Expression of granulocyte colony-stimulating factor- and granulocyte- macrophage colony-stimulating factor-associated signal transduction proteins of the JAK/STAT pathway in normal granulopoiesis and in blast cells of acute myelogenous leukemia

Experimental Hematology

Volumn 27, Issue 5, 1999, Pages 885-894

  Biethahn, Silke ^a   Alves, Frauke ^a   Wilde, Sabine ^a   Hiddemann, Wolfgang ^a   Spiekermann, Karsten ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Acute myelogenous leukemia; Colony stimulating factors; Granulopoiesis; Janus kinases; Signal transducers and activators of transcription

Indexed keywords

CD34 ANTIGEN; CYTOKINE RECEPTOR; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE; STAT1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN;

ACUTE GRANULOCYTIC LEUKEMIA; ANTIGEN EXPRESSION; ARTICLE; BLAST CELL; BONE MARROW CELL; CELL PROLIFERATION; CLINICAL ARTICLE; CLONOGENESIS; CONTROLLED STUDY; GRANULOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANTIGENS, CD34; CELL LINEAGE; DNA-BINDING PROTEINS; GRANULOCYTE COLONY-STIMULATING FACTOR; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; GRANULOCYTES; HEMATOPOIESIS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEUKEMIA, MYELOCYTIC, ACUTE; PROTEIN-TYROSINE-PHOSPHATASE; SHP1 PROTEIN TYROSINE PHOSPHATASE; SIGNAL TRANSDUCTION;

JANUS;

EID: 0032895874     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-472X(99)00017-X     Document Type: Article

References (44)

1. Shinjo K., Takeshita A., Ohnishi K., Ohno R. Granulocyte colony-stimulating factor receptor at various differentiation stages of normal and leukemic hematopoietic cells. Leuk Lymphoma. 25:1997;37.
2. Jahns-Streubel G., Reuter C., Unterhalt M., Schleyer E., Wormann B., Buchner T., Hiddemann W. Blast cell proliferative activity and sensitivity to GM-CSF in vitro are associated with early response to TAD-9 induction therapy in acute myeloid leukemia. Leukemia. 9:1995;1857.
3. Lowenberg B., van Putten W.L., Touw I.P., Delwel R., Santini V. Autonomous proliferation of leukemic cells in vitro as a determinant of prognosis in adult acute myeloid leukemia. N Engl J Med. 328:1993;614.
4. Souza L.M., Boone T.C., Gabrilove J., Lai P.H., Zsebo K.M., Murdock D.C., Chazin V.R., Bruszewski J., Lu H., Chen K.K., Barendt J., Platzer E.et al. Recombinant human granulocyte colony-stimulating factor. effects on normal and leukemic myeloid cells Science. 232:1986;61.
5. Dong F., Brynes R.K., Tidow N., Welte K., Lowenberg B., Touw I.P. Mutations in the gene for the granulocyte colony-stimulating-factor receptor in patients with acute myeloid leukemia preceded by severe congenital neutropenia. N Engl J Med. 333:1995;487.
6. Brown M.A., Gough N.M., Willson T.A., Rockman S., Begley C.G. Structure and expression of the GM-CSF receptor α and β chain genes in human leukemia. Leukemia. 7:1993;63.
7. Ihle J.N., Witthuhn B.A., Quelle F.W., Yamamoto K., Silvennoinen O. Signalling through the hematopoietic cytokine receptors. Annu Rev Immunol. 13:1995;369.
8. Darnell J.E. Jr. STATs and gene regulation. Science. 277:1997;1630.
9. Avalos B.R., Parker J.M., Ware D.A., Hunter M.G., Sibert K.A., Druker B.J. Dissociation of the Jak kinase pathway from G-CSF receptor signaling in neutrophils. Exp Hematol. 25:1997;160.
10. Al-Shami A., Mahanna W., Naccache P.H. Granulocyte-macrophage colony-stimulating factor-activated signalling pathways in human neutrophils. J Biol Chem. 273:1998;1058.
11. Schindler C., Fu X., Improta T., Aebersold R., Darnell J.E. Jr. Proteins of transcription factor ISGF-3. one gene encodes the 91- and 84-kDa ISGF-3 proteins that are activated by interferon α Proc Natl Acad Sci U S A. 89:1992;7836.
12. Shuai K., Stark G.R., Kerr I.M., Darnell J.E. Jr. A single phosphotyrosine residue of stat91 required for gene activation by interferon-γ Science. 261:1993;1744.
13. Schaefer T.S., Sanders L.K., Park O.K., Nathans D. Functional differences between Stat3α and STAT3β Mol Cell Biol. 17:1997;5307.
14. Caldenhoven E., van Dijk T.B., Solari R., Armstrong J., Raaijmakers J.A.M., Lammers J.-W.J., Koendermann L., de Groot R.P. STAT3β, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription. J Biol Chem. 271:1996;13221.
15. Azam M., Erdjument-Bromage H., Kreider B.L., Xia M., Quelle F., Basu R., Saris C., Tempst P., Ihle J.N., Schindler C. Interleukin-3 signals through multiple isoforms of Stat5. EMBO J. 14:1995;1402.
16. Rosen R.L., Winestock K.D., Chen G., Liu X., Hennighausen L., Finbloom D.S. Granulocyte-macrophage colony-stimulating factor preferentially activates the 94-kD STAT5A and an 80-kD STAT5A isoform in human peripheral blood monocytes. Blood. 88:1996;1206.
17. Denu J.M., Stuckey J.A., Saper M.A., Dixon J.E. Form and function in protein dephosphorylation. Cell. 87:1996;361.
18. David M., Chen H.E., Goelz S., Larner A.C., Neel B.G. Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1. Mol Cell Biol. 15:1995;7050.
19. Harrison D.A., Binari R., Nahreini T.S., Gilman M., Perrimon N. Activation of a Drosphila Janus kinase (JAK) causes hematopoetic neoplasia and developmental defects. EMBO J. 14:1995;2857.
20. Gouilleux-Gruart V., Gouilleux F., Desaint C., Claisse J.-F., Capiod J.C., Delobel J., Weber-Nordt R., Dusanter-Fourt I., Dreyfus F., Groner B., Prin L. STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients. Blood. 87:1996;1692.
21. Lacronique V., Boureux A., Della Valle V., Poirel H., Quang C.T., Mauchauffé M., Berthou C., Lessard M., Berger R., Ghysdael J., Bernard O.A. A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. Science. 278:1997;1309.
22. Peeters P., Raynaud S.D., Cools J., Wlodarska I., Grosgeorge J., Philip P., Monpoux F., Van Rompaey L., Baens M., van den Berghe H., Marynen P. Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase, JAK2 as a result of t(9;19) in a lymphoid and t(9:15;12) in a myeloid leukemia. Blood. 90:1997;2535.
23. Salomon D.S., Brandt R., Ciardiello F., Normanno F. Epidermal growth factor-related peptides and their receptors in human malignancies. Crit Rev Oncol Hematol. 19:1995;183.
24. Stollmann B., Fonatsch C., Havers W. Persistent Epstein-Barr virus infection associated with monosomy 7 or chromosome 3 abnormality in childhood myeloproliferative disorders. Br J Haematol. 60:1985;183.
25. ISCN (1991) Guidelines for cancer cytogenetics: Supplement to an international system for human cytogenetic nomenclature. Basel, Switzerland: S. Karger.
26. Gianni M., Terao M., Fortino I., LiCalzi M., Viggiano V., Barbui T., Rambaldi A., Garattini E. Stat1 is induced and activated by all-trans retinoic acid in acute promyelocytic leukemia cells. Blood. 89:1997;1001.
27. Matikainen S., Ronni T., Lehtonen A., Sareneva T., Melén K., Nordling S., Levy D.E., Julkunen I. Retinoic acid induces signal transducer and activator of transcription (STAT) 1, STAT2, and p48 expression in myeloid leukemia cells and enhances their responsiveness to interferons. Cell Growth Differ. 8:1997;687.
28. Rane S.G., Reddy E.P. JAK3. a novel JAK kinase associated with terminal differentiation of hematopoetic cells Oncogene. 9:1994;2415.
29. Safford M.G., Levenstein M., Tsifrina E., Amin S., Hawkins A.L., Griffin C.A., Civin C.I., Small D. JAK3. expression and mapping to chromosome 19p12-13.1 Exp Hematol. 25:1997;374.
30. Chakraborty A., White S.M., Schaefer T.S., Ball E.D., Dyer D.F., Tweardy D.J. Granulocyte colony-stimulating factor activation of Stat3α and Stat3β in immature normal and leukemic human myeloid cells. Blood. 88:1996;2442.
31. Minami M., Inoue M., Wei S., Takeda K., Matsumoto M., Kishimoto T., Akira S. STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line. Proc Natl Acad Sci U S A. 93:1996;3963.
32. Shimozaki K., Nakajima K., Hirano T., Nagata S. Involvement of STAT3 in the granulocyte colony-stimulating factor-induced differentiation of myeloid cells. J Biol Chem. 272:1997;25184.
33. Zhuang H., Patel S.V., He T.C., Sonsteby S.K., Niu Z., Wojchowski D.M. Inhibition of erythropoietin-induced mitogenesis by a kinase-deficient form of Jak2. J Biol Chem. 269:1994;21411.
34. Mui A.L.-F., Wakao H., Kinoshita T., Kitamura T., Miyajima A. Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5. role of Stat5 in proliferation EMBO J. 15:1996;2425.
35. Feldman G.M., Rosenthal L.A., Liu X., Hayes M.P., Wynshaw-Boris A., Leonhard W.J., Hennighausen L., Finbloom D.S. STAT5A-deficient mice demonstrate a defect in granulocyte-macrophage colony-stimulating factor-induced proliferation and gene expression. Blood. 90:1997;1768.
36. Brizzi M.F., Aronica M.G., Rosso A., Bagnara G.P., Yarden Y., Pegoraro L. Granulocyte-macrophage colony-stimulating factor stimulates JAK2 signaling pathway and rapidly activates p93fes, STAT1 p91, and STAT3 p92 in polymorphonuclear leukocytes. J Biol Chem. 271:1996;3562.
37. Shimoda K., Feng J., Murakami H., Nagata S., Watling D., Rogers N.C., Stark G.F., Kerr I.M., Ihle J.N. Jak1 plays an essential role for receptor phosphorylation and Stat activation in response to granulocyte colony-stimulating factor. Blood. 90:1997;597.
38. Parganas E., Wang D., Stravopodis D., Topham D.J., Marine J.-C., Teglund S., Vanin E.F., Bodner S., Colamonici O.R., van Deursen J.M., Grosveld G., Ihle J.N. Jak2 is essential for signaling through a variety of cytokine receptors. Cell. 83:1998;385.
39. Rodig S.J., Meraz M.A., White J.M., Lampe P.A., Riley J.K., Arthur C.D., King K.L., Sheehan K.C.F., Yin L., Pennica D., Johnson E.M., Schreiber R.D. Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses. Cell. 98:1998;373.
40. Motoji T., Takanashi M., Fuchinoue M., Masuda M., Oshimi K., Mizoguchi H. Effect of recombinant GM-CSF and recombinant G-CSF on colony formation of blast progenitors in acute myeloblastic leukemia. Exp Hematol. 17:1989;56.
41. Jahns-Streubel G., Haase D., Schoch C., Wörmann B., Büchner T., Fonatsch C., Hiddemann W. Cytogenetic subgroups of acute myeloid leukemia (AML) differ significantly in proliferative activity, cytokine production and sensitivity to GM-CSF Stimulation. Blood. 88:1996;2229.
42. Meydan N., Grunberger T., Dadi H., Shahar M., Arpaia E., Lapidot Z., Leeder J.S., Freedman M., Cohen A., Gazit A., Levitzki A., Roifman C.M. Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor. Nature. 379:1996;645.
43. Nielsen M., Kaltoft K., Nordahl M., Röpke C., Geisler C., Mustelin T., Dobson P., Sejgard A., Ødum N. Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides. tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines Proc Natl Acad Sci U S A. 94:1997;6764.
44. Tapley P., Shevde N.K., Schweitzer P.A., Gallina M., Christianson S.W., Lin I.L., Stein R.B., Shultz L.D., Rosen J., Lamb P. Increased G-CSF responsiveness of bone marrow cells from hematopoietic cell phosphatase deficient viable motheaten mice. Exp Hematol. 25:1997;122.