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Volumn 5, Issue 1, 1999, Pages 119-127

The nuclear factor-κB RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells

Author keywords

[No Author keywords available]

Indexed keywords

CHLORAMPHENICOL ACETYLTRANSFERASE; CURCUMIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR PROTEIN; RAF PROTEIN;

EID: 0032943591     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (651)

References (52)
  • 2
    • 0000619592 scopus 로고    scopus 로고
    • Molecular biology and the diagnosis and treatment of adenocarcinoma of the pancreas
    • DiGiuseppe, J. A., Yeo, C. J., and Hruban, R. H. Molecular biology and the diagnosis and treatment of adenocarcinoma of the pancreas. Adv. Anat. Pathol., 3: 139-155, 1996.
    • (1996) Adv. Anat. Pathol. , vol.3 , pp. 139-155
    • DiGiuseppe, J.A.1    Yeo, C.J.2    Hruban, R.H.3
  • 3
    • 0030070277 scopus 로고    scopus 로고
    • Preoperative chemoradiation, pancreaticoduodenectomy, and intraoperative radiation therapy for adenocarcinoma of the pancreatic head: Patient survival and patterns of treatment failure
    • Staley, C. A., Lee, J. E., Cleary, K. A., Abbruzzese, J. L., Ames, F. C., Fenoglio, C., and Evans, D. B. Preoperative chemoradiation, pancreaticoduodenectomy, and intraoperative radiation therapy for adenocarcinoma of the pancreatic head: patient survival and patterns of treatment failure. Am. J. Surg., 171: 118-124, 1996.
    • (1996) Am. J. Surg. , vol.171 , pp. 118-124
    • Staley, C.A.1    Lee, J.E.2    Cleary, K.A.3    Abbruzzese, J.L.4    Ames, F.C.5    Fenoglio, C.6    Evans, D.B.7
  • 6
    • 0028971289 scopus 로고
    • Rel/NF-κB/IκB family: Intimate tales of association and dissociation
    • Verma, I. M., Stevenson, J. K., Schwarz, E. M., Antwerp, D. V., and Miyamoto, S. Rel/NF-κB/IκB family: intimate tales of association and dissociation. Genes Dev., 9: 2723-2735, 1995.
    • (1995) Genes Dev. , vol.9 , pp. 2723-2735
    • Verma, I.M.1    Stevenson, J.K.2    Schwarz, E.M.3    Antwerp, D.V.4    Miyamoto, S.5
  • 7
    • 0029874138 scopus 로고    scopus 로고
    • The NF-κB and IκB proteins: New discoveries and insights
    • Baldwin, A., Jr. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol., 14: 694-681, 1996.
    • (1996) Annu. Rev. Immunol. , vol.14 , pp. 694-1681
    • Baldwin Jr., A.1
  • 8
    • 0023724778 scopus 로고
    • I kappa B: A specific inhibitor of the NF-kappa B transcription factor
    • Bacuerle, P. A., Baltimore, D. I kappa B: a specific inhibitor of the NF-kappa B transcription factor. Science (Washington DC), 242: 540-546, 1988.
    • (1988) Science (Washington DC) , vol.242 , pp. 540-546
    • Bacuerle, P.A.1    Baltimore, D.2
  • 9
    • 0027232067 scopus 로고
    • NF-kappa B and Rel: Participants in a multiform transcriptional regulatory system
    • Grilli, M., Chiu, J, J. S., and Lenardo, M. J. NF-kappa B and Rel: participants in a multiform transcriptional regulatory system. Int. Rev. Cytol., 143: 1-62, 1993.
    • (1993) Int. Rev. Cytol. , vol.143 , pp. 1-62
    • Grilli, M.1    Chiu, J.J.S.2    Lenardo, M.J.3
  • 11
    • 0028181648 scopus 로고
    • Enhanced IκBα degradation is responsible for constitutive NF-κB activity in mature murine B-cell lines
    • Miyamoto, S., Chiao, P. J., and Verma, I. M. Enhanced IκBα degradation is responsible for constitutive NF-κB activity in mature murine B-cell lines. Mol. Cell. Biol., 14: 3276-3282, 1994.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 3276-3282
    • Miyamoto, S.1    Chiao, P.J.2    Verma, I.M.3
  • 13
    • 0029146930 scopus 로고
    • Signal-induced site-specific phosphorylation targets IκBα to the ubiquitin-proteasome pathway
    • Chen, Z. J., Hagler, J., Palombella, V. J., Melandri, F., Scherer, D., Ballard, D., and Maniatis, T. Signal-induced site-specific phosphorylation targets IκBα to the ubiquitin-proteasome pathway. Genes Dev., 9: 1586-1597, 1995.
    • (1995) Genes Dev. , vol.9 , pp. 1586-1597
    • Chen, Z.J.1    Hagler, J.2    Palombella, V.J.3    Melandri, F.4    Scherer, D.5    Ballard, D.6    Maniatis, T.7
  • 14
    • 0028985190 scopus 로고
    • Phosphorylation of IκBα precedes but is not sufficient for its dissociation from NF-κB
    • Didonato, J. A., Mercurio, F., and Karin, M. Phosphorylation of IκBα precedes but is not sufficient for its dissociation from NF-κB. Mol. Cell Biol., 15: 1302-1311, 1995.
    • (1995) Mol. Cell Biol. , vol.15 , pp. 1302-1311
    • Didonato, J.A.1    Mercurio, F.2    Karin, M.3
  • 16
    • 0030611595 scopus 로고    scopus 로고
    • IκB kinase-β: NF-κB activation and complex formation with IκB kinase-α and NIK
    • Woronicz, J. D., Gao, X., Cao, Z., Rothe, M., and Goeddel, D. V. IκB kinase-β: NF-κB activation and complex formation with IκB kinase-α and NIK. Science (Washington DC), 278: 866-869, 1997.
    • (1997) Science (Washington DC) , vol.278 , pp. 866-869
    • Woronicz, J.D.1    Gao, X.2    Cao, Z.3    Rothe, M.4    Goeddel, D.V.5
  • 17
    • 0030610362 scopus 로고    scopus 로고
    • A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
    • DiDonato, J. A., Hayakawa, M., Rothwarf, D. M., Zandi, E., and Karin, M. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB. Nature (Lond.), 388: 548-554, 1997.
    • (1997) Nature (Lond.) , vol.388 , pp. 548-554
    • DiDonato, J.A.1    Hayakawa, M.2    Rothwarf, D.M.3    Zandi, E.4    Karin, M.5
  • 18
    • 0031586174 scopus 로고    scopus 로고
    • Identification and characterization of an IκB kinase
    • Regnier, C. H., Song, H. Y., Gao, X., Goeddel, D. V., Cao, Z., and Rothe, M. Identification and characterization of an IκB kinase. Cell, 90: 373-383, 1997.
    • (1997) Cell , vol.90 , pp. 373-383
    • Regnier, C.H.1    Song, H.Y.2    Gao, X.3    Goeddel, D.V.4    Cao, Z.5    Rothe, M.6
  • 19
    • 0030613551 scopus 로고    scopus 로고
    • The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation
    • Zandi, E., Rothwarf, D. M., Delhase, M., Hayakawa, M., and Karin, M. The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation. Cell, 91: 243-252, 1997.
    • (1997) Cell , vol.91 , pp. 243-252
    • Zandi, E.1    Rothwarf, D.M.2    Delhase, M.3    Hayakawa, M.4    Karin, M.5
  • 20
    • 0029947996 scopus 로고    scopus 로고
    • MEK kinase is involved in tumor necrosis factor α-induced NF-κB activation and degradation of IκBα
    • Hirano, M., Osada, S., Aoki, T., Hirai, S., Hosaakka, M., Inoue, J., and Ohno, S. MEK kinase is involved in tumor necrosis factor α-induced NF-κB activation and degradation of IκBα. J. Biol. Chem., 271: 13234-13238, 1996.
    • (1996) J. Biol. Chem. , vol.271 , pp. 13234-13238
    • Hirano, M.1    Osada, S.2    Aoki, T.3    Hirai, S.4    Hosaakka, M.5    Inoue, J.6    Ohno, S.7
  • 21
    • 0031285250 scopus 로고    scopus 로고
    • Activation of the IκBα kinase complex by MEKK1, a kinase of the JNK pathway
    • Lee, F. S., Hagler, J., Chen, Z., and Maniatis, T. Activation of the IκBα kinase complex by MEKK1, a kinase of the JNK pathway. Cell, 88: 213-222, 1997.
    • (1997) Cell , vol.88 , pp. 213-222
    • Lee, F.S.1    Hagler, J.2    Chen, Z.3    Maniatis, T.4
  • 23
    • 0026331456 scopus 로고
    • B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-κB p50
    • Neri, A., Chang, C. C., Lombardi, L., Salina, M., Corradini, P., Maiolo, A. T.; Chaganti, R. S. K., and Dalla-Favera, R. B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-κB p50. Cell, 67: 1075-1087, 1991.
    • (1991) Cell , vol.67 , pp. 1075-1087
    • Neri, A.1    Chang, C.C.2    Lombardi, L.3    Salina, M.4    Corradini, P.5    Maiolo, A.T.6    Chaganti, R.S.K.7    Dalla-Favera, R.8
  • 24
    • 0026636897 scopus 로고
    • Related subunits of NF-κB map to two distinct loci associated with translocations in leukemia: NFKB1 and NFKB2
    • Liptay, S., Schmid, R. M., Perkins, N. D., Meltzer, P., Altherr, M. R., McPherson, J. D., Wasmuth, J. J., and Nabel, G. J. Related subunits of NF-κB map to two distinct loci associated with translocations in leukemia: NFKB1 and NFKB2. Genomics, 13: 287-292, 1992.
    • (1992) Genomics , vol.13 , pp. 287-292
    • Liptay, S.1    Schmid, R.M.2    Perkins, N.D.3    Meltzer, P.4    Altherr, M.R.5    McPherson, J.D.6    Wasmuth, J.J.7    Nabel, G.J.8
  • 25
    • 0025324450 scopus 로고
    • The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control
    • Ohno, H., Takimoto, G., and McKeithan, T. W. The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control. Cell, 60: 991-997, 1990.
    • (1990) Cell , vol.60 , pp. 991-997
    • Ohno, H.1    Takimoto, G.2    McKeithan, T.W.3
  • 27
    • 0023851686 scopus 로고
    • Transformation of avian lymphoid cells by reticuloendotheliosis virus
    • Moore, B. E., and Bose, H. R. Transformation of avian lymphoid cells by reticuloendotheliosis virus. Mutat. Res., 795: 79-80, 1988.
    • (1988) Mutat. Res. , vol.795 , pp. 79-80
    • Moore, B.E.1    Bose, H.R.2
  • 28
    • 0023840515 scopus 로고
    • Expression of the v-rel oncogene in reticuloendotheliosis virus-transformed fibroblasts
    • Moore, B. E., and Bose, H. R. J. Expression of the v-rel oncogene in reticuloendotheliosis virus-transformed fibroblasts. Virology, 162: 377-387, 1988.
    • (1988) Virology , vol.162 , pp. 377-387
    • Moore, B.E.1    Bose, H.R.J.2
  • 29
    • 0023038280 scopus 로고
    • Activation of oncogenicity of the c-rel proto-oncogene
    • Sylla, B. S., and Temin, H. M. Activation of oncogenicity of the c-rel proto-oncogene. Mol. Cell. Biol., 6: 4709-4716, 1986.
    • (1986) Mol. Cell. Biol. , vol.6 , pp. 4709-4716
    • Sylla, B.S.1    Temin, H.M.2
  • 30
    • 0028172914 scopus 로고
    • Disruption of IκBα regulation by antisense RNA expression leads to malignant transformation
    • Beauparlant, P., Kwan, I., Bitaar, R., Chou, P., Koromilas, A. E., Sonenberg, N., and Hiscott, J. Disruption of IκBα regulation by antisense RNA expression leads to malignant transformation. Oncogene, 9: 3189-3197, 1994.
    • (1994) Oncogene , vol.9 , pp. 3189-3197
    • Beauparlant, P.1    Kwan, I.2    Bitaar, R.3    Chou, P.4    Koromilas, A.E.5    Sonenberg, N.6    Hiscott, J.7
  • 31
    • 0027058137 scopus 로고
    • Ablation of transplanted HTLV-I Tax-transformed tumors in mice by antisense inhibition of NF-κB
    • Kitajima, I., Shinohara, T., Bilakovics, J. D. A. B., Xu, X., and Nerenberg, M. Ablation of transplanted HTLV-I Tax-transformed tumors in mice by antisense inhibition of NF-κB. Science (Washington DC), 258: 1792-1795, 1992.
    • (1992) Science (Washington DC) , vol.258 , pp. 1792-1795
    • Kitajima, I.1    Shinohara, T.2    Bilakovics, J.D.A.B.3    Xu, X.4    Nerenberg, M.5
  • 32
    • 0027219329 scopus 로고
    • Kappa B site-dependent induction of gene expression by diverse inducers of nuclear factor kappa B requires Raf-1
    • Finco, T. S., Baldwin, A. S., Jr. Kappa B site-dependent induction of gene expression by diverse inducers of nuclear factor kappa B requires Raf-1. J. Biol. Chem., 268: 17676-17679, 1993.
    • (1993) J. Biol. Chem. , vol.268 , pp. 17676-17679
    • Finco, T.S.1    Baldwin Jr., A.S.2
  • 33
    • 0027383349 scopus 로고
    • Oncogene activation of HIV-LTR-driven expression via the NF-kappa B binding sites
    • Brader, J. T., Heidecker, G., Tan, T. H., Weske, J. C., Derse, D., and Rapp, U. R. Oncogene activation of HIV-LTR-driven expression via the NF-kappa B binding sites. Nucleic Acids Res., 21: 5229-5234, 1993.
    • (1993) Nucleic Acids Res. , vol.21 , pp. 5229-5234
    • Brader, J.T.1    Heidecker, G.2    Tan, T.H.3    Weske, J.C.4    Derse, D.5    Rapp, U.R.6
  • 35
    • 0024292722 scopus 로고
    • Most human carcinomas of the human exocrine pancreas contain mutant c-K-ras genes
    • Almoguera, C., Shibata, D., Forrester, K., Martin, J., Arnheim, N., and Perucho, M. Most human carcinomas of the human exocrine pancreas contain mutant c-K-ras genes. Cell, 53: 549-554, 1988.
    • (1988) Cell , vol.53 , pp. 549-554
    • Almoguera, C.1    Shibata, D.2    Forrester, K.3    Martin, J.4    Arnheim, N.5    Perucho, M.6
  • 36
    • 0027400286 scopus 로고
    • Nuclear uptake control of NF-κB by MAD-3, an IκB protein in the nucleus
    • Zable, U., Henkel, T., Silva, M. D. S., and Bacuerle, P. Nuclear uptake control of NF-κB by MAD-3, an IκB protein in the nucleus. EMBO J., 12: 201-211, 1993.
    • (1993) EMBO J. , vol.12 , pp. 201-211
    • Zable, U.1    Henkel, T.2    Silva, M.D.S.3    Bacuerle, P.4
  • 37
    • 0025730640 scopus 로고
    • A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells
    • Andrews, N. C., and Faller, D. V. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res., 19: 2499, 1991.
    • (1991) Nucleic Acids Res. , vol.19 , pp. 2499
    • Andrews, N.C.1    Faller, D.V.2
  • 38
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski, P., and Sacchi, N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162: 156-159, 1987.
    • (1987) Anal. Biochem. , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 41
    • 0028867742 scopus 로고
    • Activation of transcription factor NF-κB is suppressed by curcumin (diferuloylmethane)
    • Singh, S., and Aggarwal, B. B. Activation of transcription factor NF-κB is suppressed by curcumin (diferuloylmethane). J. Biol. Chem., 270: 24995-25000, 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 24995-25000
    • Singh, S.1    Aggarwal, B.B.2
  • 42
    • 0028556758 scopus 로고
    • Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells
    • Korutla, L., and Kumar, R. Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells. Biochim. Biophys. Acta, 1224: 597-600, 1994.
    • (1994) Biochim. Biophys. Acta , vol.1224 , pp. 597-600
    • Korutla, L.1    Kumar, R.2
  • 43
    • 0029858387 scopus 로고    scopus 로고
    • TNF- and cancer therapy-induced apoptosis potentiation by inhibition of NF-κB
    • Wang, C. Y., Mayo, M. W., and Baldwin, A., Jr. TNF- and cancer therapy-induced apoptosis potentiation by inhibition of NF-κB. Science (Washington DC), 274: 784-787, 1996.
    • (1996) Science (Washington DC) , vol.274 , pp. 784-787
    • Wang, C.Y.1    Mayo, M.W.2    Baldwin Jr., A.3
  • 45
    • 0027323579 scopus 로고
    • Models of pancreatic cancer
    • Hall, P. A., and Lemoine, N. R. Models of pancreatic cancer. Cancer Surv., 16: 135-155, 1993.
    • (1993) Cancer Surv. , vol.16 , pp. 135-155
    • Hall, P.A.1    Lemoine, N.R.2
  • 48
    • 0029063604 scopus 로고
    • Overexpression of RelA in transgenic mouse thymocytes: Specific increase in levels of the inhibitor protein I kappa Bα
    • Perez, P., Lira, S. A., and Bravo, R. Overexpression of RelA in transgenic mouse thymocytes: specific increase in levels of the inhibitor protein I kappa Bα. Mol. Cell. Biol., 7: 3523-3530, 1995.
    • (1995) Mol. Cell. Biol. , vol.7 , pp. 3523-3530
    • Perez, P.1    Lira, S.A.2    Bravo, R.3
  • 49
    • 0029976817 scopus 로고    scopus 로고
    • An essential role of NF-κB in preventing TNF-α-induced cell death
    • Beg, A. A., and Baltimore, D. An essential role of NF-κB in preventing TNF-α-induced cell death. Science (Washington DC), 274: 782-784, 1996.
    • (1996) Science (Washington DC) , vol.274 , pp. 782-784
    • Beg, A.A.1    Baltimore, D.2
  • 50
    • 0030882666 scopus 로고    scopus 로고
    • Oncogenic Ha-Ras-induced signaling activates NF-κB transcriptional activity, which is required for cellular transformation
    • Finco, T. S., Westwick, J. K., Norris, J. L., Beg, A. A., Der, C. J., and Baldwin, A. S., Jr. Oncogenic Ha-Ras-induced signaling activates NF-κB transcriptional activity, which is required for cellular transformation. J. Biol. Chem., 272: 24113-24116, 1997.
    • (1997) J. Biol. Chem. , vol.272 , pp. 24113-24116
    • Finco, T.S.1    Westwick, J.K.2    Norris, J.L.3    Beg, A.A.4    Der, C.J.5    Baldwin Jr., A.S.6
  • 52
    • 0029077563 scopus 로고
    • Direct interaction between Ras and the kinase domain of mitogen-activated protein kinase (MEKK1)
    • Russell, M., Lange-Carter, C. A., and Johnson, G. L. Direct interaction between Ras and the kinase domain of mitogen-activated protein kinase (MEKK1). J. Biol. Chem., 270: 11757-11760, 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 11757-11760
    • Russell, M.1    Lange-Carter, C.A.2    Johnson, G.L.3


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