Effect of prolonged topotecan infusion on topoisomerase 1 levels: A phase I and pharmacodynamic study

Clinical Cancer Research

Volumn 3, Issue 8, 1997, Pages 1245-1252

  Hochster, Howard ^a   Liebes, Leonard ^a   Speyer, James ^a   Sorich, Joan ^a   Taubes, Beth ^a   Oratz, Ruth ^a   Wernz, James ^a   Chachoua, Abraham ^a   Blum, Ronald H ^a   Zeleniuch Jacquotte, Anne ^a  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE; TOPOTECAN;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; BLOOD TOXICITY; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG INFUSION; FEMALE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; INTRAVENOUS DRUG ADMINISTRATION; MALE; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; SOLID TUMOR;

ADULT; AGED; ANTINEOPLASTIC AGENTS; DNA TOPOISOMERASES, TYPE I; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; LEUKOCYTES, MONONUCLEAR; LEUKOPENIA; MALE; MIDDLE AGED; NEOPLASMS; THROMBOCYTOPENIA; TOPOTECAN;

EID: 0030855529     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Hochster, H., Liebes, L., Speyer, J., Sorich, J., Taubes, B., Oratz, R., Wernz, J., Chachoua, A., Raphael, B., Vinci, R. Z., and Blum, R. Phase I trial of low-dose continuous topotecan infusion (7-21 days): an active and well-tolerated regimen. J. Clin. Oncol., 12: 553-559, 1994.
2. Liu, L. Biochemistry of camptothecin. In: M. Potmesil and H. Pinedo (eds.), Camptothecins. New Anticancer Agents, pp. 9-19. Boca Raton: CRC Press, 1995.
3. Potmesil, M. Camptothecins. From bench research to hospital wards. Cancer Res., 54: 1431-1439, 1994.
4. Wang, J. DNA topoisomerases. Annu. Rev. Biochem., 54: 665-697, 1985.
5. Juan, C-C., Hwang, J., Liu, A., Whang-Peng, J., Knutsen, T., Huebner, K., Croce, C., Zhang, H., Wang, J., and Liu, L. Human DNA topoisomerase I is encoded by a single-copy gene that maps to chromosomal region 20q 12-13.2% Proc. Natl. Acad. Sci. USA, 85: 8910-8913, 1988.
6. Champoux, J., and Dulbecco, R. An activity from mammalian cells that untwists superhelical DNA: a possible swivel for DNA replication. Proc. Natl. Acad. Sci. USA, 69: 143-146, 1972.
7. Giovanella, B., Stehlin, J., Wall, M., Wani, M., Nicholas, A., Liu, L., Silber, R., and Potmesil, M. DNA topoisomerase-I targeted chemotherapy of human colon cancer in xenografts. Science (Washington DC) 246: 1046-1048, 1989.
8. Liebes, L. W. C., Chachoua, A., Oratz, R., Richards, D., Hochster, H., Peace, D., Marino, D., Alba, S., Le Sher, D., Blum, R., and Vilcek, J. Modulation of monocyte functions by muramyl tripeptide phosphatidylethanolamine in a Phase II study in patients with metastatic melanoma. J. Natl. Cancer Inst., 84: 694-698, 1992.
9. Boyum, A. Isolation of mononuclear cells and granulocytes from human blood. Isolation of mononuclear cells by one centrifugation and sedimentation at 1 g. Scand. J. Clin. Lab. Invest., 21: 77-89, 1968.
10. Beijnen, J., Smith, B. R., Keijer, W. J., Van Gijn, R., Ten Bokkel Huinink, W. W., Viasveld, L. T., Rodenhuis, S., and Underberg, W. J. M. High-performance chromatographic analysis of the new antitumor drug SK&F 104864-A (NSC609699) in plasma. J. Pharmaceut. Biomed. Anal., 8: 789-794, 1990.
11. Burton, K. Determination of DNA concentration with diphenylamine. Methods Enzymol., 12: 163-167, 1967.
12. Shero, J. H., Bordwell, B., Rothfield, N. F., and Earnshaw, W. C. High titers of autoantibodies to topoisomerase-1 (Scl-70) in sera from scleroderma patients. Science (Washington DC). 231: 737-740, 1986.
13. Liu, L., and Miller, K. Eukaryotic DNA topoisomerases. Two forms of type I DNA topoisomerase from HeLa cell nuclei. Proc Natl Acad Sci. USA, 78: 3487-3491, 1981.
14. Subramanian, D., Kraut, E., Staubus, A., Young, D., and Muller, M. Analysis of topoisomerase I/DNA complexes in patients administered topotecan. Cancer Res., 55: 2097-2103, 1995.
15. Danks, M. K., Garrett, K. E., Marion, R. C., and Whipple, D. O. Subcellular redistribution of DNA topoisomerase I in anaplastic astrocytoma cells treated with topotecan. Cancer Res., 56: 1664-1673, 1996.