Topoisomerase II inhibitors induce DNA double-strand breaks at a specific site within the AML1 locus

Leukemia

Volumn 11, Issue 4, 1997, Pages 490-496

  Stanulla, M ^a,c   Wang, J ^a   Chervinsky, D S ^a   Aplan, P D ^a,b  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b CHILDREN S HOSPITAL OF BUFFALO   (United States)

^c HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

AML1; Chromosomal translocation; Secondary leukemia; Therapy related leukemia; Topoisomerase II inhibitor

Indexed keywords

AMSACRINE; DACTINOMYCIN; DNA; DOUBLE STRANDED DNA; DOXORUBICIN; ETOPOSIDE; GYRASE INHIBITOR;

ACUTE GRANULOCYTIC LEUKEMIA; ADOLESCENT; ARTICLE; CASE REPORT; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; DNA STRAND BREAKAGE; DRUG INDUCED CANCER; DRUG MECHANISM; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL;

EID: 0030898006     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2400632     Document Type: Article

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