Cardiotrophin-1: A multifunctional cytokine that signals via LIF receptor-gp130 dependent pathways

Cytokine and Growth Factor Reviews

Volumn 7, Issue 1, 1996, Pages 81-91

  Pennica, Diane ^a   Wood, William I ^a   Chien, Kenneth R ^b  

^a GENENTECH INC   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Cardiac hypertrophy; Cardiotrophin 1; Interleukin 6; Subunit gp130

Indexed keywords

CARDIOTROPHIN 1; CYTOKINE; CYTOKINE RECEPTOR; GLYCOPROTEIN GP 130; GP130 SIGNAL TRANSDUCER; INTERLEUKIN 6; LEUKEMIA INHIBITORY FACTOR; LEUKEMIA INHIBITORY FACTOR RECEPTOR; LEUKOCYTE ANTIGEN; LYMPHOKINE; MEMBRANE PROTEIN;

AMINO ACID SEQUENCE; ANIMAL; ANIMAL CELL; ANIMAL MODEL; CELL CULTURE; EMBRYO; GENE EXPRESSION; GENETICS; HEART DEVELOPMENT; HEART HYPERTROPHY; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; HUMAN; MOLECULAR CLONING; MOLECULAR GENETICS; MOUSE; NONHUMAN; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RECEPTOR BINDING; REVIEW; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; STEM CELL;

EID: 0030183049     PISSN: 13596101     EISSN: None     Source Type: Journal    
DOI: 10.1016/1359-6101(96)00007-X     Document Type: Short Survey

References (63)

1. 1. Pennica D, King KL, Shaw KJ, et al. Expression cloning of cardiotrophin-1, a cytokine that induces cardiac myocyte hypertrophy. Proc Natl Acad Sci USA 1995, 92, 1142-1146.
2. 2. Kishimoto T, Taga T, Akira S, Cytokine signal transduction. Cell 1994, 76, 253-262.
3. 3. Davis S, Aldrich TH, Ip NY, et al. Released form of CNTF receptor α component as a soluble mediator of CNTF responses. Science 1993, 259, 1736-1739.
4. 4. Gearing DP, Comeau MR, Friend DJ, et al. The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor. Science 1992, 255, 1434-1437.
5. 5. Hibi M, Murakami M, Saito M, Hirano T, Taga T, Kishimoto T. Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell 1990, 63, 1149-1157.
6. 6. Ip NY, Nye SH, Boulton TG, et al. CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130. Cell 1992, 69, 1121-1132.
7. 7. Kishimoto T, Akira S, Taga T. Interleukin-6 and its receptor: a paradigm for cytokines. Science 1992, 258, 593-597.
8. 8. Yin T, Taga T, Tsang ML, Yasukawa K, Kishimoto T, Yang Y. Involvement of Il-6 signal transducer gp130 in IL-11-mediated signal transduction. J Immunol 1993, 151, 2555-2561.
9. 9. Sheng Z, Pennica D, Wood WI, Chien KR. Cardiotrophin-1 displays early expressions in the murine heart tube and promotes cardiac myocyte survival. Development 1996, 122, 419-428.
10. 10. Wollert KC, Taga T, Kishimoto T. et al. Cardiotrophin-1 activates a distinct form of cardiac muscle cell hypertrophy: assembly of sarcomeric units in series via gp130 leukemia inhibitory factor receptor dependent pathways. J Biol Chem 1996, 271, 9535-9545.
11. 11. Chien KR, Zhu H, Knowlton KU. et al. Transcriptional regulation during cardiac growth and development. Ann Rev Physiol 1993, 55, 77-95.
12. 12. Chien KR, Knowlton KU, Zhu H, Chien S. Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response. FASEB J 1991, 5, 5037-3046.
13. 13. Chien KR. Cannon Award Lecture: Cardiac muscle diseases in genetically engineered mice: the evolution of molecular physiology. Am J Physiol 1995, 269, H753-H766.
14. 14. Knowlton KU, Baracchini E, Ross RS, et al. Co-regulation of the atrial natriuretic factor and cardiac myosin light chain-2 gene during α-adrenergic stimulation of neonatal rat ventricular cells. J Biol Chem 1991, 266, 7759-7758.
15. 1A-adrenergic receptor subtype mediates biochemical, molecular, and morphogenic features of myocardial cell hypertrophy. J Biol Chem 1993. 268, 15374-15380.
16. 16. Lee HR, Henderson SA, Reynolds R, Dunnmon P. Yuan D, Chien KR. a-1 adrenergic stimulation of cardiac gene transcription in neonatal rat myocardial cells: effects on myosin light chain-2 gene expression. J Biol Chem 1988, 263, 7352-7358.
17. 17. Dyson E, Sucov HM. Kubalak SW, et al. Atrial-like phenotype is associated with embryonic ventricular failure in RXRα - mice. Proc Natl Acad Sci USA 1995, 92, 7386-7390.
18. 18. Hunter J, Tanaka N, Rockman HA. Ross J Jr. Chien KR. Ventricular expression of a MLC-2v-Ras fusion gene induces cardiac hypertrophy and selective diastolic dysfunction in transgenic mice. J Biol Chem 1995, 270, 23173-23178.
19. 19. Rockman HA, Ono S, Ross RS. et al. Molecular and physiological alterations in murine ventricular dysfunction. Proc Natl Acad Sci USA 1994, 91, 2694-2698.
20. 20. Rockman HA, Ross RS. Harris AN, et al. Segregation of atrial specific and inducible expression of an ANF transgene in an in vivo murine model of cardiac hypertrophy. Proc Natl Acad Sci USA 1991, 88, 8277-8281.
21. 2-adrenergic receptor. Science 1994, 264, 582-586.
22. 1 adrenergic-mediated hypertrophy of rat cardiac myocytes. J Clin Invest 1987, 80, 1194-1199.
23. 23. Shubeita HE, McDonough PM, Harris AN, et al. Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes: a paracrine mechanism for myocardial cell hypertrophy. J Biol Chem 1990, 265, 20555-20562.
24. 24. Thorburn A, Thorburn J, Chen S. et al. HRas-dependent pathways can activate morphological and genetic markers of cardiac muscle cell hypertrophy. J Biol Chem 1993, 268, 2244-2249.
25. 25. Milano CA, Dolber PC, Rockman HA, et al. Myocardial expression of a constitutively active alpha 1β-adrenergic receptor in transgenic mice induces cardiac hypertrophy. Proc Natl Acad Sci USA 1994. 91, 10109-10113.
26. 26. Miller-Hance WC. LaCorbiere M, Culler SJ, et al. In vitro chamber specification during embryonic stem cell cardiogenesis: expression of the ventricular myosin light chain-2 gene is independent of heart tube formation. J Biol Chem 1993, 268, 25244-25252.
27. 27. Chien KR, Molecular advances in cardiovascular biology. Science 1993, 260, 916-917.
28. 28. Pennica D, Swanson TA, Shaw KJ. et al. Human cardiotrophin-1: protein and gene structure, biological and binding activities, and chromosomal localization. Cytokine 1996, 8, 183-189.
29. 29. Abdel-Meguid SS. Shieh HS, Smith WW, Dayringer HE, Wioland BN, Bentle LA. Three-dimensional structure of a genetically engineered variant of porcine growth hormone. Proc Natl Acad Sci USA 1987. 84, 6434-6437.
30. 30. Bazan JF. Neuropoietic cytokines in the hematopoietic fold. Neuron 1991, 7, 197-208.
31. 31. Bhatt H. Brunet LJ, Steward CL. Uterine expression of leukemia inhibitory factor coincides with the onset of blastocyst implantation. Proc Natl Acad Sci USA 1991, 88, 11408-11412.
32. 32. Robertson M, Chambers I, Rathjen P. Nichols J, Smith A, Expression of alternative forms of differentiation inhibiting activity (DIA/LIF) during murine embryogenesis and in neonatal and adult tissue. Dev Genetics 1993, 14, 165-173.
33. 33. Parker TG. Schneider MD. Growth factors proto-oncogenes and plasticity of the cardiac phenotype. Ann Rev Physiol 1991, 53, 179-200.
34. 34. Sadoshima J, Izumo S. Molecular characterization of angiotensin II-induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype. Circ Res 1993, 73, 413-423.
35. 1 mediated response. J Biol Chem 1990. 265, 13809-13817.
36. 36. Messerli JM, Eppenberger-Eberhardt ME, Rutishauser BM, et al. Remodelling of cardiomyocyte cytoarchitecture visualized by three-dimensional (3D) confocal microscopy. Histochemistry 1993, 100, 193-202.
37. 37. Anversa P, Levicky V, Beghi C. McDonald SL, Kikkawa Y. Morphometry of exercise-induced right ventricular hypertrophy in the rat. Circ Res 1983, 52, 57-64.
38. 38. Gerdes AM. Campbell SE. Hilbelink DR. Structural remodeling of cardiac myocytes in rats with arteriovenous fistulas. Lab Invest 1988, 59, 857-861.
39. 39. Morkin E. Postnatal muscle fiber assembly: localization of newly synthesized myofibrillar proteins. Science 1970, 167, 1499-1501.
40. 40. Anversa P, Ricci R, Olivetti G. Quantitative structural analysis of the myocardium during physiologic growth and induced cardiac hypertrophy: a review. J Am Coll Cardiol 1986, 7, 1140-1149.
41. 41. Calderone A, Takahashi N, Izzo NJ Jr, Thaik CM, Colucci WS. Pressure-and volume-induced left ventricular hypertrophies are associated with distinct myocyte phenotypes and differential induction of peptide growth factor mRNAs. Circulation 1995, 92, 2385-2390.
42. 42. Izumo S, Nadal-Ginard B, Mahdavi V. Proto-oncogene induction and reprogramming of cardiac gene expression produced by pressure overload. Proc Natl Acad Sci USA 1988, 85, 339-343.
43. 43. Heath JK. Can there be life without LIF? Nature 1992, 359, 17.
44. 44. Stewart CL, Kaspar P, Brunet LJ, et al. Blastocyst implantation depends on maternal expression of leukemia inhibitory factor. Nature 1992, 359, 76-79.
45. 45. Takahashi R, Yokoji H, Misawa H, Hayashi M, Hu J, Deguchi T. A null mutation in the human CNTF gene is not causally related to neurological diseases. Nature Genet 1994, 7, 79-84.
46. 46. Masu Y, Wolf E, Holtmann B, Sendtner M, Brem G, Thoenen H. Disruption of the CNTF gene results in motor neuron degeneration. Nature 1993, 365, 27-32.
47. 47. DeChiara TM, Vejsada R, Poueymirou WT, et al. Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth. Cell 1995, 83, 313-322.
48. 48. Barnard W, Bower J, Brown MA, Murphy M, Austin L. Leukemia inhibitory factor (LIF) infusion stimulates skeletal muscle regeneration after injury: injured muscle expression LIF mRNA. J Neurol Sci 1994, 123, 108-113.
49. 49. Helgren ME, Squinto SP, Divis HL, et al. Trophic effect of ciliary neurotrophic factor on denervated skeletal muscle. Cell 1994, 76, 493-504.
50. 50. Oppenheim RW, Prevette D, Qin-Wei Y, Collins F, MacDonald J. Control of embryonic motorneuron survival in vivo by ciliary neurotrophic factor. Science 1991, 251, 1616-1618.
51. 51. Martinou JC, Martinou I, Kato AC. Cholinergic differentiation factor (CDF/LIF) promotes survival of isolated rat embryonic motoneurons in vitro. Neuron 1992, 8, 737-744.
52. 52. Escary JL, Perreau J, Dumenil D, Ezine S, Brulet P. Leukemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulation. Nature 1993, 363, 361-364.
53. 53. Pennica D, Shaw KJ, Swanson TA, et al. Cardiotrophin-1: biological activities and binding to the leukemia inhibitory factor receptor/gp130 signaling complex. J Biol Chem 1995, 270, 10915-10922.
54. 54. Peters M, Roeb E, Pennica D, Meyer zum Büschenfelde K-H, Rose-John S. A new hepatocyte stimulating factor: cardiotrophin-1 (CT-1) FEBS Lett 1995, 372, 177-180.
55. 55. Richards C, Langdon C, Pennica D, Gauldie J. Murine cardiotrophin-1 stimulates the acute-phase response in rat hepatocytes and H35 hepatoma cells. J Interferon Cytokine Res 1996, 16, 69-75.
56. 56. Murakami M, Hibi M, Nakagawa N, et al. IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase. Science 1993, 260, 1808-1810.
57. 57. Davis S, Aldrich TH, Stahl N, et al. LIFRβ and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor. Science 1993, 260, 1805-1808.
58. 58. Taga T, Narazaki M, Yasukawa K, et al. Functional inhibition of hematopoietic and neurotrophic cytokines by blocking the interleukin 6 signal transducer gp130. Proc Natl Acad Sci USA 1992, 89, 10998-11001.
59. 59. Boulton TG, Stahl N, Yancopoulos GD. Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors. J Biol Chem 1994, 269, 11648-11655.
60. 60. Robinson RC, Grey LM, Staunton D, et al. The crystal structure and biological function of leukemia inhibitory factor: implications for receptor binding. Cell 1994, 77, 1101-1116.
61. 61. Ware CB, Horowitz MC, Renshaw BR, et al. Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death. Development 1995, 121, 1283-1299.
62. 62. Li M, Sendtner M, Smith A. Essential function of LIF receptor in motor neurons. Nature 1995, 378, 724-727.
63. 63. Ward LD, Hewlett GJ, Discolo G, et al. High-affinity interleukin-6 receptor is a hexameric complex consisting of two molecules each of interleukin-6, interleukin-6 receptor, and gp-130. J Biol Chem 1994, 269, 23286-23289.