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Volumn 12, Issue 2, 2000, Pages 123-132

Janus kinase 3 (Jak3) is essential for common cytokine receptor γ chain (γ(c))-dependent signaling: Comparative analysis of γ(c), Jak3, and γ(c) and Jak3 double-deficient mice

Author keywords

Apoptosis; Bcl 2; Common cytokine receptor chain; Jak3; Knockout mice

Indexed keywords

CYTOKINE RECEPTOR; DEXAMETHASONE; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 7; INTERLEUKIN 9; JANUS KINASE; PROTEIN BCL 2;

EID: 0033952813     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/12.2.123     Document Type: Article
Times cited : (118)

References (65)
  • 1
    • 0029924265 scopus 로고    scopus 로고
    • The molecular basis of X-linked severe combined immunodeficiency: Defective cytokine receptor signaling
    • Leonard, W. J. 1996. The molecular basis of X-linked severe combined immunodeficiency: defective cytokine receptor signaling. Annu. Rev. Med. 47:229.
    • (1996) Annu. Rev. Med. , vol.47 , pp. 229
    • Leonard, W.J.1
  • 3
    • 0029414787 scopus 로고
    • c)-dependent cytokines: Understanding in vivo function by gene targeting
    • c)-dependent cytokines: understanding in vivo function by gene targeting. Immunol. Rev. 148:19.
    • (1995) Immunol. Rev. , vol.148 , pp. 19
    • DiSanto, J.P.1    Kuhn, R.2    Muller, W.3
  • 5
  • 7
    • 0031740732 scopus 로고    scopus 로고
    • Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency
    • Puel, A., Ziegler, S. F., Buckley, R. H. and Leonard, W. J. 1998. Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency. Nat. Genet. 20:394.
    • (1998) Nat. Genet. , vol.20 , pp. 394
    • Puel, A.1    Ziegler, S.F.2    Buckley, R.H.3    Leonard, W.J.4
  • 9
    • 0032211699 scopus 로고    scopus 로고
    • IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation
    • Lodolce, J. P., Boone, D. L., Chai, S., Swain, R. E., Dassopoulos, T., Trettin, S. and Ma, A. 1998. IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity 9:669.
    • (1998) Immunity , vol.9 , pp. 669
    • Lodolce, J.P.1    Boone, D.L.2    Chai, S.3    Swain, R.E.4    Dassopoulos, T.5    Trettin, S.6    Ma, A.7
  • 10
  • 13
    • 0033556320 scopus 로고    scopus 로고
    • c): The requirement for Bcl-2 differs depending on the T cell receptor/MHC affinity
    • c): the requirement for Bcl-2 differs depending on the T cell receptor/MHC affinity. J. Immunol. 162:782.
    • (1999) J. Immunol. , vol.162 , pp. 782
    • Nakajima, H.1    Leonard, W.J.2
  • 14
    • 0030874326 scopus 로고    scopus 로고
    • The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression
    • von Freeden-Jeffry, U., Solvason, N., Howard, M. and Murray, R. 1997. The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression. Immunity 7:147.
    • (1997) Immunity , vol.7 , pp. 147
    • Von Freeden-Jeffry, U.1    Solvason, N.2    Howard, M.3    Murray, R.4
  • 15
    • 0031587826 scopus 로고    scopus 로고
    • Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor- deficient mice
    • Akashi, K., Kondo, M., von Freeden-Jeffry, U., Murray, R. and Weissman, I. L. 1997. Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor- deficient mice. Cell 88:1033.
    • (1997) Cell , vol.88 , pp. 1033
    • Akashi, K.1    Kondo, M.2    Von Freeden-Jeffry, U.3    Murray, R.4    Weissman, I.L.5
  • 17
    • 0030787787 scopus 로고    scopus 로고
    • Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common γ chain-deficient mice
    • Kondo, M., Akashi, K., Domen, J., Sugamura, K. and Weissman, I. L. 1997. Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common γ chain-deficient mice. Immunity 7:155.
    • (1997) Immunity , vol.7 , pp. 155
    • Kondo, M.1    Akashi, K.2    Domen, J.3    Sugamura, K.4    Weissman, I.L.5
  • 18
    • 0343812092 scopus 로고    scopus 로고
    • IL-7 receptor and VDJ recombination: Trophic versus mechanistic actions
    • Candeias, S., Muegge, K. and Durum, S. K. 1997. IL-7 receptor and VDJ recombination: trophic versus mechanistic actions. Immunity 6:501.
    • (1997) Immunity , vol.6 , pp. 501
    • Candeias, S.1    Muegge, K.2    Durum, S.K.3
  • 19
    • 0030964406 scopus 로고    scopus 로고
    • Induction of TCR gene rearrangements in uncommitted stem cells by a subset of IL-7 producing, MHC class-II-expressing thymic stromal cells
    • Oosterwegel, M. A., Haks, M. C., Jeffry, U., Murray, R. and Kruisbeek, A. M. 1997. Induction of TCR gene rearrangements in uncommitted stem cells by a subset of IL-7 producing, MHC class-II-expressing thymic stromal cells. Immunity 6:351.
    • (1997) Immunity , vol.6 , pp. 351
    • Oosterwegel, M.A.1    Haks, M.C.2    Jeffry, U.3    Murray, R.4    Kruisbeek, A.M.5
  • 20
    • 0031841989 scopus 로고    scopus 로고
    • Molecular and cellular events in early thymocyte development
    • Rodewald, H.-R. and Fehling, H. J. 1998. Molecular and cellular events in early thymocyte development. Adv. Immunol. 69:1.
    • (1998) Adv. Immunol. , vol.69 , pp. 1
    • Rodewald, H.-R.1    Fehling, H.J.2
  • 21
    • 0031919849 scopus 로고    scopus 로고
    • Jaks and STATs: Biological implications
    • Leonard, W. J. and O'Shea, J. J. 1998. Jaks and STATs: biological implications. Annu. Rev. Immunol. 16:293.
    • (1998) Annu. Rev. Immunol. , vol.16 , pp. 293
    • Leonard, W.J.1    O'Shea, J.J.2
  • 22
    • 0029962080 scopus 로고    scopus 로고
    • The interleukin-2 receptor γ chain: Its role in the multiple cytokine receptor complexes and T cell development in XSCID
    • Sugamura, K., Asao, H., Kondo, M., Tanaka, N., Ishii, N., Ohbo, K., Nakamura, M. and Takeshita, T. 1996. The interleukin-2 receptor γ chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID. Annu. Rev. Immunol. 14:179.
    • (1996) Annu. Rev. Immunol. , vol.14 , pp. 179
    • Sugamura, K.1    Asao, H.2    Kondo, M.3    Tanaka, N.4    Ishii, N.5    Ohbo, K.6    Nakamura, M.7    Takeshita, T.8
  • 25
    • 0027238222 scopus 로고
    • Reconstitution of functional interleukin 2 receptor complexes on fibroblastoid cells: Involvement of the cytoplasmic domain of the γ chain in two distinct signaling pathways
    • Asao, H., Takeshita, T., Ishii, N., Kumaki, S., Nakamura, M. and Sugamura, K. 1993. Reconstitution of functional interleukin 2 receptor complexes on fibroblastoid cells: involvement of the cytoplasmic domain of the γ chain in two distinct signaling pathways. Proc. Natl Acad. Sci. USA 90:4127.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 4127
    • Asao, H.1    Takeshita, T.2    Ishii, N.3    Kumaki, S.4    Nakamura, M.5    Sugamura, K.6
  • 26
    • 0029115353 scopus 로고
    • Critical role of the interleukin 2 (IL-2) receptor gamma-chain-associated Jak3 in the IL-2-induced c-fos and c-myc, but not bcl-2. gene induction
    • Kawahara, A., Minami, Y., Miyazaki, T., Ihle, J. N. and Taniguchi, T. 1995. Critical role of the interleukin 2 (IL-2) receptor gamma-chain-associated Jak3 in the IL-2-induced c-fos and c-myc, but not bcl-2. gene induction. Proc. Natl Acad. Sci. USA 92:8724.
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 8724
    • Kawahara, A.1    Minami, Y.2    Miyazaki, T.3    Ihle, J.N.4    Taniguchi, T.5
  • 27
    • 0033491981 scopus 로고    scopus 로고
    • Biology of the interleukin-2 receptor
    • Nelson, B. H. and Willerford, D. M. 1998. Biology of the interleukin-2 receptor. Adv. Immunol. 70:1.
    • (1998) Adv. Immunol. , vol.70 , pp. 1
    • Nelson, B.H.1    Willerford, D.M.2
  • 28
  • 29
    • 0030917141 scopus 로고    scopus 로고
    • Jak3 is associated with CD40 and is critical for CD40 induction of gene expression in B cells
    • Hanissian, S. H. and Geha, R. S. 1997. Jak3 is associated with CD40 and is critical for CD40 induction of gene expression in B cells. Immunity 6:379.
    • (1997) Immunity , vol.6 , pp. 379
    • Hanissian, S.H.1    Geha, R.S.2
  • 31
    • 0028799457 scopus 로고
    • Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3
    • Thomis, D. C., Gurniak, C. B., Tivol, E., Sharpe, A. H. and Berg, L. J. 1995. Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science 270:794.
    • (1995) Science , vol.270 , pp. 794
    • Thomis, D.C.1    Gurniak, C.B.2    Tivol, E.3    Sharpe, A.H.4    Berg, L.J.5
  • 35
    • 0021056264 scopus 로고
    • The major histocompatibility complex-restricted antigen receptor on T cells. IV. An antiidiotypic antibody predicts both antigen and l-specificity
    • Marrack, P., Shimonkevitz, R., Hannum, C., Haskins, K. and Kappler, J. 1983. The major histocompatibility complex-restricted antigen receptor on T cells. IV. An antiidiotypic antibody predicts both antigen and l-specificity. J. Exp. Med. 158:1635.
    • (1983) J. Exp. Med. , vol.158 , pp. 1635
    • Marrack, P.1    Shimonkevitz, R.2    Hannum, C.3    Haskins, K.4    Kappler, J.5
  • 36
    • 0027199233 scopus 로고
    • Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes
    • Veis, D. J., Sentman, C. L., Bach, E. A. and Korsmeye, S. J. 1993. Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes. J. Immunol. 151:2546.
    • (1993) J. Immunol. , vol.151 , pp. 2546
    • Veis, D.J.1    Sentman, C.L.2    Bach, E.A.3    Korsmeye, S.J.4
  • 37
    • 0031433362 scopus 로고    scopus 로고
    • An indirect effect of Stat5a in IL-2-induced proliferation: A critical role for Stat5a in IL-2-mediated IL-2 receptor α chain induction
    • Nakajima, H., Liu, X. W., Wynshaw-Boris, A., Rosenthal, L. A., Imada, K., Finbloom, D. S., Hennighausen, L. and Leonard, W. J. 1997. An indirect effect of Stat5a in IL-2-induced proliferation: a critical role for Stat5a in IL-2-mediated IL-2 receptor α chain induction. Immunity 7:691.
    • (1997) Immunity , vol.7 , pp. 691
    • Nakajima, H.1    Liu, X.W.2    Wynshaw-Boris, A.3    Rosenthal, L.A.4    Imada, K.5    Finbloom, D.S.6    Hennighausen, L.7    Leonard, W.J.8
  • 39
    • 0031041301 scopus 로고    scopus 로고
    • The common cytokine receptor γ chain plays an essential role in regulating lymphoid homeostasis
    • Nakajima, H., Shores, E. W., Noguchi, M. and Leonard, W. J. 1997. The common cytokine receptor γ chain plays an essential role in regulating lymphoid homeostasis. J. Exp. Med. 185:189.
    • (1997) J. Exp. Med. , vol.185 , pp. 189
    • Nakajima, H.1    Shores, E.W.2    Noguchi, M.3    Leonard, W.J.4
  • 40
    • 1842291572 scopus 로고    scopus 로고
    • Crucial role of Jak3 in negative selection of self-reactive T cells
    • Saijo, K., Park, S. Y., Ishida, Y., Arase, H. and Saito, T. 1997. Crucial role of Jak3 in negative selection of self-reactive T cells. J. Exp. Med. 185:351.
    • (1997) J. Exp. Med. , vol.185 , pp. 351
    • Saijo, K.1    Park, S.Y.2    Ishida, Y.3    Arase, H.4    Saito, T.5
  • 41
    • 0031054442 scopus 로고    scopus 로고
    • Peripheral expression of Jak3 is required to maintain T lymphocyte function
    • Thomis, D. C. and Berg, L J. 1997. Peripheral expression of Jak3 is required to maintain T lymphocyte function. J. Exp. Med. 185:197.
    • (1997) J. Exp. Med. , vol.185 , pp. 197
    • Thomis, D.C.1    Berg, L.J.2
  • 43
    • 0028106804 scopus 로고
    • Expression of the mouse interleukin-2 receptor γ chain in various cell populations of the thymus and spleen
    • Kondo, M., Ohashi, Y., Tada, K., Nakamura, M. and Sugamura, K. 1994. Expression of the mouse interleukin-2 receptor γ chain in various cell populations of the thymus and spleen. Eur. J. Immunol. 24:2026.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 2026
    • Kondo, M.1    Ohashi, Y.2    Tada, K.3    Nakamura, M.4    Sugamura, K.5
  • 44
    • 0031890632 scopus 로고    scopus 로고
    • Restoration of lymphocyte function in Janus kinase 3-deficient mice by retroviral-mediated gene transfer
    • Bunting, K. D., Sangster, M. Y., Ihle, J. N. and Sorrentino, B. P. 1998. Restoration of lymphocyte function in Janus kinase 3-deficient mice by retroviral-mediated gene transfer. Nat. Med. 4:58.
    • (1998) Nat. Med. , vol.4 , pp. 58
    • Bunting, K.D.1    Sangster, M.Y.2    Ihle, J.N.3    Sorrentino, B.P.4
  • 45
    • 0030978529 scopus 로고    scopus 로고
    • Pro-thymocyte expansion by c-kit and the common cytokine receptor γ chain is essential for repertoire formation
    • Rodewald, H.-R., Ogawa, M., Haller, C., Waskow, C. and DiSanto, J. P. 1997. Pro-thymocyte expansion by c-kit and the common cytokine receptor γ chain is essential for repertoire formation. Immunity 6:265.
    • (1997) Immunity , vol.6 , pp. 265
    • Rodewald, H.-R.1    Ogawa, M.2    Haller, C.3    Waskow, C.4    DiSanto, J.P.5
  • 46
    • 0033081225 scopus 로고    scopus 로고
    • The common cytokine receptor γ chain and the pre-T cell receptor provide independent but critically overlapping signals in early α/β T cell development
    • DiSanto, J. P., Aifantis, I., Rosmaraki, E., Garcia, C., von Boehmer, H. and Rocha, B. 1999. The common cytokine receptor γ chain and the pre-T cell receptor provide independent but critically overlapping signals in early α/β T cell development. J. Exp. Med. 189:563.
    • (1999) J. Exp. Med. , vol.189 , pp. 563
    • DiSanto, J.P.1    Aifantis, I.2    Rosmaraki, E.3    Garcia, C.4    Von Boehmer, H.5    Rocha, B.6
  • 47
    • 0028962572 scopus 로고
    • The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15
    • Lin, J.-X., Migone, T. S., Tsang, M., Friedmann, M., Weatherbee, J. A., Zhou, L., Yamauchi, A., Bloom, E. T., Mietz, J., John, S. and Leonard, W. J. 1995. The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. Immunity 2:331.
    • (1995) Immunity , vol.2 , pp. 331
    • Lin, J.-X.1    Migone, T.S.2    Tsang, M.3    Friedmann, M.4    Weatherbee, J.A.5    Zhou, L.6    Yamauchi, A.7    Bloom, E.T.8    Mietz, J.9    John, S.10    Leonard, W.J.11
  • 48
    • 0029134065 scopus 로고
    • Jak3 protein tyrosine kinase mediates interleukin-7-induced activation of phosphatidylinositol-3 kinase
    • Sharfe, N., Dadi, H. K. and Roifman, C. M. 1995. Jak3 protein tyrosine kinase mediates interleukin-7-induced activation of phosphatidylinositol-3 kinase. Blood 86:2077.
    • (1995) Blood , vol.86 , pp. 2077
    • Sharfe, N.1    Dadi, H.K.2    Roifman, C.M.3
  • 49
    • 0028048445 scopus 로고
    • Activation of phosphatidylinositol-3 kinase by ligation of the interleukin-7 receptor is dependent on protein tyrosine kinase activity
    • Dadi, H., Ke, S. and Roifman, C. M. 1994. Activation of phosphatidylinositol-3 kinase by ligation of the interleukin-7 receptor is dependent on protein tyrosine kinase activity. Blood 84:2579.
    • (1994) Blood , vol.84 , pp. 2579
    • Dadi, H.1    Ke, S.2    Roifman, C.M.3
  • 54
    • 0032213273 scopus 로고    scopus 로고
    • Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: Generation and characterization of T cell-specific stat3-deficient mice
    • Takeda, K., Kaisho, T., Yoshida, N., Takeda, J., Kishimoto, T. and Akira, S. 1998. Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice. J. Immunol. 161:4652.
    • (1998) J. Immunol. , vol.161 , pp. 4652
    • Takeda, K.1    Kaisho, T.2    Yoshida, N.3    Takeda, J.4    Kishimoto, T.5    Akira, S.6
  • 56
    • 17044444647 scopus 로고    scopus 로고
    • STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction
    • Takeshita, T., Arita, T., Higuchi, M., Asao, H., Endo, K., Kuroda, H., Tanaka, N., Murata, K., Ishii, N. and Sugamura, K. 1997. STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction. Immunity 6:449.
    • (1997) Immunity , vol.6 , pp. 449
    • Takeshita, T.1    Arita, T.2    Higuchi, M.3    Asao, H.4    Endo, K.5    Kuroda, H.6    Tanaka, N.7    Murata, K.8    Ishii, N.9    Sugamura, K.10
  • 58
    • 0033556333 scopus 로고    scopus 로고
    • Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85α
    • Fruman, D. A., Snapper, S. B., Yballe, C. M., Davidson, L., Yu, J. Y., Alt, F. W. and Cantley, L. C. 1999. Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85α. Science 283:393.
    • (1999) Science , vol.283 , pp. 393
    • Fruman, D.A.1    Snapper, S.B.2    Yballe, C.M.3    Davidson, L.4    Yu, J.Y.5    Alt, F.W.6    Cantley, L.C.7
  • 59
    • 0033555829 scopus 로고    scopus 로고
    • Xid-like immunodeficiency in mice with disruption of the p85α subunit of phosphoinositide 3-kinase
    • Suzuki, H., Terauchi, Y., Fujiwara, M., Aizawa, S., Yazaki, Y., Kadowaki, T. and Koyasu, S. 1999. Xid-like immunodeficiency in mice with disruption of the p85α subunit of phosphoinositide 3-kinase. Science 283:390.
    • (1999) Science , vol.283 , pp. 390
    • Suzuki, H.1    Terauchi, Y.2    Fujiwara, M.3    Aizawa, S.4    Yazaki, Y.5    Kadowaki, T.6    Koyasu, S.7
  • 60
    • 0033136288 scopus 로고    scopus 로고
    • Distinct roles of the phosphatidylinositol 3-kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursors
    • Pallard, C., Stegmann, A. P., van Kleffens, T., Smart, F., Venkitaraman, A. and Spits, H. 1999. Distinct roles of the phosphatidylinositol 3-kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursors. Immunity 10:525.
    • (1999) Immunity , vol.10 , pp. 525
    • Pallard, C.1    Stegmann, A.P.2    Van Kleffens, T.3    Smart, F.4    Venkitaraman, A.5    Spits, H.6
  • 61
    • 0029150110 scopus 로고
    • Immonologic self tolerance maintained by activated T cells expressing IL-2 receptor a chain (CD25)
    • Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M. and Toda, M. 1995. Immonologic self tolerance maintained by activated T cells expressing IL-2 receptor a chain (CD25). J. Immunol. 155:1151.
    • (1995) J. Immunol. , vol.155 , pp. 1151
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 63
    • 0031821875 scopus 로고    scopus 로고
    • + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
    • + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188:287.
    • (1998) J. Exp. Med. , vol.188 , pp. 287
    • Thornton, A.M.1    Shevach, E.M.2
  • 64
    • 0031757825 scopus 로고    scopus 로고
    • Role of interleukin-7 in T-cell development from hematopoietic stem cells
    • Akashi, K., Kondo, M. and Weissman, I. L. 1998. Role of interleukin-7 in T-cell development from hematopoietic stem cells. Immunol Rev 165:13.
    • (1998) Immunol Rev , vol.165 , pp. 13
    • Akashi, K.1    Kondo, M.2    Weissman, I.L.3


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