CLINICAL STUDIES OF CAMPTOTHECIN AND DERIVATIVES

Alkaloids: Chemistry and Biology

Volumn 60, Issue C, 2003, Pages 1-50

  Soepenberg, Otto ^a   Sparreboom, Alex ^a   Verweij, Jaap ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CAMPTOTHECIN; DRUG DERIVATIVE; ENZYME INHIBITOR; IRINOTECAN; MUTAGENIC AGENT; TOPOTECAN;

CHEMISTRY; CLINICAL TRIAL; DRUG RESISTANCE; HUMAN; REVIEW;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAMPTOTHECIN; CLINICAL TRIALS; DRUG RESISTANCE, NEOPLASM; ENZYME INHIBITORS; HUMANS; MUTAGENS; TOPOTECAN;

EID: 2142703918     PISSN: 10994831     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0099-9598(03)60001-5     Document Type: Review

References (332)

1. Wall M.E., Wani M.C., Cook C.E., Palmer K.H., McPhail A.T., and Sim A.T. J. Am. Chem. Soc. 88 (1966) 3888
2. Wall M.E., and Wani M.C. In: Pantazis P., Giovanella B.C., and Rothenberg M.L. (Eds). Annals of the New York Academy of Sciences 803 (1996), The New York Academy of Sciences, New York 1-12
3. Wall M.E., and Wani M.C. Cancer Res. 55 (1995) 753
4. Costin D., and Potmesil M. Adv. Pharmacol. 29B (1994) 51
5. Abang A.M. Semin. Hematol. 35 (1998) 13
6. Arbuck S.G., and Takimoto C.H. Semin. Hematol. 35 (1998) 3
7. Muggia F.M., Creaven P.J., Hansen H.H., Cohen M.H., and Selawry O.S. Cancer Chemother. Rep. 56 (1972) 515
8. Moertel C.G., Schutt A.J., Reitemeier R.J., and Hahn R.G. Cancer Chemother. Rep. 56 (1972) 649
9. Gottlieb J.A., and Luce J.K. Cancer Chemother. Rep. 56 (1972) 103
10. Mathijssen R.H., van Alphen R.J., Verweij J., Loos W.J., Nooter K., Stoter G., and Sparreboom A. Clin. Cancer Res. 7 (2001) 2182
11. Wang J.C. Annu. Rev. Biochem. 54 (1985) 665
12. Vosberg H.P. Curr. Top. Microbiol. Immunol. 114 (1985) 19
13. Juan C.C., Hwang J.L., Liu A.A., Whang-Peng J., Knutsen T., Huebner K., Croce C.M., Zhang H., Wang J.C., and Liu L.F. Proc. Natl. Acad. Sci. USA 85 (1988) 8910
14. Kunze N., Yang G.C., Jiang Z.Y., Hameister H., Adolph S., Wiedorn K.H., Richter A., and Knippers R. Hum. Genet. 84 (1989) 6
15. Redinbo M.R., Stewart L., Champoux J.J., and Hol W.G. J. Mol. Biol. 292 (1999) 685
16. Kunze N., Yang G.C., Dölberg M., Sundarp R., Knippers R., and Richter A. J. Biol. Chem. 266 (1991) 9610
17. Heiland S., Knippers R., and Kunze N. Eur. J. Biochem. 217 (1993) 813
18. Stewart L., Ireton G.C., and Champoux J.J. J. Biol. Chem. 274 (1999) 32950
19. Keck J.L., and Berger J.M. Nat. Struct. Biol. 6 (1999) 900
20. Stewart L., Ireton G.C., and Champoux J.J. J. Biol. Chem. 271 (1996) 7602
21. Stewart L., Redinbo M.R., Qiu X., Hol W.G., and Champoux J.J. Science 279 (1998) 1534
22. Redinbo M.R., Stewart L., Kuhn P., Champoux J.J., and Hol W.G. Science 279 (1998) 1504
23. Hsiang Y.H., Lihou M.G., and Liu L.F. Cancer Res. 49 (1989) 5077
24. Liu L.F., and D'Arpa P. Important Adv. Oncol. 442 (1992) 79
25. Drewinko B., Freireich E.J., and Gottlieb J.A. Cancer Res. 34 (1974) 747
26. D'Arpa P., Beardmore C., and Liu L.F. Cancer Res. 50 (1990) 6919
27. Gerrits C.J., de Jonge M.J., Schellens J.H., Stoter G., and Verweij J. Br. J. Cancer 76 (1997) 952
28. Kohn K.W., and Pommier Y. In: Liehr J.G., Giovanella B.C., and Verschraegen C.F. (Eds). Annals of the New York Academy of Sciences 922 (2000), The New York Academy of Sciences, New York 11-26
29. Hanauske H.A., Burris III A.R., Johnson R.K., Marshall M.H., Kuhn J.G., Hilsenbeck S.G., and von Hoff D.D. J. Natl. Cancer Inst. 84 (1992) 1816
30. Verweij J., and Schellens J.H. Ann. Oncol. 6 (1995) 102
31. Hashimoto H., Chatterjee S., and Berger N.A. Clin. Cancer Res. 1 (1995) 369
32. Anderson R.D., and Berger N.A. Mutat. Res. 309 (1994) 109
33. Baguley B.C., and Ferguson L.R. Biochim. Biophys. Acta 1400 (1998) 213
34. Cosentino L., and Heddle J.A. Environ. Mol. Mutagen. 34 (1999) 208
35. Shaver-Walker P.M., Urlando C., Tao K.S., Zhang X.B., and Heddle J.A. Proc. Natl. Acad. Sci. USA 92 (1995) 11470
36. Chatterjee S., Trivedi D., Petzold S.J., and Berger N.A. Cancer Res. 50 (1990) 2713
37. Holm C., Covey J.M., Kerrigan D., and Pommier Y. Cancer Res. 49 (1989) 6365
38. Chow K.C., and Ross W.E. Mol. Cell. Biol. 7 (1987) 3119
39. Berger N.A., Chatterjee S., Schmotzer J.A., and Helms S.R. Proc. Natl. Acad. Sci. USA 88 (1991) 8740
40. Andersen M.K., Johansson B., Larsen S.O., and Pedersen-Bjergaard J. Haematologica 83 (1998) 483
41. Ratain M.J., and Rowley J.D. Ann. Oncol. 3 (1992) 107
42. Andersen M.K., Christiansen D.H., Jensen B.A., Ernst P., Hauge G., and Pedersen-Bjergaard J. Br. J. Haematol. 114 (2001) 539
43. Seiter K., Feldman E.J., Sreekantaiah C., Pozzuoli M., Weisberger J., Liu D., Papageorgio C., Weiss M., Kancherla R., and Ahmed T. Leukemia 15 (2001) 963
44. Pui C.H., Ribeiro R.C., Hancock M.L., Rivera G.K., Evans W.E., Raimondi S.C., Head D.R., Behm F.G., Mahmoud M.H., Sandlund J.T., and Christ W.M. N. Engl. J. Med. 325 (1991) 1682
45. Pui C.H., Relling M.V., Rivera G.K., Hancock M.L., Raimondi S.C., Heslop H.E., Santana V.M., Ribeiro R.C., Sandlund J.T., Mahmoud H.H., Evans W.E., and Krance R.A. Leukemia 9 (1995) 1990
46. Yagita M., Ieki Y., Onishi R., Huang C.L., Adachi M., Horiike S., Konaka Y., Taki T., and Miyake M. Int. J. Oncol. 13 (1998) 91
47. Smith M.A., Rubinstein L., Cazenave L., Ungerleider R.S., Maurer H.M., Heyn R., Khan F.M., and Gehan E. J. Natl. Cancer Inst. 85 (1993) 554
48. Pedersen-Bjergaard J., Philip P., Larsen S.O., Andersson M., Daugaard G., Ersboll J., Hansen S.W., Hou-Jensen K., Nielsen D., Sigsgaard T.C., Specht L., and Osterlind K. Leukemia 7 (1993) 1975
49. Felix C.A. Biochim. Biophys. Acta 1400 (1998) 233
50. Kollmannsberger C., Beyer J., Droz J.P., Harstrick A., Hartmann J.T., Biron P., Flechon A., Schoffski P., Kuczyk M., Schmoll H.J., Kanz L., and Bokemeyer C. J. Clin. Oncol. 16 (1998) 3386
51. Leone G., Mele L., Pulsoni A., Equitani F., and Pagano L. Haematologica 84 (1999) 937
52. van Leeuwen F.E. In: Löwenberg B. (Ed). Bailliere's Clinical Haematology 9 (1996), Bailliere Tindall, London 57-85
53. Stanulla M., Wang J., Chervinsky D.S., and Aplan P.D. Leukemia 11 (1997) 490
54. Broeker P.L., Super H.G., Thirman M.J., Pomykala H., Yonebayashi Y., Tanabe S., Zeleznik-Le N., and Rowley J.D. Blood 87 (1996) 1912
55. Wang L.F., Ting C.Y., Lo C.K., Su J.S., Mickley L.A., Fojo A.T., Whang-Peng J., and Hwang J. Cancer Res. 57 (1997) 1516
56. Andoh T., Ishii K., Suzuki Y., Ikegami Y., Kusunoki Y., Takemoto Y., and Okada K. Proc. Natl. Acad. Sci. USA 84 (1987) 5565
57. Sugimoto Y., Tsukahara S., Oh-hara T., Isoe T., and Tsuruo T. Cancer Res. 50 (1990) 6925
58. Tamura H., Kohchi C., Yamada R., Ikeda T., Koiwai O., Patterson E., Keene J.D., Okada K., Kjeldsen E., Nishikawa K., and Andoh T. Nucleic Acids Res. 19 (1991) 69
59. Kubota N., Kanzawa F., Nishio K., Takeda Y., Ohmori T., Fujiwara Y., Terashima Y., and Saijo N. Biochem. Biophys. Res. Commun. 188 (1992) 571
60. Benedetti P., Fiorani P., Capuani L., and Wang J.C. Cancer Res. 53 (1993) 4343
61. Knab A.M., Fertala J., and Bjornsti M.A. J. Biol. Chem. 268 (1993) 22322
62. Tanizawa A., Beitrand R., Kohlhagen G., Tabuchi A., Jenkins J., and Pommier Y. J. Biol. Chem. 268 (1993) 25463
63. Rubin E., Pantazis P., Bharti A., Toppmeyer D., Giovanella B., and Kufe D. J. Biol. Chem. 269 (1994) 2433
64. Tsurutani J., Nitta T., Hirashima T., Komiya T., Uejima H., Tada H., Syunichi N., Tohda A., Fukuoka M., and Nakagawa K. Lung Cancer 35 (2002) 299
65. Mathijssen R.H., Loos W.J., Verweij J., and Sparreboom A. Curr. Cancer Drug Targets 2 (2002) 103
66. Iyer L., King C.D., Whitington P.F., Green M.D., Roy S.K., Tephly T.R., Coffman B.L., and Ratain M.J. J. Clin. Invest. 101 (1998) 847
67. Bosma P.J., Chowdhury J.R., Bakker C., Gantla S., de Boer A., Oostra B.A., Lindhout D., Tytgat G.N., Jansen P.L., and Oude Elferink R.P. N. Engl. J. Med. 333 (1995) 1171
68. Wasserman E., Myara A., Lokiec F., Goldwasser F., Trivin F., Mahjoubi M., Misset J.L., and Cvitkovic E. Ann. Oncol. 8 (1997) 1049
69. Rowinsky E.K., Grochow L.B., Ettinger D.S., Sartorius S.E., Lubejko B.G., Chen T.L., Rock M.K., and Donehower R.C. Cancer Res. 54 (1994) 427
70. Rothenberg M.L., Kuhn J.G., Burris III J., Nelson H.A., Eckardt J.R., Tristan-Morales M., Hilsenbeck S.G., Weiss G.R., Smith L.S., and Rodriguez G.I. J. Clin. Oncol. 11 (1993) 2194
71. Drengler R.L., Kuhn J.G., Schaaf L.J., Rodriguez G.I., Villalona-Calero M.A., Hammond L.A., Stephenson Jr. J.A., Hodges S., Kraynak M.A., Staton B.A., Elfring G.L., Locker P.K., Miller L.L., von Hoff D.D., and Rothenberg M.L. J. Clin. Oncol. 17 (1999) 685
72. Gupta E., Mick R., Ramirez J., Wang X., Lestingi T.M., Vokes E.E., and Ratain M.J. J. Clin. Oncol. 15 (1997) 1502
73. Takimoto C.H., Morrison G., Harold N., Quinn M., Monahan B.P., Band R.A., Cottrell J., Guemei A., Llorens V., Hehman H., Ismail A.S., Flemming D., Gosky D.M., Hirota H., Berger S.J., Berger N.A., Chen A.P., Shapiro J.D., Arbuck S.G., Wright J., Hamilton J.M., Allegra C.J., and Grem J.L. J. Clin. Oncol. 18 (2000) 659
74. Garcia-Carbonero R., and Supko J.G. Clin. Cancer Res. 8 (2002) 641
75. Kehrer D.F., Yamamoto W., Verweij J., de Jonge M.J., de Bruijn P., and Sparreboom A. Clin. Cancer Res. 6 (2000) 3451
76. Herben V.M., Schellens J.H., Swart M., Gruia G., Vernillet L., Beijnen J.H., and ten Bokkel Huinink W.W. J. Clin. Oncol. 17 (1999) 1897
77. Xie R., Mathijssen R.H., Sparreboom A., Verweij J., and Karlsson M.O. J. Clin. Oncol. 20 (2002) 3293
78. Kehrer D.F., Sparreboom A., Verweij J., de Bruijn P., Nierop C.A., van de Schraaf J., Ruijgrok E.J., and de Jonge M.J. Clin. Cancer Res. 7 (2001) 1136
79. Gupta E., Safa A.R., Wang X., and Ratain M.J. Cancer Res. 56 (1996) 1309
80. Rivory L.P., Haaz M.C., Canal P., Lokiec F., Armand J.P., and Robert J. Clin. Cancer Res. 3 (1997) 1261
81. Sparreboom A., de Jonge M.J., de Bruijn P., Brouwer E., Nooter K., Loos W.J., van Alphen R.J., Mathijssen R.H., Stoter G., and Verweij J. Clin. Cancer Res. 4 (1998) 2747
82. Canal P., Gay C., Dezeuze A., Douillard J.Y., Bugat R., Brunet R., Adenis A., Herait P., Lokiec F., and Mathieu-Boue A. J. Clin. Oncol. 14 (1996) 2688
83. Dodds H.M., Haaz M.C., Riou J.F., Robert J., and Rivory L.P. J. Pharmacol. Exp. Ther. 286 (1998) 578
84. Rivory L.P., Riou J.F., Haaz M.C., Sable S., Vuilhorgne M., Commercon A., Pond S.M., and Robert J. Cancer Res. 56 (1996) 3689
85. Friedman H.S., Petros W.P., Friedman A.H., Schaaf L.J., Kerby T., Lawyer J., Parry M., Houghton P.J., Lovell S., Rasheed K., Cloughsey T., Stewart E.S., Colvin O.M., Provenzale J.M., McLendon R.E., Bigner D.D., Cokgor I., Haglund M., Rich J., Ashley D., Malczyn J., Elfring G.L., and Miller L.L. J. Clin. Oncol. 17 (1999) 1516
86. Mathijssen R.H., Verweij J., de Bruijn P., Loos W.J., and Sparreboom A. J. Natl. Cancer Inst. 94 (2002) 1247
87. Kehrer D.F., Mathijssen R.H., Verweij J., de Bruijn P., and Sparreboom A. J. Clin. Oncol. 20 (2002) 3122
88. Falcone A., Di Paolo A., Masi G., Allegrini G., Danesi R., Lencioni M., Pfanner E., Comis S., Del Tacca M., and Conte P. J. Clin. Oncol. 19 (2001) 3456
89. Rothenberg M.L. Ann. Oncol. 8 (1997) 837
90. Vanhoefer U., Harstrick A., Achterrath W., Cao S., Seeber S., and Rustum Y.M. J. Clin. Oncol. 19 (2001) 1501
91. Giovanella B.C., Stehlin J.S., Wall M.E., Wani M.C., Nicholas A.W., Liu L.F., Silber R., and Potmesil M. Science 246 (1989) 1046
92. Husain I., Mohler J.L., Seigler H.F., and Besterman J.M. Cancer Res. 54 (1994) 539
93. Staley B.E., Samowitz W.S., Bronstein I.B., and Holden J.A. Mod. Pathol. 12 (1999) 356
94. Rivory L.P., and Robert J. Cancer Chemother. Pharmacol. 36 (1995) 176
95. Pitot H.C., Goldberg R.M., Reid J.M., Sloan J.A., Skaff P.A., Erlichman C., Rubin J., Burch P.A., Adjei A.A., Alberts S.A., Schaaf L.J., Elfring G., and Miller L.L. Clin. Cancer Res. 6 (2000) 2236
96. Negoro S., Fukuoka M., Masuda N., Takada M., Kusunoki Y., Matsui K., Takifuji N., Kudoh S., Niitani H., and Taguchi T. J. Natl. Cancer Inst. 83 (1991) 1164
97. Takimoto C.H., and Arbuck S.G. In: Chabner B.A., and Longo D.L. (Eds). Cancer Chemotherapy and Biotherapy: Principles and Practice. 3rd ed. (2001), Lippincott Williams & Wilkins, Philadelphia 579-646
98. von Hoff D.D., Rothenberg M.L., Pitot H.C., Elfring G.L., Mohrland J.S., and Schaff L.J. Proc. Am. Soc. Clin. Oncol. 16 (1997) 228a
99. Cunningham D., Pyrhonen S., James R.D., Punt C.J., Hickish T.F., Heikkila R., Johannesen T.B., Starkhammar H., Topham C.A., Awad L., Jacques C., and Herait P. Lancet 352 (1998) 1413
100. Rougier P., van Cutsem E., Bajetta E., Niederle N., Possinger K., Labianca R., Navarro M., Morant R., Bleiberg H., Wils J., Awad L., Herait P., and Jacques C. Lancet 352 (1998) 1407
101. Rougier P., Bugat R., Douillard J.Y., Culine S., Suc E., Brunet P., Becouarn Y., Ychou M., Marty M., Extra J.M., Bonneterre J., Adenis A., Seitz J.F., Ganem G., Namer M., Conroy T., Negrier S., Merrouche Y., Burki F., Mousseau M., Herait P., and Mahjoubi M. J. Clin. Oncol. 15 (1997) 251
102. Rothenberg M.L., Cox J.V., DeVore R.F., Hainsworth J.D., Pazdur R., Rivkin S.E., Macdonald J.S.J., Geyer Jr. C.E., Sandbach J., Wolf D.L., Mohrland J.S., Elfring G.L., Miller L.L., and von Hoff D.D. Cancer 85 (1999) 786
103. Takimoto C.H., Morrison G., Harold N., Quinn M., Monahan B.P., Band R.A., Cottrell J., Guemei A., Llorens V., Hehman H., Ismail A.S., Flemming D., Gosky D.M., Hirota H., Berger S.J., Berger N.A., Chen A.P., Shapiro J.D., Arbuck S.G., Wright J., Hamilton J.M., Allegra C.J., and Grem J.L. J. Clin. Oncol. 18 (2000) 659
104. O'Reilly S., and Rowinsky E.K. Crit. Rev. Oncol. Hematol. 24 (1996) 47
105. Wiseman L.R., and Markham A. Drugs 52 (1996) 606
106. Chabot G.G. Clin. Pharmacokinet. 33 (1997) 245
107. Siu L.L., and Rowinsky E.K. Drugs Safety 18 (1998) 395
108. Saltz L.B., Cox J.V., Blanke C., Rosen L.S., Fehrenbacher L., Moore M.J., Maroun J.A., Ackland S.P., Locker P.K., Pirotta N., Elfring G.L., and Miller L.L. N. Engl. J. Med. 343 (2000) 905
109. Douillard J.Y., Cunningham D., Roth A.D., Navarro M., James R.D., Karasek P., Jandik P., Iveson T., Carmichael J., Alakl M., Gruia G., Awad L., and Rougier P. Lancet 355 (2000) 1041
110. Stevenson J.P., Redlinger M., Kluijtmans L.A., Sun W., Algazy K., Giantonio B., Haller D.G., Hardy C., Whitehead A.S., and O'Dwyer P.J. J. Clin. Oncol. 19 (2001) 4081
111. Ford H.E., Cunningham D., Ross P.J., Rao S., Aherne G.W., Benepal T.S., Price T., Massey A., Vernillet L., and Gruia G. Br. J. Cancer 83 (2000) 146
112. Fukuda M., Nishio K., Kanzawa F., Ogasawara H., Ishida T., Arioka H., Bojanowski K., Oka M., and Saijo N. Cancer Res. 56 (1996) 789
113. Fukuoka M., and Masuda N. Cancer Chemother. Pharmacol. 34 (1994) S105
114. Ikeda K., Terashima M., Kawamura H., Takiyama I., Koeda K., Takagane A., Sato N., Ishida K., Iwaya T., Maesawa C., Yoshinari H., and Saito K. Jpn. J. Clin. Oncol. 28 (1998) 168
115. Ma J., Maliepaard M., Nooter K., Boersma A.W., Verweij J., Stoter G., and Schellens J.H. Cancer Chemother. Pharmacol. 41 (1998) 307
116. Kano Y., Suzuki K., Akutsu M., Suda K., Inoue Y., Yoshida M., Sakamoto S., and Miura Y. Int. J. Cancer 50 (1992) 604
117. Kudoh S., Takada M., Masuda N., Nakagawa K., Itoh K., Kusunoki Y., Negoro S., Matsui K., Takifuji N., Morino H., and Fukuoka M. Jpn. J. Cancer Res. 84 (1993) 203
118. Katz E.J., Vick J.S., Kling K.M., Andrews P.A., and Howell S.B. Eur. J. Cancer 26 (1990) 724
119. Kim R., Hirabayashi N., Nishiyama M., Jinushi K., Toge T., and Okada K. Int. J. Cancer 50 (1992) 760
120. de Jonge M.J.A., Sparreboom A., and Verweij J. Cancer Treat. Rev. 24 (1998) 206
121. Goldwasser F., Valenti M., Torres R., Kohn K.W., and Pommier Y. Clin. Cancer Res. 2 (1996) 687
122. Masuda N., Fukuoka M., Kudoh S., Kusunoki Y., Matsui K., Takifuji N., Nakagawa K., Tamanoi M., Nitta T., Hirashima T., Negoro S., and Takada M. Br. J. Cancer 68 (1993) 777
123. Masuda N., Fukuoka M., Takada M., Kusunoki Y., Negoro S., Matsui K., Kudoh S., Takifuji N., Nakagawa K., and Kishimoto S. J. Clin. Oncol. 10 (1992) 1775
124. Shirao K., Shimada Y., Kondo H., Saito D., Yamao T., Ono H., Yokoyama T., Fukuda H., Oka M., Watanabe Y., Ohtsu A., Boku N., Fujii T., Oda Y., Muro K., and Yoshida S. J. Clin. Oncol. 15 (1997) 921
125. Mori K., Ohnishi T., Yokoyama K., and Tominaga K. Cancer Chemother. Pharmacol. 39 (1997) 327
126. Masuda N., Fukuoka M., Kudoh S., Kusunoki Y., Matsui K., Nakagawa K., Hirashima T., Tamanoi M., Nitta T., Yana T., Negoro S., Takifuji N., and Takada M. J. Clin. Oncol. 12 (1994) 90
127. Mori K., Hirose T., Machida S., Yokoyama K., and Tominaga K. Eur. J. Cancer 33 (1997) 503
128. de Jonge M.J.A., Verweij J., Planting A.S.T., van der Burg M.E.L., Stoter G., de Boer-Dennert M.M., de Bruijn P., Brouwer E., Vernillet L., and Sparreboom A. Clin. Cancer Res. 5 (1999) 2012
129. Noda K., Nishiwaki Y., Kawahara M., Negoro S., Sugiura T., Yokoyama A., Fukuoka M., Mori K., Watanabe K., Tamura T., Yamamoto S., and Saijo N. N. Engl. J. Med. 346 (2002) 85
130. Goldwasser F., Gross-Goupil M., Tigaud J.M., di Palma M., Marceau-Suissa J., Wasserman E., Yovine A., Misset J.L., and Cvitkovic E. Ann. Oncol. 11 (2000) 1463
131. Wasserman E., Cuvier C., Lokiec F., Goldwasser F., Kalla S., Mery-Mignard D., Ouldkaci M., Besmaine A., Dupont-Andre G., Mahjoubi M., Marty M., Misset J.L., and Cvitkovic E. J. Clin. Oncol. 17 (1999) 1751
132. Scheithauer W., Kornek G.V., Raderer M., Valencak J., Weinlander G., Hejna M., Haider K., Kwasny W., and Depisch D. J. Clin. Oncol. 17 (1999) 902
133. Valencak J., Raderer M., Kornek G.V., Henja M.H., and Scheithauer W. J. Natl. Cancer Inst. 90 (1998) 160
134. Cvitkovic E., Marty M., Wasserman E., Cuvier C., Goldwasser F., and Misset J.L. J. Natl. Cancer Inst. 90 (1998) 1016
135. Dodds H.M., Bishop J.F., and Rivory L.P. J. Natl. Cancer Inst. 91 (1999) 91
136. Scheithauer W., Kornek G.V., Raderer M., Ulrich-Pur H., Fiebiger W., Gedlicka C., Schull B., Brugger S., Schneeweiss B., Lang F., Lenauer A., and Depisch D. J. Clin. Oncol. 20 (2002) 165
137. Karato A., Sasaki Y., Shinkai T., Eguchi K., Tamura T., Ohe Y., Oshita F., Nishio M., Kunikane H., Arioka H., Ohmatsu H., Nakashima H., Shiraishi J., and Saijo N. J. Clin. Oncol. 11 (1993) 2030
138. Masuda N., Fukuoka M., Kudoh S., Matsui K., Kusunoki Y., Takada M., Nakagawa K., Hirashima T., Tsukada H., Yana T., Yoshikawa A., Kubo A., Matsuura E., Nitta T., Takifuji N., Terakawa K., and Negoro S. J. Clin. Oncol. 12 (1994) 1833
139. Ando M., Eguchi K., Shinkai T., Tamura T., Ohe Y., Yamamoto N., Kurata T., Kasai T., Ohmatsu H., Kubota K., Sekine I., Hojo N., Matsumoto T., Kodama T., Kakinuma R., Nishiwaki Y., and Saijo N. Br. J. Cancer 76 (1997) 1494
140. Oshita F., Noda K., Nishiwaki Y., Fujita A., Kurita Y., Nakabayashi T., Tobise K., Abe S., Suzuki S., Hayashi I., Kawakami Y., Matsuda T., Tsuchiya S., Takahashi S., Tamura T., and Saijo N. J. Clin. Oncol. 15 (1997) 304
141. Masuda N., Matsui K., Negoro S., Takifuji N., Takeda K., Yana T., Kobayashi M., Hirashima T., Kusunoki Y., Ushijima S., Kawase I., Tada T., Sawaguchi H., and Fukuoka M. J. Clin. Oncol. 16 (1998) 3329
142. Fujishiro M., Shinkai T., Fukuda M., Tamura T., Ohe Y., Kunitoh H., Nishiwaki Y., Sekine I., Fukuda H., and Saijo N. Jpn. J. Clin. Oncol. 30 (2000) 487
143. Fukuda M., Oka M., Soda H., Terashi K., Kawabata S., Nakatomi K., Takatani H., Tsurutani J., Tsukamoto K., Noguchi Y., Fukuda M., Kinoshita A., and Kohno S. Clin. Cancer Res. 5 (1999) 3963
144. Naka N., Kawahara M., Okishio K., Hosoe S., Ogawara M., Atagi S., Takemoto Y., Ueno K., Kawaguchi T., Tsuchiyama T., and Furuse K. Lung Cancer 37 (2002) 319
145. Yamada M., Kudoh S., Fukuda H., Nakagawa K., Yamamoto N., Nishimura Y., Negoro S., Takeda K., Tanaka M., and Fukuoka M. Br. J. Cancer 87 (2002) 258
146. Adjei A.A., Argiris A., and Murren J.R. Semin. Oncol. 26 (1999) 32
147. Font A., Sanchez J.M., Rosell R., Taron M., Martinez E., Guillot M., Manzano J.L., Margeli M., Barnadas A., and Abad A. Lung Cancer 37 (2002) 213
148. Kasai T., Oka M., Soda H., Tsurutani J., Fukuda M., Nakamura Y., Kawabata S., Nakatomi K., Nagashima S., Takatani H., Fukuda M., Kinoshita A., and Kohno S. Eur. J. Cancer 38 (2002) 1871
149. Rushing D.A. Oncology (Huntingt.) 14 (2000) 63
150. Yamao T., Shirao K., Matsumura Y., Muro K., Yamada Y., Goto M., Chin K., and Shimada Y. Ann. Oncol. 12 (2001) 1729
151. Scheithauer W., Kornek G.V., Brugger S., Ullrich-Pur H., Valencak J., Raderer M., Fiebiger W., Kovats E., Lang F., and Depisch D. Cancer Invest. 20 (2002) 60
152. Pectasides D., Visvikis A., Kouloubinis A., Glotsos J., Bountouroglou N., Karvounis N., Ziras N., and Athanassiou A. Eur. J. Cancer 38 (2002) 1194
153. Fujita A., Ohkubo T., Hoshino H., Takabatake H., Tagaki S., and Sekine K. Anticancer Drugs 13 (2002) 505
154. Ohtsu T., Sasaki Y., Igarashi T., Murayama T., Kobayashi Y., and Tobinai K. Jpn. J. Clin. Oncol. 28 (1998) 502
155. Kingsbury W.D., Boehm J.C., Jakas D.R., Holden K.G., Hecht S.M., Gallagher G., Caranfa M.J., McCabe F.L., Faucette L.F., and Johnson R.K. J. Med. Chem. 34 (1991) 98
156. Rosing H., Herben V.M., van Gortel-van Zomeren D.M., Hop E., Kettenes-van den Bosch J.J., ten Bokkel Huinink W.W., and Beijnen J.H. Cancer Chemother. Pharmacol. 39 (1997) 498
157. Gelderblom H.A., de Jonge M.J., Sparreboom A., and Verweij J. Invest. New Drugs 17 (1999) 401
158. Grochow L.B., Rowinsky E.K., Johnson R., Ludeman S., Kaufmann S.H., McCabe F.L., Smith B.R., Hurowitz L., DeLisa A., and Donehower R.C. Drug Metab. Dispos. 20 (1992) 706
159. van Warmerdam L.J., Creemers G.J., Rodenhuis S., Rosing H., de Boer-Dennert M., Schellens J.H., ten Bokkel Huinink W.W., Davies B.E., Maes R.A., Verweij J., and Beijnen J.H. Cancer Chemother. Pharmacol. 38 (1996) 254
160. Rosing H., van Zomeren D.M., Doyle E., Bult A., and Beijnen J.H. Anticancer Drugs 9 (1998) 587
161. O'Reilly S., Rowinsky E., Slichenmyer W., Donehower R.C., Forastiere A., Ettinger D., Chen T.L., Sartorius S., Bowling K., Smith J., Brubaker A., Lubejko B., Ignacio V., and Grochow L.B. J. Natl. Cancer Inst. 88 (1996) 817
162. O'Reilly S., Rowinsky E.K., Slichenmyer W., Donehower R.C., Forastiere A.A., Ettinger D.S., Chen T.L., Sartorius S., and Grochow L.B. J. Clin. Oncol. 14 (1996) 3062
163. O'Dwyer P.J., LaCreta F.P., Haas N.B., Halbherr T., Frucht H., Goosenberg E., and Yao K.S. Cancer Chemother. Pharmacol. 34 (1994) S46
164. Wall J.G., Rodriguez H.A., Burris III D.D., von Hoff G., Kneuper-Hall R., Shaffer D., O'Rourke T., Brown T., Weiss G., Clark G., McVea S., Brown J., Johnson R., Friedman C., Smith B., Mann W.S., and Kuhn J. Anticancer Drugs 3 (1992) 337
165. van Warmerdam L.J., Verweij J., Schellens J.H., Rosing H., Davies B.E., de Boer-Dennert M., Maes R.A., and Beijnen J.H. Cancer Chemother. Pharmacol. 35 (1995) 237
166. Schellens J.H., Creemers G.J., Beijnen J.H., Rosing H., de Boer-Dennert M., McDonald M., Davies B., and Verweij J. Br. J. Cancer 73 (1996) 1268
167. Haas N.B., LaCreta F.P., Walczak J., Hudes G.R., Brennan J.M., Ozols R.F., and O'Dwyer P.J. Cancer Res. 54 (1994) 1220
168. van Warmerdam L.J., ten Bokkel Huinink W.W., Rodenhuis S., Koier I., Davies B.E., Rosing H., Maes R.A., and Beijnen J.H. J. Clin. Oncol. 13 (1995) 1768
169. Abbruzzese J.L., Madden T., Sugarman S.M., Ellis A.L., Loughlin S., Hess K.R., Newman R.A., Zwelling L.A., and Raber M.N. Clin. Cancer Res. 2 (1996) 1489
170. Creemers G.J., Gerrits C.J., Schellens J.H., Planting A.S., van der Burg M.E., van Beurden V.M., de Boer-Dennert M., Harteveld M., Loos W., Hudson I., Stoter G., and Verweij J. J. Clin. Oncol. 14 (1996) 2540
171. Herben V.M., ten Bokkel Huinink W.W., Schot M.E., Hudson I., and Beijnen J.H. Anticancer Drugs 9 (1998) 411
172. Saltz L., Sirott M., Young C., Tong W., Niedzwiecki D., Tzy-Jyun Y., Tao Y., Trochanowski B., Wright P., and Barbosa K. J. Natl. Cancer Inst. 85 (1993) 1499
173. Stewart C.F., Gajjar A.J., Heideman R.L., and Houghton P.J. Onkologie 21 (1998) 22
174. Zamboni W.C., Lüftner D.I., Egorgin M.J., Schweigert M., Sezer O., Richter T., Natale J.J., and Possinger K. Ann. Oncol. 12 (2001) 119
175. Blaney S.M., Takimoto C., Murry D.J., Kuttesch N., McCully C., Cole D.E., Godwin K., and Balis F.M. Cancer Chemother. Pharmacol. 41 (1998) 464
176. Gelderblom H., Loos W.J., Verweij J., de Jonge M.J., and Sparreboom A. Clin. Cancer Res. 6 (2000) 1288
177. Hofstra L.S., Bos A.M., de Vries E.G., van der Zee A.G., Beijnen J.H., Rosing H., Mulder N.H., Aalders J.G., and Willemse P.H. Br. J. Cancer 85 (2001) 1627
178. Plaxe S.C., Christen R.D., O'Quigley J., Braly P.S., Freddo J.L., McClay E., Heath D., and Howell S.B. Invest. New Drugs 16 (1998) 147
179. Herben V.M., Schoemaker E., Rosing H., van Zomeren D.M., ten Bokkel Huinink W.W., Dubbelman R., Hearn S., Schellens J.H., and Beijnen J.H. Cancer Chemother. Pharmacol. 50 (2002) 59
180. Davies B.E., Minthorn E.A., Dennis M.J., Rosing H., and Beijnen J.H. Pharm. Res. 14 (1997) 1461
181. Jonker J.W., Smit J.W., Brinkhuis R.F., Maliepaard M., Beijnen J.H., Schellens J.H., and Schinkel A.H. J. Natl. Cancer Inst. 92 (2000) 1651
182. Gallo J.M., Laub P.B., Rowinsky E.K., Grochow L.B., and Baker S.D. J. Clin. Oncol. 18 (2000) 2459
183. Creemers G.J., Lund B., and Verweij J. Cancer Treat. Rev. 20 (1994) 73
184. Rowinsky E.K., Grochow L.B., Hendricks C.B., Ettinger D.S., Forastiere A.A., Hurowitz L.A., McGuire W.P., Sartorius S.E., Lubejko B.G., Kaufmann S.H., and Donehower R.C. J. Clin. Oncol. 10 (1992) 647
185. Verweij J., Lund B., Beijnen J., Planting A., de Boer-Dennert M., Koier I., Rosing H., and Hansen H. Ann. Oncol. 4 (1993) 673
186. Saltz L., Sirott M., Young C., Tong W., Niedzwiecki D., Tzy-Jyun Y., Tao Y., Trochanowski B., Wright P., Barbosa K., Toomasi F., and Kelsen D. J. Natl. Cancer Inst. 85 (1993) 1499
187. Schiller J.H., Kim K., Hutson P., DeVore R., Glick J., Stewart J., and Johnson D. J. Clin. Oncol. 14 (1996) 2345
188. Herben V.M., ten Bokkel Huinink W.W., Schot M.E., Hudson I., and Beijnen J.H. Anticancer Drugs 9 (1998) 411
189. Frasci G., Nicolella G., Comella P., Carreca I., DeCataldis G., Muci D., Brunetti C., Natale M., Piantedosi F., Russo A., Palmeri S., Comella G., and Panza N. Br. J. Cancer 84 (2001) 1166
190. Ardizzoni A., Hansen H., Dombernowsky P., Gamucci T., Kaplan S., Postmus P., Giaccone G., Schaefer B., Wanders J., and Verweij J. J. Clin. Oncol. 15 (1997) 2090
191. ten Bokkel Huinink W., Gore M., Carmichael J., Gordon A., Malfetano J., Hudson I., Broom C., Scarabelli C., Davidson N., Spanczynski M., Bolis G., Malmstrom H., Coleman R., Fields S.C., and Heron J.F. J. Clin. Oncol. 15 (1997) 2183
192. ten Bokkel Huinink W., Carmichael J., Armstrong D., Gordon A., and Malfetano J. Semin. Oncol. 24 (1997) S5-S19
193. Creemers G.J., Bolis G., Gore M., Scarfone G., Lacave A.J., Guastalla J.P., Despax R., Favalli G., Kreinberg R., van Belle S., Hudson I., Verweij J., and ten Bokkel Huinink W.W. J. Clin. Oncol. 14 (1996) 3056
194. Kudelka A.P., Tresukosol D., Edwards C.L., Freedman R.S., Levenback C., Chantarawiroj P., Gonzalez de Leon C., Kim E.E., Madden T., Wallin B., Hord M., Verschraegen C., Raber M., and Kavanagh J.J. J. Clin. Oncol. 14 (1996) 1552
195. Rose P.G., Gordon N.H., Fusco N., Fluellen L., Rodriguez M., Ingalls S.T., and Hoppel C.L. Gynecol. Oncol. 78 (2000) 228
196. Markman M., Blessing J.A., DeGeest K., Morgan M., Look K.Y., Herzog T.J., and Rose P.G. Gynecol. Oncol. 75 (1999) 444
197. Markman M., Blessing J.A., Alvarez R.D., Hanjani P., Waggoner S., and Hall K. Gynecol. Oncol. 77 (2000) 112
198. Kalish T.J., Lynch Jr. L., Strauss G., Elias A., Skarin A., Shulman L.N., Posner M., and Frei III E. J. Clin. Oncol. 12 (1994) 347
199. Perez-Soler R., Fossella F.V., Glisson B.S., Lee J.S., Murphy W.K., Shin D.M., Kemp B.L., Lee J.J., Kane J., Robinson R.A., Lippman S.M., Kurie J.M., Huber M.H., Raber M.N., and Hong W.K. J. Clin. Oncol. 14 (1996) 503
200. Creemers G.J., Wanders J., Gamucci T., Vallentin S., Dirix L.Y., Schoffski P., Hudson I., and Verweij J. Ann. Oncol. 6 (1995) 844
201. Macdonald J.S., Benedetti J.K., Modiano M., and Alberts D.S. Invest. New Drugs 15 (1997) 357
202. Murphy B.A., Leong T., Burkey B., Langer C., and Forastiere A. Am. J. Clin. Oncol. 24 (2001) 64
203. Miller D.S., Blessing J.A., Kilgore L.C., Mannel R., and van Le L. Am. J. Clin. Oncol. 23 (2000) 355
204. Macdonald J.S., Jacobson J.L., Ketchel S.J., Weiss G., Taylor S., Mills G., Kuebler J.P., Rivkin S., and Conrad M. Invest. New Drugs 18 (2000) 199
205. Weitz J.J., Sloan Jr. R.F., Marschke J.A., Grill J.P., Jett J.R., Knost J.A., Hatfield A.K., Zenk D.W., Bate W.W., and Schaefer P.L. Lung Cancer 28 (2000) 157
206. Levine E.G., Cirrincione C.T., Szatrowski T.P., Canellos G., Norton L., and Henderson I.C. Am. J. Clin. Oncol. 22 (1999) 218
207. Maksymiuk A.W., Marschke Jr. R.F., Tazelaar H.D., Grill J., Nair S., Marks R.S., Brooks B.J., Mailliard J.A., Burton G.M., and Jett J.R. Am. J. Clin. Oncol. 21 (1998) 610
208. Witte R.S., Manola J., Burch P.A., Kuzel T., Weinshel E.L., and Loehrer Sr. P.J. Invest. New Drugs 16 (1998) 191
209. Kindler H.L., Kris M.G., Smith I.E., Miller V.A., Grant S.C., Krebs J.B., Ross G.A., and Slevin M.L. Am. J. Clin. Oncol. 21 (1998) 438
210. Stevenson J.P., Scher R.M., Kosierowski R., Fox S.C., Simmonds M., Yao K.S., Green F., Broom C., Fields S.Z., Krebs J.B., and O'Dwyer P.J. Eur. J. Cancer 34 (1998) 1358
211. Saltz L.B., Schwartz G.K., Ilson D.H., Quan V., and Kelsen D.P. Am. J. Clin. Oncol. 20 (1997) 621
212. Benedetti J.K., Balcerzak H.A., Burris III S.P., and Macdonald J.S. Invest. New Drugs 15 (1997) 261
213. Wall J.G., Benedetti J.K., O'Rourke M.A., Natale R.B., and Macdonald J.S. Invest. New Drugs 15 (1997) 257
214. Kraut E.H., Walker M.J., Staubus A., Gochnour D., and Balcerzak S.P. Cancer Invest. 15 (1997) 318
215. O'Reilly S., Donehower R.C., Rowinsky E.K., Ord S., and Grochow L.B. Anticancer Drugs 7 (1996) 410
216. Macdonald D., Cairncross G., Stewart D., Forsyth P., Sawka C., Wainman N., and Eisenhauer E. Ann. Oncol. 7 (1996) 205
217. Scher R.M., Kosierowski R., Lusch C., Alexander R., Fox S., Redei I., Green F., Raskay B., Amfoh K., Engstrom P.F., and O'Dwyer P.J. Invest. New Drugs 13 (1996) 347
218. Armstrong D., and O'Reilly S. Oncologist 3 (1998) 4
219. Heron J.F. Oncologist 3 (1998) 390
220. Hochster H., Liebes L., Speyer J., Sorich J., Taubes B., Oratz R., Wernz J., Chachoua A., Raphael B., Vinci R.Z., and Blum R.H. J. Clin. Oncol. 12 (1994) 553
221. Hochster H., Wadler S., Runowicz C., Liebes L., Cohen H., Wallach R., Sorich J., Taubes B., and Speyer J. J. Clin. Oncol. 17 (1999) 2553
222. Creemers G.J., Gerrits C.J., Eckardt J.R., Schellens J.H., Burris H.A., Planting A.S., Rodriguez G.I., Loos W.J., Hudson I., Broom C., Verweij J., and von Hoff D.D. J. Clin. Oncol. 15 (1997) 1087
223. Kuhn J., Dizzo J., Eckhardt J., Fields S., Cobb P., Rodriguez R., Rinaldi D., Drendgler R., Smith L., Peacock N., Thurman A., Delacruz P., Hodges S., von Hoff D., and Burris H. Proc. Am. Soc. Clin. Oncol. 14 (1995) 474 (abstr. 1538)
224. Gerrits C.J., Burris H., Schellens J.H., Eckardt J.R., Planting A.S., van der Burg M.E., Rodriguez G.I., Loos W.J., van Beurden V., Hudson I., Fields S., von Hoff D.D., and Verweij J. Clin. Cancer Res. 4 (1998) 1153
225. Hochster H., Liebes L., Speyer J., Sorich J., Taubes B., Oratz R., Wernz J., Chachoua A., Blum R.H., and Zeleniuch-Jacquotte A. Clin. Cancer Res. 3 (1997) 1245
226. Gerrits C.J., Burris H., Schellens J.H., Planting A.S., van den Burg M.E., Rodriguez G.I., van Beurden V., Loos W.J., Hudson I., Fields S., Verweij J., and von Hoff D.D. Eur. J. Cancer 34 (1998) 1030
227. Gerrits C.J., Schellens J.H., Burris H., Eckardt J.R., Planting A.S., van der Burg M.E., Rodriguez G.I., Loos W.J., van Beurden V., Hudson I., von Hoff D.D., and Verweij J. Clin. Cancer Res. 5 (1999) 69
228. Rowinsky E.K., Kaufmann S.H., Baker S.D., Miller C.B., Sartorius S.E., Bowling M.K., Chen T.L., Donehower R.C., and Gore S.D. Clin. Cancer Res. 2 (1996) 1921
229. Brogden R.N., and Wiseman L.R. Drugs 56 (1998) 709
230. Robert F., Soong S., and Wheeler R.H. Am. J. Clin. Oncol. 20 (1997) 298
231. Hudes G.R., Kosierowski R., Greenberg R., Ramsey H.E., Fox S.C., Ozols R.F., McAleer C.A., and Giantonio B.J. Invest. New Drugs 13 (1995) 235
232. Gore M., ten Bokkel Huinink W., Carmichael J., Gordon A., Davidson N., Coleman R., Spaczynski M., Heron J.F., Bolis G., Malmstrom H., Malfetano J., Scarabelli C., Vennin P., Ross G., and Fields S.Z. J. Clin. Oncol. 19 (2001) 1893
233. Gore M., Oza A., Rustin G., Malfetano J., Calvert H., Clarke-Pearson D., Carmichael J., Ross G., Beckman R.A., and Fields S.Z. Eur. J. Cancer 38 (2002) 57
234. von Pawel J., Schiller J.H., Shepherd F.A., Fields S.Z., Kleisbauer J.P., Chrysson N.G., Stewart D.J., Clark P.I., Palmer M.C., Depierre A., Carmichael J., Krebs J.B., Ross G., Lane S.R., and Gralla R. J. Clin. Oncol. 17 (1999) 658
235. Schiller J.H., Kim K., Hutson P., DeVore R., Glick J., Stewart J., and Johnson D. J. Clin. Oncol. 14 (1996) 2345
236. von Pawel J., Gatzemeier U., Pujol J.L., Moreau L., Bildat S., Ranson M., Richardson G., Steppert C., Riviere A., Camlett I., Lane S., and Ross G. J. Clin. Oncol. 19 (2001) 1743
237. Kantarjian H. Semin. Hematol. 35 (1998) 1
238. Beran M., Kantarjian H., O'Brien S., Koller C., al-Bitar M., Arbuck S., Pierce S., Moore M., Abbruzzese J.L., Andreeff M., Keating M., and Estey E. Blood 88 (1996) 2473
239. Beran M., and Kantarjian H. Semin. Hematol. 35 (1998) 26
240. Kraut E.H., Crowley J.J., Wade J.L., Laufman L.R., Alsina M., Taylor S.A., and Salmon S.E. J. Clin. Oncol. 16 (1998) 589
241. Kraut E.H., Ju R., and Muller M. Semin. Hematol. 35 (1998) 32
242. Kehrer D.F., Soepenberg O., Loos W.J., Verweij J., and Sparreboom A. Anticancer Drugs 12 (2001) 89
243. Houghton P.J., Cheshire P.J., Hallman II L., Lutz J.D., Friedman H.S., Danks M.K., and Houghton J.A. Cancer Chemother. Pharmacol. 36 (1995) 393
244. Daoud S.S., Fetouh M.I., and Giovanella B.C. Anticancer Drugs 6 (1995) 83
245. Giovanella B.C., Hinz H.R., Kozielski A.J., Stehlin Jr. J.S., Silber R., and Potmesil M. Cancer Res. 51 (1991) 3052
246. Pantazis P., Hinz H.R., Mendoza J.T., Kozielski A.J., Williams Jr. J.S., Stehlin Jr. B.C., and Giovanella L.J. Cancer Res. 52 (1992) 3980
247. Hochster H., Liebes L., Speyer J., Sorich J., Taubes B., Oratz R., Wernz J., Chachoua A., Blum R.H., and Zeleniuch-Jacquotte A. Clin. Cancer Res. 3 (1997) 1245
248. Hochster H., Wadler S., Runowicz C., Liebes L., Cohen H., Wallach R., Sorich J., Taubes B., and Speyer J. J. Clin. Oncol. 17 (1999) 2553
249. Liu G., Franssen E., Fitch M.I., and Warner E. J. Clin. Oncol. 15 (1997) 110
250. Sparreboom A., de Jonge M.J., and Verweij J. Eur. J. Cancer 38 (2002) 18
251. DeMario M.D., and Ratain M.J. J. Clin. Oncol. 16 (1998) 2557
252. Herben V.M., Rosing H., ten Bokkel Huinink W.W., Van Zomeren D., Batchelor D., Doyle E., Beusenberg F.D., Beijnen J.H., and Schellens J.H. Br. J. Cancer 80 (1999) 1380
253. Kruijtzer C.M., Beijnen J.H., Rosing H., ten Bokkel Huinink W.W., Schot M., Jewell R.C., Paul E.M., and Schellens J.H. J. Clin. Oncol. 20 (2002) 2943
254. Hudes G. J. Clin. Oncol. 20 (2002) 2918
255. Sinha B.K. Drugs 49 (1995) 11
256. Herben V.M., van Gijn R., Schellens J.H., Schot M., Lieverst J., Hillebrand M.J., Schoemaker N.E., Porro M.G., Beijnen J.H., and ten Bokkel Huinink W.W. J. Clin. Oncol. 17 (1999) 1906
257. Siu L.L., Oza A.M., Eisenhauer E.A., Firby P.S., Thiessen J.J., Michael M., Wainman N., Manzo J., Feld R., Goldberg R.A., and Moore M.J. J. Clin. Oncol. 16 (1998) 1122
258. Rubin E., Wood V., Bharti A., Trites D., Lynch C., Hurwitz S., Bartel S., Levy S., Rosowsky A., Toppmeyer D., and Kufe D. Clin. Cancer Res. 1 (1995) 269
259. Dahut W., Harold N., Takimoto C., Allegra C., Chen A., Hamilton J.M., Arbuck S., Sorensen M., Grollman F., Nakashima H., Lieberman R., Liang M., Corse W., and Grem J. J. Clin. Oncol. 14 (1996) 1236
260. Eder Jr. J.G., Supko J.P., Lynch T., Bryant M., Vosburgh E., Shulman L.N., Xu G., and Kufe D.W. Clin. Cancer Res. 4 (1998) 317
261. Langevin A.M., Casto D.T., Thomas P.J., Weitman S.D., Kretschmar C., Grier H., Pratt C., Dubowy R., Bernstein M., Blaney S., and Vietti T. J. Clin. Oncol. 16 (1998) 2494
262. Thomas R.R., Dahut W., Harold N., Grem J.L., Monahan B.P., Liang M., Band R.A., Cottrell J., Llorens V., Smith J.A., Corse W., Arbuck S.G., Wright J., Chen A.P., Shapiro J.D., Hamilton J.M., Allegra C.J., and Takimoto C.H. Cancer Chemother. Pharmacol. 48 (2001) 215
263. Vey N., Kantarjian H., Tran H., Beran M., O'Brien S., Bivins C., Giles F., Cortes J., Cheson B., Arbuck S., and Estey E. Ann. Oncol. 10 (1999) 577
264. Muggia F., Liebes L., Potmesil M., Hamilton A., Hochster H., Hornreich G., Sorich J., Downey A., and Wasserstrom H. In: Liehr J.G., Giovanella B.C., and Verschraegen C.F. (Eds). Annals of the New York Academy of Sciences 922 (2000), The New York Academy of Sciences, New York 178-187
265. Sparreboom A., de Jonge M.J., Punt C.J., Nooter K., Loos W.J., Porro M.G., and Verweij J. Clin. Cancer Res. 4 (1998) 1915
266. Mani S., Iyer L., Janisch L., Wang X., Fleming G.F., Schilsky R.L., and Ratain M.J. Cancer Chemother. Pharmacol. 42 (1998) 84
267. de Jonge M.J., Punt C.J., Gelderblom A.H., Loos W.J., van Beurden V., Planting A.S., van der Burg M.E., van Maanen L.W., Dallaire B.K., Verweij J., Wagener D.J., and Sparreboom A. J. Clin. Oncol. 17 (1999) 2219
268. Kraut E.H., Balcerzak S.P., Young D., O'Rourke M.A., Petrus J.J., Kuebler J.P., and Mayernik D.G. Cancer Invest. 18 (2000) 28
269. Pazdur R., Diaz-Canton E., Ballard W.P., Bradof J.E., Graham S., Arbuck S.G., Abbruzzese J.L., and Winn R. J. Clin. Oncol. 15 (1997) 2905
270. Saltz L.B., Kemeny N.E., Tong W., Harrison J., Berkery R., and Kelsen D.P. Cancer 80 (1997) 1727
271. Pazdur R., Medgyesy D.C., Winn R.J., Dakhil S.R., Moore Jr. D.F., Scalzo A., Hoff P.M., Arbuck S.G., and Abbruzzese J.L. Invest. New Drugs 16 (1998) 341
272. Pitot H.C., Knost J.A., Mahoney M.R., Kugler J., Krook J.E., Hatfield A.K., Sargent D.J., and Goldberg R.M. Cancer 89 (2000) 1699
273. Hochberg F., Grossman S.A., Mikkelsen T., Glantz M., Fisher J.D., and Piantadosi S. Neuro-oncol. 2 (2000) 29
274. Lad T., Rosen F., Sciortino D., Brockstein B., Keubler J.P., Arietta R., and Vokes E. Invest. New Drugs 18 (2000) 261
275. Wilson W.H., Little R., Pearson D., Jaffe E.S., Steinberg S.M., Cheson B.D., Humphrey R., Kohler D.R., and Elwood P. J. Clin. Oncol. 16 (1998) 2345
276. Argiris A., Heald P., Kuzel T., Foss F.M., DiStasio S., Cooper D.L., Arbuck S., and Murren J.R. Invest. New Drugs 19 (2001) 321
277. Vokes E.E., Ansari R.H., Masters G.A., Hoffman P.C., Klepsch A., Ratain M.J., Sciortino D.F., Lad T.E., Krauss S., Fishkin P.A., and Golomb H.M. Ann. Oncol. 9 (1998) 1085
278. Vokes E.E., Gordon G.S., Rudin C.M., Mauer A.M., Watson S., Krauss S., Arrieta R., Golomb H.M., and Hoffman P.C. Invest. New Drugs 19 (2001) 329
279. Loos W.J., Verweij J., Gelderblom H.J., de Jonge M.J., Brouwer E., Dallaire B.K., and Sparreboom A. Anticancer Drugs 10 (1999) 705
280. Li M.L., Horn L., Firby P.S., and Moore M.J. Clin. Cancer Res. 7 (2001) 168
281. Kirstein M.H., Houghton P.J., Cheshire P.J., Richmond L.B., Smith A.K., Hanna S.K., and Stewart C.F. Clin. Cancer Res. 7 (2001) 358
282. Sakuma S., Lu Z.R., Kopeckova P., and Kopecek J. J. Controlled Release 75 (2001) 365
283. Prijovich Z.M., Chen B.M., Leu Y.L., Chern J.W., and Roffler S.R. Br. J. Cancer 86 (2002) 1634
284. de Groot F., Busscher G., Aben R., and Scheeren H. Bioorg. Med. Chem. Lett. 12 (2002) 2371
285. Pantazis P., Early J.A., Mendoza J.T., DeJesus A.R., and Giovanella B.C. Cancer Res. 54 (1994) 771
286. Karaberis E., and Mourelatos D. Teratog. Carcinog. Mutagen. 20 (2000) 141
287. Hinz H.R., Harris N.J., Natelson E.A., and Giovanella B.C. Cancer Res. 54 (1994) 3096
288. Natelson E.A., Giovanella B.C., Verschraegen C.F., Fehir K.M., de Ipolyi P.D., Harris N., and Stehlin J.S. In: Pantazis P., Giovanella B.C., and Rothenberg M.L. (Eds). Annals of the New York Academy of Sciences 803 (1996), The New York Academy of Sciences, New York 224-230
289. Verschraegen C.F., Natelson E.A., Giovanella B.C., Kavanagh J.J., Kudelka A.P., Freedman R.S., Edwards C.L., Ende K., and Stehlin J.S. Anticancer Drugs 9 (1998) 36
290. Verschraegen C.F., Jaeckle K., Giovanella B., Knight V., and Gilbert B.E. In: Liehr J.G., Giovanella B.C., and Verschraegen C.F. (Eds). Annals of the New York Academy of Sciences 922 (2000), The New York Academy of Sciences, New York 237-246
291. Koshkina N.V., Kleinerman E.S., Waidrep C., Jia S.F., Worth L.L., Gilbert B.E., and Knight V. Clin. Cancer Res. 6 (2000) 2876
292. Stehlin J.S., Giovanella B.C., Natelson E.A., de Ipolyi P.D., Coil D., Davis B., Wolk D., Wallace P., and Trojacek A. Int. J. Oncol. 14 (1999) 821
293. Konstadoulakis M.M., Antonakis P.T., Tsibloulis B.G., Stathopoulos G.P., Manouras A.P., Mylonaki D.B., and Golematis B.X. Cancer Chemother. Pharmacol. 48 (2001) 417
294. Verschraegen C.F., Gupta E., Loyer E., Kavanagh J.J., Kudelka A.P., Freedman R.S., Edwards C.L., Harris N., Steger M., Steltz V., Giovanella B.C., and Stehlin J.S. Anticancer Drugs 10 (1999) 375
295. Schoffski P., Herr A., Vermorken J.B., van den Brande J., Beijnen J.H., Rosing H., Volk J., Ganser A., Adank S., Botma H.J., and Wanders J. Eur. J. Cancer 38 (2002) 807
296. Raymond E., Campone M., Stupp R., Menten J., Chollet P., Lesimple T., Fety-Deporte R., Lacombe D., Paoletti X., and Fumoleau P. Eur. J. Cancer 38 (2002) 1348
297. Ellerhorst J.A., Bedikian A.Y., Smith T.M., Papadopoulos N.E., Plager C., and Eton O. Anticancer Drugs 13 (2002) 169
298. Mitsui I., Kumazawa E., Hirota Y., Aonuma M., Sugimori M., Ohsuki S., Uoto K., Ejima A., Terasawa H., and Sato K. Jpn. J. Cancer Res. 86 (1995) 776
299. de Jager R., Cheverton P., Tamanoi K., Coyle J., Ducharme M., Sakamoto N., Satomi M., and Suzuki M. In: Liehr J.G., Giovanella B.C., and Verschraegen C.F. (Eds). Annals of the New York Academy of Sciences 922 (2000), The New York Academy of Sciences, New York 260-273
300. Oguma T., Yamada M., Konno T., Inukai K., and Nakaoka M. Biol. Pharm. Bull. 24 (2001) 176
301. Lawrence R.A., Izbicka E., de Jager R.L., Tohgo A., Clark G.M., Weitman S.D., Rowinsky E.K., and von Hoff D.D. Anticancer Drugs 10 (1999) 655
302. Vey N., Giles F.J., Kantarjian H., Smith T.L., Beran M., and Jeha S. Clin. Cancer Res. 6 (2000) 731
303. Kumazawa E., Jimbo T., Ochi Y., and Tohgo A. Cancer Chemother. Pharmacol. 42 (1998) 210
304. Takiguchi S., Kumazawa E., Shimazoe T., Tohgo A., and Kono A. Jpn. J. Cancer Res. 88 (1997) 760
305. Nomoto T., Nishio K., Ishida T., Mori M., and Saijo N. Jpn. J. Cancer Res. 89 (1998) 1179
306. Ishii M., Iwahana M., Mitsui I., Minami M., Imagawa S., Tohgo A., and Ejima A. Anticancer Drugs 11 (2000) 353
307. Oguma T., Konno T., Inaba A., and Nakaoka M. Biomed. Chromatogr. 15 (2001) 108
308. Oguma T., Ohshima Y., and Nakaoka M. J. Chromatogr. B Biomed. Sci. Appl. 740 (2000) 237
309. Rowinsky E.K., Johnson T.R., Geyer Jr. L.A., Hammond C.E., Eckhardt S.G., Drengler R., Smetzer L., Coyle J., Rizzo J., Schwartz G., Tolcher A., von Hoff D.D., and de Jager R.L. J. Clin. Oncol. 18 (2000) 3151
310. Royce M.E., Hoff P.M., Dumas P., Lassere Y., Lee J.J., Coyle J., Ducharme M.P., de Jager R., and Pazdur R. J. Clin. Oncol. 19 (2001) 1493
311. Sharma S., Kemeny N., Schwartz G.K., Kelsen D., O'Reilly E., Ilson D., Coyle J., de Jager R.L., Ducharme M.P., Kleban S., Hollywood E., and Saltz L.B. Clin. Cancer Res. 7 (2001) 3963
312. Minami H., Fujii H., Igarashi T., Itoh K., Tamanoi K., Oguma T., and Sasaki Y. Clin. Cancer Res. 7 (2001) 3056
313. Boige V., Raymond E., Faivre S., Gatineau M., Meely K., Mekhaldi S., Pautier P., Ducreux M., Rixe O., and Armand J.P. J. Clin. Oncol. 18 (2000) 3986
314. Giles F.J., Cortes J.E., Thomas D.A., Garcia-Manero G., Faderl S., Jeha S., de Jager R.L., and Kantarjian H.M. Clin. Cancer Res. 8 (2002) 2134
315. Verschraegen C.F., Levenback C., Vincent M., Wolf J., Bevers M., Loyer E., Kudelka A.P., and Kavanagh J.J. In: Liehr J.G., Giovanella B.C., and Verschraegen C.F. (Eds). Annals of the New York Academy of Sciences 922 (2000), The New York Academy of Sciences, New York 349-351
316. Lavergne O., Demarquay D., Kasprzyk P.G., and Bigg D.C. In: Liehr J.G., Giovanella B.C., and Verschraegen C.F. (Eds). Annals of the New York Academy of Sciences 922 (2000), The New York Academy of Sciences, New York 100-111
317. H. Gelderblom, "Pharmacologic aspects of new classes of anti-cancer agents: inhibitors of topoisomerase I or tubulin." Ph.D. Thesis, Erasmus University at Rotterdam, The Netherlands, 2001
318. Lesueur-Ginot L., Demarquay D., Kiss R., Kasprzyk P.G., Dassonneville L., Bailly C., Camara J., Lavergne O., and Bigg D.C. Cancer Res. 59 (1999) 2939
319. Lavergne O., Demarquay D., Bailly C., Lanco C., Rolland A., Huchet M., Coulomb H., Muller N., Baroggi N., Camara J., Le Breton C., Manginot E., Cazaux J.B., and Bigg D.C. J. Med. Chem. 43 (2000) 2285
320. Philippart P., Harper L., Chaboteaux C., Decaestecker C., Bronckart Y., Gordover L., Lesueur-Ginot L., Malonne H., Lavergne O., Bigg D.C., da Costa P.M., and Kiss R. Clin. Cancer Res. 6 (2000) 1557
321. Bailly C., Lansiaux A., Dassonneville L., Demarquay D., Coulomb H., Huchet M., Lavergne O., and Bigg D.C. Biochemistry 38 (1999) 15556
322. Mathijssen R.H., Verweij J., de Jonge M.J., Nooter K., Stoter G., and Sparreboom A. J. Clin. Oncol. 20 (2002) 81
323. Gerrits C.J., Schellens J.H., Creemers G.J., Wissel P., Planting A.S., Pritchard J.F., DePee S., de Boer-Dennert M., Harteveld M., and Verweij J. Br. J. Cancer 76 (1997) 946
324. Emerson D.L., Besterman J.M., Brown H.R., Evans M.G., Leitner P.P., Luzzio M.J., Shaffer J.E., Sternbach D.D., Uehling D., and Vuong A. Cancer Res. 55 (1995) 603
325. Gerrits C.J., Creemers G.J., Schellens J.H., Wissel P., Planting A.S., Kunka R., Selinger K., de Boer-Dennert M., Marijnen Y., Harteveld M., and Verweij J. Br. J. Cancer 73 (1996) 744
326. Eckhardt S.G., Baker S.D., Eckardt J.R., Burke T.G., Warner D.L., Kuhn J.G., Rodriguez G., Fields S., Thurman A., Smith L., Rothenberg M.L., White L., Wissel P., Kunka R., DePee S., Littlefield D., Burris H.A., von Hoff D.D., and Rowinsky E.K. Clin. Cancer Res. 4 (1998) 595
327. Paz-Ares L., Kunka R., DeMaria D., Cassidy J., Alden M., Beranek P., Kaye S., Littlefield D., Reilly D., Depee S., Wissel P., Twelves C., and O'Dwyer P. Br. J. Cancer 78 (1998) 1329
328. Stevenson J.P., DeMaria D., Sludden J., Kaye S.B., Paz-Ares L., Grochow L.B., McDonald A., Selinger K., Wissel P., O'Dwyer P.J., and Twelves C. Ann. Oncol. 10 (1999) 339
329. Gamucci T., Paridaens R., Heinrich B., Schellens J.H., Pavlidis N., Verweij J., Sessa C., Kaye S., Roelvink M., Wanders J., and Hanauske A. Ann. Oncol. 11 (2000) 793
330. Sessa C., Wanders J., Roelvink M., Dombernowsky P., Nielsen D., Morant R., Drings P., Wissel P., and Hanauske A.R. Ann. Oncol. 11 (2000) 207
331. Emerson D.L., Bendele R., Brown E., Chiang S., Desjardins J.P., Dihel L.C., Gill S.C., Hamilton M., LeRay J.D., Moon-McDermott L., Moynihan K., Richardson F.C., Tomkinson B., Luzzio M.J., and Baccanari D. Clin. Cancer Res. 6 (2000) 2903
332. Kehrer D.F., Bos A.M., Verweij J., Groen H.J., Loos W.J., Sparreboom A., de Jonge M.J., Hamilton M., Cameron T., and de Vries E.G. J. Clin. Oncol. 20 (2002) 1222