메뉴 건너뛰기




Volumn 33, Issue 4, 1997, Pages 245-259

Clinical pharmacokinetics of irinotecan

Author keywords

[No Author keywords available]

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; ANTINEOPLASTIC ALKALOID; CARBOXYLIC ACID; DNA TOPOISOMERASE; IRINOTECAN; LACTONE;

EID: 0030883212     PISSN: 03125963     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003088-199733040-00001     Document Type: Review
Times cited : (236)

References (114)
  • 1
    • 7144248725 scopus 로고
    • Plant antitumor agents I. the isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata
    • Wall ME, Wani MC, Cook CE, et al. Plant antitumor agents I. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata. J Am Chem Soc 1966; 88: 3888-90
    • (1966) J Am Chem Soc , vol.88 , pp. 3888-3890
    • Wall, M.E.1    Wani, M.C.2    Cook, C.E.3
  • 2
    • 0028267240 scopus 로고
    • Camptothecins: From bench research to hospital wards
    • Potmesil M. Camptothecins: from bench research to hospital wards. Cancer Res 1994; 54: 1431-4
    • (1994) Cancer Res , vol.54 , pp. 1431-1434
    • Potmesil, M.1
  • 3
    • 0002769833 scopus 로고
    • Camptothecin and analogs: From discovery to clinic
    • Potmesil M, Pinedo H, editors Boca Raton (FL): CRC Press, Inc.
    • Wall ME, Wani MC. Camptothecin and analogs: from discovery to clinic. In: Potmesil M, Pinedo H, editors. Camptothecins: new anticancer agents. Boca Raton (FL): CRC Press, Inc., 1995: 21-41
    • (1995) Camptothecins: New Anticancer Agents , pp. 21-41
    • Wall, M.E.1    Wani, M.C.2
  • 4
    • 0030477737 scopus 로고    scopus 로고
    • Camptothecin: Discovery to clinic
    • Wall ME, Wani MC. Camptothecin: discovery to clinic. Ann NY Acad Sci 1996; 803: 112
    • (1996) Ann NY Acad Sci , vol.803 , pp. 112
    • Wall, M.E.1    Wani, M.C.2
  • 5
    • 0023924786 scopus 로고
    • Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin
    • Hsiang YH, Liu LF: Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin. Cancer Res 1988; 48: 1722-6
    • (1988) Cancer Res , vol.48 , pp. 1722-1726
    • Hsiang, Y.H.1    Liu, L.F.2
  • 6
    • 0024560495 scopus 로고
    • Structure-activity study of the actions of camptothecin derivatives on mammalian toopoisomerase I. Evidence for a specific receptor site and for a relation to antitumor activity
    • Jaxel C, Kohn K, Wani MC, et al. Structure-activity study of the actions of camptothecin derivatives on mammalian toopoisomerase I. Evidence for a specific receptor site and for a relation to antitumor activity. Cancer Res 1989; 49: 1465-9
    • (1989) Cancer Res , vol.49 , pp. 1465-1469
    • Jaxel, C.1    Kohn, K.2    Wani, M.C.3
  • 7
    • 0024356003 scopus 로고
    • DNA topoisomerase I mediated DNA cleavage and cytotoxicity of camptothecin analogues
    • Hsiang YH, Liu LF, Wall ME, et al. DNA topoisomerase I mediated DNA cleavage and cytotoxicity of camptothecin analogues Cancer Res 1989; 49: 4835-9.
    • (1989) Cancer Res , vol.49 , pp. 4835-4839
    • Hsiang, Y.H.1    Liu, L.F.2    Wall, M.E.3
  • 8
    • 0024358188 scopus 로고
    • DNA topoisomerase I-targeted chemotherapy of human colon cancer in xenografts
    • Giovanella BC, Stehlin JS, Wall ME, et al. DNA topoisomerase I-targeted chemotherapy of human colon cancer in xenografts. Science 1989; 246: 1046-8
    • (1989) Science , vol.246 , pp. 1046-1048
    • Giovanella, B.C.1    Stehlin, J.S.2    Wall, M.E.3
  • 9
    • 0023897804 scopus 로고
    • Resistance of human leukemic and normal lymphocytes to drug-induced DNA cleavage and low levels of DNA topoisomerase II
    • Potmesil M, Hsiang YH, Liu LF, et al. Resistance of human leukemic and normal lymphocytes to drug-induced DNA cleavage and low levels of DNA topoisomerase II. Cancer Res 1988; 48: 3537-43
    • (1988) Cancer Res , vol.48 , pp. 3537-3543
    • Potmesil, M.1    Hsiang, Y.H.2    Liu, L.F.3
  • 10
    • 0023552964 scopus 로고
    • Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxy-camptothecin, a novel water-soluble derivative of camptothecin, against murine tumors
    • Kunimoto T, Nitta K, Tanaka T, et al. Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxy-camptothecin, a novel water-soluble derivative of camptothecin, against murine tumors. Cancer Res 1987; 47: 5944-7
    • (1987) Cancer Res , vol.47 , pp. 5944-5947
    • Kunimoto, T.1    Nitta, K.2    Tanaka, T.3
  • 11
    • 0026099599 scopus 로고
    • Synthesis of water-soluble (aminoalkyl) camptothecin analogues: Inhibition of topoisomerase I and antitumor activity
    • Kingsbury WD, Boehm JC, Jakas DR, et al. Synthesis of water-soluble (aminoalkyl) camptothecin analogues: inhibition of topoisomerase I and antitumor activity. J Med Chem 1991; 34: 98-107
    • (1991) J Med Chem , vol.34 , pp. 98-107
    • Kingsbury, W.D.1    Boehm, J.C.2    Jakas, D.R.3
  • 12
    • 0023034927 scopus 로고
    • Plant antitumor agents: 23. Synthesis and antileukemic activity of camptothecin analogues
    • Wani MC, Nicholas AW, Wall ME. Plant antitumor agents: 23. Synthesis and antileukemic activity of camptothecin analogues. J Med Chem 1986; 29: 2358-63
    • (1986) J Med Chem , vol.29 , pp. 2358-2363
    • Wani, M.C.1    Nicholas, A.W.2    Wall, M.E.3
  • 13
    • 0024324205 scopus 로고
    • On the mechanism of topoisomerase 1 inhibition by eamptothecin: Evidence for binding to an enzyme-DNA complex
    • Hertzberg RP, Caranfa MJ, Hecht S. On the mechanism of topoisomerase 1 inhibition by eamptothecin: evidence for binding to an enzyme-DNA complex. Biochemistry 1989; 28: 4629-38
    • (1989) Biochemistry , vol.28 , pp. 4629-4638
    • Hertzberg, R.P.1    Caranfa, M.J.2    Hecht, S.3
  • 14
    • 0015500913 scopus 로고
    • Camptothecin effects on DNA synthesis in murine leukemia cells
    • Kessel D, Bosmann HB, Lohr K. Camptothecin effects on DNA synthesis in murine leukemia cells. Biochem Biophys Acta 1972; 269: 210-6
    • (1972) Biochem Biophys Acta , vol.269 , pp. 210-216
    • Kessel, D.1    Bosmann, H.B.2    Lohr, K.3
  • 15
    • 0021891888 scopus 로고
    • DNA topoisomerases
    • Wang JC. DNA topoisomerases. Annu Rev Biochem 1985; 54: 665-97
    • (1985) Annu Rev Biochem , vol.54 , pp. 665-697
    • Wang, J.C.1
  • 16
    • 0024316466 scopus 로고
    • DNA topoisomerase poisons as antitumor drugs
    • Liu LF. DNA topoisomerase poisons as antitumor drugs. Annu Rev Biochem 1989; 58: 351-75
    • (1989) Annu Rev Biochem , vol.58 , pp. 351-375
    • Liu, L.F.1
  • 17
    • 0025996996 scopus 로고
    • Intracellular roles of SN-38. a metabolite of the camptothecin derivative. CPT-II, in the antitumor effect of CPT-11
    • Kawato Y, Aonuma M, Hirota Y, et al. Intracellular roles of SN-38. a metabolite of the camptothecin derivative. CPT-II, in the antitumor effect of CPT-11. Cancer Res 1991; 51: 4187-91
    • (1991) Cancer Res , vol.51 , pp. 4187-4191
    • Kawato, Y.1    Aonuma, M.2    Hirota, Y.3
  • 18
    • 0028796779 scopus 로고
    • Intracellular carboxylesterase activity is a determinant of cellular sensitivity to the antineoplastic agent KW-2189 in cell lines resistant to cisplatin and CPT-11
    • Ogasawara H, Nishio K, Kanzawa F, et al. Intracellular carboxylesterase activity is a determinant of cellular sensitivity to the antineoplastic agent KW-2189 in cell lines resistant to cisplatin and CPT-11. Jpn J Cancer Res 1995; 86: 124-9
    • (1995) Jpn J Cancer Res , vol.86 , pp. 124-129
    • Ogasawara, H.1    Nishio, K.2    Kanzawa, F.3
  • 19
    • 0031046059 scopus 로고    scopus 로고
    • CPT-11 in human colon cancer cell lines and xenografts: Characterization of cellular sensitivity determinants
    • Jansen WJ, Zwaer B, Hulscher ST, et al. CPT-11 in human colon cancer cell lines and xenografts: characterization of cellular sensitivity determinants. Int J Cancer 1997; 70: 335-40
    • (1997) Int J Cancer , vol.70 , pp. 335-340
    • Jansen, W.J.1    Zwaer, B.2    Hulscher, S.T.3
  • 20
    • 0030601330 scopus 로고    scopus 로고
    • Chemotherapeutic agent CPT-11 induces the new expression of the apoptosis initiator to the cytoplasm
    • Suzuki A, Kato M. Chemotherapeutic agent CPT-11 induces the new expression of the apoptosis initiator to the cytoplasm. Exp Cell Res 1996; 227: 154-9
    • (1996) Exp Cell Res , vol.227 , pp. 154-159
    • Suzuki, A.1    Kato, M.2
  • 21
    • 0027005977 scopus 로고
    • Camptothecin hyper-resistant P388 cells: Drug-dependent reduction in topoisomerase I content
    • Woessner RD, Eng WK, Hofmann FA, et al. Camptothecin hyper-resistant P388 cells: drug-dependent reduction in topoisomerase I content. Oncol Res 1992; 4: 481-8
    • (1992) Oncol Res , vol.4 , pp. 481-488
    • Woessner, R.D.1    Eng, W.K.2    Hofmann, F.A.3
  • 22
    • 0023739308 scopus 로고
    • Camptothecin-resistant mutants of Chinese hamster ovary cells containing a resistant form of topoisomerase I
    • Gupta RS, Gupta R, Eng B, et al. Camptothecin-resistant mutants of Chinese hamster ovary cells containing a resistant form of topoisomerase I. Cancer Res 1988; 48: 6404-10
    • (1988) Cancer Res , vol.48 , pp. 6404-6410
    • Gupta, R.S.1    Gupta, R.2    Eng, B.3
  • 23
    • 0025084410 scopus 로고
    • Establishment of a camptothecin analogue (CPT-11) resistant cell line of human small cell lung cancer: Characterization and mechanism of resistance
    • Kanzawa F, Sugimoto Y, Minato K, et al. Establishment of a camptothecin analogue (CPT-11) resistant cell line of human small cell lung cancer: characterization and mechanism of resistance. Cancer Res 1990; 50: 5919-24
    • (1990) Cancer Res , vol.50 , pp. 5919-5924
    • Kanzawa, F.1    Sugimoto, Y.2    Minato, K.3
  • 24
    • 0025151823 scopus 로고
    • Decreased expression of DNA topoisomerase I in camptothecin-resistant tumor cell lines as determined by a monoclonal antibody
    • Sugimoto Y, Tsukahara S, Oh-Hara T, et al. Decreased expression of DNA topoisomerase I in camptothecin-resistant tumor cell lines as determined by a monoclonal antibody. Cancer Res 1990; 50: 6925-30
    • (1990) Cancer Res , vol.50 , pp. 6925-6930
    • Sugimoto, Y.1    Tsukahara, S.2    Oh-Hara, T.3
  • 25
    • 0006892915 scopus 로고
    • Molecular cloning of a cDNA of a camptothecin-resistant human DNA topoisomerase I and identification of mutation sites
    • Tamura H, Kohchi C, Yamada R. Molecular cloning of a cDNA of a camptothecin-resistant human DNA topoisomerase I and identification of mutation sites. Nucleic Acids Res 1991; 51: 1129-36
    • (1991) Nucleic Acids Res , vol.51 , pp. 1129-1136
    • Tamura, H.1    Kohchi, C.2    Yamada, R.3
  • 26
    • 0029029436 scopus 로고
    • Topoisonierase I-related parameters and eamptothecin activity in the colon carcinoma cell lines from the National Cancer Institute anticancer screen
    • Goldwasser F, Bae I, Valenti M, et al. Topoisonierase I-related parameters and eamptothecin activity in the colon carcinoma cell lines from the National Cancer Institute anticancer screen. Cancer Res 1995; 55: 2116-21
    • (1995) Cancer Res , vol.55 , pp. 2116-2121
    • Goldwasser, F.1    Bae, I.2    Valenti, M.3
  • 27
    • 0026339352 scopus 로고
    • Camptothecin overcomes MDRI-mediated resistance in human KB carcinoma cells
    • Chen AY, Yu C, Potmesil M, et al. Camptothecin overcomes MDRI-mediated resistance in human KB carcinoma cells. Cancer Res 1991; 51: 6039-44
    • (1991) Cancer Res , vol.51 , pp. 6039-6044
    • Chen, A.Y.1    Yu, C.2    Potmesil, M.3
  • 28
    • 0026452119 scopus 로고
    • Camptothecin analog (CPT-11)-sensitive human pancreatic tumor cell line QGP-IN shows resistance to SN-38. an active metabolite of CPT-11
    • Takeda S, Shimazoe T, Kuga H, et al. Camptothecin analog (CPT-11)-sensitive human pancreatic tumor cell line QGP-IN shows resistance to SN-38. an active metabolite of CPT-11. Biochem Biophys Res Commun 1992; 188: 70-7
    • (1992) Biochem Biophys Res Commun , vol.188 , pp. 70-77
    • Takeda, S.1    Shimazoe, T.2    Kuga, H.3
  • 29
    • 0031026792 scopus 로고    scopus 로고
    • A lymphoma cell line resistant to 4-piperidinopiperidine was less sensitive to CPT-11
    • Onishi Y, Oguro M, Kizaki H. A lymphoma cell line resistant to 4-piperidinopiperidine was less sensitive to CPT-11. Cancer Chemother Pharmacol 1997; 39: 473-8
    • (1997) Cancer Chemother Pharmacol , vol.39 , pp. 473-478
    • Onishi, Y.1    Oguro, M.2    Kizaki, H.3
  • 30
    • 0025785082 scopus 로고
    • Antitumor activity of a camptothecin derivative. CPT-11, against human tumor xenografts in nude mice
    • Kawato Y, Furuta T, Aonuma M, et al. Antitumor activity of a camptothecin derivative. CPT-11, against human tumor xenografts in nude mice. Cancer Chemother Pharmacol 1991; 28: 192-8
    • (1991) Cancer Chemother Pharmacol , vol.28 , pp. 192-198
    • Kawato, Y.1    Furuta, T.2    Aonuma, M.3
  • 31
    • 0030014198 scopus 로고    scopus 로고
    • Experimental antitumor activity and pharmacokinetics of the camptothecin analog irinotecan (CPT-11) in mice
    • Bissery MC, Vrignaud P, Lavelle F, et al. Experimental antitumor activity and pharmacokinetics of the camptothecin analog irinotecan (CPT-11) in mice. Anti-Cancer Drugs 1996; 7: 437-60
    • (1996) Anti-Cancer Drugs , vol.7 , pp. 437-460
    • Bissery, M.C.1    Vrignaud, P.2    Lavelle, F.3
  • 32
    • 0028225471 scopus 로고
    • Comparison of topoisomcnise I inhibition. DNA damage, and cytotoxicity of camptothecin derivatives presently in clinical trials
    • Tanizawa A, Fujimori A, Fugimori Y, et al. Comparison of topoisomcnise I inhibition. DNA damage, and cytotoxicity of camptothecin derivatives presently in clinical trials. J Natl Cancer Inst 1994; 86: 836-42
    • (1994) J Natl Cancer Inst , vol.86 , pp. 836-842
    • Tanizawa, A.1    Fujimori, A.2    Fugimori, Y.3
  • 33
    • 0029931995 scopus 로고    scopus 로고
    • Preclinical evaluation of CPT-11 and its active metabolite SN-38
    • Lavelle F, Bissery MC, André S, et al. Preclinical evaluation of CPT-11 and its active metabolite SN-38. Semin Oncol 1996; 3 (1 Suppl.): 11-20
    • (1996) Semin Oncol , vol.3 , Issue.1 SUPPL. , pp. 11-20
    • Lavelle, F.1    Bissery, M.C.2    André, S.3
  • 34
    • 0027324850 scopus 로고
    • Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10-(4-[1-piperidino]-1-piperidino)-carbonyloxy-camptothecin against human tumor xenografts: Lack of cross-resistance in vivo in tumors with acquired resistance to the topoisomerase I inhibitor 9-dimethylaminomethyl-10-hydroxycamptothecin
    • Houghton PJ, Cheshire PJ, Hallman JC, et al. Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10-(4-[1-piperidino]-1-piperidino)-carbonyloxy-camptothecin against human tumor xenografts: lack of cross-resistance in vivo in tumors with acquired resistance to the topoisomerase I inhibitor 9-dimethylaminomethyl-10-hydroxycamptothecin. Cancer Res 1993; 53: 2823-9
    • (1993) Cancer Res , vol.53 , pp. 2823-2829
    • Houghton, P.J.1    Cheshire, P.J.2    Hallman, J.C.3
  • 35
    • 9444258554 scopus 로고    scopus 로고
    • Therapeutic activity of CPT-11, a DNA-topoisomerase I inhibitor, against peripheral primitive neuroectodermal tumour and neuroblastoma xenografts
    • Vassal G, Terrier-Lacombe MJ, Bissery MC, et al. Therapeutic activity of CPT-11, a DNA-topoisomerase I inhibitor, against peripheral primitive neuroectodermal tumour and neuroblastoma xenografts. Br J Cancer 1996; 74: 537-45
    • (1996) Br J Cancer , vol.74 , pp. 537-545
    • Vassal, G.1    Terrier-Lacombe, M.J.2    Bissery, M.C.3
  • 36
    • 0028072804 scopus 로고
    • Effects of CPT-11 (a unique DNA topoisomerase I inhibitor) on a highly malignant xenotransplanted neuroblastoma
    • Komuro H, Li P, Tsuchida Y, et al. Effects of CPT-11 (a unique DNA topoisomerase I inhibitor) on a highly malignant xenotransplanted neuroblastoma. Med Pediatr Oncol 1994; 23: 487-92
    • (1994) Med Pediatr Oncol , vol.23 , pp. 487-492
    • Komuro, H.1    Li, P.2    Tsuchida, Y.3
  • 37
    • 0031060230 scopus 로고    scopus 로고
    • Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10-(4-[1-piperidino]-1-piperidino)-carboxyloxy-camptothecin against pediatric and adult central nervous system tumor xenografts
    • Hare CB, Elion GB, Houghton PJ, et al. Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10-(4-[1-piperidino]-1-piperidino)-carboxyloxy-camptothecin against pediatric and adult central nervous system tumor xenografts. Cancer Chemother Pharmacol 1997; 38: 187-91
    • (1997) Cancer Chemother Pharmacol , vol.38 , pp. 187-191
    • Hare, C.B.1    Elion, G.B.2    Houghton, P.J.3
  • 38
    • 0023864510 scopus 로고
    • Antitumor effect of CPT-11, a new derivative of camptothecin, against pleiotropic drug-resistant tumors in vitro and in vivo
    • Tsuruo T, Matsuzaki T, Matsushita M, et al. Antitumor effect of CPT-11, a new derivative of camptothecin, against pleiotropic drug-resistant tumors in vitro and in vivo. Cancer Chemother Pharmacol 1988; 21: 71-4
    • (1988) Cancer Chemother Pharmacol , vol.21 , pp. 71-74
    • Tsuruo, T.1    Matsuzaki, T.2    Matsushita, M.3
  • 39
    • 0025266608 scopus 로고
    • Phase I clinical study of CPT-11: Research Group of CPT-11
    • Taguchi T, Wakui A, Hasegawa K. Phase I clinical study of CPT-11: Research Group of CPT-11. Jpn J Cancer Chemother 1990; 17: 115-20
    • (1990) Jpn J Cancer Chemother , vol.17 , pp. 115-120
    • Taguchi, T.1    Wakui, A.2    Hasegawa, K.3
  • 40
    • 0025851286 scopus 로고
    • Phase I study of weekly intravenous infusion of CPT-11, a new derivative of camptothecin, in the treatment of advance non-small cell lung cancer
    • Negoro S, Fukuoka M, Masuda N, et al. Phase I study of weekly intravenous infusion of CPT-11, a new derivative of camptothecin, in the treatment of advance non-small cell lung cancer. J Natl Cancer Inst 1991; 83: 1164-8
    • (1991) J Natl Cancer Inst , vol.83 , pp. 1164-1168
    • Negoro, S.1    Fukuoka, M.2    Masuda, N.3
  • 41
    • 0026631164 scopus 로고
    • Phase I study and pharmacokinetics of CPT-11 with 5-day continuous infusion
    • Ohe Y, Sasaki Y, Shinkai T, et al. Phase I study and pharmacokinetics of CPT-11 with 5-day continuous infusion. J Natl Cancer Inst 1992; 84: 972-4
    • (1992) J Natl Cancer Inst , vol.84 , pp. 972-974
    • Ohe, Y.1    Sasaki, Y.2    Shinkai, T.3
  • 42
    • 0027140524 scopus 로고
    • Phase I and pharmacokinetic trial of weekly CPT-11
    • Rothenberg ML, Kuhn JG, Burris III HA, et al. Phase I and pharmacokinetic trial of weekly CPT-11. J Clin Oncol 1993; 11: 2194-204
    • (1993) J Clin Oncol , vol.11 , pp. 2194-2204
    • Rothenberg, M.L.1    Kuhn, J.G.2    Burris III, H.A.3
  • 43
    • 0028158012 scopus 로고
    • Phase I and pharmacological study of the novel topoisomerase I inhibitor 7-ethyl-10-[4-(4-piperidino)-1-piperidino]carbonyl-oxycamptothecin (CPT-11) administered as a ninety-minute infusion every 3 weeks
    • Rowinsky EK, Grochow LB, Ettinger DS, et al. Phase I and pharmacological study of the novel topoisomerase I inhibitor 7-ethyl-10-[4-(4-piperidino)-1-piperidino]carbonyl-oxycamptothecin (CPT-11) administered as a ninety-minute infusion every 3 weeks. Cancer Res 1994; 54: 427-36
    • (1994) Cancer Res , vol.54 , pp. 427-436
    • Rowinsky, E.K.1    Grochow, L.B.2    Ettinger, D.S.3
  • 44
    • 0028840093 scopus 로고
    • Phase I and pharmacokinetic study of irinotecan (CPT-11) administered daily for three consecutive days every three weeks in patients with advanced solid tumors
    • Catimel G, Chabot GG, Guastalla JP, et al. Phase I and pharmacokinetic study of irinotecan (CPT-11) administered daily for three consecutive days every three weeks in patients with advanced solid tumors. Ann Oncol 1995; 6: 133-40
    • (1995) Ann Oncol , vol.6 , pp. 133-140
    • Catimel, G.1    Chabot, G.G.2    Guastalla, J.P.3
  • 45
    • 0027933519 scopus 로고
    • Phase I and pharmacokinetic study of the camptothecin derivative irinotecan administered on a weekly schedule in cancer patients
    • de Forni M, Bugat R, Chabot GG, et al. Phase I and pharmacokinetic study of the camptothecin derivative irinotecan administered on a weekly schedule in cancer patients. Cancer Res 1994; 54: 4347-54
    • (1994) Cancer Res , vol.54 , pp. 4347-4354
    • Forni, M.1    Bugat, R.2    Chabot, G.G.3
  • 46
    • 0028854897 scopus 로고
    • Phase I and pharmacologic studies of the camptothecin analog irinotecan administered every 3 weeks in cancer patients
    • Abigerges D, Chabot GG, Armand JP, et al. Phase I and pharmacologic studies of the camptothecin analog irinotecan administered every 3 weeks in cancer patients. J Clin Oncol 1995; 13: 210-21
    • (1995) J Clin Oncol , vol.13 , pp. 210-221
    • Abigerges, D.1    Chabot, G.G.2    Armand, J.P.3
  • 47
    • 0027534590 scopus 로고
    • CPT-11-Induced cholinergic effects in cancer patients
    • Gandia D, Abigerges D, Armand JP, et al. CPT-11-Induced cholinergic effects in cancer patients [letter]. J Clin Oncol 1993; 11: 196-7
    • (1993) J Clin Oncol , vol.11 , pp. 196-197
    • Gandia, D.1    Abigerges, D.2    Armand, J.P.3
  • 48
    • 0031059575 scopus 로고    scopus 로고
    • High dose-intensity of irinotecan administered every 3 weeks in advanced cancer patients: A feasibility study
    • Merrouche Y, Extra JM, Abigerges D, et al. High dose-intensity of irinotecan administered every 3 weeks in advanced cancer patients: a feasibility study. J Clin Oncol 1997; 15: 1080-6
    • (1997) J Clin Oncol , vol.15 , pp. 1080-1086
    • Merrouche, Y.1    Extra, J.M.2    Abigerges, D.3
  • 49
    • 0001209644 scopus 로고
    • Pathophysiology and therapy of irinotecan (CPT-11) induced delayed onset diarrhoea: A prospective assessment
    • Hagipantelli R, Saliba F, Misset JL, et al. Pathophysiology and therapy of irinotecan (CPT-11) induced delayed onset diarrhoea: a prospective assessment (abstract). Proc Am Soc Clin Oncol 1995; 14: 464
    • (1995) Proc Am Soc Clin Oncol , vol.14 , pp. 464
    • Hagipantelli, R.1    Saliba, F.2    Misset, J.L.3
  • 50
    • 0028050008 scopus 로고
    • Preventive effect of TJ-14, a kampo medicine, on diarrhoea induced by irinotecan hydrochloride
    • Sakata Y, Suzuki, H, Kamataki T. Preventive effect of TJ-14, a kampo medicine, on diarrhoea induced by irinotecan hydrochloride [in Japanese]. Jpn J Cancer Chemother (Gan To Kagaku Ryoho) 1994; 21: 1241-4
    • (1994) Jpn J Cancer Chemother (Gan to Kagaku Ryoho) , vol.21 , pp. 1241-1244
    • Sakata, Y.1    Suzuki, H.2    Kamataki, T.3
  • 51
    • 0029741368 scopus 로고    scopus 로고
    • Involvement of -glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor camptothecin derivative irinotecan hydrochloride (CPT-11) in rats
    • Takasuna K, Hagiwara T, Hirohashi M, et al. Involvement of -glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor camptothecin derivative irinotecan hydrochloride (CPT-11) in rats. Cancer Res 1996; 56: 3752-7
    • (1996) Cancer Res , vol.56 , pp. 3752-3757
    • Takasuna, K.1    Hagiwara, T.2    Hirohashi, M.3
  • 53
    • 0029870413 scopus 로고    scopus 로고
    • CPT-11: An original spectrum of clinical activity
    • Rothenberg ML, CPT-11: an original spectrum of clinical activity. Semin Oncol 1996; 23 (1 Suppl. 3): 21-6
    • (1996) Semin Oncol , vol.23 , Issue.1 SUPPL. 3 , pp. 21-26
    • Rothenberg, M.L.1
  • 54
    • 0029084773 scopus 로고
    • CPT-11 (irinotecan) in the treatment of colorectal cancer
    • Armand JP, Ducreux M, Mahjoubi M, et al. CPT-11 (irinotecan) in the treatment of colorectal cancer. Eur J Cancer 1995; 31A: 1283-7
    • (1995) Eur J Cancer , vol.31 A , pp. 1283-1287
    • Armand, J.P.1    Ducreux, M.2    Mahjoubi, M.3
  • 55
    • 0027194943 scopus 로고
    • Phase II study of CPT-11. a new camptothecin derivative, in inetastatic colorectal cancer: CRT-11 Gastrointestinal Cancer Study Group
    • Shimada Y, Yoshino M, Wakui A, et al. Phase II study of CPT-11. a new camptothecin derivative, in inetastatic colorectal cancer: CRT-11 Gastrointestinal Cancer Study Group. J Clin Oncol 1993; 11: 909-13
    • (1993) J Clin Oncol , vol.11 , pp. 909-913
    • Shimada, Y.1    Yoshino, M.2    Wakui, A.3
  • 56
    • 0029919598 scopus 로고    scopus 로고
    • Irinotecan is an active agent in untreated patients with metastatic colorectal cancer
    • Conti JA, Kemeny NE, Saltz LB, et al. Irinotecan is an active agent in untreated patients with metastatic colorectal cancer. J Clin Oncol 1996; 14: 709-15
    • (1996) J Clin Oncol , vol.14 , pp. 709-715
    • Conti, J.A.1    Kemeny, N.E.2    Saltz, L.B.3
  • 57
    • 0029973982 scopus 로고    scopus 로고
    • Efficacy of CPT-11 (irinotecan) as a single agent in metastatic colorectal cancer
    • Shimada Y, Rougier P, Pilot H. Efficacy of CPT-11 (irinotecan) as a single agent in metastatic colorectal cancer. Eur J Can 1996; 3 (32A Suppl.): S13-7
    • (1996) Eur J Can , vol.3 , Issue.32 A SUPPL.
    • Shimada, Y.1    Rougier, P.2    Pilot, H.3
  • 58
    • 0029966672 scopus 로고    scopus 로고
    • Phase II trial of irinotecan in patients with progressive or rapidly recurrent colorectal cancer
    • Rothenberg ML, Eckardt JR, Burris III HA, et al. Phase II trial of irinotecan in patients with progressive or rapidly recurrent colorectal cancer. J Clin Oncol 1996; 14: 1128-35
    • (1996) J Clin Oncol , vol.14 , pp. 1128-1135
    • Rothenberg, M.L.1    Eckardt, J.R.2    Burris III, H.A.3
  • 59
    • 0031014627 scopus 로고    scopus 로고
    • Phase II study of irinotecan in the treatment of advanced colorectal cancer in chemotherapy-naive patients and patients pretreated with fluorouracil-based chemotherapy
    • Rougier P, Bugal R, Douillard JY, et al. Phase II study of irinotecan in the treatment of advanced colorectal cancer in chemotherapy-naive patients and patients pretreated with fluorouracil-based chemotherapy. J Clin Oncol 1997; 15: 251-60
    • (1997) J Clin Oncol , vol.15 , pp. 251-260
    • Rougier, P.1    Bugal, R.2    Douillard, J.Y.3
  • 60
    • 0026531753 scopus 로고
    • A phase II study of CPT-11, a new derivative of camptothecin, for previously untreated non-small cell lung cancer
    • Fukuoka M, Nitani H, Suzuki A, et al. A phase II study of CPT-11, a new derivative of camptothecin, for previously untreated non-small cell lung cancer. J Clin Oncol 1992; 10: 16-20
    • (1992) J Clin Oncol , vol.10 , pp. 16-20
    • Fukuoka, M.1    Nitani, H.2    Suzuki, A.3
  • 61
    • 0026680292 scopus 로고
    • CPT-11: A new derivative of camptothecin for the treatment of refractory or relapsed small-cell lung cancer
    • Masuda N, Fukuoka M, Kusunoki Y, et al. CPT-11: a new derivative of camptothecin for the treatment of refractory or relapsed small-cell lung cancer. J Clin Oncol 1992; 10: 1225-9
    • (1992) J Clin Oncol , vol.10 , pp. 1225-1229
    • Masuda, N.1    Fukuoka, M.2    Kusunoki, Y.3
  • 62
    • 0027082880 scopus 로고
    • CPT-11 in combination with cisplatin for advanced non-small-cell lung cancer
    • Masuda N, Fukuoka M, Takada M, et al. CPT-11 in combination with cisplatin for advanced non-small-cell lung cancer. J Clin Oncol 1992; 10: 1775-80
    • (1992) J Clin Oncol , vol.10 , pp. 1775-1780
    • Masuda, N.1    Fukuoka, M.2    Takada, M.3
  • 63
    • 0000055807 scopus 로고
    • Phase II trial of CPT-11 in advanced cervical carcinoma
    • Chevallier B, Lhomme C, Dieras V, et al. Phase II trial of CPT-11 in advanced cervical carcinoma [abstract]. Proc Am Soc Clin Oncol 1995; 14: 267
    • (1995) Proc Am Soc Clin Oncol , vol.14 , pp. 267
    • Chevallier, B.1    Lhomme, C.2    Dieras, V.3
  • 64
    • 0011852066 scopus 로고
    • Irinotecan (CPT-11) in advanced squamous cell carcinoma of the cervix (Phase II) (abstract)
    • Potkul RK, Price VT, Bailey H, et al. Irinotecan (CPT-11) in advanced squamous cell carcinoma of the cervix (Phase II) (abstract). Proc Am Suc Clin Oncol 1995; 14: 279
    • (1995) Proc Am Suc Clin Oncol , vol.14 , pp. 279
    • Potkul, R.K.1    Price, V.T.2    Bailey, H.3
  • 65
    • 0031037244 scopus 로고    scopus 로고
    • Phase II study of irinotecan in prior chemotherapy-treated squamous cell carcinoma of the cervix
    • Verschraegen CF, Levy T, Kudelka AP, et al. Phase II study of irinotecan in prior chemotherapy-treated squamous cell carcinoma of the cervix. J Clin Oncol 1997; 15: 625-31
    • (1997) J Clin Oncol , vol.15 , pp. 625-631
    • Verschraegen, C.F.1    Levy, T.2    Kudelka, A.P.3
  • 66
    • 0028236635 scopus 로고
    • A late phase II study of CPT-11, irinotecan hydrochloride, in patients with advanced pancreatic cancer
    • Sakata Y, Shimada Y, Yoshino M, et al. A late phase II study of CPT-11, irinotecan hydrochloride, in patients with advanced pancreatic cancer [in Japanese]. Gan To Kagaku Ryoho 1994; 21: 1039-46
    • (1994) Gan to Kagaku Ryoho , vol.21 , pp. 1039-1046
    • Sakata, Y.1    Shimada, Y.2    Yoshino, M.3
  • 67
    • 0028839053 scopus 로고
    • Phase II trial of CPT-11 in patients with advanced pancreatic cancer, an EORTC early clinical trials group study
    • Wagener DJ, Verdonk HE, Dirix LY, et al. Phase II trial of CPT-11 in patients with advanced pancreatic cancer, an EORTC early clinical trials group study. Ann Oncol 1995; 6: 129-32
    • (1995) Ann Oncol , vol.6 , pp. 129-132
    • Wagener, D.J.1    Verdonk, H.E.2    Dirix, L.Y.3
  • 68
    • 0028276113 scopus 로고
    • A late Phase II study of irinotecan hydrochloride (CPT-11) in advanced gastric cancer: CPT-11 Gastrointestinal Cancer Study Group
    • Futatsuki K, Wakui A, Nakao I, et al. A late Phase II study of irinotecan hydrochloride (CPT-11) in advanced gastric cancer: CPT-11 Gastrointestinal Cancer Study Group [in Japanese). Gan To Kagaku Ryoho 1994; 21: 1033-8
    • (1994) Gan to Kagaku Ryoho , vol.21 , pp. 1033-1038
    • Futatsuki, K.1    Wakui, A.2    Nakao, I.3
  • 69
    • 0002625490 scopus 로고
    • A Phase II study of a new camtothecin analog CPT-11 in previously treated advanced breast cancer patients
    • Bonneterre J, Pion JM, Adenis A, et al. A Phase II study of a new camtothecin analog CPT-11 in previously treated advanced breast cancer patients [abstract]. Proc Am Soc Clin Oncol 1993; 12: 94
    • (1993) Proc Am Soc Clin Oncol , vol.12 , pp. 94
    • Bonneterre, J.1    Pion, J.M.2    Adenis, A.3
  • 70
    • 0028291372 scopus 로고
    • A late phase II study of CPT-11 (irinotecan) in advanced breast cancer. CPT-11 Study Group on Breast Cancer
    • Taguchi T, Tominaga T, Ogawa M, et al. A late phase II study of CPT-11 (irinotecan) in advanced breast cancer. CPT-11 Study Group on Breast Cancer [in Japanese]. Jpn J Cancer Chemother (Gan To Kagaku Ryoho) 1994; 21: 1017-24
    • (1994) Jpn J Cancer Chemother (Gan to Kagaku Ryoho) , vol.21 , pp. 1017-1024
    • Taguchi, T.1    Tominaga, T.2    Ogawa, M.3
  • 71
    • 0025129894 scopus 로고
    • An early phase II study of CPT-11: A new derivative of camptothecin for the treatment of leukemia and lymphoma
    • Ohno R, Okada K, Masaoka T, et al. An early phase II study of CPT-11: a new derivative of camptothecin for the treatment of leukemia and lymphoma. J Clin Oncol 1990; 8: 1907-12
    • (1990) J Clin Oncol , vol.8 , pp. 1907-1912
    • Ohno, R.1    Okada, K.2    Masaoka, T.3
  • 72
    • 0028145132 scopus 로고
    • Treatment of adult T-cell leukaemia-lymphoma with irinotecan hydrochloride (CPT-11): CPT-11 Study Group on Hematological Malignancy
    • Tsuda H, Takatsuki K, Ohno R, et al. Treatment of adult T-cell leukaemia-lymphoma with irinotecan hydrochloride (CPT-11): CPT-11 Study Group on Hematological Malignancy. Br J Cancer 1994; 70: 771-4
    • (1994) Br J Cancer , vol.70 , pp. 771-774
    • Tsuda, H.1    Takatsuki, K.2    Ohno, R.3
  • 73
    • 0025272187 scopus 로고
    • Metabolism and pharmacokinetics of the camptothecin analogue CPT-11 in the mouse
    • Kaneda N, Nagata H, Furuta T, et al. Metabolism and pharmacokinetics of the camptothecin analogue CPT-11 in the mouse. Cancer Res 1990; 50: 1715-20
    • (1990) Cancer Res , vol.50 , pp. 1715-1720
    • Kaneda, N.1    Nagata, H.2    Furuta, T.3
  • 74
    • 0026538734 scopus 로고
    • Simultaneous determination of the camptothecin analogue CPT-11 and its active metabolite SN-38 by high-performance liquid chromatography: Application to plasma pharmacokinetic studies in cancer patients
    • Barilero I, Gandia D, Armand JP, et al. Simultaneous determination of the camptothecin analogue CPT-11 and its active metabolite SN-38 by high-performance liquid chromatography: application to plasma pharmacokinetic studies in cancer patients. J Chromatogr Biomed Appl 1992; 575: 275-80
    • (1992) J Chromatogr Biomed Appl , vol.575 , pp. 275-280
    • Barilero, I.1    Gandia, D.2    Armand, J.P.3
  • 75
    • 0026332806 scopus 로고
    • Selective and sensitive determination of lactone and hydroxy acid forms of camptothecin and two derivatives (CPT-11 and SN-38) by high-performance liquid chromatography with fluorescence detection
    • Akimoto K, Goto A, Ohya K. Selective and sensitive determination of lactone and hydroxy acid forms of camptothecin and two derivatives (CPT-11 and SN-38) by high-performance liquid chromatography with fluorescence detection. J Chromatogr 1991; 588: 165-70
    • (1991) J Chromatogr , vol.588 , pp. 165-170
    • Akimoto, K.1    Goto, A.2    Ohya, K.3
  • 76
    • 0027937924 scopus 로고
    • Reversed-phase high-performance liquid chromatographic method for the simultaneous quantitation of the carboxylate and lactone forms of the camptothecin derivative irinotecan, CPT-11, and its metabolite SN-38 in plasma
    • Rivory LP, Robert J. Reversed-phase high-performance liquid chromatographic method for the simultaneous quantitation of the carboxylate and lactone forms of the camptothecin derivative irinotecan, CPT-11, and its metabolite SN-38 in plasma. J Chromatogr Biomed Appl 1994; 661: 133-41
    • (1994) J Chromatogr Biomed Appl , vol.661 , pp. 133-141
    • Rivory, L.P.1    Robert, J.2
  • 77
    • 0030891273 scopus 로고    scopus 로고
    • Simple and versatile high-performance liquid chromatographic method for the simultaneous quantitation of the lactone and carboxylate forms of camptothecin anticancer drugs
    • Warner DL, Burke TG. Simple and versatile high-performance liquid chromatographic method for the simultaneous quantitation of the lactone and carboxylate forms of camptothecin anticancer drugs. J Chromatogr B Biomed Appl 1997; 691: 161-71
    • (1997) J Chromatogr B Biomed Appl , vol.691 , pp. 161-171
    • Warner, D.L.1    Burke, T.G.2
  • 78
    • 0029164578 scopus 로고
    • High-performance liquid chromatographic determination of irinotecan (CPT-11) and its active metabolite (SN-38) in human plasma
    • Sumiyoshi H, Fujiwara Y, Ohune T, et al. High-performance liquid chromatographic determination of irinotecan (CPT-11) and its active metabolite (SN-38) in human plasma. J Chromatogr B Biomed Appl 1995; 670: 309-16
    • (1995) J Chromatogr B Biomed Appl , vol.670 , pp. 309-316
    • Sumiyoshi, H.1    Fujiwara, Y.2    Ohune, T.3
  • 79
    • 0028843263 scopus 로고
    • Pharmacological correlation between total drug concentration and lactones of CPT-11 and SN-38 in patients treated with CPT-11
    • Sasaki Y, Yoshida Y, Sudoh K, et al. Pharmacological correlation between total drug concentration and lactones of CPT-11 and SN-38 in patients treated with CPT-11. Jpn J Cancer Res 1995; 86: 111-6
    • (1995) Jpn J Cancer Res , vol.86 , pp. 111-116
    • Sasaki, Y.1    Yoshida, Y.2    Sudoh, K.3
  • 80
    • 0028813952 scopus 로고
    • A pharmacokinetic and pharmacodynamic analysis of CPT-11 and its active metabolite SN-38
    • Sasaki Y, Hakusui H, Mizuno S, et al. A pharmacokinetic and pharmacodynamic analysis of CPT-11 and its active metabolite SN-38. Jpn J Cancer Res 1995; 86: 101-10
    • (1995) Jpn J Cancer Res , vol.86 , pp. 101-110
    • Sasaki, Y.1    Hakusui, H.2    Mizuno, S.3
  • 81
    • 0028670840 scopus 로고
    • Kinetics of the in vivo interconversion of the carboxylate and lactone forms of irinotecan (CPT-11) and of its metabolite SN-38 in patients
    • Rivory LP, Chatelut E, Canal P, et al. Kinetics of the in vivo interconversion of the carboxylate and lactone forms of irinotecan (CPT-11) and of its metabolite SN-38 in patients. Cancer Res 1994; 54: 6330-3
    • (1994) Cancer Res , vol.54 , pp. 6330-6333
    • Rivory, L.P.1    Chatelut, E.2    Canal, P.3
  • 82
    • 0025827281 scopus 로고
    • CPT-11 converting enzyme from rat serum: Purification and some properties
    • Tsuji T, Kaneda N, Kado K, et al. CPT-11 converting enzyme from rat serum: purification and some properties. J Pharmacobiodyn 1991; 14: 341-9
    • (1991) J Pharmacobiodyn , vol.14 , pp. 341-349
    • Tsuji, T.1    Kaneda, N.2    Kado, K.3
  • 83
    • 0028364014 scopus 로고
    • Metabolic activation of CPT-11, 7-ethyl-10-[4-(1-piperidino)-1-piperidinocarbonyloxy camptothecin, a novel antitumor agent, by carboxyesterase
    • Satoh T, Hosokawa M, Atsumi K, et al. Metabolic activation of CPT-11, 7-ethyl-10-[4-(1-piperidino)-1-piperidino)carbonyloxy camptothecin, a novel antitumor agent, by carboxyesterase. Biol Pharm Bull 1994; 17: 662-4
    • (1994) Biol Pharm Bull , vol.17 , pp. 662-664
    • Satoh, T.1    Hosokawa, M.2    Atsumi, K.3
  • 84
    • 0030580064 scopus 로고    scopus 로고
    • Conversion of irinotecan (CPT-11) to its active metabolite. 7-ethyl-10-hydroxycamptothecin (SN-38). by human liver carboxyesterase
    • Rivory LP, Bowles MR, Robert J, et al. Conversion of irinotecan (CPT-11) to its active metabolite. 7-ethyl-10-hydroxycamptothecin (SN-38). by human liver carboxyesterase. Biochem Pharmacol 1996; 52: 1103-11
    • (1996) Biochem Pharmacol , vol.52 , pp. 1103-1111
    • Rivory, L.P.1    Bowles, M.R.2    Robert, J.3
  • 85
    • 0028853410 scopus 로고
    • Population pharmacokinetics and pharmacodynamics of irinotecan (CPT-11) and active metabolite SN-38 during phase I trials
    • Chabot GG, Abigerges D, Catimel G, et al. Population pharmacokinetics and pharmacodynamics of irinotecan (CPT-11) and active metabolite SN-38 during phase I trials. Ann Oncol 1995; 6: 141-51
    • (1995) Ann Oncol , vol.6 , pp. 141-151
    • Chabot, G.G.1    Abigerges, D.2    Catimel, G.3
  • 86
    • 0028989171 scopus 로고
    • Identification and kinetics of a beta-glucuronide metabolite of SN-38 in human plasma after administration of the camptothecin derivative irinotecan
    • Rivory LP, Robert J. Identification and kinetics of a beta-glucuronide metabolite of SN-38 in human plasma after administration of the camptothecin derivative irinotecan. Cancer Chemother Pharmacol 1995; 36: 176-9
    • (1995) Cancer Chemother Pharmacol , vol.36 , pp. 176-179
    • Rivory, L.P.1    Robert, J.2
  • 87
    • 0031058320 scopus 로고    scopus 로고
    • Glucuronidation of SN-38. the active metabolite of irinotecan, by human hepatic microsomes
    • Haaz MC, Rivory L, Jantet S, et al. Glucuronidation of SN-38. the active metabolite of irinotecan, by human hepatic microsomes. Pharmacol Toxicol 1997; 80: 91-6
    • (1997) Pharmacol Toxicol , vol.80 , pp. 91-96
    • Haaz, M.C.1    Rivory, L.2    Jantet, S.3
  • 88
    • 0028022585 scopus 로고
    • Metabolic fate of irinotecan in humans: Correlation of glucuronidation with diarrhoea
    • Gupta E, Lestingi TM, Mick R, et al. Metabolic fate of irinotecan in humans: correlation of glucuronidation with diarrhoea. Cancer Res 1994; 54: 3723-5
    • (1994) Cancer Res , vol.54 , pp. 3723-3725
    • Gupta, E.1    Lestingi, T.M.2    Mick, R.3
  • 89
    • 0029760995 scopus 로고    scopus 로고
    • Identification and properties of a major plasma metabolite of irinotecan (CPT-11) isolated from the plasma of patients
    • Rivory LP, Riou JF, Haaz MC, et al. Identification and properties of a major plasma metabolite of irinotecan (CPT-11) isolated from the plasma of patients. Cancer Res 1996; 56: 3689-94
    • (1996) Cancer Res , vol.56 , pp. 3689-3694
    • Rivory, L.P.1    Riou, J.F.2    Haaz, M.C.3
  • 91
    • 0027372606 scopus 로고
    • Phase I and pharmacologic study of irinotecan in combination with cisplatin for advanced lung cancer
    • Masuda N, Fukuoka M, Kudoh S, et al. Phase I and pharmacologic study of irinotecan in combination with cisplatin for advanced lung cancer. Br J Cancer 1993; 68: 777-82
    • (1993) Br J Cancer , vol.68 , pp. 777-782
    • Masuda, N.1    Fukuoka, M.2    Kudoh, S.3
  • 92
    • 0028035248 scopus 로고
    • Phase I and pharmacologic study of irinotecan and etoposide with recombinant human granulocyte colony stimulating factor support for advanced lung cancer
    • Masuda N, Fukuoka M, Kudoh S, et al. Phase I and pharmacologic study of irinotecan and etoposide with recombinant human granulocyte colony stimulating factor support for advanced lung cancer. J Clin Oncol 1994; 12: 1833-41
    • (1994) J Clin Oncol , vol.12 , pp. 1833-1841
    • Masuda, N.1    Fukuoka, M.2    Kudoh, S.3
  • 93
    • 0010917253 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of irinotecan during a phase II clinical trial in colorectal cancer
    • Canal P, Gay C, Dezeuze A, et al. Pharmacokinetics and pharmacodynamics of irinotecan during a phase II clinical trial in colorectal cancer. J Clin Oncol 1996; 14: 2688-95
    • (1996) J Clin Oncol , vol.14 , pp. 2688-2695
    • Canal, P.1    Gay, C.2    Dezeuze, A.3
  • 94
    • 0030856521 scopus 로고    scopus 로고
    • Pharmacokinetic inter-relationships of irinotecan (CPT-11) and its three major plasma metabolites in patients enrolled in phase I-II trials
    • Rivory LP, Haaz MC, Canal P, et al. Pharmacokinetic inter-relationships of irinotecan (CPT-11) and its three major plasma metabolites in patients enrolled in phase I-II trials. Clin Cancer Res 1997; 3: 1261-6
    • (1997) Clin Cancer Res , vol.3 , pp. 1261-1266
    • Rivory, L.P.1    Haaz, M.C.2    Canal, P.3
  • 95
    • 1842340863 scopus 로고    scopus 로고
    • UGT isoform 1.1 (UGT*1.1) glucuronidates SN-38, the active metabolite of irinotecan
    • Iyer L, King C, Tephly T, et al. UGT isoform 1.1 (UGT*1.1) glucuronidates SN-38, the active metabolite of irinotecan [abstract 707]. Proc Am Soc Clin Oncol 1997; 16: 201a
    • (1997) Proc Am Soc Clin Oncol , vol.16
    • Iyer, L.1    King, C.2    Tephly, T.3
  • 96
    • 85036482421 scopus 로고    scopus 로고
    • Data on file Rhône-Poulenc Rorer, S.A Antony, France
    • Data on file Rhône-Poulenc Rorer, S.A Antony, France
  • 97
    • 0028012774 scopus 로고
    • The structural basis of camptothecin interactions with human serum albumin: Impact on drug stability
    • Burke TG, Mi Z. The structural basis of camptothecin interactions with human serum albumin: impact on drug stability. J Med Chem 1994; 37: 40-6
    • (1994) J Med Chem , vol.37 , pp. 40-46
    • Burke, T.G.1    Mi, Z.2
  • 98
    • 0000291599 scopus 로고    scopus 로고
    • A Phase I trial to evaluate orally administered irinotecan HCI (CPT-11) given daily X 5 every 3 weeks in patients with refractory malignancies
    • Burris H, Dietz A, Eckardt J, et al. A Phase I trial to evaluate orally administered irinotecan HCI (CPT-11) given daily X 5 every 3 weeks in patients with refractory malignancies [abstract]. Proc Am Soc Clin Oncol 1996; 15: 489
    • (1996) Proc Am Soc Clin Oncol , vol.15 , pp. 489
    • Burris, H.1    Dietz, A.2    Eckardt, J.3
  • 99
    • 0028952739 scopus 로고
    • Pharmacokinetics of irinotecan and its metabolites in human blood, bile, and urine
    • Lokiec F, Canal P, Gay C, et al. Pharmacokinetics of irinotecan and its metabolites in human blood, bile, and urine. Cancer Chemother Pharmacol 1995; 36: 79-82
    • (1995) Cancer Chemother Pharmacol , vol.36 , pp. 79-82
    • Lokiec, F.1    Canal, P.2    Gay, C.3
  • 100
    • 0028598336 scopus 로고
    • Factors involved in clinical pharmacology variability in oncology
    • Chabot GG. Factors involved in clinical pharmacology variability in oncology. Anticancer Res 1994; 14: 2269-72
    • (1994) Anticancer Res , vol.14 , pp. 2269-2272
    • Chabot, G.G.1
  • 101
    • 0030958098 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic evaluation of the topoisomerase inhibitor irinotecan in cancer patients
    • Gupta E, Mick R, Ramirez J, et al. Pharmacokinetic and pharmacodynamic evaluation of the topoisomerase inhibitor irinotecan in cancer patients. J Clin Oncol 1997; 15: 1502-10
    • (1997) J Clin Oncol , vol.15 , pp. 1502-1510
    • Gupta, E.1    Mick, R.2    Ramirez, J.3
  • 102
    • 0031055238 scopus 로고    scopus 로고
    • Modulation of glucuronidation of SN-38, the active metabolite of irinotecan, by valproic acid and phenobarbital
    • Gupta E, Wang X, Ramirez J, et al. Modulation of glucuronidation of SN-38, the active metabolite of irinotecan, by valproic acid and phenobarbital. Cancer Chemother Pharmacol 1997; 39: 440-4
    • (1997) Cancer Chemother Pharmacol , vol.39 , pp. 440-444
    • Gupta, E.1    Wang, X.2    Ramirez, J.3
  • 103
    • 0029876561 scopus 로고    scopus 로고
    • Pharmacokinetic modulation of irinotecan and metabolites by cyclosporin A
    • Gupta E, Safa AR, Wang X, et al. Pharmacokinetic modulation of irinotecan and metabolites by cyclosporin A. Cancer Res 1996; 56: 1309-14
    • (1996) Cancer Res , vol.56 , pp. 1309-1314
    • Gupta, E.1    Safa, A.R.2    Wang, X.3
  • 104
    • 0028340348 scopus 로고
    • Simultaneous administration of CPT-11 and fluorouracil: Alteration of the pharmacokinetics of CPT-11 and SN-38 in patients with advanced colorectal cancer
    • Sasaki Y, Ohtsu A, Shimada Y, et al. Simultaneous administration of CPT-11 and fluorouracil: alteration of the pharmacokinetics of CPT-11 and SN-38 in patients with advanced colorectal cancer. J Natl Cancer Inst 1994; 86: 1096-8
    • (1994) J Natl Cancer Inst , vol.86 , pp. 1096-1098
    • Sasaki, Y.1    Ohtsu, A.2    Shimada, Y.3
  • 105
    • 0013628787 scopus 로고    scopus 로고
    • A phase I pharmacokinetics study of concomitant CPT-11 and 5FU combination
    • Grossin F, Barhault H, Benhammouda A, et al. A phase I pharmacokinetics study of concomitant CPT-11 and 5FU combination (abstract 1156). Proc Am Assoc Cancer Res 1996; 37: 168
    • (1996) Proc Am Assoc Cancer Res , vol.37 , pp. 168
    • Grossin, F.1    Barhault, H.2    Benhammouda, A.3
  • 106
    • 0008461578 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of irinotecan, fluorouracil, and leucovorin in patients with advanced solid tumors
    • Saltz LB, Kanowitz J, Kemeny NE, et al. Phase I clinical and pharmacokinetic study of irinotecan, fluorouracil, and leucovorin in patients with advanced solid tumors. J Clin Oncol 1996; 14: 2959-67
    • (1996) J Clin Oncol , vol.14 , pp. 2959-2967
    • Saltz, L.B.1    Kanowitz, J.2    Kemeny, N.E.3
  • 107
    • 9844258262 scopus 로고
    • Pharmacokinetic study in the dose escalation study of CPT-11 and VP-16. [abstract]
    • Karato A, Sasaki Y, Shiraishi J, et al. Pharmacokinetic study in the dose escalation study of CPT-11 and VP-16. [abstract]. Proc Am Assoc Cancer Res 1993; 34: 2325
    • (1993) Proc Am Assoc Cancer Res , vol.34 , pp. 2325
    • Karato, A.1    Sasaki, Y.2    Shiraishi, J.3
  • 108
    • 0000907355 scopus 로고    scopus 로고
    • Phase I dose-finding and pharmacokinetic (PK) study of docetaxel (D) in combination with irinotecan (I) in advanced solid tumors
    • Couteau C, Lokiec F, Vernillet L, et al. Phase I dose-finding and pharmacokinetic (PK) study of docetaxel (D) in combination with irinotecan (I) in advanced solid tumors [abstract 709]. Proc Am Soc Clin Oncol 1997; 16: 202a
    • (1997) Proc Am Soc Clin Oncol , vol.16
    • Couteau, C.1    Lokiec, F.2    Vernillet, L.3
  • 109
    • 0028947192 scopus 로고
    • Relationship between the pharmacokinetics of irinotecan and diarrhoea during combination chemotherapy wilh cisplatin
    • Kudoh S, Fukuoka M, Masuda N, et al. Relationship between the pharmacokinetics of irinotecan and diarrhoea during combination chemotherapy wilh cisplatin. Jpn J Cancer Res 1995; 86: 406-13
    • (1995) Jpn J Cancer Res , vol.86 , pp. 406-413
    • Kudoh, S.1    Fukuoka, M.2    Masuda, N.3
  • 110
    • 0029902106 scopus 로고    scopus 로고
    • Limited-sampling models for irinotecan pharmacokinetics-pharmacodynamics: Prediction of biliary index and intestinal toxicity
    • Mick R, Gupta E, Vokes EE, et al. Limited-sampling models for irinotecan pharmacokinetics-pharmacodynamics: prediction of biliary index and intestinal toxicity. J Clin Oncol 1996; 14: 2012-9
    • (1996) J Clin Oncol , vol.14 , pp. 2012-2019
    • Mick, R.1    Gupta, E.2    Vokes, E.E.3
  • 111
    • 0029089278 scopus 로고
    • Limited sampling models for simultaneous estimation of the pharmacokinetics of irinotecan and its active metabolite SN-38
    • Chabot GG. Limited sampling models for simultaneous estimation of the pharmacokinetics of irinotecan and its active metabolite SN-38. Cancer Chemother Pharmacol 1995; 36: 463-72
    • (1995) Cancer Chemother Pharmacol , vol.36 , pp. 463-472
    • Chabot, G.G.1
  • 112
    • 0029004492 scopus 로고
    • Efficient sampling strategies for forecasting pharmacokinetic parameters of irinotecan (CPT-11): Implication for area under the concentration-time curve monitoring
    • Nakashima H, Lieberman, R, Karato A, et al. Efficient sampling strategies for forecasting pharmacokinetic parameters of irinotecan (CPT-11): implication for area under the concentration-time curve monitoring. Ther Drug Monit 1995; 17: 221-9
    • (1995) Ther Drug Monit , vol.17 , pp. 221-229
    • Nakashima, H.1    Lieberman, R.2    Karato, A.3
  • 113
    • 0028887473 scopus 로고
    • A limited sampling model for estimating pharmacokinetics of CPT-11 and its metabolite SN-38
    • Sasaki Y, Mizuno S, Fujii H, et al. A limited sampling model for estimating pharmacokinetics of CPT-11 and its metabolite SN-38. Jpn J Cancer Res 1995; 86: 117-23
    • (1995) Jpn J Cancer Res , vol.86 , pp. 117-123
    • Sasaki, Y.1    Mizuno, S.2    Fujii, H.3
  • 114
    • 0028168687 scopus 로고
    • CPT-11: Population pharmacokinetic model and estimation of pharmacokinetics using the Bayesian method in patients with lung cancer
    • Yamamoto N, Ramura T, Karato A, et al. CPT-11: population pharmacokinetic model and estimation of pharmacokinetics using the Bayesian method in patients with lung cancer. Jpn J Cancer Res 1994; 85: 972-7
    • (1994) Jpn J Cancer Res , vol.85 , pp. 972-977
    • Yamamoto, N.1    Ramura, T.2    Karato, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.