Activation of JAK-STAT and MAP kinases by leukemia inhibitory factor through gp130 in cardiac myocytes

Circulation

Volumn 94, Issue 10, 1996, Pages 2626-2632

  Kunisada, Keita ^a   Hirota, Hisao ^a   Fujio, Yasushi ^a   Matsui, Hideo ^a   Tani, Yoshihiko ^a   Yamauchi Takihara, Keiko ^a   Kishimoto, Tadamitsu ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

gp130; hypertrophy; interleukins; signal transduction

Indexed keywords

BLOCKING ANTIBODY; CYTOKINE; GLYCOPROTEIN GP 130; INTERLEUKIN 6; LEUKEMIA INHIBITORY FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOTRANSFERASE; POLYCLONAL ANTIBODY; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL LYSATE; CELL STIMULATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME INHIBITION; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MALE; MOUSE; NEWBORN; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

EID: 0029843527     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.94.10.2626     Document Type: Article

References (35)

1. Shubeita HE, McDonough PM, Harris AN, Knowlton KU, Glem-botski CC, Brown JH, Chien KR. Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes: a paracrine mechanism for myocardial cell hypertrophy. J Biol Chem. 1990;265:20555-20562.
2. Ito H, Hirata Y, Hiroe M, Tsujino M, Adachi S, Takamoto T, Nitta M, Taniguchi K, Marumo F. Endothelin-1 induces hypertrophy with enhanced expression of muscle specific genes in cultured neonatal rat cardiomyocyte. Circ Res 1991;69:209-215.
3. 1-adrenergic receptor interaction. Circ Res. 1985;56:884-894.
4. 1adrenoceptor-mediated hypertrophy of rat cardiac myocytes. J clin Invest. 1987;80:1194-1199.
5. Baker KM, Aceto JF. Angiotensin II stimulation of protein synthesis and cell growth in chick heart cells. Am J Physiol. 1990;259: H610-H618.
6. Pennica D, King KL, Shaw KJ, Luis E, Rullamas J, Luoh S-M, Darbonne WC, Knutzon DS, Yen R, Chien KR, Baker JB, Wood WI. Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy. Proc Natl Acad Sci U S A. 1995;92: 1142-1146.
7. Murakami M, Hibi M, Nakagawa N, Nakagawa T, Yasukawa K, Yamanishi K, Taga T, Kishimoto T. IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase. Science. 1993;260:1808-1810.
8. Hirota H, Yoshida K, Kishimoto T, Taga T. Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice. Proc Natl Acad Sci U S A. 1995;92:4862-4866.
9. Kishimoto T, Taga T, Akira S. Cytokine signal transduction. Cell. 1994;76:253-262.
10. Bogoyevitch MA, Glennon PE, Sugden PH. Endothelin-1, phorbol esters and phenylephrine stimulate MAP kinase activities in ventricular cardiomyocytes. FEES Lett. 1993;317:271-275.
11. Bogoyevitch MA, Glennon PE, Andersson MB, Clerk A, Lazou A, Marshall CJ, Parker PJ, Sugden PH. Endothelin-1 and fibroblast growth factors stimulate the mitogen-activated protein kinase signaling cascade in cardiac myocytes: the potential role of the cascade in the integration of two signaling pathways leading to myocyte hypertrophy. J Biol Chem. 1994;269:1110-1119.
12. Lazou A, Bogoyevitch MA, Clerk A, Fuller SJ, Marshall CJ, Sugden PH. Regulation of mitogen-activated protein kinase cascade in adult rat heart preparations in vitro. Circ Res. 1994;75:932-941.
13. Yamazaki T, Tobe K, Hoh E, Maemura K, Kaida T, Komuro I, Tamemoto H, Kadowaki T, Nagai R, Yazaki Y. Mechanical loading activates mitogen-activated protein kinase and S6 peptide kinase in cultured rat cardiac myocytes. J Biol Chem. 1993;268:12069-12076.
14. Yamauchi-Takihara K, Ihara Y, Ogata A, Yoshizaki K, Azuma J, Kishimoto T. Hypoxic stress induced cardiac myocyte derived inter-leukin-6. Circulation. 1995;91:1520-1524.
15. Ferby IM, Waga I, Sakanaka C, Kume K, Shimizu T. Wortmannin inhibits mitogen-activated protein kinase activation induced by platelet-activating factor in guinea pig neutrophils. J Biol Chem. 1994;269:30485-30488.
16. Clark-Lewis I, Sanghera JS, Pelech SL. Definition of a consensus sequence for peptide substrate recognition by p44mpk, the miosis-activated myelin basic protein kinase. J Biol Chem. 1991;266:15180-15184.
17. Stahl N, Boulton TG, Farrugella T, Ip NY, Davis S, Witthuhn BA, Quelle FW, Silvennoinen O, Barbieri G, Pellegrini S, Ihle JN, Yancopoulos GD. Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL6 β receptor components. Science. 1994;263: 92-95.
18. Narazaki M, Witthuhn BA, Yoshida K, Silvennoinen O, Yasukawa K, Ihle JN, Kishimoto T, Taga T. Activation of Jak 2 kinase mediated by the interleukin 6 signal transducer gp130. Proc Natl Acad Sci U S A. 1994;91:2285-2289.
19. Pennica D, Shaw KJ, Swanson TA, Moore MW, Shelton DL, Zion-check KA, Rosenthal A, Taga T, Paoni NF, Wood WI. Cardiotrophin-1: biological activities and binding to the leukemia inhibitory factor receptor/gp130 signaling complex. J Biol Chem. 1995;270: 10915-10922.
20. Wollert KC, Taga T, Saito M, Narazaki M, Kishimoto T, Glembotski CC, Vernallis AB, Heath JK, Pennica D, Wood WI, Chien KR. Cardiotrophin-1 activates a distinct form of cardiac muscle cell hypertrophy. J Biol Chem. 1996;271:9335-9545.
21. Akira S, Nishio Y, Inoue M, Wang XJ, Wei S, Matsusaka T, Yoshida K, Sudo T, Naruto M, Kishimoto T. Molecular cloning of AFRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell. 1994;77: 63-71.
22. Levy DE, Kessler DS, Pine R, Reick N, Darnell JE Jr. Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control. Genes Dev. 1988;2:383-393.
23. Schindler C, Fu XY, Improta T, Aebersold R, Darnell JE Jr. Proteins of transcription factor ISGF-3: one gene encode the 91 and 84-kDa ISGF-3 proteins that are activated by interferon-α. Proc Natl Acad Sci U S A. 1992;89:7836-7839.
24. Fu XY, Schindler C, Improta T, Aebersold R, Darnell JE Jr. The proteins of ISGF-3, the Interferon α-induced transcriptional activator, define a gene family involved in signal transduction. Proc Natl Acad Sci U S A. 1992;89:7840-7843.
25. Zhong Z, Wen Z, Darnell JE Jr. Stat 3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science. 1994;264:95-98.
26. Yamamoto K, Quelle FW, Thierfelder WE, Kreider BL, Gilbert DJ, Jenkins NA, Copeland NG, Silvennoinen O, Ihle JN. Stat 4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation. Mol Cell Biol 1994;14:4342-4349.
27. Wakao H, Gouilleux F, Groner B. Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confer the prolactin response. EMBO J. 1994;13: 2182-2191.
28. Hou J, Schindler U, Henzel WJ, Ho TC, Brasseur M, Mcknight SL. An interleukin-4-induced transcription factor: IL-4 Stat. Science. 1994;265:1701-1706.
29. Ip NY, Nye SH, Boulton TG, Davis S, Taga T, Li Y, Birren SJ, Yasukawa K, Kishimoto T, Andersen DJ, Stahl N, Yancopoulos GD. CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130. Cell. 1992;69:1121-1132.
30. Matsui H, Fujio Y, Kunisada K, Hirota H, Yamauchi-Takihara K. Leukemia inhibitory factor induces a hypertrophic response mediated by gp130 in murine cardiac myocytes. Res Commun Mol Pathol Pharmacol. In press.
31. Yamauchi-Takihara K, Ihara Y, Takahashi K, Kishimoto T. Hypoxic stress induces cardiac myocyte-derived interleukin-6 (IL-6): IL-6 gene activation is mediated by nuclear factor (NF)-IL6 and NF-κB binding site. In: Yazaki Y, ed. Cardiac Development and Gene Regulation. Tokyo, Japan: Excerpta Medica Ltd; 1995:111-126.
32. Schiemann WP, Nathanson NM. Involvement of protein kinase C during activation of the mitogen-activated protein kinase cascade by leukemia inhibitory factor: evidence for participation of multiple signaling pathways. J Biol Chem. 1994;269:6376-6382.
33. Suematsu S, Matsuda T, Aozasa K, Akira S, Nakano N, Ohno S, Miyazaki J, Yamamura K, Hirano T, Kishimoto T. IgG1 plasmacytosis in interleukin 6 transgenic mice. Proc Natl Acad Sci U S A. 1989;86:7547-7551.
34. 2+-dependent signaling. Circ Res. 1995;76:1-15.
35. Yoshida K, Taga T, Saito M, Suematsu S, Kumanogoh A, Tanaka T, Fujiwara H, Hirata M, Yamagami T, Nakahata T, Hirabayashi T, Yoneda Y, Tanaka K, Wang WZ, Mon C, Shiota K, Yoshida N, Kishimoto T. Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders. Proc Natl Acad Sci U S A. 1996;93: 407-411.