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Volumn 24, Issue 2, 2001, Pages 176-180
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High-performance liquid chromatographic analysis of lactone and hydroxy acid of new antitumor drug, DX-8951 (Exatecan), in mouse plasma
a
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Author keywords
Camptothecin; Fluorometric detection; HPLC; Pharmacokinetic study; Plasma
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Indexed keywords
ACETONITRILE;
ANTINEOPLASTIC AGENT;
BUFFER;
CAMPTOTHECIN DERIVATIVE;
DNA TOPOISOMERASE;
DNA TOPOISOMERASE INHIBITOR;
DW 8579;
EXATECAN;
GLYCOPROTEIN P;
HYDROXYACID;
IRINOTECAN;
LACTONE DERIVATIVE;
NEW DRUG;
PHOSPHATE;
POTASSIUM DIHYDROGEN PHOSPHATE;
QUINOLINE DERIVATIVE;
SODIUM HYDROXIDE;
TOPOTECAN;
UNCLASSIFIED DRUG;
ANIMAL EXPERIMENT;
ANIMAL MODEL;
AREA UNDER THE CURVE;
ARTICLE;
BLOOD ANALYSIS;
COLUMN CHROMATOGRAPHY;
CONTROLLED STUDY;
DOSE RESPONSE;
DRUG BLOOD LEVEL;
DRUG DETERMINATION;
DRUG FORMULATION;
DRUG HALF LIFE;
DRUG STRUCTURE;
FLOW RATE;
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
LINEAR SYSTEM;
MALE;
MOUSE;
NONHUMAN;
PLASMA;
PLASMA CLEARANCE;
QUANTITATIVE ASSAY;
REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
SOLID PHASE EXTRACTION;
STRUCTURE ANALYSIS;
ANIMALS;
ANTINEOPLASTIC AGENTS;
CALIBRATION;
CAMPTOTHECIN;
CHROMATOGRAPHY, HIGH PRESSURE LIQUID;
HYDROXY ACIDS;
LACTONES;
MALE;
MICE;
MICE, INBRED BALB C;
REPRODUCIBILITY OF RESULTS;
SENSITIVITY AND SPECIFICITY;
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EID: 0035102345
PISSN: 09186158
EISSN: None
Source Type: Journal
DOI: 10.1248/bpb.24.176 Document Type: Article |
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Times cited : (9)
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References (11)
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