A functional linker in human topoisomerase I is required for maximum sensitivity to camptothecin in a DNA relaxation assay

Journal of Biological Chemistry

Volumn 274, Issue 46, 1999, Pages 32950-32960

  Stewart, Lance ^a,b   Ireton, Gregory C ^a   Champoux, James J ^a,c  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b Emerald BioStructures   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE;

ARTICLE; CATALYSIS; COMPLEX FORMATION; COVALENT BOND; CRYSTAL STRUCTURE; DNA BINDING; DNA REPLICATION; DNA SUPERCOILING; ENZYME ACTIVITY; ENZYME RECONSTITUTION; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CAMPTOTHECIN; DNA TOPOISOMERASES, TYPE I; DNA, SUPERHELICAL; DNA-BINDING PROTEINS; ELECTROPHORESIS, AGAR GEL; HUMANS; KINETICS; MODELS, MOLECULAR; OLIGODEOXYRIBONUCLEOTIDES; PEPTIDE FRAGMENTS; PLASMIDS; PROTEIN BINDING; RECOMBINANT PROTEINS; SUBTILISIN;

EID: 0032752373     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.46.32950     Document Type: Article

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