Sci. U. S. A. 94, 6910-6915.
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 6910-6915
    • Chen, M.1    Cheng, A.2    Chen, Y.Q.3    Hymel, A.4    Hanson, E.P.5    Kimmel, E.6
  • 125
    • 0025280867 scopus 로고
    • Prognostic implications of echocardiographically determined left ventricular mass in the Framingham heart study
    • Levy, D., Garrison, R. J., Savage, D. D., Kannel, W. B., and Castelli, W. P. (1990) Prognostic implications of echocardiographically determined left ventricular mass in the Framingham heart study. N. Engl. J. Med. 322, 1561-1566.
    • (1990) N. Engl. J. Med. , vol.322 , pp. 1561-1566
    • Levy, D.1    Garrison, R.J.2    Savage, D.D.3    Kannel, W.B.4    Castelli, W.P.5
  • 126
    • 0003081740 scopus 로고
    • Factors controlling cardiac growth
    • (Zak, R., ed.), Raven, NY
    • Zak, R. (1984) Factors controlling cardiac growth, in Growth of the Heart in Health and Disease (Zak, R., ed.), Raven, NY, pp. 165-185.
    • (1984) Growth of the Heart in Health and Disease , pp. 165-185
    • Zak, R.1
  • 127
    • 0022507205 scopus 로고
    • Value of echocardiographic measurement of left ventricular mass in predicting cardiovascular morbid events in hypertensive men
    • Casale, P. N., Devereux, R. B., Milner, M., Zullo, G., Harshueld, G. A., Pickering, T. G., et al. (1986) Value of echocardiographic measurement of left ventricular mass in predicting cardiovascular morbid events in hypertensive men. Ann. Intern. Med. 105, 173-178.
    • (1986) Ann. Intern. Med. , vol.105 , pp. 173-178
    • Casale, P.N.1    Devereux, R.B.2    Milner, M.3    Zullo, G.4    Harshueld, G.A.5    Pickering, T.G.6
  • 128
    • 0029001634 scopus 로고
    • Cardiac hypertrophy induced by alpha- and beta-adrenergic receptor stimulation
    • Zimmer, H. G., Kolbeck-Ruhmkorff, C., and Zierhut, W. (1995) Cardiac hypertrophy induced by alpha- and beta-adrenergic receptor stimulation. Cardioscience 6, 47-57.
    • (1995) Cardioscience , vol.6 , pp. 47-57
    • Zimmer, H.G.1    Kolbeck-Ruhmkorff, C.2    Zierhut, W.3
  • 130
    • 0027521065 scopus 로고
    • Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: Potential involvement of autocrine/paracrine mechanism
    • Sadoshima, J. and Izumo, S. (1993) Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of autocrine/paracrine mechanism. EMBO J. 12, 1681-1692.
    • (1993) EMBO J. , vol.12 , pp. 1681-1692
    • Sadoshima, J.1    Izumo, S.2
  • 132
    • 0029914655 scopus 로고    scopus 로고
    • Mechanical stretch activates the stress-activated protein kinases in cardiac myocytes
    • Komuro, I., Kudo, S., Yamazaki, T., Zou, Y., Shiojima, I., and Yazaki, Y. (1996) Mechanical stretch activates the stress-activated protein kinases in cardiac myocytes. FASEB J. 10, 631-636.
    • (1996) FASEB J. , vol.10 , pp. 631-636
    • Komuro, I.1    Kudo, S.2    Yamazaki, T.3    Zou, Y.4    Shiojima, I.5    Yazaki, Y.6
  • 133
    • 0027298699 scopus 로고
    • Mechanical loading activates mitogen-activated protein kinase and S6 peptide kinase in cultured rat cardiac myocytes
    • Yamaziki, T., Tobe, K., Hoh, E., Maemura, K., Kaida, T., Komuro, I., et al. (1993) Mechanical loading activates mitogen-activated protein kinase and S6 peptide kinase in cultured rat cardiac myocytes. J. Biol. Chem. 268, 12069-12076.
    • (1993) J. Biol. Chem. , vol.268 , pp. 12069-12076
    • Yamaziki, T.1    Tobe, K.2    Hoh, E.3    Maemura, K.4    Kaida, T.5    Komuro, I.6
  • 134
    • 0027722248 scopus 로고
    • Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro
    • Sadoshima, J. Xu, Y., Slayter, H. S., and Izumo, S. (1993) Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Cell 75, 977-984.
    • (1993) Cell , vol.75 , pp. 977-984
    • Sadoshima, J.1    Xu, Y.2    Slayter, H.S.3    Izumo, S.4
  • 135
    • 24644476055 scopus 로고
    • Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes
    • Ito, H., Hirata, Y., Adachi, S., Tanaka, M., Tsujino, M., Koike, A., et al. (1993) Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes. Circ. Res. 81, 656-663.
    • (1993) Circ. Res. , vol.81 , pp. 656-663
    • Ito, H.1    Hirata, Y.2    Adachi, S.3    Tanaka, M.4    Tsujino, M.5    Koike, A.6
  • 136
    • 0030696081 scopus 로고    scopus 로고
    • Leukemia inhibitory factor, a potent cardiac hypertrophic cytokine, activates the JAK/STAT pathway in cardiomyocytes
    • Kodama, H., Fukada, K., Pan, J., Makino, S., Baba, A., Hori, S., et al. (1997) Leukemia inhibitory factor, a potent cardiac hypertrophic cytokine, activates the JAK/STAT pathway in cardiomyocytes. Circ. Res. 81, 656-663.
    • (1997) Circ. Res. , vol.81 , pp. 656-663
    • Kodama, H.1    Fukada, K.2    Pan, J.3    Makino, S.4    Baba, A.5    Hori, S.6
  • 137
    • 0029843527 scopus 로고    scopus 로고
    • Activation of JAK-STAT and MAP kinases by leukemia inhibitory factor through gp130 in cardiac myocytes
    • Kunisada, K., Hirota, H., Fujio, Y., Matsui, H., Tani, Y., Yamauchi-Takihara, K., et al. (1996) Activation of JAK-STAT and MAP kinases by leukemia inhibitory factor through gp130 in cardiac myocytes. Circulation 94, 2626-2632.
    • (1996) Circulation , vol.94 , pp. 2626-2632
    • Kunisada, K.1    Hirota, H.2    Fujio, Y.3    Matsui, H.4    Tani, Y.5    Yamauchi-Takihara, K.6
  • 138
    • 0030183049 scopus 로고    scopus 로고
    • Cardiotrophin-1: A multifunctional cytokine that signals via LIF receptor-gp130 dependent pathways
    • Pennica, D., Wood, W. I., and Chien, K. R. (1996) Cardiotrophin-1: a multifunctional cytokine that signals via LIF receptor-gp130 dependent pathways. Cytokine Growth Factor Rev. 7, 81-91.
    • (1996) Cytokine Growth Factor Rev. , vol.7 , pp. 81-91
    • Pennica, D.1    Wood, W.I.2    Chien, K.R.3
  • 139
    • 0030765570 scopus 로고    scopus 로고
    • Role of angiotensin II in activation of the JAK/STAT pathway induced by acute pressure overload in the rat heart
    • Pan, J., Keiichi, F., Hiroaki, K., Shinji, M., Toshiyuki, T., Motoaki, S., et al. (1997) Role of angiotensin II in activation of the JAK/STAT pathway induced by acute pressure overload in the rat heart. Circ. Res. 81, 611-617.
    • (1997) Circ. Res. , vol.81 , pp. 611-617
    • Pan, J.1    Keiichi, F.2    Hiroaki, K.3    Shinji, M.4    Toshiyuki, T.5    Motoaki, S.6
  • 140
    • 13044255533 scopus 로고    scopus 로고
    • Involvement of gp130-mediated signaling in pressure overload-induced activation of the JAK/STAT pathway in rodent heart
    • Pan, J., Fukuda, K., Kodama, H., Sano, M., Takahashi, T., Makino, S., et al. (1998) Involvement of gp130-mediated signaling in pressure overload-induced activation of the JAK/STAT pathway in rodent heart. Heart Vessels 13, 199-208.
    • (1998) Heart Vessels , vol.13 , pp. 199-208
    • Pan, J.1    Fukuda, K.2    Kodama, H.3    Sano, M.4    Takahashi, T.5    Makino, S.6
  • 141
    • 0033612183 scopus 로고    scopus 로고
    • Mechanical stretch activates the JAK/STAT pathway in rat cardiomyocytes
    • Pan, J., Fukudo, K., Saito, M., Matsuzaki, J., Kodama, H., Sano, M., et al. (1999) Mechanical stretch activates the JAK/STAT pathway in rat cardiomyocytes. Circ. Res. 84, 1127-1136.
    • (1999) Circ. Res. , vol.84 , pp. 1127-1136
    • Pan, J.1    Fukudo, K.2    Saito, M.3    Matsuzaki, J.4    Kodama, H.5    Sano, M.6
  • 142
  • 143
    • 0028905072 scopus 로고
    • Cardiotrophin-1: Biological activities and binding to the leukemia inhibitory factor receptor/gp130 signaling complex
    • Pennica, D., Shaw, K. J., Swanson, T. A., Moore, M. W., Shelton, D. L., Zioncheck, K. A., et al. (1995) Cardiotrophin-1: biological activities and binding to the leukemia inhibitory factor receptor/gp130 signaling complex. J. Biol. Chem. 270, 10915-10922.
    • (1995) J. Biol. Chem. , vol.270 , pp. 10915-10922
    • Pennica, D.1    Shaw, K.J.2    Swanson, T.A.3    Moore, M.W.4    Shelton, D.L.5    Zioncheck, K.A.6
  • 144
    • 0034086490 scopus 로고    scopus 로고
    • Cardiotrophin-1 increases angiotensinogen mRNA in rat cardiac myocytes through STAT3: An autocrine loop for hypertrophy
    • Fukuzawa, J., Booz, G. W., Hunt, R. A., Shimizu, N., Karoor, V., Baker, K. M., et al. (2000) Cardiotrophin-1 increases angiotensinogen mRNA in rat cardiac myocytes through STAT3: an autocrine loop for hypertrophy Hypertension 35, 1191-1196.
    • (2000) Hypertension , vol.35 , pp. 1191-1196
    • Fukuzawa, J.1    Booz, G.W.2    Hunt, R.A.3    Shimizu, N.4    Karoor, V.5    Baker, K.M.6
  • 145
    • 0033592754 scopus 로고    scopus 로고
    • Signaling pathways for cardiac hypertrophy and failure
    • Hunter, J. J. and Chien, K. R. (1999) Signaling pathways for cardiac hypertrophy and failure. N. Engl. J. Med. 341, 1276-1283.
    • (1999) N. Engl. J. Med. , vol.341 , pp. 1276-1283
    • Hunter, J.J.1    Chien, K.R.2
  • 146
    • 0037448803 scopus 로고    scopus 로고
    • Alterations in janus kinase (JAK)-signal transducers and activators of transcription (STAT) signalling in patients with end-stage dilated cardiomyopathy
    • Podewski, E. K., Hilfiker-Kleiner, D., Hilfiker, A., Moraweitz, H., Lichtenberg, A., Wollert, K. C., et al. (2003) Alterations in janus kinase (JAK)-signal transducers and activators of transcription (STAT) signalling in patients with end-stage dilated cardiomyopathy. Circulation 107, 798-802.
    • (2003) Circulation , vol.107 , pp. 798-802
    • Podewski, E.K.1    Hilfiker-Kleiner, D.2    Hilfiker, A.3    Moraweitz, H.4    Lichtenberg, A.5    Wollert, K.C.6
  • 147
    • 0022970945 scopus 로고
    • Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium
    • Murry, C. E., Jennings, R. B., and Reimer, K. A. (1986) Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 74, 1124-1136.
    • (1986) Circulation , vol.74 , pp. 1124-1136
    • Murry, C.E.1    Jennings, R.B.2    Reimer, K.A.3
  • 148
    • 0034711508 scopus 로고    scopus 로고
    • The late phase of preconditioning
    • Bolli, R. (2000) The late phase of preconditioning. Circ. Res. 87, 972-983.
    • (2000) Circ. Res. , vol.87 , pp. 972-983
    • Bolli, R.1
  • 149
    • 0027222962 scopus 로고
    • Delayed effects of sublethal ischemia on the acquisition of tolerance to ischemia
    • Kuzuya, T., Hoshida, S., Yamashita, N., Fuji, H., Oe, H., Hori, M., et al. (1993) Delayed effects of sublethal ischemia on the acquisition of tolerance to ischemia. Circ. Res. 72, 1293-1299.
    • (1993) Circ. Res. , vol.72 , pp. 1293-1299
    • Kuzuya, T.1    Hoshida, S.2    Yamashita, N.3    Fuji, H.4    Oe, H.5    Hori, M.6
  • 150
    • 0027163384 scopus 로고
    • Cardiac stress protein elevation 24 hours after brief ischemic or heat stress is associated with resistance to myocardial infarction
    • Marber, M. S., Latchman, D. S., Walker, J. M., and Yellon, D. M. (1993) Cardiac stress protein elevation 24 hours after brief ischemic or heat stress is associated with resistance to myocardial infarction. Circulation 88, 1264-1272.
    • (1993) Circulation , vol.88 , pp. 1264-1272
    • Marber, M.S.1    Latchman, D.S.2    Walker, J.M.3    Yellon, D.M.4
  • 151
    • 0030026058 scopus 로고    scopus 로고
    • Evidence for an essential role of reactive oxygen species in the genesis of late preconditioning against myocardial stunning in conscious pigs
    • Sun, J. Z., Tang, X. L., Park, S. W., Qiu, Y., Turrens, J. F., and Bolli, R. (1996) Evidence for an essential role of reactive oxygen species in the genesis of late preconditioning against myocardial stunning in conscious pigs. J. Clin. Invest 97, 562-576.
    • (1996) J. Clin. Invest , vol.97 , pp. 562-576
    • Sun, J.Z.1    Tang, X.L.2    Park, S.W.3    Qiu, Y.4    Turrens, J.F.5    Bolli, R.6
  • 153
    • 13044250456 scopus 로고    scopus 로고
    • The late phase of ischemic preconditioning is abrogated by targeted disruption of the iNOS gene
    • Guo, Y., Jones, W. K., Xuan, Y. T., Tang, X. L., Bao, W., Wu, W. J., et al. (1999) The late phase of ischemic preconditioning is abrogated by targeted disruption of the iNOS gene. Proc. Natl. Acad. Sci. U. S. A. 96, 11507-11512.
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 11507-11512
    • Guo, Y.1    Jones, W.K.2    Xuan, Y.T.3    Tang, X.L.4    Bao, W.5    Wu, W.J.6
  • 154
    • 0034730120 scopus 로고    scopus 로고
    • Cyclooxygenase-2 mediates the cardioprotective effects of the late phase of ischemic preconditioning in conscious rabbits
    • Shinmura, K., Tang, X. L., Wang, Y., Xuan, Y. T., Liu, S. Q., Takano, H., et al. (2000) Cyclooxygenase-2 mediates the cardioprotective effects of the late phase of ischemic preconditioning in conscious rabbits. Proc. Natl. Acad. Sci. U. S A. 97, 10197-10202.
    • (2000) Proc. Natl. Acad. Sci. U. S A. , vol.97 , pp. 10197-10202
    • Shinmura, K.1    Tang, X.L.2    Wang, Y.3    Xuan, Y.T.4    Liu, S.Q.5    Takano, H.6
  • 155
    • 0037047696 scopus 로고    scopus 로고
    • Aldose reductase is an obligatory mediator of the late phase of ischemic preconditioning
    • Shinmura, K., Bolli, R., Liu, S. Q., Tang, X. L., Kodani, E., Xuan, Y. T., et al. (2002) Aldose reductase is an obligatory mediator of the late phase of ischemic preconditioning. Circ. Res. 91, 240-246.
    • (2002) Circ. Res. , vol.91 , pp. 240-246
    • Shinmura, K.1    Bolli, R.2    Liu, S.Q.3    Tang, X.L.4    Kodani, E.5    Xuan, Y.T.6
  • 156
    • 0035979176 scopus 로고    scopus 로고
    • An essential role of the JAKSTAT pathway in ischemic preconditioning
    • Xuan, Y. T., Guo, Y., Han, H., Zhu, Y., and Bolli, R. (2001) An essential role of the JAKSTAT pathway in ischemic preconditioning,. Proc. Natl. Acad. Sci. U. S. A. 98, 9050-9055.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 9050-9055
    • Xuan, Y.T.1    Guo, Y.2    Han, H.3    Zhu, Y.4    Bolli, R.5
  • 157
  • 158
    • 0029031668 scopus 로고
    • Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects
    • Harrison, D. A., Binari, R., Nahreini, T. S., Gilman, M., and Perrimon, N. (1995) Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects. EMBO J. 14, 2857-2865.
    • (1995) EMBO J. , vol.14 , pp. 2857-2865
    • Harrison, D.A.1    Binari, R.2    Nahreini, T.S.3    Gilman, M.4    Perrimon, N.5
  • 159
    • 15444339209 scopus 로고    scopus 로고
    • A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia
    • Lacronique, V., Boureux, A., Valle, V. D., Poirel, H., Quang, C. T., Mauchauffe, M., et al. (1997) A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. Science 278, 1309-1312.
    • (1997) Science , vol.278 , pp. 1309-1312
    • Lacronique, V.1    Boureux, A.2    Valle, V.D.3    Poirel, H.4    Quang, C.T.5    Mauchauffe, M.6
  • 160
    • 0030852328 scopus 로고    scopus 로고
    • Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia
    • Peeters, P., Raynaud, S. D., Cools, J., Wlodarska, I., Grosgeorge, J., Philip, P., et al. (1997) Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia. Blood 90, 2535-2540.
    • (1997) Blood , vol.90 , pp. 2535-2540
    • Peeters, P.1    Raynaud, S.D.2    Cools, J.3    Wlodarska, I.4    Grosgeorge, J.5    Philip, P.6
  • 161
    • 0344517071 scopus 로고    scopus 로고
    • Fusion of the ets transcription factor TEL to Jak2 results in constitutive Jak-Stat signaling
    • Ho, J. M., Beattie, B. K., Squire, J. A., Frank, D. A., and Barber, D. L. (1999) Fusion of the ets transcription factor TEL to Jak2 results in constitutive Jak-Stat signaling. Blood 93, 4354-4364.
    • (1999) Blood , vol.93 , pp. 4354-4364
    • Ho, J.M.1    Beattie, B.K.2    Squire, J.A.3    Frank, D.A.4    Barber, D.L.5
  • 162
    • 0034653478 scopus 로고    scopus 로고
    • Transforming properties of chimeric TEL-JAK proteins in BA/F3 cells
    • Lacronique, V., Boureux, A., Monni, R., Dumon, S., Mauchauffe, M., Mayeux, P., et al. (2000) Transforming properties of chimeric TEL-JAK proteins in BA/F3 cells. Blood 95, 2076-2083.
    • (2000) Blood , vol.95 , pp. 2076-2083
    • Lacronique, V.1    Boureux, A.2    Monni, R.3    Dumon, S.4    Mauchauffe, M.5    Mayeux, P.6
  • 164
    • 0033544859 scopus 로고    scopus 로고
    • Growth hormone-induced alteration in ErbB-2 phosphorylation status in 3T3-F442a fibroblasts
    • Kim, S. O., Houtman, J. C., Jiang, J., Ruppert, J. M., Bertics, P. J., and Frank, S. J. (1999) Growth hormone-induced alteration in ErbB-2 phosphorylation status in 3T3-F442a fibroblasts. J. Biol. Chem. 274, 36015-36024.
    • (1999) J. Biol. Chem. , vol.274 , pp. 36015-36024
    • Kim, S.O.1    Houtman, J.C.2    Jiang, J.3    Ruppert, J.M.4    Bertics, P.J.5    Frank, S.J.6
  • 165
    • 0035910507 scopus 로고    scopus 로고
    • Constitutive activation of JAK-STAT3 signaling by BRCA1 in human prostate cancer cells
    • Gao, B., Shen, X., Kunos, G., Meng, Q., Goldberg., I. D., Rosen, E. M., et al. (2001) Constitutive activation of JAK-STAT3 signaling by BRCA1 in human prostate cancer cells. FEBS Lett. 488, 179-184.
    • (2001) FEBS Lett. , vol.488 , pp. 179-184
    • Gao, B.1    Shen, X.2    Kunos, G.3    Meng, Q.4    Goldberg, I.D.5    Rosen, E.M.6


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