메뉴 건너뛰기




Volumn 93, Issue 12, 1999, Pages 4354-4364

Fusion of the ets transcription factor TEL to Jak2 results in constitutive Jak-Stat signaling

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC PROTEIN; HYBRID PROTEIN; INTERLEUKIN 3; PROTEIN TYROSINE KINASE; TRANSCRIPTION FACTOR;

EID: 0344517071     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.12.4354     Document Type: Article
Times cited : (89)

References (65)
  • 3
    • 18244432009 scopus 로고    scopus 로고
    • Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis
    • Neubauer H, Cumano A, Muller M, Wu H, Huffstadt U, Pfeffer K: Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell 93:397, 1998
    • (1998) Cell , vol.93 , pp. 397
    • Neubauer, H.1    Cumano, A.2    Muller, M.3    Wu, H.4    Huffstadt, U.5    Pfeffer, K.6
  • 6
    • 0028799457 scopus 로고
    • Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3
    • Thomis DC, Gurniak CB, Tivol E, Sharpe AH, Berg LJ: Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science 270:794, 1995
    • (1995) Science , vol.270 , pp. 794
    • Thomis, D.C.1    Gurniak, C.B.2    Tivol, E.3    Sharpe, A.H.4    Berg, L.J.5
  • 7
    • 1842291572 scopus 로고    scopus 로고
    • Crucial role of Jak3 in negative selection of self-reactive T cells
    • Saijo K, Park SY, Ishida Y, Arase H, Saito T: Crucial role of Jak3 in negative selection of self-reactive T cells. J Exp Med 185:351, 1997
    • (1997) J Exp Med , vol.185 , pp. 351
    • Saijo, K.1    Park, S.Y.2    Ishida, Y.3    Arase, H.4    Saito, T.5
  • 10
    • 0029937270 scopus 로고    scopus 로고
    • Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
    • Kaplan MH, Sun YL, Hoey T, Grusby MJ: Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382:174, 1996
    • (1996) Nature , vol.382 , pp. 174
    • Kaplan, M.H.1    Sun, Y.L.2    Hoey, T.3    Grusby, M.J.4
  • 14
    • 0029784886 scopus 로고    scopus 로고
    • Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines
    • Weber-Nordt RM, Egen C, Wehinger J, Ludwig W, Gouilleux-Gruart V, Mertelsmann R, Finke J: Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines. Blood 88:809, 1996
    • (1996) Blood , vol.88 , pp. 809
    • Weber-Nordt, R.M.1    Egen, C.2    Wehinger, J.3    Ludwig, W.4    Gouilleux-Gruart, V.5    Mertelsmann, R.6    Finke, J.7
  • 15
    • 0029785520 scopus 로고    scopus 로고
    • Interleukin-7 signaling in human B cell precursor acute lymphoblastic leukemia cells and murine BAF3 cells involves activation of STAT1 and STAT5 mediated via the interleukin-7 receptor alpha chain
    • van der Plas DC, Smiers F, Pouwels K, Hoefsloot LH, Lowenberg B, Touw IP: Interleukin-7 signaling in human B cell precursor acute lymphoblastic leukemia cells and murine BAF3 cells involves activation of STAT1 and STAT5 mediated via the interleukin-7 receptor alpha chain. Leukemia 10:1317, 1996
    • (1996) Leukemia , vol.10 , pp. 1317
    • Van Der Plas, D.C.1    Smiers, F.2    Pouwels, K.3    Hoefsloot, L.H.4    Lowenberg, B.5    Touw, I.P.6
  • 17
    • 0031038744 scopus 로고    scopus 로고
    • The function of BCR/ABL and related proto-oncogenes
    • Gotoh A, Broxmeyer HE: The function of BCR/ABL and related proto-oncogenes. Curr Opin Hematol 4:3, 1997
    • (1997) Curr Opin Hematol , vol.4 , pp. 3
    • Gotoh, A.1    Broxmeyer, H.E.2
  • 20
    • 0028224348 scopus 로고
    • Fusion of PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation
    • Golub TR, Barker GF, Lovett M, Gilliland DG: Fusion of PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell 77:307, 1994
    • (1994) Cell , vol.77 , pp. 307
    • Golub, T.R.1    Barker, G.F.2    Lovett, M.3    Gilliland, D.G.4
  • 24
    • 0028025641 scopus 로고
    • Erythropoietin and interleukin-2 activate distinct JAK kinase family members
    • Barber DL, D'Andrea AD: Erythropoietin and interleukin-2 activate distinct JAK kinase family members. Mol Cell Biol 14:6506, 1994
    • (1994) Mol Cell Biol , vol.14 , pp. 6506
    • Barber, D.L.1    D'Andrea, A.D.2
  • 27
    • 0032519545 scopus 로고    scopus 로고
    • Altered IL-12 responsiveness in Th1 and Th2 cells is associated with the differential activation of STAT5 and STAT1
    • Gollob JA, Murhy EA, Mahajan S, Schnipper CP, Ritz J, Frank DA: Altered IL-12 responsiveness in Th1 and Th2 cells is associated with the differential activation of STAT5 and STAT1. Blood 91:1341, 1998
    • (1998) Blood , vol.91 , pp. 1341
    • Gollob, J.A.1    Murhy, E.A.2    Mahajan, S.3    Schnipper, C.P.4    Ritz, J.5    Frank, D.A.6
  • 28
    • 0028217452 scopus 로고
    • Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response
    • Wakao H, Gouilleux F, Groner B: Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response. EMBO J 13:2182, 1994
    • (1994) EMBO J , vol.13 , pp. 2182
    • Wakao, H.1    Gouilleux, F.2    Groner, B.3
  • 29
    • 0028097932 scopus 로고
    • Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN alpha and IFN gamma, and is likely to autoregulate the p91 gene
    • Pine R, Canova A, Schindler C: Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN alpha and IFN gamma, and is likely to autoregulate the p91 gene. EMBO J 13:158, 1994
    • (1994) EMBO J , vol.13 , pp. 158
    • Pine, R.1    Canova, A.2    Schindler, C.3
  • 31
    • 0027518831 scopus 로고
    • The drosophila gene pointed encodes two ETS-like proteins which are involved in the development of the midline glial cells
    • Klambt C: The Drosophila gene pointed encodes two ETS-like proteins which are involved in the development of the midline glial cells. Development 117:163, 1993
    • (1993) Development , vol.117 , pp. 163
    • Klambt, C.1
  • 32
    • 0029966854 scopus 로고    scopus 로고
    • The TEL/platelet-derived growth factor β-receptor (PDGFβR) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates pdgfβr kinase-dependent signaling pathways
    • Carroll M, Tomasson MH, Barker GF, Golub TR, Gilliland DG: The TEL/platelet-derived growth factor β-receptor (PDGFβR) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGFβR kinase-dependent signaling pathways. Proc Natl Acad Sci USA 93:14845, 1996
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 14845
    • Carroll, M.1    Tomasson, M.H.2    Barker, G.F.3    Golub, T.R.4    Gilliland, D.G.5
  • 33
    • 0028244396 scopus 로고
    • Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells
    • Witthuhn BA, Silvennoinen O, Miura O, Lai KS, Cwik C, Liu ET, Ihle JN: Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature 370:153, 1994
    • (1994) Nature , vol.370 , pp. 153
    • Witthuhn, B.A.1    Silvennoinen, O.2    Miura, O.3    Lai, K.S.4    Cwik, C.5    Liu, E.T.6    Ihle, J.N.7
  • 35
    • 0029060110 scopus 로고
    • Interleukin 2 and erythropoietin activate STAT5/MGF via distinct pathways
    • Wakao H, Harada N, Kitamura T, Mui AL, Miyajima A: Interleukin 2 and erythropoietin activate STAT5/MGF via distinct pathways. EMBO J 14:2527, 1995
    • (1995) EMBO J , vol.14 , pp. 2527
    • Wakao, H.1    Harada, N.2    Kitamura, T.3    Mui, A.L.4    Miyajima, A.5
  • 38
    • 0028963550 scopus 로고
    • Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs
    • Mui AL, Wakao H, O'Farrell AM, Harada N, Miyajima A: Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs. EMBO J 14:1166, 1995
    • (1995) EMBO J , vol.14 , pp. 1166
    • Mui, A.L.1    Wakao, H.2    O'Farrell, A.M.3    Harada, N.4    Miyajima, A.5
  • 39
    • 0029066310 scopus 로고
    • Prolactin, growth hormone, erythropoietin and granulocyte-macrophage colony stimulating factor induce MGF-Stat5 DNA binding activity
    • Gouilleux F, Pallard C, Dusanter-Fourt I, Wakao H, Haldosen LA, Norstedt G, Levy D, Groner B: Prolactin, growth hormone, erythropoietin and granulocyte-macrophage colony stimulating factor induce MGF-Stat5 DNA binding activity. EMBO J 14:2005, 1995
    • (1995) EMBO J , vol.14 , pp. 2005
    • Gouilleux, F.1    Pallard, C.2    Dusanter-Fourt, I.3    Wakao, H.4    Haldosen, L.A.5    Norstedt, G.6    Levy, D.7    Groner, B.8
  • 40
    • 0028785893 scopus 로고
    • Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation
    • Damen JE, Wakao H, Miyajima A, Krosl J, Humphries RK, Cutler RL, Krystal G: Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation. EMBO J 14:5557, 1995
    • (1995) EMBO J , vol.14 , pp. 5557
    • Damen, J.E.1    Wakao, H.2    Miyajima, A.3    Krosl, J.4    Humphries, R.K.5    Cutler, R.L.6    Krystal, G.7
  • 41
    • 0029738317 scopus 로고    scopus 로고
    • Multiple tyrosine residues in the cytosolic domain of the erythropoietin receptor promote activation of STAT5
    • Klingmuller U, Bergelson S, Hsiao JG, Lodish HF: Multiple tyrosine residues in the cytosolic domain of the erythropoietin receptor promote activation of STAT5. Proc Natl Acad Sci USA 93:8324, 1996
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 8324
    • Klingmuller, U.1    Bergelson, S.2    Hsiao, J.G.3    Lodish, H.F.4
  • 42
    • 0029866781 scopus 로고    scopus 로고
    • Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response
    • Quelle FW, Wang D, Nosaka T, Thierfelder WE, Stravopodis D, Weinstein Y, Ihle JN: Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response. Mol Cell Biol 16:1622, 1996
    • (1996) Mol Cell Biol , vol.16 , pp. 1622
    • Quelle, F.W.1    Wang, D.2    Nosaka, T.3    Thierfelder, W.E.4    Stravopodis, D.5    Weinstein, Y.6    Ihle, J.N.7
  • 43
    • 17144463437 scopus 로고    scopus 로고
    • A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFRβ oncoprotein
    • Jousset C, Carron C, Boureux A, Quang CT, Oury C, Dusanter-Fourt I, Charon M, Levin J, Bernard O, Ghysdael J: A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFRβ oncoprotein. EMBO J 16:69, 1997
    • (1997) EMBO J , vol.16 , pp. 69
    • Jousset, C.1    Carron, C.2    Boureux, A.3    Quang, C.T.4    Oury, C.5    Dusanter-Fourt, I.6    Charon, M.7    Levin, J.8    Bernard, O.9    Ghysdael, J.10
  • 44
    • 26144460036 scopus 로고    scopus 로고
    • A new partner gene of the ETV6/TEL, ARG (Abl related gene, or ABL2) cloned in a AML-M3 cell line with t(1;12)(q25;p13)
    • abstr
    • Sato Y, Iijima Y, Ito T, Oikawa T, Eguchi M, Eguchi-Ishimae M, Kamada N, Kishi K, Asano S, Sakaki Y: A new partner gene of the ETV6/TEL, ARG (Abl related gene, or ABL2) cloned in a AML-M3 cell line with t(1;12)(q25;p13). Blood 93:592a, 1998 (abstr, suppl 1)
    • (1998) Blood , vol.93 , Issue.SUPPL. 1
    • Sato, Y.1    Iijima, Y.2    Ito, T.3    Oikawa, T.4    Eguchi, M.5    Eguchi-Ishimae, M.6    Kamada, N.7    Kishi, K.8    Asano, S.9    Sakaki, Y.10
  • 47
    • 26144439872 scopus 로고    scopus 로고
    • Constitutive activation of STK-1 tyrosine kinase by HLH domain of transcription factor TEL
    • abstr
    • Tse KF, Civin C, Small D: Constitutive activation of STK-1 tyrosine kinase by HLH domain of transcription factor TEL. Blood 90:311a, 1997 (abstr, suppl 1)
    • (1997) Blood , vol.90 , Issue.SUPPL. 1
    • Tse, K.F.1    Civin, C.2    Small, D.3
  • 49
    • 0029899183 scopus 로고    scopus 로고
    • A constitutively activated chimeric cytokine receptor confers factor-independent growth in hematopoietic cell lines
    • Shikama Y, Barber DL, D'Andrea AD, Sieff CA: A constitutively activated chimeric cytokine receptor confers factor-independent growth in hematopoietic cell lines. Blood 88:455, 1996
    • (1996) Blood , vol.88 , pp. 455
    • Shikama, Y.1    Barber, D.L.2    D'Andrea, A.D.3    Sieff, C.A.4
  • 52
    • 0030928462 scopus 로고    scopus 로고
    • Interleukin-2 (IL-2)-mediated induction of the IL-2 receptor alpha chain gene. Critical role of two functionally redundant tyrosine residues in the IL-2 receptor beta chain cytoplasmic domain and suggestion that these residues mediate more than Stat5 activation
    • Ascherman DP, Migone TS, Friedmann MC, Leonard WJ: Interleukin-2 (IL-2)-mediated induction of the IL-2 receptor alpha chain gene. Critical role of two functionally redundant tyrosine residues in the IL-2 receptor beta chain cytoplasmic domain and suggestion that these residues mediate more than Stat5 activation. J Biol Chem 272:8704, 1997
    • (1997) J Biol Chem , vol.272 , pp. 8704
    • Ascherman, D.P.1    Migone, T.S.2    Friedmann, M.C.3    Leonard, W.J.4
  • 53
    • 0031931409 scopus 로고    scopus 로고
    • Definition of the role of tyrosine residues of the common beta subunit regulating multiple signaling pathways of granulocyte-macrophage colony-stimulating factor receptor
    • Itoh T, Liu R, Yokota T, Arai KI, Watanabe S: Definition of the role of tyrosine residues of the common beta subunit regulating multiple signaling pathways of granulocyte-macrophage colony-stimulating factor receptor. Mol Cell Biol 18:742, 1998
    • (1998) Mol Cell Biol , vol.18 , pp. 742
    • Itoh, T.1    Liu, R.2    Yokota, T.3    Arai, K.I.4    Watanabe, S.5
  • 54
    • 0029991793 scopus 로고    scopus 로고
    • Differential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. II. Src homology SH2 domains define the specificity of stat factor activation
    • Hemmann U, Gerhartz C, Heesel B, Sasse J, Kurapkat G, Grotzinger J, Wollmer A, Zhong Z, Darnell JE Jr, Graeve L, Heinrich PC, Horn F: Differential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. II. Src homology SH2 domains define the specificity of stat factor activation. J Biol Chem 271:12999, 1996
    • (1996) J Biol Chem , vol.271 , pp. 12999
    • Hemmann, U.1    Gerhartz, C.2    Heesel, B.3    Sasse, J.4    Kurapkat, G.5    Grotzinger, J.6    Wollmer, A.7    Zhong, Z.8    Darnell J.E., Jr.9    Graeve, L.10    Heinrich, P.C.11    Horn, F.12
  • 56
    • 0029887373 scopus 로고    scopus 로고
    • Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. I. Definition of a novel phosphotyrosine motif mediating STAT1 activation
    • Gerhartz C, Heesel B, Sasse J, Hemmann U, Landgraf C, Schneider-Mergener J, Horn F, Heinrich PC, Graeve L: Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. I. Definition of a novel phosphotyrosine motif mediating STAT1 activation. J Biol Chem 271:12991, 1996
    • (1996) J Biol Chem , vol.271 , pp. 12991
    • Gerhartz, C.1    Heesel, B.2    Sasse, J.3    Hemmann, U.4    Landgraf, C.5    Schneider-Mergener, J.6    Horn, F.7    Heinrich, P.C.8    Graeve, L.9
  • 57
    • 0029863169 scopus 로고    scopus 로고
    • Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl
    • Carlesso N, Frank DA, Griffin JD: Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl. J Exp Med 183:811, 1996
    • (1996) J Exp Med , vol.183 , pp. 811
    • Carlesso, N.1    Frank, D.A.2    Griffin, J.D.3
  • 58
    • 0029810923 scopus 로고    scopus 로고
    • Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia
    • Shuai K, Halpern J, Hoeve JT, Rao X, Sawyers CL: Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia. Oncogene 13:247, 1996
    • (1996) Oncogene , vol.13 , pp. 247
    • Shuai, K.1    Halpern, J.2    Hoeve, J.T.3    Rao, X.4    Sawyers, C.L.5
  • 59
    • 0029796725 scopus 로고    scopus 로고
    • BCR/abl leads to the constitutive activation of Stat proteins, and shares an epitope with tyrosine phosphorylated Stats
    • Frank DA, Varticovski L: BCR/abl leads to the constitutive activation of Stat proteins, and shares an epitope with tyrosine phosphorylated Stats. Leukemia 10:1724, 1996
    • (1996) Leukemia , vol.10 , pp. 1724
    • Frank, D.A.1    Varticovski, L.2
  • 60
    • 0031573141 scopus 로고    scopus 로고
    • Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients
    • Chai SK, Nichols GL, Rothman P: Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients. J Immunol 159:4720, 1997
    • (1997) J Immunol , vol.159 , pp. 4720
    • Chai, S.K.1    Nichols, G.L.2    Rothman, P.3
  • 61
    • 0032525270 scopus 로고    scopus 로고
    • Secondary mutation maintains the transformed state in BaF3 cells with inducible BCR/ABL expression
    • Klucher KM, Lopez DV, Daley GQ: Secondary mutation maintains the transformed state in BaF3 cells with inducible BCR/ABL expression. Blood 91:3927, 1998
    • (1998) Blood , vol.91 , pp. 3927
    • Klucher, K.M.1    Lopez, D.V.2    Daley, G.Q.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.