Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells

Cancer Research

Volumn 56, Issue 13, 1996, Pages 2973-2978

  Carlson, Bradley A ^a   Dubay, Marja M ^b   Sausville, Edward A ^a   Brizuela, Leonardo ^b   Worland, Peter J ^a,b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b GPC Biotech Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYCLIN DEPENDENT KINASE; CYCLINE; FLAVONE DERIVATIVE; FLAVOPIRIDOL; PROTEIN P53; RETINOBLASTOMA PROTEIN; TYROSINE; CDK2 PROTEIN, HUMAN; CDK4 PROTEIN, HUMAN; CYCLIN D; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; ENZYME INHIBITOR; FLAVONOID; ONCOPROTEIN; PIPERIDINE DERIVATIVE; PROTEIN SERINE THREONINE KINASE;

ARTICLE; BREAST CARCINOMA; CELL CYCLE G1 PHASE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; AMINO ACID SEQUENCE; BREAST TUMOR; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; METABOLISM; MOLECULAR GENETICS; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; SERODIAGNOSIS;

AMINO ACID SEQUENCE; BREAST NEOPLASMS; CDC2-CDC28 KINASES; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASES; CYCLINS; ENZYME INHIBITORS; FLAVONOIDS; G1 PHASE; HUMANS; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PIPERIDINES; PRECIPITIN TESTS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; RETINOBLASTOMA PROTEIN; TUMOR CELLS, CULTURED;

EID: 0029665778     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (62)

1. Kaur, G., Stetler-Stevenson, M., Sebers, S , Worland, P , Sedlacek, H., Myers, C., Czech, J , Naik, R., and Sausville, E. Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275. J Natl. Cancer Inst., 84: 1736-1740, 1992.
2. Worland, P. J , Kaur G., Stetler-Stevenson, M., Sebers, S., Sartor O., and Sausville, E. A Alteration of the phosphorylation state of p34cdc2 kinase by the flavone L86-8275 in breast carcinoma cells. Biochem. Pharmacol. 46: 1831-1840, 1993.
3. Czech, J., Hoffmann, D , Naik, R., and Sedlacek, H. Antitumoral activity of flavone L 86-8275 Int. J Oncol., 6: 31-36, 1994.
4. Losiewicz, M. D , Carlson, B A , Kaur, G , Sausville, E A., and Worland, P J Potent inhibition of cdc2 kinase activity by the flavonoid L86-8275. Biochem Biophys. Res. Commun , 201: 589-595, 1994
5. 1 phase progression cycling on cue. Cell, 79. 551-555, 1994.
6. Hunter, T., and Pines, J. Cyclins and cancer. II. Cyclin D and CDK inhibitors come of age Cell, 79. 573-582, 1994.
7. King, R. W , Jackson, P. K., and Kirschner M W Mitosis in transition. Cell, 79 563-571, 1994.
8. Morgan, D O Principles of cdk regulation Nature (Lond ), 374. 131-134, 1995.
9. 1 cyclins. Cell, 73: 1059-1065, 1993.
10. 1-to-S transition in mammalian cells. Oncogene, 8: 1593-1602, 1993.
11. 1-to-S phase transition. Mol. Cell Biol., 15: 2612-2624, 1994.
12. Solomon, M. J., Lee, T., and Kirschner, M. W. Role of phosphorylation in p34cdc2 activation: identification of an activating kinase. Mol. Biol. Cell, 3: 13-27, 1992.
13. Gu, Y., Rosenblatt, J., and Morgan, D. O. Cell cycle regulation of cdk2 activity by phosphorylation of thr160 and tyr15. EMBO J., 11: 3995-4005, 1992
14. Kato, J-Y., Matsuoka, M., Strom, D. K., and Sherr, C. J. Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase. Mol. Cell Biol., 14: 2713-2721, 1994.
15. Matsuoka, M., Kato, J-Y., Fisher, R. P., Morgan, D. O., and Sherr, C. J. Activation of cyclin-dependent kinase 4 (cdk4) by mouse MO15-associated kinase. Mol. Cell. Biol , 14: 7265-7275, 1994.
16. McGowan, C. H., and Russell, P. Human wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on tyr15. EMBO J., 12: 75-85, 1993.
17. Featherstone, C., and Russell, P. Fission yeast p107 mitotic inhibitor is a tyrosine/ serine kinase. Nature (Lond.), 349: 808-811, 1993.
18. Parker, L L., Atherton-Fessler, S , and Piwnica-Worms, H. p107wee1 is a dual specificity kinase that phosphorylates p34cdc2 on tyrosine 15. Proc. Natl. Acad. Sci. USA, 89: 2917-2921, 1992.
19. Rowley, R., Hudson, J., and Young, P. G. The wee1 protein kinase is required for radiation-induced mitotic delay. Nature (Lond.), 356. 353-355, 1992.
20. Heald, R., McLoughlin, M., and McKeon, F. Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated cdc2 kinase Cell, 74: 463-474, 1993.
21. 1 arrest induced by ultraviolet irradiation Nature (Lond.), 376. 358-362, 1995.
22. Murray, A. W., Solomon, M. J., and Kirschner, M W. The role of cyclin synthesis and degradation in the control of maturation promoting factor activity. Nature (Lond.), 339: 280-286, 1993.
23. Glotzer, M., Murray, A. W., and Kirschner, M. W. Cyclin is degraded by the ubiquitin pathway Nature (Lond.), 349. 132-138, 1991.
24. Serrano, M , Hannon, G. J , and Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature (Lond.), 366: 704-707, 1993.
25. Hannon, G. J., and Beach, D. p15ink4B is a potential effector of TGF-β-induced cell cycle arrest. Nature (Lond.), 371: 257-260, 1994.
26. 1 and S phase protein phosphatase that associates with cdk2. Cell, 75: 791-803, 1993.
27. 1 cyclin-dependent kinases. Cell, 75: 805-816, 1993.
28. El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K W., and Vogelstein, B Waf1, a potential mediator of p53 tumor suppression Cell, 75: 817-825, 1993
29. Lee, M , Reynisdottir, I , and Massague, J. Cloning of p57kip2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution. Genes & Dev , 9: 639-649, 1995.
30. Matsuoka, S , Edwards, M. C , Bai, C., Parker, S , Zhang, P , Baldini, A., Harper, J. W., and Elledge, S. J p57kip2, a structurally distinct member of the p21cip1 cdk inhibitor family, is a candidate tumor suppressor gene. Genes & Dev , 9: 650-662, 1995.
31. Chan, F. K. M., Zhang, J , Cheng, L., Shapiro, D., and Winoto, A. Identification of human and mouse p19, a novel cdk4and cdk6 inhibitor with homology to p16ink4 Mol. Cell. Biol., 15: 2682-2688, 1995.
32. Hirai, H., Roussel, M. F., Kato, J., Ashmun, R. A., and Sherr, C. Novel Ink4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases cdk4 and cdk6 Mol. Cell. Biol., 15: 2672-2681, 1995
33. 1 arrest. Cell 76: 1013-1023, 1994.
34. Li, Y , Jenkins, C W., Nichols, M A., and Xiong, Y. Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21. Oncogene, 9. 2261-2268, 1994.
35. Li, Y., Nichols, M. A., Shay, J W., and Xiong, Y Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p167 by the retinoblastoma susceptibility gene product pRb. Cancer Res., 54: 6078-6082, 1994.
36. Tam, S. W., Shay, J. W., and Pagano, M Differential expression and cell cycle regulation of the cyclin-dependent kinase 4 inhibitor p16ink4. Cancer Res , 54: 5816-5820, 1994.
37. Guan, K-I., Jenkins, C. W , Li, Y., Nichols, M. A., Wu, X , O'Keefe, C L., Matera, A G., and Xiong, Y. Growth suppression by p18, a p16INK4/MTS1-and p14INK4B/ MTS2-related CDK6 inhibitor, correlates with wild-type pRb function Genes & Dev., 8: 2939-2952, 1994.
38. Polyak, K., Kato, J-Y, Solomon, M. J., Sherr, C. J., Massague, J., Roberts, J M., and Koff, A. p27kip1, a cyclin-cdk inhibitor, links transforming growth factor-β and contact inhibition to cell cycle arrest. Genes & Dev., 8: 9-22, 1994.
39. Slingerland, J. M., Hengst, L., Pan, C-H., Alexander, D , Stampfer M. R , and Reed, S. I A novel inhibitor of cyclin-cdk activity detected in transforming growth factor b-arrested epithelial cells. Mol. Cell, Biol , 14: 3683-3694, 1994.
40. Kato, J-Y., Matsuoka, M., Polyak, K., Massague, J., and Sherr, C. J. Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase Cell, 79. 487-496, 1994
41. Gu, Y., Turck, C. W., and Morgan, D. O. Cell cycle regulation of cdk2 activity by phosphorylation of thr160 and tyr15. Nature (Lond.), 366: 707-710, 1993.
42. Xiong, Y., Hannon, G., Zhang, H., Casso, D , Kobayashi, R , and Beach, D. p21 is a universal inhibitor of cyclin kinases. Nature (Lond.), 366: 701-704, 1993
43. Hussussian, C. J., Struewing, J P., Goldstein, A. M., Higgins, P. A. T., Ally, D. S., Sheahan, M D., Clark, W. H., Jr., Tucker, M. A., and Dracopoli, N. C. Germline p16 mutations in familial melanoma. Nat. Genet., 8: 15-21, 1993.
44. Nobori, T, Miura, K., Wu, D J , Lois, A., Takabayashi, K., and Carson, D. A. Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature (Lond.), 368: 753-756, 1994
45. Danilenko, M , Worland, P., Carlson, B , Sausville, E , and Sharoni, Y. Selective effects of mastoparan analogues: separation of G-protein-directed and membrane perturbing activities Biochem. Biophys. Res. Commun , 196: 1296-1302, 1993.
46. Ewen, M E , Sluss, H. K., Whitehouse, L. L , and Livingston, D. M. TGF-β inhibition of cdk4 synthesis is linked to cell cycle arrest. Cell, 74. 1009-1020, 1993.
47. 1. Genes & Dev., 7: 812-822, 1993.
48. Kamijo, M., Yasuda, H., Yau, P. M., Yamashita, M , Nagahama, Y., and Ohba, Y. Preference of human cdc2 kinase for peptide substrate Pept Res., 5: 281-285, 1992.
49. Kaelin, W. G., Jr., Pallas, D. C., DeCaprio, J. A., Kaye, F. J., and Livingston, D. M. Identification of cellular proteins that can interact specifically with the T/E1A-binding region of the retinoblastoma gene product. Cell, 64: 521-532, 1991.
50. 1 progression Oncogene, 9: 2663-2674, 1994.
51. 1 control in retinoblastoma gene-deficient cells independently of cdk4 activity. Mol. Cell. Biol., 15: 2600-2611, 1995.
52. Bartek, J., Iggo, R., Gannon, J., and Lane, D. P Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines. Oncogene, 5: 893-899, 1990.
53. Nigro, J. M., Baker, S. J., Preisinger, A C., Jessup, J. M., Hostetter, R., Cleary, K., Bigner, S. H., Davidson, N., Baylin, S , Devilee, P., Glover, T , Collins, F. S., Weston, A., Modali, R., Harris, C. C., and Vogelstein, B. Mutations in the p53 gene occur in diverse human tumour types. Nature (Lond.), 342: 705-708, 1989.
54. Lee, E. Y-H P., To, H., Shew, J., Bookstein, R., Scully, P., and Lee, W. Inactivation of the retinoblastoma susceptibility gene in human breast cancers. Science (Washington DC), 241: 218-221, 1988.
55. T'Ang, A., Varley, J M., Chakraborty, S., Murphree, A. L., and Fung, Y. T. Structural rearrangement of the retinoblastoma gene in human breast carcinoma. Science (Washington DC), 242 263-266, 1988.
56. Otterson, G. A., Kratzke, R. A , Coxon, A., Kim, Y. W., and Kaye, F J. Absence of p16ink4 protein is restricted to the subset of lung cancer lines that retains wildtype Rb. Oncogene, 9: 3375-3378, 1994.
57. Müller, H., Lukas, J , Schneider, A., Warthoe, P., Bartek, J., Eilers, M , and Strauss, M. Cyclin D1 expression is regulated by the retinoblastoma protein Proc. Natl. Acad. Sci. USA, 91: 2945-2949, 1994.
58. Bates, S , Parry, D., Bonetta, L., Vousden, K., Dickson, C., and Peters, G. Cdk6 (PLSTIRE) and cdk4(PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1. Oncogene, 9: 1633-1640, 1994
59. Parry, D., Bates, S., Mann, D J , and Peters, G. Lack of cyclin D-cdk complexes in Rb-negative cells correlates with high levels of p16 tumour suppressor gene product. EMBO J., 14: 503-511, 1995.
60. Dowdy, S. F., Hinds, P W., Louie, K., Reed, S. I., Arnold, A., and Weinberg, R. A Physical interaction of the retinoblastoma protein with human D cyclins. Cell, 73: 499-511, 1993.
61. De Bondt, H. L., Rosenblatt, J , Jancarik, J., Jones, H. D., Morgan, D. O., and Kim, S-H. Crystal structure of cyclin dependent kinase 2. Nature (Lond.), 363: 595-602, 1993.
62. Jeffrey, P. D , Russ, A. A., Polyak, K., Gibbs, E., Hurwitz, J., Massague, J., and Pavletich, N. P Mechanism of CDK activation revealed by the structure of a cyclin A-CDK2 complex Nature (Lond.), 376: 313-320, 1995