메뉴 건너뛰기




Volumn 18, Issue 3, 2000, Pages 659-667

Phase I and pharmacologic study of irinotecan administered as a 96-hour infusion weekly to adult cancer patients

Author keywords

[No Author keywords available]

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; IRINOTECAN;

EID: 0033950287     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/jco.2000.18.3.659     Document Type: Article
Times cited : (59)

References (32)
  • 1
    • 0000760112 scopus 로고    scopus 로고
    • The camptothecins
    • Chabner BA, Longo DL (eds). Philadelphia, PA, Lippincott-Raven
    • Takimoto CH, Arbuck SG: The camptothecins, in Chabner BA, Longo DL (eds): Cancer Chemotherapy and Biotherapy, (ed 2) Philadelphia, PA, Lippincott-Raven, 1996, pp 463-484
    • (1996) Cancer Chemotherapy and Biotherapy, (Ed 2) , pp. 463-484
    • Takimoto, C.H.1    Arbuck, S.G.2
  • 3
    • 0029966672 scopus 로고    scopus 로고
    • Phase II trial of irinotecan in patients with progressive or rapidly recurrent colorectal cancer
    • Rothenberg ML, Eckardt JR, Kuhn JG, et al: Phase II trial of irinotecan in patients with progressive or rapidly recurrent colorectal cancer. J Clin Oncol 14:1128-1135, 1996
    • (1996) J Clin Oncol , vol.14 , pp. 1128-1135
    • Rothenberg, M.L.1    Eckardt, J.R.2    Kuhn, J.G.3
  • 4
    • 0030818926 scopus 로고    scopus 로고
    • Phase II trial of irinotecan in patients with metastatic colorectal carcinoma
    • Pitot HC, Wender DB, O'Connell MJ, et al: Phase II trial of irinotecan in patients with metastatic colorectal carcinoma. J Clin Oncol 15:2910-2919, 1997
    • (1997) J Clin Oncol , vol.15 , pp. 2910-2919
    • Pitot, H.C.1    Wender, D.B.2    O'Connell, M.J.3
  • 5
    • 0029919598 scopus 로고    scopus 로고
    • Irinotecan is an active agent in untreated patients with metastatic colorectal cancer
    • Conti JA, Kemeny NE, Saltz LB, et al: Irinotecan is an active agent in untreated patients with metastatic colorectal cancer. J Clin Oncol 14:709-715, 1996
    • (1996) J Clin Oncol , vol.14 , pp. 709-715
    • Conti, J.A.1    Kemeny, N.E.2    Saltz, L.B.3
  • 6
    • 0031014627 scopus 로고    scopus 로고
    • Phase II study of irinotecan in the treatment of advanced colorectal cancer in chemotherapy-naive patients and patients pretreated with fluorouracil-based chemotherapy
    • Rougier P, Bugat R, Douillard JY, et al: Phase II study of irinotecan in the treatment of advanced colorectal cancer in chemotherapy-naive patients and patients pretreated with fluorouracil-based chemotherapy. J Clin Oncol 15:251-260, 1997
    • (1997) J Clin Oncol , vol.15 , pp. 251-260
    • Rougier, P.1    Bugat, R.2    Douillard, J.Y.3
  • 7
    • 0030752757 scopus 로고    scopus 로고
    • Topoisomerase I inhibitors: The relevance of prolonged exposure for present clinical development
    • Gerrits CJ, de Jonge MJ, Schellens JH, et al: Topoisomerase I inhibitors: The relevance of prolonged exposure for present clinical development. Br J Cancer 76:952-962, 1997
    • (1997) Br J Cancer , vol.76 , pp. 952-962
    • Gerrits, C.J.1    De Jonge, M.J.2    Schellens, J.H.3
  • 8
    • 0029116438 scopus 로고
    • Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors
    • Houghton PJ, Cheshire PJ, Hallman JD, et al: Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors. Cancer Chemother Pharmacol 36:393-403, 1995
    • (1995) Cancer Chemother Pharmacol , vol.36 , pp. 393-403
    • Houghton, P.J.1    Cheshire, P.J.2    Hallman, J.D.3
  • 9
    • 0028357995 scopus 로고
    • Phase I trial of low-dose continuous topotecan infusion in patients with cancer: An active and well-tolerated regimen
    • Hochster H, Liebes L, Speyer J, et al: Phase I trial of low-dose continuous topotecan infusion in patients with cancer: An active and well-tolerated regimen. J Clin Oncol 12:553-559, 1994
    • (1994) J Clin Oncol , vol.12 , pp. 553-559
    • Hochster, H.1    Liebes, L.2    Speyer, J.3
  • 10
    • 0343447737 scopus 로고    scopus 로고
    • A phase I trial of a prolonged infusion of 9-aminocamptothecin (9-AC) in adult patients with solid tumors
    • abstr 1554
    • Takimoto C, Dahut W, Harold H, et al: A phase I trial of a prolonged infusion of 9-aminocamptothecin (9-AC) in adult patients with solid tumors. Proc Am Soc Clin Oncol 14:471, 1996 (abstr 1554)
    • (1996) Proc Am Soc Clin Oncol , vol.14 , pp. 471
    • Takimoto, C.1    Dahut, W.2    Harold, H.3
  • 11
    • 9544234452 scopus 로고    scopus 로고
    • Phase II and pharmacologic study of topotecan administered as a 21-day continuous infusion to patients with colorectal cancer
    • Creemers GJ, Gerrits CJ, Schellens JH, et al: Phase II and pharmacologic study of topotecan administered as a 21-day continuous infusion to patients with colorectal cancer. J Clin Oncol 14:2540-2545, 1996
    • (1996) J Clin Oncol , vol.14 , pp. 2540-2545
    • Creemers, G.J.1    Gerrits, C.J.2    Schellens, J.H.3
  • 12
    • 0342748911 scopus 로고    scopus 로고
    • Comparison of intermittent and continuous exposure to topotecan in medulloblastoma cells
    • abstr
    • Danks MK, Marion RC: Comparison of intermittent and continuous exposure to topotecan in medulloblastoma cells. Proc Am Assoc Cancer Res 37:436, 1996 (abstr)
    • (1996) Proc Am Assoc Cancer Res , vol.37 , pp. 436
    • Danks, M.K.1    Marion, R.C.2
  • 13
    • 0026631164 scopus 로고
    • Phase I study and pharmacokinetics of CPT-11 with 5-day continuous infusion
    • Ohe Y, Sasaki Y, Shinkai T, et al: Phase I study and pharmacokinetics of CPT-11 with 5-day continuous infusion. J Natl Cancer Inst 84:972-974, 1992
    • (1992) J Natl Cancer Inst , vol.84 , pp. 972-974
    • Y, O.1    Sasaki, Y.2    Shinkai, T.3
  • 15
    • 0028346901 scopus 로고
    • Irinotecan (CPT-11) high-dose escalation using intensive high-dose loperamide to control diarrhea
    • Abigerges D, Armand JP, Chabot GG, et al: Irinotecan (CPT-11) high-dose escalation using intensive high-dose loperamide to control diarrhea. J Natl Cancer Inst 86:446-449, 1994
    • (1994) J Natl Cancer Inst , vol.86 , pp. 446-449
    • Abigerges, D.1    Armand, J.P.2    Chabot, G.G.3
  • 16
    • 0027937924 scopus 로고
    • Reversed-phase high-performance liquid chromatographic method for the simultaneous quantitation of the carboxylate and lactone forms of the camptothecin derivative irinotecan, CPT-11, and its metabolite SN-38 in plasma
    • Rivory LP, Robert J: Reversed-phase high-performance liquid chromatographic method for the simultaneous quantitation of the carboxylate and lactone forms of the camptothecin derivative irinotecan, CPT-11, and its metabolite SN-38 in plasma. J Chromatogr B Biomed Appl 661:133-141, 1994
    • (1994) J Chromatogr B Biomed Appl , vol.661 , pp. 133-141
    • Rivory, L.P.1    Robert, J.2
  • 17
    • 0028022585 scopus 로고
    • Metabolic fate of irinotecan in humans: Correlation of glucuronidation with diarrhea
    • Gupta E, Lestingi TM, Mick R, et al: Metabolic fate of irinotecan in humans: Correlation of glucuronidation with diarrhea Cancer Res 54:3723-3725, 1994
    • (1994) Cancer Res , vol.54 , pp. 3723-3725
    • Gupta, E.1    Lestingi, T.M.2    Mick, R.3
  • 19
    • 0029902106 scopus 로고    scopus 로고
    • Limited-sampling models for irinotecan pharmacokinetics-pharmacodynamics: Prediction of biliary index and intestinal toxicity
    • Mick R, Gupta E, Vokes EE, et al: Limited-sampling models for irinotecan pharmacokinetics-pharmacodynamics: Prediction of biliary index and intestinal toxicity. J Clin Oncol 14:2012-2019, 1996
    • (1996) J Clin Oncol , vol.14 , pp. 2012-2019
    • Mick, R.1    Gupta, E.2    Vokes, E.E.3
  • 20
    • 0027140524 scopus 로고
    • Phase I and pharmacokinetic trial of weekly CPT-11
    • Rothenberg ML, Kuhn JG, Burris HA III, et al: Phase I and pharmacokinetic trial of weekly CPT-11. J Clin Oncol 11:2194-2204, 1993
    • (1993) J Clin Oncol , vol.11 , pp. 2194-2204
    • Rothenberg, M.L.1    Kuhn, J.G.2    Burris H.A. III3
  • 21
    • 0028854897 scopus 로고
    • Phase I and pharmacologic studies of the camptothecin analog irinotecan administered every 3 weeks in cancer patients
    • Abigerges D, Chabot GG, Armand JP, et al: Phase I and pharmacologic studies of the camptothecin analog irinotecan administered every 3 weeks in cancer patients. J Clin Oncol 13:210-221, 1995
    • (1995) J Clin Oncol , vol.13 , pp. 210-221
    • Abigerges, D.1    Chabot, G.G.2    Armand, J.P.3
  • 22
    • 0028853410 scopus 로고
    • Population pharmacokinetics and pharmacodynamics of irinotecan (CKT-11) and active metabolite SN-38 during phase I trials
    • Chabot GG, Abigerges D, Catimel G, et al: Population pharmacokinetics and pharmacodynamics of irinotecan (CKT-11) and active metabolite SN-38 during phase I trials. Ann Oncol 6:141-151, 1995
    • (1995) Ann Oncol , vol.6 , pp. 141-151
    • Chabot, G.G.1    Abigerges, D.2    Catimel, G.3
  • 23
    • 0028158012 scopus 로고
    • Phase I and pharmacological study of the novel topoisomerase I inhibitor 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) administered as a ninety-minute infusion every 3 weeks
    • Rowinsky EK, Grochow LB, Ettinger DS, et al: Phase I and pharmacological study of the novel topoisomerase I inhibitor 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) administered as a ninety-minute infusion every 3 weeks. Cancer Res 54:427-436, 1994
    • (1994) Cancer Res , vol.54 , pp. 427-436
    • Rowinsky, E.K.1    Grochow, L.B.2    Ettinger, D.S.3
  • 24
    • 0027933519 scopus 로고
    • Phase I and pharmacokinetic study of the camptothecin derivative irinotecan, administered on a weekly schedule in cancer patients
    • de Fomi M, Bugat R, Chabot GG, et al: Phase I and pharmacokinetic study of the camptothecin derivative irinotecan, administered on a weekly schedule in cancer patients. Cancer Res 54:4347-4354, 1994
    • (1994) Cancer Res , vol.54 , pp. 4347-4354
    • De Fomi, M.1    Bugat, R.2    Chabot, G.G.3
  • 25
    • 0028813952 scopus 로고
    • A pharmacokinetic and pharmacodynamic analysis of CPT-11 and its active metabolite SN-38
    • Sasaki Y, Hakusui H, Mizuno S, et al: A pharmacokinetic and pharmacodynamic analysis of CPT-11 and its active metabolite SN-38. Jpn J Cancer Res 86:101-110, 1995
    • (1995) Jpn J Cancer Res , vol.86 , pp. 101-110
    • Sasaki, Y.1    Hakusui, H.2    Mizuno, S.3
  • 26
    • 0010917253 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of irinotecan during a phase II clinical trial in colorectal cancer: Pharmacology and Molecular Mechanisms Group of the European Organization for Research and Treatment of Cancer
    • Canal P, Gay C, Dezeuze A, et al: Pharmacokinetics and pharmacodynamics of irinotecan during a phase II clinical trial in colorectal cancer: Pharmacology and Molecular Mechanisms Group of the European Organization for Research and Treatment of Cancer. J Clin Oncol 14:2688-2695, 1996
    • (1996) J Clin Oncol , vol.14 , pp. 2688-2695
    • Canal, P.1    Gay, C.2    Dezeuze, A.3
  • 27
    • 15444357985 scopus 로고    scopus 로고
    • Studies of the efficacy and pharmacology of irinotecan against human colon tumor xenograft models
    • Zamboni WC, Stewart CF, Cheshire PJ, et al: Studies of the efficacy and pharmacology of irinotecan against human colon tumor xenograft models. Clin Cancer Res 4:743-753, 1998
    • (1998) Clin Cancer Res , vol.4 , pp. 743-753
    • Zamboni, W.C.1    Stewart, C.F.2    Cheshire, P.J.3
  • 28
    • 0030790137 scopus 로고    scopus 로고
    • The transformation of irinotecan (CPT-11) to its active metabolite SN-38 by human liver microsomes: Differential hydrolysis for the lactone and carboxylate forms
    • Haaz MC, Rivory LP, Riche C, et al: The transformation of irinotecan (CPT-11) to its active metabolite SN-38 by human liver microsomes: Differential hydrolysis for the lactone and carboxylate forms. Naunyn Schmiedebergs Arch Pharmacol 356:257-262, 1997
    • (1997) Naunyn Schmiedebergs Arch Pharmacol , vol.356 , pp. 257-262
    • Haaz, M.C.1    Rivory, L.P.2    Riche, C.3
  • 29
    • 0025827281 scopus 로고
    • CPT-11 converting enzyme from rat serum: Purification and some properties
    • Tsuji T, Kaneda N, Kado K, et al: CPT-11 converting enzyme from rat serum: Purification and some properties. J Pharmacobio-Dyn 14:341-349, 1991
    • (1991) J Pharmacobio-dyn , vol.14 , pp. 341-349
    • Tsuji, T.1    Kaneda, N.2    Kado, K.3
  • 30
    • 0030863434 scopus 로고    scopus 로고
    • Bioactivation of the anticancer agent CPT-11 to SN-38 by human hepatic microsomal carboxylesterases and the in vitro assessment of potential drug interactions
    • Slatter JG, Su P, Sams JP, et al: Bioactivation of the anticancer agent CPT-11 to SN-38 by human hepatic microsomal carboxylesterases and the in vitro assessment of potential drug interactions. Drug Metab Dispos 25:1157-1164, 1998
    • (1998) Drug Metab Dispos , vol.25 , pp. 1157-1164
    • Slatter, J.G.1    Su, P.2    Sams, J.P.3
  • 31
    • 4244097588 scopus 로고    scopus 로고
    • Pharmacokinetics of irinotecan and its active metabolite SN-38 in children with recurrent solid tumors after protracted low dose IV irinotecan
    • abstr 715
    • Stewart DF, Ma M, Furman WL, et al: Pharmacokinetics of irinotecan and its active metabolite SN-38 in children with recurrent solid tumors after protracted low dose IV irinotecan. Proc Am Soc Clin Oncol 17:186a, 1998 (abstr 715)
    • (1998) Proc Am Soc Clin Oncol , vol.17
    • Stewart, D.F.1    Ma, M.2    Furman, W.L.3
  • 32
    • 0028843263 scopus 로고
    • Pharmacological correlation between total drug concentration and lactones of CPT-11 and SN-38 in patients treated with CPT-11
    • Sasaki Y, Yoshida Y, Sudoh K, et al: Pharmacological correlation between total drug concentration and lactones of CPT-11 and SN-38 in patients treated with CPT-11. Jpn J Cancer Res 86:111-116, 1995
    • (1995) Jpn J Cancer Res , vol.86 , pp. 111-116
    • Sasaki, Y.1    Yoshida, Y.2    Sudoh, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.