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Volumn 16, Issue 7, 1998, Pages 2557-2567

Oral chemotherapy: Rationale and future directions

Author keywords

[No Author keywords available]

Indexed keywords

5 ETHYNYLURACIL; 9 AMINOCAMPTOTHECIN; ALKYLATING AGENT; ANTIMETABOLITE; CAMPTOTHECIN DERIVATIVE; CAPECITABINE; CYCLOPHOSPHAMIDE; CYTOCHROME P450 ISOENZYME; EPIPODOPHYLLOTOXIN DERIVATIVE; ETOPOSIDE; FLUOROURACIL; FOLINIC ACID; GLYCOPROTEIN P; HYDROXYUREA; IRINOTECAN; LOMUSTINE; MELPHALAN; MERCAPTOPURINE; METHOTREXATE; NAVELBINE; PLATINUM DERIVATIVE; PROCARBAZINE; SATRAPLATIN; TEGAFUR; TIOGUANINE; TOPOTECAN; UFT; UNINDEXED DRUG; URACIL DERIVATIVE; VINCA ALKALOID;

EID: 0031859489     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.1998.16.7.2557     Document Type: Review
Times cited : (280)

References (128)
  • 2
    • 0025652974 scopus 로고
    • The national economic burden of cancer: An update
    • Brown ML: The national economic burden of cancer: An update. J Natl Cancer Inst 82:1811-1814, 1990
    • (1990) J Natl Cancer Inst , vol.82 , pp. 1811-1814
    • Brown, M.L.1
  • 5
    • 0028210950 scopus 로고
    • Adjuvant therapy for stage III colon cancer: Economics returns to research and cost-effectiveness of treatment
    • Brown ML, Nayfield SG, Shibley LM: Adjuvant therapy for stage III colon cancer: Economics returns to research and cost-effectiveness of treatment. J Natl Cancer Inst 86:424-430, 1994
    • (1994) J Natl Cancer Inst , vol.86 , pp. 424-430
    • Brown, M.L.1    Nayfield, S.G.2    Shibley, L.M.3
  • 6
    • 0024996201 scopus 로고
    • Counting the costs of chemotherapy in a National Cancer Institute of Canada randomized trial in nonsmall-cell lung cancer
    • Jaakkimainen L, Goodwin PJ, Pater P, et al: Counting the costs of chemotherapy in a National Cancer Institute of Canada randomized trial in nonsmall-cell lung cancer. J Clin Oncol 8:1301-1309, 1990
    • (1990) J Clin Oncol , vol.8 , pp. 1301-1309
    • Jaakkimainen, L.1    Goodwin, P.J.2    Pater, P.3
  • 7
    • 0027213135 scopus 로고
    • Assessing the cost effectiveness of adjuvant therapies in early breast cancer using a decision analysis model
    • Hillner BE, Smith TJ, Desch CE: Assessing the cost effectiveness of adjuvant therapies in early breast cancer using a decision analysis model. Breast Cancer Res Treat 25:97-105, 1993
    • (1993) Breast Cancer Res Treat , vol.25 , pp. 97-105
    • Hillner, B.E.1    Smith, T.J.2    Desch, C.E.3
  • 8
    • 0028945766 scopus 로고
    • Cost-effectiveness of palliative chemotherapy in advanced gastrointestinal cancer
    • Glimelius B, Hoffman K, Graf W, et al: Cost-effectiveness of palliative chemotherapy in advanced gastrointestinal cancer. Ann Oncol 6:267-274, 1995
    • (1995) Ann Oncol , vol.6 , pp. 267-274
    • Glimelius, B.1    Hoffman, K.2    Graf, W.3
  • 9
    • 0029923056 scopus 로고    scopus 로고
    • The effect of medicare reimbursement policies on the cost and setting of cancer chemotherapy
    • Cowan DH: The effect of medicare reimbursement policies on the cost and setting of cancer chemotherapy. Cancer Invest 14:184-186, 1996
    • (1996) Cancer Invest , vol.14 , pp. 184-186
    • Cowan, D.H.1
  • 10
    • 0030037491 scopus 로고    scopus 로고
    • Comparison of costs for infusion versus bolus chemotherapy administration - Part II
    • Lokich JJ, Moore CL, Anderson NR: Comparison of costs for infusion versus bolus chemotherapy administration - Part II. Cancer 78:300-303, 1996
    • (1996) Cancer , vol.78 , pp. 300-303
    • Lokich, J.J.1    Moore, C.L.2    Anderson, N.R.3
  • 11
    • 0029836814 scopus 로고    scopus 로고
    • An economic exploration of oral and intravenous ganciclovir in the induction and maintenance treatment of AIDS-related cytomegalovirus retinitis
    • Davies L, Maynard A: An economic exploration of oral and intravenous ganciclovir in the induction and maintenance treatment of AIDS-related cytomegalovirus retinitis. Int J STD AIDS 7:415-421, 1996
    • (1996) Int J STD AIDS , vol.7 , pp. 415-421
    • Davies, L.1    Maynard, A.2
  • 12
    • 0030011156 scopus 로고    scopus 로고
    • An economic evaluation of oral compared with intravenous ganciclovir for maintenance treatment of newly diagnosed cytomegalovirus retinitis in AIDS patients
    • Sullivan SD, Mozaffari E, Johnson ES, et al: An economic evaluation of oral compared with intravenous ganciclovir for maintenance treatment of newly diagnosed cytomegalovirus retinitis in AIDS patients. Clin Therapeut 18:546-558, 1996
    • (1996) Clin Therapeut , vol.18 , pp. 546-558
    • Sullivan, S.D.1    Mozaffari, E.2    Johnson, E.S.3
  • 13
    • 0031017851 scopus 로고    scopus 로고
    • Patient preference for oral versus intravenous palliative chemotherapy
    • Liu G, Franssen E, Fitch M, et al: Patient preference for oral versus intravenous palliative chemotherapy. J Clin Oncol 15:110-115, 1997
    • (1997) J Clin Oncol , vol.15 , pp. 110-115
    • Liu, G.1    Franssen, E.2    Fitch, M.3
  • 14
    • 0027537102 scopus 로고
    • Bioavailability of low dose oral etoposide
    • Hande KR, Krozely MG, Greco FA, et al: Bioavailability of low dose oral etoposide. J Clin Oncol 11:374-377, 1993
    • (1993) J Clin Oncol , vol.11 , pp. 374-377
    • Hande, K.R.1    Krozely, M.G.2    Greco, F.A.3
  • 15
    • 0021986492 scopus 로고
    • Bioavailability and pharmacokinetics of etoposide (VP16)
    • Smyth, RD, Pfeffer M, Scalzo A, et al: Bioavailability and pharmacokinetics of etoposide (VP16). Semin Oncol 12:48-51, 1985 (suppl 2)
    • (1985) Semin Oncol , vol.12 , Issue.2 SUPPL. , pp. 48-51
    • Smyth, R.D.1    Pfeffer, M.2    Scalzo, A.3
  • 16
    • 0023481795 scopus 로고
    • Absorption kinetics of orally administered leucovorin calcium
    • McGuire B, Sia L, Haynes J, et al: Absorption kinetics of orally administered leucovorin calcium. NCI Monogr 5:47-56, 1987
    • (1987) NCI Monogr , vol.5 , pp. 47-56
    • McGuire, B.1    Sia, L.2    Haynes, J.3
  • 17
    • 0028838201 scopus 로고
    • Pharmacological attempts to improve the bioavailability of oral etoposide
    • Joel SP, Clark PI, Heap L, et al: Pharmacological attempts to improve the bioavailability of oral etoposide. Cancer Chemother Pharmacol 37:125-133, 1995
    • (1995) Cancer Chemother Pharmacol , vol.37 , pp. 125-133
    • Joel, S.P.1    Clark, P.I.2    Heap, L.3
  • 18
    • 0030444901 scopus 로고    scopus 로고
    • Interpatient variability in bioavailability is related to the extent of absorption: Implications for bioavailability and bioequivalence studies
    • Hellreiegel ET, Bjornsson TD, Hauck WW: Interpatient variability in bioavailability is related to the extent of absorption: Implications for bioavailability and bioequivalence studies. Clin Pharmacol Ther 60:601-607, 1996
    • (1996) Clin Pharmacol Ther , vol.60 , pp. 601-607
    • Hellreiegel, E.T.1    Bjornsson, T.D.2    Hauck, W.W.3
  • 19
    • 0022355776 scopus 로고
    • Variable bioavailability following repeated doses of etoposide
    • Harvey VJ, Slevin M, Joel SP, et al: Variable bioavailability following repeated doses of etoposide. Eur J Cancer Clin Oncol 21:1315-1319, 1985
    • (1985) Eur J Cancer Clin Oncol , vol.21 , pp. 1315-1319
    • Harvey, V.J.1    Slevin, M.2    Joel, S.P.3
  • 20
    • 0027934151 scopus 로고
    • Busulfan bioavailability
    • Hassan M, Ljungman P, Bolme P et al: Busulfan bioavailability. Blood 84:2144-2150, 1994
    • (1994) Blood , vol.84 , pp. 2144-2150
    • Hassan, M.1    Ljungman, P.2    Bolme, P.3
  • 21
    • 0027989630 scopus 로고
    • Intraindividual variability of the bioavailability of low dose methotrexate after oral administration in rheumatoid arthritis
    • Lebbe C, Beyeler C, Gerber N, et al: Intraindividual variability of the bioavailability of low dose methotrexate after oral administration in rheumatoid arthritis. Ann Rheum Dis 53:475-477, 1994
    • (1994) Ann Rheum Dis , vol.53 , pp. 475-477
    • Lebbe, C.1    Beyeler, C.2    Gerber, N.3
  • 22
    • 0020534019 scopus 로고
    • Variable bioavailability of oral mercaptopurine: Is maintenance chemotherapy in ALL being optimally delivered?
    • Zimm S, Collins JM, Riccardi R, et al: Variable bioavailability of oral mercaptopurine: Is maintenance chemotherapy in ALL being optimally delivered? N Engl J Med 308:1005-1009, 1983
    • (1983) N Engl J Med , vol.308 , pp. 1005-1009
    • Zimm, S.1    Collins, J.M.2    Riccardi, R.3
  • 23
    • 0041301863 scopus 로고
    • Identification of an inducible form of cytochrome P-450 in human liver
    • Watkins PB, Wrighton SA, Maurel P, et al: Identification of an inducible form of cytochrome P-450 in human liver. Proc Natl Acad Sci USA 82:6310-6314, 1985
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 6310-6314
    • Watkins, P.B.1    Wrighton, S.A.2    Maurel, P.3
  • 24
    • 0001291464 scopus 로고
    • Expression of P450IIIA4 in duodenal mucosa: Interpatient variability and regulation in cultured expiants
    • abstr
    • Kolars JC, Schmeidlin-Ron J, Scheutz M, et al: Expression of P450IIIA4 in duodenal mucosa: Interpatient variability and regulation in cultured expiants. Gastroenterology 100:A221, 1991 (abstr)
    • (1991) Gastroenterology , vol.100
    • Kolars, J.C.1    Schmeidlin-Ron, J.2    Scheutz, M.3
  • 25
    • 0025719746 scopus 로고
    • First pass metabolism of cyclosporine by the gut
    • Kolars JC, Awni W, Merion R, et al: First pass metabolism of cyclosporine by the gut. Lancet 338:1488-1490, 1991
    • (1991) Lancet , vol.338 , pp. 1488-1490
    • Kolars, J.C.1    Awni, W.2    Merion, R.3
  • 26
    • 0027369366 scopus 로고
    • Differential activation of cyclophosphamide and ifosfamide by cytochromes P-450 2B and 3A in human liver microsomes
    • Chang TK, Weber GF, Crespi CL, et al: Differential activation of cyclophosphamide and ifosfamide by cytochromes P-450 2B and 3A in human liver microsomes. Cancer Res 53:5629-5637, 1993
    • (1993) Cancer Res , vol.53 , pp. 5629-5637
    • Chang, T.K.1    Weber, G.F.2    Crespi, C.L.3
  • 27
    • 0028009274 scopus 로고
    • O-demetheylation of epipodophyllotoxins is catalyzed by human cytochrome P450 3 A4
    • Relling MV, Nemec J, Schuetz E, et al: O-demetheylation of epipodophyllotoxins is catalyzed by human cytochrome P450 3 A4. Mol Pharmacol 45:352-358, 1994
    • (1994) Mol Pharmacol , vol.45 , pp. 352-358
    • Relling, M.V.1    Nemec, J.2    Schuetz, E.3
  • 28
    • 0029028792 scopus 로고
    • Overlapping substrate specificities and tissue distribution of cytochrome P4503A and P-glycoprotein: Implications for drug delivery and activity in cancer chemotherapy
    • Wacher MJ, Chi-Yuan W, Benet LZ: Overlapping substrate specificities and tissue distribution of cytochrome P4503A and P-glycoprotein: Implications for drug delivery and activity in cancer chemotherapy. Mol Carcinogen 13:129-134, 1995
    • (1995) Mol Carcinogen , vol.13 , pp. 129-134
    • Wacher, M.J.1    Chi-Yuan, W.2    Benet, L.Z.3
  • 29
    • 0028097366 scopus 로고
    • Comparison of mechanisms responsible for resistance to idarubicin and daunorubicin in multidrug resisitant LoVo cell lines
    • Toffoli G, Simone F, Gigante M, et al: Comparison of mechanisms responsible for resistance to idarubicin and daunorubicin in multidrug resisitant LoVo cell lines. Biochem Pharmacol 48:1871-1881, 1994
    • (1994) Biochem Pharmacol , vol.48 , pp. 1871-1881
    • Toffoli, G.1    Simone, F.2    Gigante, M.3
  • 30
    • 0027957132 scopus 로고
    • Metabolism of Taxol by human hepatic microsomes and liver slices: Participation of cytochrome P450 3A4 and and unknown P450 enzyme
    • Harris JW, Rahman A, Bok-Ryang K, et al: Metabolism of Taxol by human hepatic microsomes and liver slices: Participation of cytochrome P450 3A4 and and unknown P450 enzyme. Cancer Res 54:4026-4035, 1994
    • (1994) Cancer Res , vol.54 , pp. 4026-4035
    • Harris, J.W.1    Rahman, A.2    Bok-Ryang, K.3
  • 31
    • 0026772298 scopus 로고
    • Effect of P-glycoprotein expression on the accumulation and cytotoxicity of topotecan (SK & F 104864), a new camptothecin analogue
    • Hendricks C, Rowinsky E, Grochow L , et al: Effect of P-glycoprotein expression on the accumulation and cytotoxicity of topotecan (SK & F 104864), a new camptothecin analogue. Cancer Res 52:2268-2278, 1992
    • (1992) Cancer Res , vol.52 , pp. 2268-2278
    • Hendricks, C.1    Rowinsky, E.2    Grochow, L.3
  • 32
    • 0027080065 scopus 로고
    • Preclinical and clinical pharmacology of vinca alkaloids
    • Zhou X, Rahmani R : Preclinical and clinical pharmacology of vinca alkaloids Drugs 44:1-16, 1992 (suppl 4)
    • (1992) Drugs , vol.44 , Issue.4 SUPPL. , pp. 1-16
    • Zhou, X.1    Rahmani, R.2
  • 33
    • 0029165313 scopus 로고
    • P-glycoprotein mediated resistance to 5'-nor-anhydro-vinblastine (Navelbine)
    • Adams D, Knick V: P-glycoprotein mediated resistance to 5'-nor-anhydro-vinblastine (Navelbine). Invest New Drugs 13:13-21, 1995
    • (1995) Invest New Drugs , vol.13 , pp. 13-21
    • Adams, D.1    Knick, V.2
  • 34
    • 0000604128 scopus 로고    scopus 로고
    • A phase I study of CYP3A4 modulation of oral etoposide with ketoconazole in patients with advanced cancer
    • abstr 1489
    • Kobayashi K, Ratain MJ, Fleming GF, et al: A phase I study of CYP3A4 modulation of oral etoposide with ketoconazole in patients with advanced cancer. Proc Am Soc Cin Oncol 15:471, 1996 (abstr 1489)
    • (1996) Proc Am Soc Cin Oncol , vol.15 , pp. 471
    • Kobayashi, K.1    Ratain, M.J.2    Fleming, G.F.3
  • 35
    • 0026536551 scopus 로고
    • Characterization of human cytochrome P450 enzymes
    • Guengerich, FP: Characterization of human cytochrome P450 enzymes. FASEB J 6:745-748, 1992
    • (1992) FASEB J , vol.6 , pp. 745-748
    • Guengerich, F.P.1
  • 36
    • 0028113492 scopus 로고
    • Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel: Lack of prediction by the erythromycin breath test
    • Lown, KS, Kolars JC, Thummel KE, et al: Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel: Lack of prediction by the erythromycin breath test. Drug Metab Dispos 22:947-955, 1994
    • (1994) Drug Metab Dispos , vol.22 , pp. 947-955
    • Lown, K.S.1    Kolars, J.C.2    Thummel, K.E.3
  • 37
    • 0027427551 scopus 로고
    • Regulation of human liver cytochromes P-450in family 3A in primary and continuous culture of human hepatocytes
    • Schuetz E, Schuetz J, Strom S, et al: Regulation of human liver cytochromes P-450in family 3A in primary and continuous culture of human hepatocytes. Hepatology 18:1254-1262, 1993
    • (1993) Hepatology , vol.18 , pp. 1254-1262
    • Schuetz, E.1    Schuetz, J.2    Strom, S.3
  • 38
    • 0025872863 scopus 로고
    • Identification of the cytochrome P450 IIIA family as the enzymes involved in the N-demethylation of tamoxifen in human liver microsomes
    • Jacolot F, Simon I, Dreano Y, et al: Identification of the cytochrome P450 IIIA family as the enzymes involved in the N-demethylation of tamoxifen in human liver microsomes. Biochem Pharmacol 41:1911-1919, 1991
    • (1991) Biochem Pharmacol , vol.41 , pp. 1911-1919
    • Jacolot, F.1    Simon, I.2    Dreano, Y.3
  • 39
    • 0022467917 scopus 로고
    • Oxidation of quinidine by human liver cytochrome P450
    • Guengerich F, Muller-Enoch D, Blair I: Oxidation of quinidine by human liver cytochrome P450. Mol Pharmacol 30:287-295, 1986
    • (1986) Mol Pharmacol , vol.30 , pp. 287-295
    • Guengerich, F.1    Muller-Enoch, D.2    Blair, I.3
  • 40
    • 0027443019 scopus 로고
    • Involvement of human liver cytochrome P450 3A in vinblastine metabolism: Drug interactions
    • Zhou-Pan XR, Seree E, Zhou XJ, et al: Involvement of human liver cytochrome P450 3A in vinblastine metabolism: Drug interactions. Cancer Res 53:5121-5126, 1993
    • (1993) Cancer Res , vol.53 , pp. 5121-5126
    • Zhou-Pan, X.R.1    Seree, E.2    Zhou, X.J.3
  • 41
    • 0026457407 scopus 로고
    • Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction
    • Herbert MF, Roberts JP, Prueksaritanost T, et al: Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction. Clinical Pharmacol Ther 52:453-457, 1992
    • (1992) Clinical Pharmacol Ther , vol.52 , pp. 453-457
    • Herbert, M.F.1    Roberts, J.P.2    Prueksaritanost, T.3
  • 42
    • 0023952327 scopus 로고
    • Erythromycin enhances the absorption of cyclosporine
    • Gupta SK: Erythromycin enhances the absorption of cyclosporine. Br J Clin Pharmacol 25:401-402, 1988
    • (1988) Br J Clin Pharmacol , vol.25 , pp. 401-402
    • Gupta, S.K.1
  • 43
    • 0029123393 scopus 로고
    • The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine
    • Gomez DY, Wacher VJ, Tomlanovich SJ, et al: The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine. Clin Pharmacol Ther 58:15-19, 1995
    • (1995) Clin Pharmacol Ther , vol.58 , pp. 15-19
    • Gomez, D.Y.1    Wacher, V.J.2    Tomlanovich, S.J.3
  • 44
    • 0029089702 scopus 로고
    • Ketoconazole to reduce the need for cyclosporine after cardiac transplantation
    • Keogh A, Spratt P, McCosker C, et al: Ketoconazole to reduce the need for cyclosporine after cardiac transplantation. N Engl J Med 333:628-633, 1995
    • (1995) N Engl J Med , vol.333 , pp. 628-633
    • Keogh, A.1    Spratt, P.2    McCosker, C.3
  • 45
    • 0023447098 scopus 로고
    • Cellular localization ot the multidrug resistance gene product P-glycoprotein in normal human tissues
    • Thiebaut F, Tsuruo T, Hamada H, et al: Cellular localization ot the multidrug resistance gene product P-glycoprotein in normal human tissues. Proc Natl Acad Sci USA 84:7735-7738, 1987
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 7735-7738
    • Thiebaut, F.1    Tsuruo, T.2    Hamada, H.3
  • 46
    • 0027987065 scopus 로고
    • Polarized transport of docetaxel and vinblastine mediated by P-glycoprotein in human intestinal epithelial cell monolayers
    • Wils P, Phung B, Warney A, et al: Polarized transport of docetaxel and vinblastine mediated by P-glycoprotein in human intestinal epithelial cell monolayers. Biochem Pharmacol 48:1528-1530, 1994
    • (1994) Biochem Pharmacol , vol.48 , pp. 1528-1530
    • Wils, P.1    Phung, B.2    Warney, A.3
  • 47
    • 12644278301 scopus 로고    scopus 로고
    • Limited oral bioavailability and active epithelial excretion of pacllitaxel (Taxol) caused by P-glycoprotein in the intestine
    • Sparreboom A, Van Asperen J, Mayer U, et al: Limited oral bioavailability and active epithelial excretion of pacllitaxel (Taxol) caused by P-glycoprotein in the intestine. Proc Natl Acad Sci USA 94:2031-2035, 1997
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 2031-2035
    • Sparreboom, A.1    Van Asperen, J.2    Mayer, U.3
  • 48
    • 0028801904 scopus 로고
    • Inhibition of intestinal P-glycoprotein and effects on etoposide absorption
    • Leu BL, Huang JD: Inhibition of intestinal P-glycoprotein and effects on etoposide absorption. Cancer Chemother Pharmacol 35:432-436, 1995
    • (1995) Cancer Chemother Pharmacol , vol.35 , pp. 432-436
    • Leu, B.L.1    Huang, J.D.2
  • 49
    • 0001942669 scopus 로고    scopus 로고
    • Enhanced oral bioavailability of paclitaxel in mice treated wtih the P-glycoprotein blocker SDZ PSC 833 or cyclosporin A
    • abstr 33
    • Van Asperen J, Van Tellingen O, Sparreboom A, et al: Enhanced oral bioavailability of paclitaxel in mice treated wtih the P-glycoprotein blocker SDZ PSC 833 or cyclosporin A. Proc Am Soc Cancer Res 38:5, 1997 (abstr 33)
    • (1997) Proc Am Soc Cancer Res , vol.38 , pp. 5
    • Van Asperen, J.1    Van Tellingen, O.2    Sparreboom, A.3
  • 50
    • 0019378585 scopus 로고
    • Dose-response effect of adjuvant chemotherapy in breast cancer
    • Bonadonna G, Valagussa P: Dose-response effect of adjuvant chemotherapy in breast cancer. N Engl J Med 304:10-15, 1981
    • (1981) N Engl J Med , vol.304 , pp. 10-15
    • Bonadonna, G.1    Valagussa, P.2
  • 51
    • 0025138455 scopus 로고
    • Patient noncompliance with self administered chemotherapy
    • Lebovits AH, Strain J, Schleifer SJ, et al: Patient noncompliance with self administered chemotherapy. Cancer 65:17-22, 1990
    • (1990) Cancer , vol.65 , pp. 17-22
    • Lebovits, A.H.1    Strain, J.2    Schleifer, S.J.3
  • 52
    • 0023580351 scopus 로고
    • Compliance with oral drug therapy in patients with hematologic malignancy
    • Levine AM, Richardson JL, Marks G, et al: Compliance with oral drug therapy in patients with hematologic malignancy J Clin Oncol 5:1469-1476, 1987
    • (1987) J Clin Oncol , vol.5 , pp. 1469-1476
    • Levine, A.M.1    Richardson, J.L.2    Marks, G.3
  • 53
    • 0024273336 scopus 로고
    • The influence of symptoms of disease and side effects of treatment on compliance with cancer therapy
    • Richardson JL, Marks G, Levine AM: The influence of symptoms of disease and side effects of treatment on compliance with cancer therapy. J Clin Oncol 6:1746-1752, 1988
    • (1988) J Clin Oncol , vol.6 , pp. 1746-1752
    • Richardson, J.L.1    Marks, G.2    Levine, A.M.3
  • 54
    • 0026633085 scopus 로고
    • Patient compliance with oral chemotherapy as assessed by a novel oral technique
    • Lee CR, Nicholson PW, Souhami RL, et al: Patient compliance with oral chemotherapy as assessed by a novel oral technique. J. Clin Oncol 10:1007-1013, 1992
    • (1992) J. Clin Oncol , vol.10 , pp. 1007-1013
    • Lee, C.R.1    Nicholson, P.W.2    Souhami, R.L.3
  • 55
    • 0027409347 scopus 로고
    • Patient compliance with prolonged low-dose oral etoposide for small cell lung cancer
    • Lee C, Nicholson P, Souhami R, et al: Patient compliance with prolonged low-dose oral etoposide for small cell lung cancer. Br J Cancer 67:630-634, 1993
    • (1993) Br J Cancer , vol.67 , pp. 630-634
    • Lee, C.1    Nicholson, P.2    Souhami, R.3
  • 56
    • 0024317509 scopus 로고
    • Oral 5-fluorouracil in psoriasis: Pharmacokinetic-pharmacodynamic relationships
    • Abernethy DR, Alper JC, Wiemann, MC, et al: Oral 5-fluorouracil in psoriasis: Pharmacokinetic-pharmacodynamic relationships. Pharmacology 39:78-88, 1989
    • (1989) Pharmacology , vol.39 , pp. 78-88
    • Abernethy, D.R.1    Alper, J.C.2    Wiemann, M.C.3
  • 57
    • 0016215029 scopus 로고
    • Clinical pharmacology of oral and intravenous 5- fluorouracil
    • Cohen JL, Irwin LE, Marshall GJ, et al: Clinical pharmacology of oral and intravenous 5- fluorouracil. Cancer Chemother Rep 58:723-731, 1974
    • (1974) Cancer Chemother Rep , vol.58 , pp. 723-731
    • Cohen, J.L.1    Irwin, L.E.2    Marshall, G.J.3
  • 58
    • 0018406637 scopus 로고
    • Plasma levels of 5-FU after oral and intravenous administration in cancer patients
    • Finch, RE, Bending, MR, Lant AF: Plasma levels of 5-FU after oral and intravenous administration in cancer patients. Br J Pharmacol 7:613-617, 1979
    • (1979) Br J Pharmacol , vol.7 , pp. 613-617
    • Finch, R.E.1    Bending, M.R.2    Lant, A.F.3
  • 59
    • 0019139183 scopus 로고
    • Pharmacokinetics of oral and intravenous fluorouracil in humans
    • Phillips TA, Howell A, Grieve R, et al: Pharmacokinetics of oral and intravenous fluorouracil in humans. J Pharm Sci 69:1428-1431, 1980
    • (1980) J Pharm Sci , vol.69 , pp. 1428-1431
    • Phillips, T.A.1    Howell, A.2    Grieve, R.3
  • 60
    • 0018095703 scopus 로고
    • Fluorouracil therapy in patients with carcinoma of the large bowel: A pharmacokinetic comparison of various rates and routes of administration
    • Christophidis N, Vajda FJE, Lucas I, et al: Fluorouracil therapy in patients with carcinoma of the large bowel: A pharmacokinetic comparison of various rates and routes of administration. Clin Pharmacokinet 3:330-336, 1978
    • (1978) Clin Pharmacokinet , vol.3 , pp. 330-336
    • Christophidis, N.1    Vajda, F.J.E.2    Lucas, I.3
  • 61
    • 10544243363 scopus 로고    scopus 로고
    • Pharmacokinetic, oral bioavailability, and safety study of fluorouracil in patients treated with 776C85, an inactivator of dihydropyrimidine dehydrogenase
    • Baker SD, Khor SP, Adjei AA, et al: Pharmacokinetic, oral bioavailability, and safety study of fluorouracil in patients treated with 776C85, an inactivator of dihydropyrimidine dehydrogenase. J Clin Oncol 14:3085-3096, 1996
    • (1996) J Clin Oncol , vol.14 , pp. 3085-3096
    • Baker, S.D.1    Khor, S.P.2    Adjei, A.A.3
  • 63
    • 0019275803 scopus 로고
    • A review of the U.S. clinical experience of the fluoro- pyrimidine, ftorafur
    • Friedman MA, Ignoffo RS: A review of the U.S. clinical experience of the fluoro- pyrimidine, ftorafur. Cancer Treat Rev 7:205-213, 1980
    • (1980) Cancer Treat Rev , vol.7 , pp. 205-213
    • Friedman, M.A.1    Ignoffo, R.S.2
  • 64
    • 0021812781 scopus 로고
    • Relevance of the pharmacology of oral tegafur to its use as a 5-fluorouracil prodrug
    • Byfield JE, Hornbeck CL, Frankel SS, et al: Relevance of the pharmacology of oral tegafur to its use as a 5-fluorouracil prodrug. Cancer Treat Rep 69:645-652, 1985
    • (1985) Cancer Treat Rep , vol.69 , pp. 645-652
    • Byfield, J.E.1    Hornbeck, C.L.2    Frankel, S.S.3
  • 65
    • 0018746994 scopus 로고
    • Pharmacokinetics and metabolism of ftorafur in man
    • Au JL, Wu AT, Friedman MA, et al: Pharmacokinetics and metabolism of ftorafur in man. Cancer Treat Rep 63: 343-350, 1979
    • (1979) Cancer Treat Rep , vol.63 , pp. 343-350
    • Au, J.L.1    Wu, A.T.2    Friedman, M.A.3
  • 66
    • 0001560702 scopus 로고
    • Capecitabine: An orally available fluoropyrimidine with tumor selective activity
    • abstr
    • Ishitsuka H, Miwa M, Ishikawa T, et al: Capecitabine: An orally available fluoropyrimidine with tumor selective activity. Proc Am Assoc Cancer Res 36:407, 1995 (abstr)
    • (1995) Proc Am Assoc Cancer Res , vol.36 , pp. 407
    • Ishitsuka, H.1    Miwa, M.2    Ishikawa, T.3
  • 67
    • 0022486648 scopus 로고
    • The pharmacology of orally-administered chemotherapy: A reappraisal
    • Poplack DG, Balis FM, Zimm S: The pharmacology of orally-administered chemotherapy: A reappraisal. Cancer 58:473-480, 1986
    • (1986) Cancer , vol.58 , pp. 473-480
    • Poplack, D.G.1    Balis, F.M.2    Zimm, S.3
  • 68
    • 0021028642 scopus 로고
    • Inhibition of first-pass metabolism in cancer chemotherapy: Interaction of 6-mercaptopurine and allopurinol
    • Zimm S, Collins JM, Oneill D, et al: Inhibition of first-pass metabolism in cancer chemotherapy: Interaction of 6-mercaptopurine and allopurinol. Clin Pharmacol Ther 34: 810-817, 1983
    • (1983) Clin Pharmacol Ther , vol.34 , pp. 810-817
    • Zimm, S.1    Collins, J.M.2    Oneill, D.3
  • 72
    • 0017873070 scopus 로고
    • The clinical pharmacology of methotrexate: New applications of an old drug
    • Bleyer WA: The clinical pharmacology of methotrexate: New applications of an old drug. Cancer 41:36-51, 1978
    • (1978) Cancer , vol.41 , pp. 36-51
    • Bleyer, W.A.1
  • 73
    • 85038532221 scopus 로고
    • Laboratories Lederle, Pearl River, NY
    • Product Information, Methotrexate, Laboratories Lederle, Pearl River, NY, 1989
    • (1989) Product Information, Methotrexate
  • 74
    • 0029102155 scopus 로고
    • Pharmacology, relative bioavailability and toxicity of three different oral cyclophosphamide preparations in a randomized, cross over study
    • Stewart DJ, Morgan LR, Verma S, et al: Pharmacology, relative bioavailability and toxicity of three different oral cyclophosphamide preparations in a randomized, cross over study. Invest New Drugs 13:99-107, 1995
    • (1995) Invest New Drugs , vol.13 , pp. 99-107
    • Stewart, D.J.1    Morgan, L.R.2    Verma, S.3
  • 75
    • 0344154490 scopus 로고
    • Roche Pharmaceuticals, Nutley, NJ
    • Product Information, Matulane, Roche Pharmaceuticals, Nutley, NJ, 1994
    • (1994) Product Information, Matulane
  • 79
    • 0024311445 scopus 로고
    • Pharmacokinetic and metabolic studies of high-dose busulfan in adults
    • Hassan M, Oberg G, Ehrsson H, et al: Pharmacokinetic and metabolic studies of high-dose busulfan in adults. Eur J Clin Pharmacol 36:525-530, 1989
    • (1989) Eur J Clin Pharmacol , vol.36 , pp. 525-530
    • Hassan, M.1    Oberg, G.2    Ehrsson, H.3
  • 81
    • 0029089517 scopus 로고
    • A phase I and pharmacology study of on oral platinum complex, JM216: Dose-dependent pharmacokinetics with single dose administration
    • McKeage MJ, Mistry P, Ward J, et al: A phase I and pharmacology study of on oral platinum complex, JM216: Dose-dependent pharmacokinetics with single dose administration. Cancer Chemother Pharmacol 36:451-458, 1995
    • (1995) Cancer Chemother Pharmacol , vol.36 , pp. 451-458
    • McKeage, M.J.1    Mistry, P.2    Ward, J.3
  • 82
    • 0030742993 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of an oral platinum complex given daily for 5 days in patients with cancer
    • McKeage MJ, Raynaud, F, Ward J, et al: Phase I and pharmacokinetic study of an oral platinum complex given daily for 5 days in patients with cancer. J Clin Oncol 15:2691-2700, 1997
    • (1997) J Clin Oncol , vol.15 , pp. 2691-2700
    • McKeage, M.J.1    Raynaud, F.2    Ward, J.3
  • 83
    • 0029947258 scopus 로고    scopus 로고
    • Biotransformation of the platinum drug JM-216 following oral administration to cancer patients
    • Raynaud FI., Mistry P, Donaghue A, et al: Biotransformation of the platinum drug JM-216 following oral administration to cancer patients. Cancer Chemother Pharmacol 38:155-162, 1996
    • (1996) Cancer Chemother Pharmacol , vol.38 , pp. 155-162
    • Raynaud, F.I.1    Mistry, P.2    Donaghue, A.3
  • 84
    • 0027502954 scopus 로고
    • New chemotherapeutic agents in non small cell lung cancer
    • Feigal EG, Christian M, Chesson B, et al: New chemotherapeutic agents in non small cell lung cancer. Semin Oncol 20:185-201, 1993
    • (1993) Semin Oncol , vol.20 , pp. 185-201
    • Feigal, E.G.1    Christian, M.2    Chesson, B.3
  • 85
    • 0025949951 scopus 로고
    • Pharmacokinetics of navelbine after oral administration
    • Zhou XJ, Bore P, Monjanel S, et al: Pharmacokinetics of navelbine after oral administration. Cancer Chemother Pharmacol 29:66-70, 1991
    • (1991) Cancer Chemother Pharmacol , vol.29 , pp. 66-70
    • Zhou, X.J.1    Bore, P.2    Monjanel, S.3
  • 86
    • 0028829131 scopus 로고
    • Topotecan in colorectal cancer: A phase II study of the EORTC Early Clinical Trials Group
    • suppl
    • Creemers GL, Wanders J, Gamucci T, et al: Topotecan in colorectal cancer: A phase II study of the EORTC Early Clinical Trials Group. Ann Oncol 6:844-846, 1995 (suppl)
    • (1995) Ann Oncol , vol.6 , pp. 844-846
    • Creemers, G.L.1    Wanders, J.2    Gamucci, T.3
  • 87
    • 0027972726 scopus 로고
    • Topoisomerase I inhibitors: Topotecan and irinotecan
    • Creemers GL, Lund BJ, Verweijt J: Topoisomerase I inhibitors: Topotecan and irinotecan. Cancer Treat Rev 20:73-96, 1994
    • (1994) Cancer Treat Rev , vol.20 , pp. 73-96
    • Creemers, G.L.1    Lund, B.J.2    Verweijt, J.3
  • 88
    • 0029973829 scopus 로고    scopus 로고
    • Bioavailability and pharmacokinetics of oral topotecan: A new topoisomerase I inhibitor
    • Schellens JHM, Creemers GJ, Beijnen JL, et al: Bioavailability and pharmacokinetics of oral topotecan: A new topoisomerase I inhibitor. Br J Cancer 73:1268-1271, 1996
    • (1996) Br J Cancer , vol.73 , pp. 1268-1271
    • Schellens, J.H.M.1    Creemers, G.J.2    Beijnen, J.L.3
  • 89
    • 0010296059 scopus 로고
    • Oral bioavailability of 9-aminocamptothecin in adult patients with solid tumors
    • abstr 504
    • Sparreboom A, Stoter G, Loos WJ, et al: Oral bioavailability of 9-aminocamptothecin in adult patients with solid tumors. Proc Am Assoc Cancer Res 38:75, 1007 (abstr 504)
    • (1007) Proc Am Assoc Cancer Res , vol.38 , pp. 75
    • Sparreboom, A.1    Stoter, G.2    Loos, W.J.3
  • 90
    • 1842340863 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of oral 9-aminocamptothecin (9-AC)
    • abstr 706
    • Mani S, Iyer L, Janisch L, et al: Phase I clinical and pharmacokinetic study of oral 9-aminocamptothecin (9-AC). Proc Am Soc Clin Oncol 16:201a, 1997 (abstr 706)
    • (1997) Proc Am Soc Clin Oncol , vol.16
    • Mani, S.1    Iyer, L.2    Janisch, L.3
  • 91
    • 0018869414 scopus 로고
    • Activation of ftorafur to 5-fluorouracil and gamma-butyrolactone
    • Au JL, Sadee W: Activation of ftorafur to 5-fluorouracil and gamma-butyrolactone. Cancer Res 40:2814-2819, 1980
    • (1980) Cancer Res , vol.40 , pp. 2814-2819
    • Au, J.L.1    Sadee, W.2
  • 92
    • 0018216763 scopus 로고
    • Effect of uracil and its derivatives on antitumor activity of 5-fluorouracil and 1-(2-tetrahydrofuryl)-5-fluorouracil
    • Fujii S, Ikenaka K, Fukushima M, et al: Effect of uracil and its derivatives on antitumor activity of 5-fluorouracil and 1-(2-tetrahydrofuryl)-5-fluorouracil. Jpn J Cancer Res 69:763-772, 1978
    • (1978) Jpn J Cancer Res , vol.69 , pp. 763-772
    • Fujii, S.1    Ikenaka, K.2    Fukushima, M.3
  • 93
    • 0029972388 scopus 로고    scopus 로고
    • A phase I and pharmacokinetic study of oral uracil, ftorafur, and leucovorin in patients with advanced cancer
    • Meropol NJ, Rustum YM, Petrelli NJ, et al: A phase I and pharmacokinetic study of oral uracil, ftorafur, and leucovorin in patients with advanced cancer. Cancer Chemother Pharmacol 37:581-586, 1996
    • (1996) Cancer Chemother Pharmacol , vol.37 , pp. 581-586
    • Meropol, N.J.1    Rustum, Y.M.2    Petrelli, N.J.3
  • 94
    • 0028820944 scopus 로고
    • A fixed-ratio combination of uracil and ftorafur UFT. with low dose leucovorin: An active oral regimen for advanced colon cancer
    • Saltz LB, Leichman CG, Young CW, et al: A fixed-ratio combination of uracil and ftorafur (UFT. with low dose leucovorin: An active oral regimen for advanced colon cancer. Cancer 75:782-785, 1995
    • (1995) Cancer , vol.75 , pp. 782-785
    • Saltz, L.B.1    Leichman, C.G.2    Young, C.W.3
  • 95
    • 0023726563 scopus 로고
    • Report on nationwide pooled data and cohort investigation in UFT phase II study
    • Ota K, Taguchi T, Kimura K: Report on nationwide pooled data and cohort investigation in UFT phase II study. Cancer Chemother Pharmacol 22:333-338, 1988
    • (1988) Cancer Chemother Pharmacol , vol.22 , pp. 333-338
    • Ota, K.1    Taguchi, T.2    Kimura, K.3
  • 96
    • 0028099423 scopus 로고
    • Phase II trial of uracil and tegafur plus oral leucovorin: An effective oral regimen in the treatment of metastatic colorectal carcinoma
    • Pazdur R, Lassere Y, Rhodes V, et al: Phase II trial of uracil and tegafur plus oral leucovorin: An effective oral regimen in the treatment of metastatic colorectal carcinoma. J Clin Oncol 12:2296-2300, 1994
    • (1994) J Clin Oncol , vol.12 , pp. 2296-2300
    • Pazdur, R.1    Lassere, Y.2    Rhodes, V.3
  • 97
    • 0023614204 scopus 로고
    • Oral ftorafur versus intravenous 5-fluorouracil: A comparative study in patients with colorectal cancer
    • Andersen E, Pedersen H: Oral ftorafur versus intravenous 5-fluorouracil: A comparative study in patients with colorectal cancer. Acta Oncol 26:433-436, 1987
    • (1987) Acta Oncol , vol.26 , pp. 433-436
    • Andersen, E.1    Pedersen, H.2
  • 98
    • 0020530463 scopus 로고
    • Activation of 5'-deoxy-5-fluorouridine by thymidine phosphorylase in human tumors
    • Kono A, Hara Y, Sugata S, et al: Activation of 5'-deoxy-5-fluorouridine by thymidine phosphorylase in human tumors. Chem Pharm Bull 31:175-178, 1983
    • (1983) Chem Pharm Bull , vol.31 , pp. 175-178
    • Kono, A.1    Hara, Y.2    Sugata, S.3
  • 99
    • 0018821981 scopus 로고
    • Role of uridine phosphorylase for antitumor activity of 5'-deoxy-5-fluorouridine
    • Ishitsuka H, Miwa M, Takemoto K, et al: Role of uridine phosphorylase for antitumor activity of 5'-deoxy-5-fluorouridine. Gann 71:112-123, 1980
    • (1980) Gann , vol.71 , pp. 112-123
    • Ishitsuka, H.1    Miwa, M.2    Takemoto, K.3
  • 100
    • 0000636011 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of capecitabine in two phase I studies
    • abstr 1509
    • Twelves C, Budman DR, Creaven, PJ, et al: Pharmacokinetics and pharmacodynamics of capecitabine in two phase I studies. Proc Am Soc Clin Oncol 16:476, 1996 (abstr 1509)
    • (1996) Proc Am Soc Clin Oncol , vol.16 , pp. 476
    • Twelves, C.1    Budman, D.R.2    Creaven, P.J.3
  • 101
    • 0000447472 scopus 로고    scopus 로고
    • Tumor selectivity of Xeloda in colorectal cancer patients
    • abstr 797
    • Schuller J, Cassidy J, Reigner BG, et al: Tumor selectivity of Xeloda in colorectal cancer patients. Proc Am Soc Clin Oncol 16:227, 1997 (abstr 797)
    • (1997) Proc Am Soc Clin Oncol , vol.16 , pp. 227
    • Schuller, J.1    Cassidy, J.2    Reigner, B.G.3
  • 102
    • 0000344523 scopus 로고    scopus 로고
    • A randomised phase II study of Xeloda (capecitabine) in patients with advanced colorectal cancer
    • abstr 7
    • Findlay M, Van Cutsem E, Kocha W, et al: A randomised phase II study of Xeloda (capecitabine) in patients with advanced colorectal cancer. Proc Am Soc Clin Oncol 16:227, 1997 (abstr 7)
    • (1997) Proc Am Soc Clin Oncol , vol.16 , pp. 227
    • Findlay, M.1    Van Cutsem, E.2    Kocha, W.3
  • 103
    • 0002685062 scopus 로고
    • Fluorinated pyrimidines
    • Chabner BA, Collins JA (eds): Philadelphia, PA, Lippincott
    • Grem JL: Fluorinated pyrimidines, in Chabner BA, Collins JA (eds): Cancer Chemotherapy Priniciples and Practice. Philadelphia, PA, Lippincott, 1990, pp 180-224
    • (1990) Cancer Chemotherapy Priniciples and Practice , pp. 180-224
    • Grem, J.L.1
  • 104
    • 0027135995 scopus 로고
    • 5-Ethynyluracil (776C85): Inactivation of dihydropyridine dehydrogenase in vivo
    • Spector T, Harrington JA, Porter DJ: 5-Ethynyluracil (776C85): Inactivation of dihydropyridine dehydrogenase in vivo. Biochem Pharmacol 46:2243-2248, 1993
    • (1993) Biochem Pharmacol , vol.46 , pp. 2243-2248
    • Spector, T.1    Harrington, J.A.2    Porter, D.J.3
  • 105
    • 0027489763 scopus 로고
    • 776C85: Effects on the pharmacokinetics and antitumor activity of 5-fluorouracil
    • Baccanari DP, Davis ST, Knick VC et al: 776C85: Effects on the pharmacokinetics and antitumor activity of 5-fluorouracil. Proc Natl Acad Sci USA 90:11064-11068, 1993
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 11064-11068
    • Baccanari, D.P.1    Davis, S.T.2    Knick, V.C.3
  • 106
    • 0028281781 scopus 로고
    • 5-Ethynyluracil (776C85): Modulation of 5-fluorouracil efficacy and therapeutic index in rats bearing advanced colorectal carcinoma
    • Cao S, Rustum YM, Spector T: 5-Ethynyluracil (776C85): Modulation of 5-fluorouracil efficacy and therapeutic index in rats bearing advanced colorectal carcinoma. Cancer Res 54:1507-1510, 1994
    • (1994) Cancer Res , vol.54 , pp. 1507-1510
    • Cao, S.1    Rustum, Y.M.2    Spector, T.3
  • 107
    • 0000513126 scopus 로고    scopus 로고
    • A phase n study of a five day regimen of oral 5-fluorouracil (5-FU) plus GW776 (776C85) with or without leucovorin in patients with metastatic colorectal cancer
    • abstr 961
    • Schilsky R, Bukowski R, Burris H, et al: A phase n study of a five day regimen of oral 5-fluorouracil (5-FU) plus GW776 (776C85) with or without leucovorin in patients with metastatic colorectal cancer. Proc Am Soc Clin Oncol 16:271a, 1997 (abstr 961)
    • (1997) Proc Am Soc Clin Oncol , vol.16
    • Schilsky, R.1    Bukowski, R.2    Burris, H.3
  • 108
    • 0028025381 scopus 로고
    • Schedule dependency of orally administered bis-aceto-ammine-dichloro-cyclohexylamine-platinum (IV) (JM216) in vivo
    • McKeage MJ, Kelland LR, Boxall FE, et al: Schedule dependency of orally administered bis-aceto-ammine-dichloro-cyclohexylamine-platinum (IV) (JM216) in vivo. Cancer Res 54:4118-4122, 1994
    • (1994) Cancer Res , vol.54 , pp. 4118-4122
    • McKeage, M.J.1    Kelland, L.R.2    Boxall, F.E.3
  • 109
    • 0344586076 scopus 로고    scopus 로고
    • A phase I pharmacokinetic study of the oral platinum analogue JM216
    • abstr 754
    • Fujii H, Sasaki Y, Tamura T, et al: A phase I pharmacokinetic study of the oral platinum analogue JM216. Proc Am Soc Clin Oncol 16:215, 1997 (abstr 754)
    • (1997) Proc Am Soc Clin Oncol , vol.16 , pp. 215
    • Fujii, H.1    Sasaki, Y.2    Tamura, T.3
  • 110
    • 0345017039 scopus 로고    scopus 로고
    • Phase II trial of oral BMS-182751 (JM-216) in hormone refractory prostate cancer (HRPC)
    • abstr 1210
    • Peerebom DM, Wood L, Connell J, et al: Phase II trial of oral BMS-182751 (JM-216) in hormone refractory prostate cancer (HRPC). Proc Am Soc Clin Oncol 16:339, 1997 (abstr 1210)
    • (1997) Proc Am Soc Clin Oncol , vol.16 , pp. 339
    • Peerebom, D.M.1    Wood, L.2    Connell, J.3
  • 111
    • 0027215201 scopus 로고
    • Lack of nephrotoxicity of oral ammine/amine platinum(IV) dicarboxylate complexes in rodents
    • McKeage MJ, Morgan SE, Boxall FE, et al: Lack of nephrotoxicity of oral ammine/amine platinum(IV) dicarboxylate complexes in rodents. Br J Cancer 67:996-1000, 1993
    • (1993) Br J Cancer , vol.67 , pp. 996-1000
    • McKeage, M.J.1    Morgan, S.E.2    Boxall, F.E.3
  • 112
    • 0027958608 scopus 로고
    • Lack of neurotoxicity or oral bis-aceto-ammine- Dichloro-cyclohexylamine-platinum (IV) (JM216) in comparison to cisplatin and tetraplatin in the rat
    • McKeage, MJ, Boxall F, Jones M, et al: Lack of neurotoxicity or oral bis-aceto-ammine- dichloro-cyclohexylamine-platinum (IV) (JM216) in comparison to cisplatin and tetraplatin in the rat. Cancer Res 54:629-631, 1994
    • (1994) Cancer Res , vol.54 , pp. 629-631
    • McKeage, M.J.1    Boxall, F.2    Jones, M.3
  • 113
    • 0010267330 scopus 로고    scopus 로고
    • A phase II study of oral platinum JM-216 as a first line treatment in small cell lung cancer
    • abstr 1128
    • Groen HJM, Smit EF, Bauer J, et al: A phase II study of oral platinum JM-216 as a first line treatment in small cell lung cancer. Proc Am Soc Clin Oncol 15:378, 1996 (abstr 1128)
    • (1996) Proc Am Soc Clin Oncol , vol.15 , pp. 378
    • Groen, H.J.M.1    Smit, E.F.2    Bauer, J.3
  • 114
    • 0031159653 scopus 로고    scopus 로고
    • A phase II trail of oral platinum complex JM-216 in non-small-cell lung cancer: An EORTC Early Clinical Studies Group investigation
    • Judson I, Cerny T, Epelbaum R, et al: A phase II trail of oral platinum complex JM-216 in non-small-cell lung cancer: An EORTC Early Clinical Studies Group investigation. Ann Oncol 8:604-606, 1997
    • (1997) Ann Oncol , vol.8 , pp. 604-606
    • Judson, I.1    Cerny, T.2    Epelbaum, R.3
  • 115
    • 0027996614 scopus 로고
    • The clinical pharmacokinetics of vinorelbine (navelbine)
    • Wargin W, Lucas V: The clinical pharmacokinetics of vinorelbine (navelbine). Semin Oncol 21:21-27, 1994
    • (1994) Semin Oncol , vol.21 , pp. 21-27
    • Wargin, W.1    Lucas, V.2
  • 116
    • 0027987481 scopus 로고
    • Pharmacokinetic, bioavailability and feasibility study of oral vinorelbine in patients with solid tumors
    • Rowinsky E, Noe D, Trump D, et al: Pharmacokinetic, bioavailability and feasibility study of oral vinorelbine in patients with solid tumors. J Clin Oncol 12:1754-1763, 1994
    • (1994) J Clin Oncol , vol.12 , pp. 1754-1763
    • Rowinsky, E.1    Noe, D.2    Trump, D.3
  • 117
    • 0028931164 scopus 로고
    • Multicenter phase II study of weekly oral vinorelbine for stage IV non-small-cell lung cancer
    • Vokes E, Rosenberg R, Jahanzeb M, et al: Multicenter phase II study of weekly oral vinorelbine for stage IV non-small-cell lung cancer. J Clin Oncol 13:637-644, 1995
    • (1995) J Clin Oncol , vol.13 , pp. 637-644
    • Vokes, E.1    Rosenberg, R.2    Jahanzeb, M.3
  • 118
    • 0001373390 scopus 로고
    • A US multicenter phase II trial of oral Navelbine in elderly women with advanced breast cancer
    • abstr 24
    • Winer E, O'Rourke M, Vogel C, et al: A US multicenter phase II trial of oral Navelbine in elderly women with advanced breast cancer. Breast Cancer Res Treat 27:136, 1993 (abstr 24)
    • (1993) Breast Cancer Res Treat , vol.27 , pp. 136
    • Winer, E.1    O'Rourke, M.2    Vogel, C.3
  • 119
    • 0029116438 scopus 로고
    • Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts in human tumors
    • Houghton PJ, Cheshire PJ, Hallman JD, et al: Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts in human tumors. Cancer Chemother Pharamcol 36:393-403, 1995
    • (1995) Cancer Chemother Pharamcol , vol.36 , pp. 393-403
    • Houghton, P.J.1    Cheshire, P.J.2    Hallman, J.D.3
  • 120
    • 0028225686 scopus 로고
    • Comparative activity of oral and parenteral topotecan in murine tumor models: Efficacy of oral topotecan
    • McCabe FL, Johnson RK: Comparative activity of oral and parenteral topotecan in murine tumor models: Efficacy of oral topotecan. Cancer Invest 12:308-313, 1994
    • (1994) Cancer Invest , vol.12 , pp. 308-313
    • McCabe, F.L.1    Johnson, R.K.2
  • 121
    • 0029973829 scopus 로고    scopus 로고
    • Bioavailability and pharmacokinetics of oral topotecan: A new topoisomerase inhibitor
    • Schellens JHM, Creemers GJ, Beijnen JH, et al: Bioavailability and pharmacokinetics of oral topotecan: A new topoisomerase inhibitor. Br J Cancer 73:1268-1271, 1996
    • (1996) Br J Cancer , vol.73 , pp. 1268-1271
    • Schellens, J.H.M.1    Creemers, G.J.2    Beijnen, J.H.3
  • 122
    • 0042602937 scopus 로고    scopus 로고
    • Prolonged exposure to oral topotecan, correlates between pharmacokinetics and toxicity
    • abstr 768
    • Gerrits C, Schellens J, Burris H, et al: Prolonged exposure to oral topotecan, correlates between pharmacokinetics and toxicity. Proc Am Soc Clin Oncol 16:224, 1997 (abstr 768)
    • (1997) Proc Am Soc Clin Oncol , vol.16 , pp. 224
    • Gerrits, C.1    Schellens, J.2    Burris, H.3
  • 123
    • 85038538666 scopus 로고    scopus 로고
    • Oral efficacy of irinotecan (CPT-11) in tumor bearing mice
    • abstr 499
    • Bissery MC, Vrignaud P, Lavelle F: Oral efficacy of irinotecan (CPT-11) in tumor bearing mice. Proc Am Assoc Cancer Res 38:74, 1997 (abstr 499)
    • (1997) Proc Am Assoc Cancer Res , vol.38 , pp. 74
    • Bissery, M.C.1    Vrignaud, P.2    Lavelle, F.3
  • 124
    • 0000291599 scopus 로고    scopus 로고
    • A phase I trial to evaluate orally administered irinotecan HCl (CPT-11) given daily × 5 every 3 weeks in patients with refractory malignancies
    • abstr 1560
    • Drengler R, Burris H, Dietz J, et al: A phase I trial to evaluate orally administered irinotecan HCl (CPT-11) given daily × 5 every 3 weeks in patients with refractory malignancies. Proc Am Soc Clin Oncol 15:489, 1996 (abstr 1560)
    • (1996) Proc Am Soc Clin Oncol , vol.15 , pp. 489
    • Drengler, R.1    Burris, H.2    Dietz, J.3
  • 125
    • 0008935028 scopus 로고    scopus 로고
    • A phase I and pharmacodynamic study of camptothecin (CPT-11) and etoposide (E) in patients with advanced malignancies
    • abstr 713
    • Toppmeyer D, Gupta E, Saleem A, et al: A phase I and pharmacodynamic study of camptothecin (CPT-11) and etoposide (E) in patients with advanced malignancies. Proc Am Soc Clin Oncol 16:203a, 1997 (abstr 713)
    • (1997) Proc Am Soc Clin Oncol , vol.16
    • Toppmeyer, D.1    Gupta, E.2    Saleem, A.3
  • 126
    • 0030997205 scopus 로고    scopus 로고
    • Population-based investigation of relative clearance of digoxin in Japanese patients by multiple trough screen analysis: An update
    • Yukawa E, Honda T, Shigehiro O, et al: Population-based investigation of relative clearance of digoxin in Japanese patients by multiple trough screen analysis: an update. J Clin Pharmacol 37:92-100, 1997
    • (1997) J Clin Pharmacol , vol.37 , pp. 92-100
    • Yukawa, E.1    Honda, T.2    Shigehiro, O.3
  • 127
    • 13244300645 scopus 로고    scopus 로고
    • Population pharmacokinetics of phenytoin in Japanese patients with epilepsy: Analysis with a dose-dependent clearance model
    • Odani A, Hashimoto Y, Takayanagi K, et al: Population pharmacokinetics of phenytoin in Japanese patients with epilepsy: Analysis with a dose-dependent clearance model. Biol Pharm Bull 19:444-448, 1996
    • (1996) Biol Pharm Bull , vol.19 , pp. 444-448
    • Odani, A.1    Hashimoto, Y.2    Takayanagi, K.3
  • 128
    • 0030052559 scopus 로고    scopus 로고
    • Bioavailability of 50 and 75 mg oral etoposide in lung cancer patients
    • Fujiwara Y, Ohune T, Okusaki K, et al: Bioavailability of 50 and 75 mg oral etoposide in lung cancer patients. Cancer Chemother Pharmacol 37:327-331, 1996
    • (1996) Cancer Chemother Pharmacol , vol.37 , pp. 327-331
    • Fujiwara, Y.1    Ohune, T.2    Okusaki, K.3


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