Bradykinin activates the Janus-activated kinase/signal transducers and activators of transcription (JAK/STAT) pathway in vascular endothelial cells: Localization of JAK/STAT signalling proteins in plasmalemmal caveolae

Biochemical Journal

Volumn 351, Issue 1, 2000, Pages 257-264

  Ju, H ^a   Venema, V J ^a   Liang, H ^a   Harris, M B ^a   Zou, R ^a   Venema, R C ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

B2 receptor; Caveolin 1; Mitogen activated protein kinase; STAT3; Tyk2

Indexed keywords

BRADYKININ; BRADYKININ B2 RECEPTOR; CARRIER PROTEIN; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; STAT PROTEIN; STAT3 PROTEIN;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; COMPLEX FORMATION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMAL; AORTA; BRADYKININ; CATTLE; CAVEOLAE; CAVEOLINS; CELL NUCLEUS; CELLS, CULTURED; DNA-BINDING PROTEINS; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; MUSCLE, SMOOTH, VASCULAR; PHOSPHORYLATION; PHOSPHOSERINE; PHOSPHOTYROSINE; PROTEIN BINDING; PROTEINS; RECEPTORS, BRADYKININ; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANS-ACTIVATORS;

EID: 0034306129     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3510257     Document Type: Article

References (44)

1. Molecular responses of endothelial tissue to kinins
2. 2 bradykinin receptor
3. Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor
4. Ion channels and regulation of intracellular calcium in vascular endothelial cells
5. 2+-independent pathways for release of arachidonic acid from phosphatidylinositol in endothelial cells
6. Resting distribution and stimulated translocation of protein kinase C isoforms alpha, epsilon and zeta in response to bradykinin and TNF in human endothelial cells
7. Calcium signaling in endothelial cells involves activation of tyrosine kinases and leads to activation of mitogen-activated protein kinases
8. Bradykinin-stimulated protein tyrosine phosphorylation promotes endothelial nitric oxide synthase translocation to the cytoskeleton
9. Bradykinin stimulates the tyrosine phosphorylation and bradykinin B2 receptor association of phospholipase Cγ 1 in vascular endothelial cells
10. Endothelial nitric oxide synthase interactions with G-protein-coupled receptors
11. 2+-induced regulation of ion channel and MAP kinase functions
12. A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation
13. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
14. 1 receptor
15. Molecular mechanisms of angiotensin II in modulating cardiac function: Intracardiac effects and signal transduction pathways
16. Phosphorylation of JAK2 in thrombin-stimulated human ptatelets
17. α-Thrombin stimulates sis-inducing factor-A DNA binding activity in rat aortic smooth muscle cells
18. Identification and localization of a skeletal muscle serotonin 5-HT(2A) receptor coupled to the Jak/STAT pathway
19. Endothelin stimulates sis-inducing factor-like DNA binding activity in CHO-K1 cells expressing ET(A) receptors
20. 1 MF-2 smooth muscle cells
21. Inhibitory interactions of the bradykinin B2 receptor with endothelial nitric-oxide synthase
22. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
23. Co-purification and direct interaction of Ras with caveolin, and integral membrane protein of caveolae microdomains: Detergent-free purification of caveolae membranes
24. Caveolin-1 detergent-solubility and association with endothelial nitric oxide synthase is modulated by tyrosine phosphorylation
25. STATs and gone regulation
26. Genistein, a specific inhibitor of tyrosine-specific protein kinases
27. Src kinases and not JAKs activate STATs during IL-3 induced myeloid cell proliferation
28. Regulation of angiotensin II-induced phosphorylation of STAT3 in vascular smooth muscle cells
29. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor: Study of Lck- and FynT-dependent T cell activation
30. Angiotensin II-induced tyrosine phosphorylation of signal transducers and activators of transcription 1 is regulated by janus-activated kinase 2 and Fyn kinases and mitogen-activated protein kinase phosphatase 1
31. Tyrphostin B42 inhibits IL-12-induced tyrosine phosphorylation and activation of janus kinase-2 and prevents experimental allergic encephalomyelitis
32. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
33. Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3
34. Hyperglycemia enhances angiotensin II-induced JAK/STAT signaling in vascular smooth muscle cells
35. Requirement of serine phosphorylation for formation of STAT-promoter complexes
36. A synthetic inhibitor of the mitogen-activated protein kinase cascade
37. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
38. 1 receptor
39. Regulation of angiotensin II-induced JAK2 tyrosine phosphorylation: Roles of SHP-1 and SHP-2
40. The type I angiotensin II receptor couples to Stat1 and Stat3 activation through Jak2 kinase in neonatal rat cardiac myocytes
41. Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor
42. 2 bradykinin receptors
43. Caveolins, a family of scaffolding proteins for organizing ' preassembled signaling complexes' at the plasma membrane
44. Urokinase receptor is associated with the components of the JAK1/STAT1 signaling pathway and leads to activation of this pathway upon receptor clustering in the human kidney epithelial tumor cell line TCL-598