Constitutive activation of STAT3 and STAT5 is induced by leukemic fusion proteins with protein tyrosine kinase activity and is sufficient for transformation of hematopoietic precursor cells

Experimental Hematology

Volumn 30, Issue 3, 2002, Pages 262-271

  Spiekermann, Karsten ^a   Pau, Michael ^a   Schwab, Ruth ^a   Schmieja, Karin ^a   Franzrahe, Sabine ^a   Hiddemann, Wolfgang ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE RECEPTOR; HYBRID PROTEIN; PROTEIN PML RARALPHA; PROTEIN TYROSINE KINASE INHIBITOR; RAS PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; UNCLASSIFIED DRUG;

ACUTE DISEASE; ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL CELL; APOPTOSIS; ARTICLE; BCR ABL GENE; CARCINOGENESIS; CELL GROWTH; CELL STRAIN; CELL TRANSFORMATION; CHRONIC DISEASE; CONTROLLED STUDY; ENZYME ACTIVITY; EPITHELIUM CELL; GENE; GENETIC TRANSFECTION; GROWTH INHIBITION; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; STEM CELL; TEL ABL GENE; TEL JAK2 GENE;

ANIMALS; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; DNA-BINDING PROTEINS; FUSION PROTEINS, BCR-ABL; GENE EXPRESSION; HEMATOPOIETIC STEM CELLS; HUMANS; LEUKEMIA, MYELOCYTIC, ACUTE; MICE; MILK PROTEINS; ONCOGENE PROTEINS, FUSION; PROTEIN-TYROSINE KINASES; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; STAT5 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSFECTION;

EID: 0036190076     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-472X(01)00787-1     Document Type: Article

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