-
1
-
-
0024316466
-
DNA topoisomerase poisons as antitumor drugs
-
Liu LF: DNA topoisomerase poisons as antitumor drugs. Annu Rev Biochem 58:351-375, 1989
-
(1989)
Annu Rev Biochem
, vol.58
, pp. 351-375
-
-
Liu, L.F.1
-
3
-
-
0027972726
-
Topoisomerase I inhibitors: Topotecan and irinotecan
-
Creemerst GJ, Lund B, Verweij J: Topoisomerase I inhibitors: Topotecan and irinotecan. Cancer Treat Rev 20:73-96, 1994
-
(1994)
Cancer Treat Rev
, vol.20
, pp. 73-96
-
-
Creemerst, G.J.1
Lund, B.2
Verweij, J.3
-
4
-
-
0024324205
-
On the mechanism of topoisomerase I inhibition by camptothecin: Evidence for binding to an enzyme-DNA complex
-
Hertzberg RP, Caranfa MJ, Hecht SM: On the mechanism of topoisomerase I inhibition by camptothecin: Evidence for binding to an enzyme-DNA complex. Biochemistry 28:4629-4638, 1989
-
(1989)
Biochemistry
, vol.28
, pp. 4629-4638
-
-
Hertzberg, R.P.1
Caranfa, M.J.2
Hecht, S.M.3
-
5
-
-
0024420685
-
Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin
-
Hsiang YH, Lihou MG, Liu LF: Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin. Cancer Res 49:5077-5082, 1989
-
(1989)
Cancer Res
, vol.49
, pp. 5077-5082
-
-
Hsiang, Y.H.1
Lihou, M.G.2
Liu, L.F.3
-
6
-
-
0025115965
-
Development of a stable camptothecin-resistant subline of P388 leukemia with reduced topoisomerase I content
-
Eng WK, McCabe FL, Tan KB, et al: Development of a stable camptothecin-resistant subline of P388 leukemia with reduced topoisomerase I content. Mol Pharmacol 38:471-480, 1990
-
(1990)
Mol Pharmacol
, vol.38
, pp. 471-480
-
-
Eng, W.K.1
McCabe, F.L.2
Tan, K.B.3
-
7
-
-
0026694495
-
Topoisomerase I alteration in a camptothecin-resistant cell line derived from Chinese hamster DC3F cells in culture
-
Tanizawa A, Pommier Y: Topoisomerase I alteration in a camptothecin-resistant cell line derived from Chinese hamster DC3F cells in culture. Cancer Res 52:1848-1854, 1992
-
(1992)
Cancer Res
, vol.52
, pp. 1848-1854
-
-
Tanizawa, A.1
Pommier, Y.2
-
8
-
-
0015378084
-
Phase I clinical trial of weekly and daily treatment with camptothecin (NSC-100880): Correlation with preclinical studies
-
Muggia FM, Creaven PJ, Hansen HS, et al: Phase I clinical trial of weekly and daily treatment with camptothecin (NSC-100880): Correlation with preclinical studies. Cancer Chemother Rep 56:515-521, 1972
-
(1972)
Cancer Chemother Rep
, vol.56
, pp. 515-521
-
-
Muggia, F.M.1
Creaven, P.J.2
Hansen, H.S.3
-
9
-
-
0024560495
-
Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: Evidence for a specific receptor site and a relation to antitumor activity
-
Jaxel C, Kohn KW, Wani MC, et al: Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: Evidence for a specific receptor site and a relation to antitumor activity. Cancer Res 49:1465-1469, 1989
-
(1989)
Cancer Res
, vol.49
, pp. 1465-1469
-
-
Jaxel, C.1
Kohn, K.W.2
Wani, M.C.3
-
10
-
-
0024537205
-
Modification of the hydroxy lactone ring of camptothecin: Inhibition of mammalian topoisomerase I and biological activity
-
Hertzberg RP, Caranfa MJ, Holden KG, et al: Modification of the hydroxy lactone ring of camptothecin: Inhibition of mammalian topoisomerase I and biological activity. J Med Chem 32:715-720, 1989
-
(1989)
J Med Chem
, vol.32
, pp. 715-720
-
-
Hertzberg, R.P.1
Caranfa, M.J.2
Holden, K.G.3
-
11
-
-
0024356003
-
DNA topoisomerase I-mediated DNA cleavage and cytotoxicity of camptothecin analogues
-
Hsiang Y-H, Liu LF, Wall ME, et al: DNA topoisomerase I-mediated DNA cleavage and cytotoxicity of camptothecin analogues. Cancer Res 49:4385-4389, 1989
-
(1989)
Cancer Res
, vol.49
, pp. 4385-4389
-
-
Hsiang, Y.-H.1
Liu, L.F.2
Wall, M.E.3
-
12
-
-
0028225471
-
Comparison of topoisomerase I inhibition, DNA damage, and cytotoxicity of camptothecin derivatives presently in clinical trials
-
Tanizawa A, Fujimori A, Fujimori Y, et al: Comparison of topoisomerase I inhibition, DNA damage, and cytotoxicity of camptothecin derivatives presently in clinical trials. J Natl Cancer Inst 86:836-842, 1994
-
(1994)
J Natl Cancer Inst
, vol.86
, pp. 836-842
-
-
Tanizawa, A.1
Fujimori, A.2
Fujimori, Y.3
-
13
-
-
0026537874
-
Phase I and pharmacologic study of Topotecan: A novel topoisomerase I inhibitor
-
Rowinsky EK, Grochow LB, Hendricks CB, et al: Phase I and pharmacologic study of Topotecan: A novel topoisomerase I inhibitor. J Clin Oncol 10:647-656, 1992
-
(1992)
J Clin Oncol
, vol.10
, pp. 647-656
-
-
Rowinsky, E.K.1
Grochow, L.B.2
Hendricks, C.B.3
-
14
-
-
0027454410
-
Phase I and pharmacokinetics study of Topotecan, a new topoisomerase I inhibitor
-
Verweij J, Lund B, Beijnen J, et al: Phase I and pharmacokinetics study of Topotecan, a new topoisomerase I inhibitor. Ann Oncol 4:673-678, 1993
-
(1993)
Ann Oncol
, vol.4
, pp. 673-678
-
-
Verweij, J.1
Lund, B.2
Beijnen, J.3
-
15
-
-
0026697849
-
A phase I clinical and pharmacokinetic study of the topoisomerase I inhibitor Topotecan (SK&K 104864) given as an intravenous bolus every 21 days
-
Wall JG, Burris HA III, Von Hoff DD, et al: A phase I clinical and pharmacokinetic study of the topoisomerase I inhibitor Topotecan (SK&K 104864) given as an intravenous bolus every 21 days. Anticancer Drugs 3:337-345, 1992
-
(1992)
Anticancer Drugs
, vol.3
, pp. 337-345
-
-
Wall, J.G.1
Burris III, H.A.2
Von Hoff, D.D.3
-
16
-
-
0010267346
-
Phase I/pharmacokinetic study of Topotecan by 24-hour continuous infusion weekly
-
Haas NB, LaCreta FP, Walczak J, et al: Phase I/pharmacokinetic study of Topotecan by 24-hour continuous infusion weekly. Cancer Res 54:1220-1226, 1994
-
(1994)
Cancer Res
, vol.54
, pp. 1220-1226
-
-
Haas, N.B.1
LaCreta, F.P.2
Walczak, J.3
-
17
-
-
0028357995
-
Phase I trial of low-dose continuous Topotecan infusion in patients with cancer: An active and well-tolerated regimen
-
Hochster H, Liebes L, Speyer J, et al: Phase I trial of low-dose continuous Topotecan infusion in patients with cancer: An active and well-tolerated regimen. J Clin Oncol 12:553-559, 1994
-
(1994)
J Clin Oncol
, vol.12
, pp. 553-559
-
-
Hochster, H.1
Liebes, L.2
Speyer, J.3
-
18
-
-
0027323646
-
Phase I clinical and pharmacology study of Topotecan given daily for 5 consecutive days to patients with advanced solid tumors, with attempt at dose intensification using recombinant granulocyte colony-stimulating factor
-
Saltz L, Sirott M, Young C, et al: Phase I clinical and pharmacology study of Topotecan given daily for 5 consecutive days to patients with advanced solid tumors, with attempt at dose intensification using recombinant granulocyte colony-stimulating factor. J Natl Cancer Inst 85:1499-1507, 1993
-
(1993)
J Natl Cancer Inst
, vol.85
, pp. 1499-1507
-
-
Saltz, L.1
Sirott, M.2
Young, C.3
-
19
-
-
0003335131
-
An open phase II study to evaluate the efficacy and toxicity of Topotecan administered intravenously as 5 daily infusions every 21 days to women with advanced epithelial ovarian carcinoma
-
abstr
-
Kudelka A, Edwards C, Freedman B, et al: An open phase II study to evaluate the efficacy and toxicity of Topotecan administered intravenously as 5 daily infusions every 21 days to women with advanced epithelial ovarian carcinoma. Proc Am Soc Clin Oncol 12:1993 (abstr)
-
(1993)
Proc Am Soc Clin Oncol
, vol.12
-
-
Kudelka, A.1
Edwards, C.2
Freedman, B.3
-
20
-
-
0000943872
-
Phase II study of Topotecan in extensive stage small cell lung cancer
-
abstr
-
Schiller JH, Kim K, Johnson D, et al: Phase II study of Topotecan in extensive stage small cell lung cancer. Proc Am Soc Clin Oncol 13:330, 1994 (abstr)
-
(1994)
Proc Am Soc Clin Oncol
, vol.13
, pp. 330
-
-
Schiller, J.H.1
Kim, K.2
Johnson, D.3
-
21
-
-
0000943873
-
Phase II study of Topotecan in advanced head and neck cancer: Identification of an active new agent
-
abstr
-
Robert F, Wheeler RH, Molthrop DC, et al: Phase II study of Topotecan in advanced head and neck cancer: Identification of an active new agent. Proc Am Soc Clin Oncol 13:281, 1994 (abstr)
-
(1994)
Proc Am Soc Clin Oncol
, vol.13
, pp. 281
-
-
Robert, F.1
Wheeler, R.H.2
Molthrop, D.C.3
-
22
-
-
0027501999
-
Phase I study of Topotecan, a new topoisomerase I inhibitor, in patients with refractory or relapsed acute leukemia
-
Kantarjian HM, Beran M, Ellis A, et al: Phase I study of Topotecan, a new topoisomerase I inhibitor, in patients with refractory or relapsed acute leukemia. Blood 81:1146-1151, 1993
-
(1993)
Blood
, vol.81
, pp. 1146-1151
-
-
Kantarjian, H.M.1
Beran, M.2
Ellis, A.3
-
23
-
-
0028147296
-
Phase II study of Topotecan in metastatic non-small-cell lung cancer
-
Lynch TJ Jr, Kalish L, Strauss G, et al: Phase II study of Topotecan in metastatic non-small-cell lung cancer. J Clin Oncol 12:347-352, 1994
-
(1994)
J Clin Oncol
, vol.12
, pp. 347-352
-
-
Lynch Jr., T.J.1
Kalish, L.2
Strauss, G.3
-
24
-
-
0001730741
-
A Phase II trial of Topotecan (TPT) for the treatment of advanced, measurable colorectal cancer
-
abstr
-
Sugarman SM, Ajani JA, Daugherty K, et al: A Phase II trial of Topotecan (TPT) for the treatment of advanced, measurable colorectal cancer. Proc Am Soc Clin Oncol 13:225, 1994 (abstr)
-
(1994)
Proc Am Soc Clin Oncol
, vol.13
, pp. 225
-
-
Sugarman, S.M.1
Ajani, J.A.2
Daugherty, K.3
-
25
-
-
84871469781
-
-
Amsterdam, The Netherlands
-
Creemers GJ, Wanders J, Calabresi F, et al: Eighth NCI-EORTC Symposium on New Drugs in Cancer Therapy. Amsterdam, The Netherlands, 1994, p 191
-
(1994)
Eighth NCI-EORTC Symposium on New Drugs in Cancer Therapy
, pp. 191
-
-
Creemers, G.J.1
Wanders, J.2
Calabresi, F.3
-
26
-
-
0026531753
-
A phase II study of CPT-11, a new derivative of camptothecin, for previously untreated non-small-cell lung cancer
-
Fukuoka M, Niitani H, Suzuki A, et al: A phase II study of CPT-11, a new derivative of camptothecin, for previously untreated non-small-cell lung cancer. J Clin Oncol 10:16-20, 1992
-
(1992)
J Clin Oncol
, vol.10
, pp. 16-20
-
-
Fukuoka, M.1
Niitani, H.2
Suzuki, A.3
-
27
-
-
0026680292
-
CPT-11: A new derivative of campothecin for the treatment of refractory or relapsed small-cell lung cancer
-
Masuda N, Fukuoka M, Kusunoki T, et al: CPT-11: A new derivative of campothecin for the treatment of refractory or relapsed small-cell lung cancer. J Clin Oncol 10:1225-1229, 1992
-
(1992)
J Clin Oncol
, vol.10
, pp. 1225-1229
-
-
Masuda, N.1
Fukuoka, M.2
Kusunoki, T.3
-
28
-
-
0001796567
-
CPT-11 (irinotecan) as second-line therapy in advanced colorectal cancer (CRC): Preliminary results of multicentric phase II study
-
abstr
-
Bugat R, Sue E, Rougier P, et al: CPT-11 (irinotecan) as second-line therapy in advanced colorectal cancer (CRC): Preliminary results of multicentric phase II study. Proc Am Soc Clin Oncol 13:200, 1994 (abstr)
-
(1994)
Proc Am Soc Clin Oncol
, vol.13
, pp. 200
-
-
Bugat, R.1
Sue, E.2
Rougier, P.3
-
29
-
-
0001271895
-
A phase II trial of CPT-11 (irinotecan) in patients with metastatic colorectal carcinoma: A North Central Cancer Treatment Group (NCCTG) study
-
Pilot HC, Wender D, O'Connell MJ, et al: A phase II trial of CPT-11 (irinotecan) in patients with metastatic colorectal carcinoma: A North Central Cancer Treatment Group (NCCTG) study. Proc Am Soc Clin Oncol 13:197, 1994
-
(1994)
Proc Am Soc Clin Oncol
, vol.13
, pp. 197
-
-
Pilot, H.C.1
Wender, D.2
O'Connell, M.J.3
-
30
-
-
0028158012
-
Phase I and pharmacological study of the novel topoisomerase I inhibitor 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbony-loxycamptothecin (CPT-11) administered as a ninety-minute infusion every 3 weeks
-
Rowinsky EK, Grochow LB, Ettinger DS, et al: Phase I and pharmacological study of the novel topoisomerase I inhibitor 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbony-loxycamptothecin (CPT-11) administered as a ninety-minute infusion every 3 weeks. Cancer Res 54:427-436, 1994
-
(1994)
Cancer Res
, vol.54
, pp. 427-436
-
-
Rowinsky, E.K.1
Grochow, L.B.2
Ettinger, D.S.3
-
31
-
-
0026631164
-
Phase I study of pharmacokinetics of CPT-11 with 5-day continuous infusion
-
Ohe Y, Sasaki Y, Shinkai T, et al: Phase I study of pharmacokinetics of CPT-11 with 5-day continuous infusion. J Natl Cancer Inst 84:972-974, 1992
-
(1992)
J Natl Cancer Inst
, vol.84
, pp. 972-974
-
-
Ohe, Y.1
Sasaki, Y.2
Shinkai, T.3
-
33
-
-
33845382806
-
Nonparametric estimation from incomplete observations
-
Kaplan EL, Meier P: Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457-481, 1958
-
(1958)
J Am Stat Assoc
, vol.53
, pp. 457-481
-
-
Kaplan, E.L.1
Meier, P.2
-
34
-
-
0027292119
-
Higher expression of topoisomerase II in lung cancers than normal lung tissues: Different expression pattern from topoisomerase I
-
Hasegawa T, Isobe K, Nakashima I, et al: Higher expression of topoisomerase II in lung cancers than normal lung tissues: Different expression pattern from topoisomerase I. Biochem Biophys Res Commun 195:409-414, 1993
-
(1993)
Biochem Biophys Res Commun
, vol.195
, pp. 409-414
-
-
Hasegawa, T.1
Isobe, K.2
Nakashima, I.3
-
35
-
-
0004922422
-
Quantitation of proliferating cell fraction (PCF) in non-small cell cancer (NSCLC) using immunostaining for proliferating cell nuclear antigen (PCNA)
-
abstr
-
Lee JS, Ro JY, Sahin A, et al: Quantitation of proliferating cell fraction (PCF) in non-small cell cancer (NSCLC) using immunostaining for proliferating cell nuclear antigen (PCNA). Proc Am Assoc Cancer Res 31:22, 1990 (abstr)
-
(1990)
Proc Am Assoc Cancer Res
, vol.31
, pp. 22
-
-
Lee, J.S.1
Ro, J.Y.2
Sahin, A.3
-
36
-
-
0025834698
-
Chemotherapy of non-small cell lung cancer according to disease extent: A meta-analysis of the literature
-
Donnadieu N, Paesmans M, Sculier J-P: Chemotherapy of non-small cell lung cancer according to disease extent: A meta-analysis of the literature. Lung Cancer 7:243-252, 1991
-
(1991)
Lung Cancer
, vol.7
, pp. 243-252
-
-
Donnadieu, N.1
Paesmans, M.2
Sculier, J.-P.3
-
37
-
-
0024312867
-
Cisplatin versus cisplatin plus etoposide in the treatment of advanced non-small-cell lung cancer
-
Klastersky J, Sculier JP, Bureau G, et al: Cisplatin versus cisplatin plus etoposide in the treatment of advanced non-small-cell lung cancer. J Clin Oncol 7:1087-1092, 1989
-
(1989)
J Clin Oncol
, vol.7
, pp. 1087-1092
-
-
Klastersky, J.1
Sculier, J.P.2
Bureau, G.3
-
38
-
-
0025313120
-
Etoposide versus etoposide plus high-dose cisplatin in the management of advanced non-small cell lung cancer
-
Rosso R, Salvati F, Ardizzoni A, et al: Etoposide versus etoposide plus high-dose cisplatin in the management of advanced non-small cell lung cancer. Cancer 66:130-134, 1990
-
(1990)
Cancer
, vol.66
, pp. 130-134
-
-
Rosso, R.1
Salvati, F.2
Ardizzoni, A.3
-
39
-
-
0025146178
-
A randomized study comparing cisplatin or carboplatin with etoposide in patients with advanced non-small-cell lung cancer: European Organization for Research and Treatment of Cancer protocol 07861
-
Klastersky J, Sculier JP, Lacroix G, et al: A randomized study comparing cisplatin or carboplatin with etoposide in patients with advanced non-small-cell lung cancer: European Organization for Research and Treatment of Cancer protocol 07861. J Clin Oncol 8:1556-1562, 1990
-
(1990)
J Clin Oncol
, vol.8
, pp. 1556-1562
-
-
Klastersky, J.1
Sculier, J.P.2
Lacroix, G.3
-
40
-
-
0022640642
-
A randomized trial of the four most active regimens for metastatic non-small-cell lung cancer
-
Ruckdeschel JC, Finkelstein DM, Ettinger DS, et al: A randomized trial of the four most active regimens for metastatic non-small-cell lung cancer. J Clin Oncol 4:14-22, 1986
-
(1986)
J Clin Oncol
, vol.4
, pp. 14-22
-
-
Ruckdeschel, J.C.1
Finkelstein, D.M.2
Ettinger, D.S.3
-
41
-
-
0024426659
-
Combination chemotherapy versus single agents followed by combination chemotherapy in stage IV non-small-cell lung cancer: A study of the Eastern Cooperative Oncology Group
-
Bonomi PD, Finkelstein DM, Ruckdeschel JC, et al: Combination chemotherapy versus single agents followed by combination chemotherapy in stage IV non-small-cell lung cancer: A study of the Eastern Cooperative Oncology Group. J Clin Oncol 7:1602-1613, 1989
-
(1989)
J Clin Oncol
, vol.7
, pp. 1602-1613
-
-
Bonomi, P.D.1
Finkelstein, D.M.2
Ruckdeschel, J.C.3
-
42
-
-
0027993707
-
Efficacy and safety profile of gemcitabine in non-small-cell lung cancer: A phase II study
-
Abratt RP, Bezwoda WR, Falkson G, et al: Efficacy and safety profile of gemcitabine in non-small-cell lung cancer: A phase II study. J Clin Oncol 12:1535-1540, 1994
-
(1994)
J Clin Oncol
, vol.12
, pp. 1535-1540
-
-
Abratt, R.P.1
Bezwoda, W.R.2
Falkson, G.3
-
43
-
-
0028033227
-
Single-agent activity of weekly gemcitabine in advanced non-small-cell lung cancer: A phase II study
-
Anderson H, Lund B, Bach F, et al: Single-agent activity of weekly gemcitabine in advanced non-small-cell lung cancer: A phase II study. J Clin Oncol 12:1821-1826, 1994
-
(1994)
J Clin Oncol
, vol.12
, pp. 1821-1826
-
-
Anderson, H.1
Lund, B.2
Bach, F.3
-
44
-
-
0003295681
-
Phase I/II study of gemcitabine by 30 minute weekly IV m/min × 3 weeks every 4 weeks for non-small cell lung cancer
-
abstr
-
Fossella FV, Lippman S, Pang A, et al: Phase I/II study of gemcitabine by 30 minute weekly IV m/min × 3 weeks every 4 weeks for non-small cell lung cancer. Proc Am Soc Clin Oncol 12:326, 1993 (abstr)
-
(1993)
Proc Am Soc Clin Oncol
, vol.12
, pp. 326
-
-
Fossella, F.V.1
Lippman, S.2
Pang, A.3
-
45
-
-
84871467748
-
Gemcitabine in non-small cell lung cancer: The Japanese experience, in Efficacy, Symptomatology and Cost as Decision Points in Lung Cancer Treatment: Investigational Experience with Gemcitabine
-
Colorado Springs, CO, July
-
Fukuoka M, Kurita Y, Niitani H: Gemcitabine in non-small cell lung cancer: The Japanese experience, in Efficacy, Symptomatology and Cost as Decision Points in Lung Cancer Treatment: Investigational Experience With Gemcitabine. Seventh World Conference of Lung Cancer Mini-Symposium, Colorado Springs, CO, July 1994
-
(1994)
Seventh World Conference of Lung Cancer Mini-Symposium
-
-
Fukuoka, M.1
Kurita, Y.2
Niitani, H.3
-
46
-
-
23444459189
-
Phase II study of docetaxel for recurrent or metastatic non-small-cell lung cancer
-
Fossella FV, Lee JS, Murphy WK, et al: Phase II study of docetaxel for recurrent or metastatic non-small-cell lung cancer. J Clin Oncol 12:1238-1244, 1994
-
(1994)
J Clin Oncol
, vol.12
, pp. 1238-1244
-
-
Fossella, F.V.1
Lee, J.S.2
Murphy, W.K.3
-
47
-
-
0028944053
-
Phase II study of docetaxel (Taxotere) for advanced or metastatic platinum-refractory non-small-cell lung cancer
-
Fossella FV, Lee JS, Shin DM, et al: Phase II study of docetaxel (Taxotere) for advanced or metastatic platinum-refractory non-small-cell lung cancer. J Clin Oncol 13:645-651, 1995
-
(1995)
J Clin Oncol
, vol.13
, pp. 645-651
-
-
Fossella, F.V.1
Lee, J.S.2
Shin, D.M.3
-
48
-
-
0028154069
-
Randomized study of vinorelbine and cisplatin versus vindesine and cisplatin versus vinorelbine alone in advanced non-small-cell lung cancer: Results of a European multicenter trial including 612 patients
-
Le Chevalier T, Brisgand D, Douillard J-Y, et al: Randomized study of vinorelbine and cisplatin versus vindesine and cisplatin versus vinorelbine alone in advanced non-small-cell lung cancer: Results of a European multicenter trial including 612 patients. J Clin Oncol 12:360-367, 1994
-
(1994)
J Clin Oncol
, vol.12
, pp. 360-367
-
-
Le Chevalier, T.1
Brisgand, D.2
Douillard, J.-Y.3
-
49
-
-
0025996996
-
Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11
-
Kawato Y, Aonuma M, Hirota Y, et al: Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. Cancer Res 51:4187-4191, 1991
-
(1991)
Cancer Res
, vol.51
, pp. 4187-4191
-
-
Kawato, Y.1
Aonuma, M.2
Hirota, Y.3
-
50
-
-
0026595541
-
Mechanism of cross-resistance to a camptothecin analogue (CPT-11) in a human ovarian cancer cell line selected by cisplatin
-
Niimi S, Nakagawa K, Sugimoto Y, et al: Mechanism of cross-resistance to a camptothecin analogue (CPT-11) in a human ovarian cancer cell line selected by cisplatin. Cancer Res 52:328-333, 1992
-
(1992)
Cancer Res
, vol.52
, pp. 328-333
-
-
Niimi, S.1
Nakagawa, K.2
Sugimoto, Y.3
-
51
-
-
0026646768
-
Pharmacokinetics and pharmacodynamics of Topotecan in patients with advanced cancer
-
Grochow LB, Rowinsky EK, Johnson R, et al: Pharmacokinetics and pharmacodynamics of Topotecan in patients with advanced cancer. Drug Metab Dispos 20:706-713, 1992
-
(1992)
Drug Metab Dispos
, vol.20
, pp. 706-713
-
-
Grochow, L.B.1
Rowinsky, E.K.2
Johnson, R.3
-
52
-
-
0025342506
-
Nonlinear pharmacokinetics of CPT-11 in rats
-
Kaneda N, Yokokura T: Nonlinear pharmacokinetics of CPT-11 in rats. Cancer Res 50:1721-1725, 1990
-
(1990)
Cancer Res
, vol.50
, pp. 1721-1725
-
-
Kaneda, N.1
Yokokura, T.2
-
53
-
-
0026339352
-
Camptothecin overcomes mdr1-mediated resistance in human Kb carcinoma cells
-
Chen AY, Yu C, Potmesil M, et al: Camptothecin overcomes mdr1-mediated resistance in human Kb carcinoma cells. Cancer Res 51:6039-6044, 1991
-
(1991)
Cancer Res
, vol.51
, pp. 6039-6044
-
-
Chen, A.Y.1
Yu, C.2
Potmesil, M.3
-
54
-
-
0026772298
-
Effect of P-glycoprotein expression on the accumulation and cytotoxicity of Topotecan (SK&F 104864), a new camptothecin analogue
-
Hendricks CB, Rowinsky EK, Grochow LB, et al: Effect of P-glycoprotein expression on the accumulation and cytotoxicity of Topotecan (SK&F 104864), a new camptothecin analogue. Cancer Res 52:2268-2278, 1992
-
(1992)
Cancer Res
, vol.52
, pp. 2268-2278
-
-
Hendricks, C.B.1
Rowinsky, E.K.2
Grochow, L.B.3
-
55
-
-
0027324850
-
Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10-(4-[1-piperidino]-l-piperidino)-carbonyloxy-camptothecin against human tumor xenografts: Lack of cross-resistance in vivo in tumors with acquired resistance to the topoisomerase I inhibitor 9-dimethy-lamino-methyl-10-hydroxycamptothecin
-
Houghton PJ, Cheshire PJ, Hallman JC, et al: Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10-(4-[1-piperidino]-l-piperidino)-carbonyloxy-camptothecin against human tumor xenografts: Lack of cross-resistance in vivo in tumors with acquired resistance to the topoisomerase I inhibitor 9-dimethy-lamino-methyl-10-hydroxycamptothecin. Cancer Res 53:2823-2829, 1993
-
(1993)
Cancer Res
, vol.53
, pp. 2823-2829
-
-
Houghton, P.J.1
Cheshire, P.J.2
Hallman, J.C.3
-
56
-
-
0000339156
-
Randomized phase II trial of two schedules of Topotecan for the treatment of advanced stage non-small cell lung carcinoma (NSCLC): A North Central Cancer Treatment Group (NCCTG) trial
-
abstr
-
Weitz JJ, Jung SH, Marschke RF, et al: Randomized phase II trial of two schedules of Topotecan for the treatment of advanced stage non-small cell lung carcinoma (NSCLC): A North Central Cancer Treatment Group (NCCTG) trial. Proc Am Soc Clin Oncol 14:348, 1995 (abstr)
-
(1995)
Proc Am Soc Clin Oncol
, vol.14
, pp. 348
-
-
Weitz, J.J.1
Jung, S.H.2
Marschke, R.F.3
-
57
-
-
0001951950
-
Combination regimens with Topotecan in animal tumor models
-
Amsterdam, The Netherlands
-
Johnson R, McCabe F, Yu Y: Combination regimens with Topotecan in animal tumor models. Seventh NCI-EORTC Symposium on New Drugs in Cancer Therapy. Amsterdam, The Netherlands, 1992, p 85
-
(1992)
Seventh NCI-EORTC Symposium on New Drugs in Cancer Therapy
, pp. 85
-
-
Johnson, R.1
McCabe, F.2
Yu, Y.3
-
58
-
-
0011808822
-
Sequence-dependent effects of Topotecan and cisplatin in a phase I and pharmacokinetic study
-
abstr
-
Rowinsky E, Grochow L, Kaufmann S, et al: Sequence-dependent effects of Topotecan and cisplatin in a phase I and pharmacokinetic study. Proc Am Soc Clin Oncol 13:142, 1994 (abstr)
-
(1994)
Proc Am Soc Clin Oncol
, vol.13
, pp. 142
-
-
Rowinsky, E.1
Grochow, L.2
Kaufmann, S.3
-
59
-
-
0343976837
-
Phase I trial of cisplatin plus Topotecan on a daily × 5 schedule in patients with advanced solid tumors
-
abstr
-
Saltz L, Kanowitz J, Schwartz G, et al: Phase I trial of cisplatin plus Topotecan on a daily × 5 schedule in patients with advanced solid tumors. Proc Am Soc Clin Oncol 14:475, 1995 (abstr)
-
(1995)
Proc Am Soc Clin Oncol
, vol.14
, pp. 475
-
-
Saltz, L.1
Kanowitz, J.2
Schwartz, G.3
-
60
-
-
0026580034
-
Effects of concomitant cisplatin and radiotherapy on inoperable non-small cell lung cancer
-
Schaake-Koning C, Van den Bogaert W, Dalesio O, et al: Effects of concomitant cisplatin and radiotherapy on inoperable non-small cell lung cancer. N Engl J Med 326:524-530,1992
-
(1992)
N Engl J Med
, vol.326
, pp. 524-530
-
-
Schaake-Koning, C.1
Van Den Bogaert, W.2
Dalesio, O.3
-
61
-
-
0026328062
-
Synergistic cell killing by ionizing radiation and topoisomerase I inhibitor Topotecan (SK&F 104864)
-
Mattern MR, Hofmann GA, McCabe FL, et al: Synergistic cell killing by ionizing radiation and topoisomerase I inhibitor Topotecan (SK&F 104864). Cancer Res 51:5813-5816, 1991
-
(1991)
Cancer Res
, vol.51
, pp. 5813-5816
-
-
Mattern, M.R.1
Hofmann, G.A.2
McCabe, F.L.3
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