-
1
-
-
0034162636
-
Preclinical and clinical development of cyclin-dependent kinase modulators
-
Senderowicz, A., and Sausville, E. Preclinical and clinical development of cyclin-dependent kinase modulators. J. Natl. Cancer Inst. (Bethesda), 92: 376-385, 2000.
-
(2000)
J. Natl. Cancer Inst. (Bethesda)
, vol.92
, pp. 376-385
-
-
Senderowicz, A.1
Sausville, E.2
-
2
-
-
0029993339
-
Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase
-
De Azevedo, W. F., Jr., Mueller-Dieckmann, H. J., Schylze-Gahmen, U., Worland, P. J., Sausville, E., and Kim, S. H. Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase. Proc. Natl. Acad. Sci. USA, 93: 2735-2740, 1996.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 2735-2740
-
-
De Azevedo, W.F.1
Mueller-Dieckmann, H.J.2
Schylze-Gahmen, U.3
Worland, P.J.4
Sausville, E.5
Kim, S.H.6
-
3
-
-
0033568521
-
1 by transcriptional repression in MCF-7 human breast carcinoma cells induced by flavopiridol
-
1 by transcriptional repression in MCF-7 human breast carcinoma cells induced by flavopiridol. Cancer Res., 59: 4634-4641, 1999.
-
(1999)
Cancer Res.
, vol.59
, pp. 4634-4641
-
-
Carlson, B.1
Lahusen, T.2
Singh, S.3
Loaiza-Perez, A.4
Worland, P.J.5
Pestell, R.6
Albanese, C.7
Sausville, E.A.8
Senderowicz, A.M.9
-
4
-
-
0027433237
-
Alteration of the phosphorylation state of p34cdc2 kinase by the flavone L86-8275 in breast carcinoma cells. Correlation with decreased H1 kinase activity
-
Worland, P. J., Daur, G., Stetler-Stevenson, M., Sebers, S., Sartor, O., and Sausville, E. A. Alteration of the phosphorylation state of p34cdc2 kinase by the flavone L86-8275 in breast carcinoma cells. Correlation with decreased H1 kinase activity. Biochem. Pharmacol., 46: 1831-1840, 1993.
-
(1993)
Biochem. Pharmacol.
, vol.46
, pp. 1831-1840
-
-
Worland, P.J.1
Daur, G.2
Stetler-Stevenson, M.3
Sebers, S.4
Sartor, O.5
Sausville, E.A.6
-
5
-
-
0034722901
-
Small molecule modulators of cyclin-dependent kinases for cancer therapy
-
Senderowicz, A. Small molecule modulators of cyclin-dependent kinases for cancer therapy. Oncogene, 19: 6600-6606. 2000.
-
(2000)
Oncogene
, vol.19
, pp. 6600-6606
-
-
Senderowicz, A.1
-
6
-
-
0032533599
-
Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53
-
Byrd, J. C., Shinn, C., Waselenko, K. J., Fuchs, E. J., Lehman, T. A., Nguyen, P. L., Fllinn, I. W., Diehl, L. F., Sausville, E., and Grever, M. R. Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53. Blood, 92: 3804-3816, 1998.
-
(1998)
Blood
, vol.92
, pp. 3804-3816
-
-
Byrd, J.C.1
Shinn, C.2
Waselenko, K.J.3
Fuchs, E.J.4
Lehman, T.A.5
Nguyen, P.L.6
Fllinn, I.W.7
Diehl, L.F.8
Sausville, E.9
Grever, M.R.10
-
7
-
-
0034935026
-
Flavopiridol circumvents Bcl-2 family mediated inhibition of apoptosis and drug resistance in B-cell chronic lymphocytic leukaemia
-
Pepper, C., Thomas, A., Hoy, T., Fegan, C., and Bentley, P. Flavopiridol circumvents Bcl-2 family mediated inhibition of apoptosis and drug resistance in B-cell chronic lymphocytic leukaemia. Br. J. Haematol., 114: 70-77, 2001.
-
(2001)
Br. J. Haematol.
, vol.114
, pp. 70-77
-
-
Pepper, C.1
Thomas, A.2
Hoy, T.3
Fegan, C.4
Bentley, P.5
-
8
-
-
0036138680
-
Growth inhibition and apoptosis of myeloma cells by the CDK inhibitor flavopiridol
-
Semenov, I., Akyuz, C., Roginskaya, V., Chauhan, D., and Corey, S. J. Growth inhibition and apoptosis of myeloma cells by the CDK inhibitor flavopiridol. Leuk. Res., 26: 271-280, 2002.
-
(2002)
Leuk. Res.
, vol.26
, pp. 271-280
-
-
Semenov, I.1
Akyuz, C.2
Roginskaya, V.3
Chauhan, D.4
Corey, S.J.5
-
9
-
-
0034661538
-
Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia
-
Kitada, S., Zapata, J. M., Andreef, M., and Reed, J. C. Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia. Blood, 96: 393-397, 2000.
-
(2000)
Blood
, vol.96
, pp. 393-397
-
-
Kitada, S.1
Zapata, J.M.2
Andreef, M.3
Reed, J.C.4
-
10
-
-
0033960068
-
Induction of apoptosis and inhibition of c-erbB-2 in breast cancer cells by flavopiridol
-
Li, Y., Bhuiyan, M., Alhasan, S., Senderowicz, A. M., and Sarkar, F. Induction of apoptosis and inhibition of c-erbB-2 in breast cancer cells by flavopiridol. Clin. Cancer Res., 5: 223-229, 2000.
-
(2000)
Clin. Cancer Res.
, vol.5
, pp. 223-229
-
-
Li, Y.1
Bhuiyan, M.2
Alhasan, S.3
Senderowicz, A.M.4
Sarkar, F.5
-
11
-
-
0033082995
-
IAP family of proteins: Suppressors of apoptosis
-
Deveraux, Q. L., and Reed, J. C. IAP family of proteins: suppressors of apoptosis. Genes Dev., 13: 239-252. 1999
-
(1999)
Genes Dev.
, vol.13
, pp. 239-252
-
-
Deveraux, Q.L.1
Reed, J.C.2
-
12
-
-
0032522738
-
IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases
-
Deveraux, Q. L., Roy, N., Stennicke, H. R., Van Arsdale, T., Zhou, Q., Srinivasula, S. M., Alnemri, E. S., Salvesen, G. S., and Reed, J. C. IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J., 17: 2215-2223, 1998.
-
(1998)
EMBO J.
, vol.17
, pp. 2215-2223
-
-
Deveraux, Q.L.1
Roy, N.2
Stennicke, H.R.3
Van Arsdale, T.4
Zhou, Q.5
Srinivasula, S.M.6
Alnemri, E.S.7
Salvesen, G.S.8
Reed, J.C.9
-
13
-
-
0032506524
-
Control of apoptosis and mitotic spindle checkpoint by survivin
-
Li, F., Ambrosini, G., Chu, E. Y., Plescia, J., Tognin, S., Marchisio, P. C., and Altieri, D. C. Control of apoptosis and mitotic spindle checkpoint by survivin. Nature (Lond.), 396: 580-584, 1998.
-
(1998)
Nature (Lond.)
, vol.396
, pp. 580-584
-
-
Li, F.1
Ambrosini, G.2
Chu, E.Y.3
Plescia, J.4
Tognin, S.5
Marchisio, P.C.6
Altieri, D.C.7
-
14
-
-
0032403126
-
IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs
-
Tamm, I., Wang, Y., Sausville, E., Scudiero, D. A., Vigna, N., Oltersdorf, T., and Reed, J. C. IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res., 58: 5315-5320, 1998.
-
(1998)
Cancer Res.
, vol.58
, pp. 5315-5320
-
-
Tamm, I.1
Wang, Y.2
Sausville, E.3
Scudiero, D.A.4
Vigna, N.5
Oltersdorf, T.6
Reed, J.C.7
-
15
-
-
9144247196
-
Down-regulation of survivin by antisense oligonucleotides increases apoptosis, inhibits cytokinesis and anchorage-independent growth
-
Chen, J., Wu, W., Tahir, S. K., Kroeger, P. E., Rosenberg, S. H., Cowsert, L. M., Bennett, F., Krajewski, S., Krajewska, M., Welsh, K., Reed, J. C., and Ng, S. C. Down-regulation of survivin by antisense oligonucleotides increases apoptosis, inhibits cytokinesis and anchorage-independent growth. Neoplasia, 2: 235-241, 2000.
-
(2000)
Neoplasia
, vol.2
, pp. 235-241
-
-
Chen, J.1
Wu, W.2
Tahir, S.K.3
Kroeger, P.E.4
Rosenberg, S.H.5
Cowsert, L.M.6
Bennett, F.7
Krajewski, S.8
Krajewska, M.9
Welsh, K.10
Reed, J.C.11
Ng, S.C.12
-
16
-
-
0034667372
-
Down-regulation of X-linked inhibitor of apoptosis protein induces apoptosis in chemoresistant human ovarian cancer cells
-
Sasaki, H., Sheng, Y., Kotsuji, F., and Tsang, B. K. Down-regulation of X-linked inhibitor of apoptosis protein induces apoptosis in chemoresistant human ovarian cancer cells. Cancer Res., 60: 5659-5666, 2000.
-
(2000)
Cancer Res.
, vol.60
, pp. 5659-5666
-
-
Sasaki, H.1
Sheng, Y.2
Kotsuji, F.3
Tsang, B.K.4
-
17
-
-
0342657718
-
A novel antisense oligonucleotide targeting survivin expression induces apoptosis and sensitizes lung cancer cells to chemotherapy
-
Olie, R. A., Simoes-Wust, A. P., Baumann, B., Leech, S. H., Fabbro, D., Stahel, R. A., and Zangemeister-Wittke, U. A novel antisense oligonucleotide targeting survivin expression induces apoptosis and sensitizes lung cancer cells to chemotherapy. Cancer Res., 60: 2805-2809, 2000.
-
(2000)
Cancer Res.
, vol.60
, pp. 2805-2809
-
-
Olie, R.A.1
Simoes-Wust, A.P.2
Baumann, B.3
Leech, S.H.4
Fabbro, D.5
Stahel, R.A.6
Zangemeister-Wittke, U.7
-
18
-
-
0035233239
-
Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol
-
Lam, L., Pickeral, O., Peng, A., Rosenwald, A., Hurt, E., Gilmane, J., Averett, L., Zhao, H., Davis, R. E., Sathyamoorthy, M., Wahl, L., Harris, L., Harris, E., Mikovits, J., Monks, A., Hollingshead, M., Sausville, E., and Staudt, L. Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol. Genome Biol., 2: 0041.1-0041.11, 2001.
-
(2001)
Genome Biol.
, vol.2
, pp. 411
-
-
Lam, L.1
Pickeral, O.2
Peng, A.3
Rosenwald, A.4
Hurt, E.5
Gilmane, J.6
Averett, L.7
Zhao, H.8
Davis, R.E.9
Sathyamoorthy, M.10
Wahl, L.11
Harris, L.12
Harris, E.13
Mikovits, J.14
Monks, A.15
Hollingshead, M.16
Sausville, E.17
Staudt, L.18
-
19
-
-
0034665961
-
Flavopiridol inhibits P-TEFb and blocks HIV-1 replication
-
Chao, S. H., Fujinaga, K., Marion, J. E., Taube, R., Sausville, E. A., Senderowicz, A. M., Peterlin, B. M., and Price, D. H. Flavopiridol inhibits P-TEFb and blocks HIV-1 replication. J. Biol. Chem., 275: 28345-28348, 2000.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 28345-28348
-
-
Chao, S.H.1
Fujinaga, K.2
Marion, J.E.3
Taube, R.4
Sausville, E.A.5
Senderowicz, A.M.6
Peterlin, B.M.7
Price, D.H.8
-
20
-
-
0034111019
-
P-TEFb, a cyclin-dependent kinase controlling elongation by RNA polymerase II
-
Price, D. H. P-TEFb, a cyclin-dependent kinase controlling elongation by RNA polymerase II. Mol. Cell. Biol., 20: 2629-2634, 2000.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 2629-2634
-
-
Price, D.H.1
-
21
-
-
0034194254
-
Flavopiridol binds to duplex DNA
-
Bible, K. C., Bible, R. H., Jr., Kottke, T. J., Svingen, P. A., Xu, K., Pang, Y. P., Hajdu, E., and Kaufmann, S. H. Flavopiridol binds to duplex DNA. Cancer Res., 60: 2419-2428, 2000.
-
(2000)
Cancer Res.
, vol.60
, pp. 2419-2428
-
-
Bible, K.C.1
Bible, R.H.2
Kottke, T.J.3
Svingen, P.A.4
Xu, K.5
Pang, Y.P.6
Hajdu, E.7
Kaufmann, S.H.8
-
22
-
-
0002478350
-
Malignant tumors of the breast
-
V. T. Devita, Jr., S. Hellman, and S. A. Rosenberg (eds.). Philadelphia: Lippincott-Raven Publishers
-
Winer, E., Morrow, M., Osborne, C. K., and Harris, J. Malignant tumors of the breast. In: V. T. Devita, Jr., S. Hellman, and S. A. Rosenberg (eds.), Cancer: Principles and Practice of Oncology, 6th ed., pp. 1651-1716. Philadelphia: Lippincott-Raven Publishers, 2000.
-
(2000)
Cancer: Principles and Practice of Oncology, 6th Ed.
, pp. 1651-1716
-
-
Winer, E.1
Morrow, M.2
Osborne, C.K.3
Harris, J.4
-
23
-
-
0034892578
-
New cytotoxic agents and schedules for advanced breast cancer
-
Burstein, H., Bunnell, C., and Winer, E. New cytotoxic agents and schedules for advanced breast cancer. Semin. Oncol., 28: 344-358, 2001.
-
(2001)
Semin. Oncol.
, vol.28
, pp. 344-358
-
-
Burstein, H.1
Bunnell, C.2
Winer, E.3
-
24
-
-
0033052777
-
Mechanisms of action of and resistance to antitubulin agents: Microtubule dynamics, drug transport, and cell death
-
Dumontet, C., and Sikic, B. Mechanisms of action of and resistance to antitubulin agents: microtubule dynamics, drug transport, and cell death. J. Clin. Oncol., 17: 1061-1070, 1999.
-
(1999)
J. Clin. Oncol.
, vol.17
, pp. 1061-1070
-
-
Dumontet, C.1
Sikic, B.2
-
25
-
-
0029049468
-
Epothilones, a new class of microtubule-stabilizing agents with a Taxol-like mechanism of action
-
Bollag, D. M., McQueney, P. A., Zhu, J., Hensens, O., Koupal, L., Liesch, J., Goetz, M., Lazarides, E., and Woods, C. M. Epothilones, a new class of microtubule-stabilizing agents with a Taxol-like mechanism of action. Cancer Res., 55: 2325-2333, 1995.
-
(1995)
Cancer Res.
, vol.55
, pp. 2325-2333
-
-
Bollag, D.M.1
McQueney, P.A.2
Zhu, J.3
Hensens, O.4
Koupal, L.5
Liesch, J.6
Goetz, M.7
Lazarides, E.8
Woods, C.M.9
-
26
-
-
0031762486
-
Temporal relationship of CDKI activation and mitotic arrest to cytosolic accumulation of cytochrome c and caspase-3 activity during Taxol-induced apoptosis
-
Ibrado, A. M., Kim, C. N., and Bhalla, K. Temporal relationship of CDKI activation and mitotic arrest to cytosolic accumulation of cytochrome c and caspase-3 activity during Taxol-induced apoptosis. Leukemia (Baltimore), 12: 1930-1936, 1998.
-
(1998)
Leukemia (Baltimore)
, vol.12
, pp. 1930-1936
-
-
Ibrado, A.M.1
Kim, C.N.2
Bhalla, K.3
-
27
-
-
0030615086
-
L overexpression inhibits progression of molecular events leading to paclitaxel-induced apoptosis of human AML HL-60 cells
-
L overexpression inhibits progression of molecular events leading to paclitaxel-induced apoptosis of human AML HL-60 cells. Cancer Res., 57: 1109-1115, 1997.
-
(1997)
Cancer Res.
, vol.57
, pp. 1109-1115
-
-
Ibrado, A.M.1
Liu, L.2
Bhalla, K.3
-
28
-
-
0034895987
-
BMS-247550: A novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy
-
Lee, F. Y., Borzilleri, R., Fairchild, C. R., Kim, S. H., Long, B. H., Reventos-Suarez, C., Vite, G. D., Rose, W. C., and Kramer, R. A. BMS-247550: a novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy. Clin. Cancer Res., 7: 1429-1437, 2001.
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 1429-1437
-
-
Lee, F.Y.1
Borzilleri, R.2
Fairchild, C.R.3
Kim, S.H.4
Long, B.H.5
Reventos-Suarez, C.6
Vite, G.D.7
Rose, W.C.8
Kramer, R.A.9
-
29
-
-
0037081329
-
Epothilone B analogue (BMS-247550)-mediated cytotoxicity through induction of Bax conformational change in human breast cancer cells
-
Yamaguchi, H., Paranawithana, S. R., Lee, M. W., Huang, Z., Bhalla, K. N., and Wang, H. G. Epothilone B analogue (BMS-247550)-mediated cytotoxicity through induction of Bax conformational change in human breast cancer cells. Cancer Res., 62: 466-471, 2002.
-
(2002)
Cancer Res.
, vol.62
, pp. 466-471
-
-
Yamaguchi, H.1
Paranawithana, S.R.2
Lee, M.W.3
Huang, Z.4
Bhalla, K.N.5
Wang, H.G.6
-
30
-
-
0030812207
-
Cytotoxic synergy between flavopiridol (NSC 649890, L86-8275) and various antineoplastic agents: The importance of sequence of administration
-
Bible, K. C., and Kaufmann, S. H. Cytotoxic synergy between flavopiridol (NSC 649890, L86-8275) and various antineoplastic agents: the importance of sequence of administration. Cancer Res., 57: 3375-3380, 1997.
-
(1997)
Cancer Res.
, vol.57
, pp. 3375-3380
-
-
Bible, K.C.1
Kaufmann, S.H.2
-
31
-
-
0035679234
-
Augmentation of apoptosis and tumor regression by flavopiridol in the presence of CPT-11 in Hct116 colon cancer monolayers and xenografts
-
Motwani, M., Jung, C., Sirotnak, F. M., She, Y., Shah, M. A., Gonen, M., and Schwartz, G. K. Augmentation of apoptosis and tumor regression by flavopiridol in the presence of CPT-11 in Hct116 colon cancer monolayers and xenografts. Clin. Cancer Res., 7: 4209-4219, 2001.
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 4209-4219
-
-
Motwani, M.1
Jung, C.2
Sirotnak, F.M.3
She, Y.4
Shah, M.A.5
Gonen, M.6
Schwartz, G.K.7
-
32
-
-
0032804733
-
Sequential dependent enhancement of caspase activation and apoptosis by flavopiridol on paclitaxel-treated human gastric and breast cancer cells
-
Motwani, M., Delohery, T. M., and Schwartz, G. K. Sequential dependent enhancement of caspase activation and apoptosis by flavopiridol on paclitaxel-treated human gastric and breast cancer cells. Clin. Cancer Res., 5: 1876-1883, 1999.
-
(1999)
Clin. Cancer Res.
, vol.5
, pp. 1876-1883
-
-
Motwani, M.1
Delohery, T.M.2
Schwartz, G.K.3
-
33
-
-
0034616945
-
Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
-
Du, C., Fang, M., Li, Y., Li, L., and Wang, X. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell. 102: 33-42, 2000.
-
(2000)
Cell
, vol.102
, pp. 33-42
-
-
Du, C.1
Fang, M.2
Li, Y.3
Li, L.4
Wang, X.5
-
34
-
-
0034676267
-
Induction of p21 WAF1/CIP1 and cyelin D1 expression by the Src oncoprotein in mouse fibroblasts: Role of activated STAT3 signaling
-
Sinibaldi, D., Wharton, W., Turkson, J., Bowman, T., Pledger, W. J., and Jove, R. Induction of p21 WAF1/CIP1 and cyelin D1 expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling. Oncogene, 19: 5419-5427, 2000.
-
(2000)
Oncogene
, vol.19
, pp. 5419-5427
-
-
Sinibaldi, D.1
Wharton, W.2
Turkson, J.3
Bowman, T.4
Pledger, W.J.5
Jove, R.6
-
35
-
-
0029658187
-
Bcl-xL overexpression inhibits Taxol-induced Yama protease activity and apoptosis
-
Ibrado, A. M., Huang, Y., Fang, G., and Bhalla, K. Bcl-xL overexpression inhibits Taxol-induced Yama protease activity and apoptosis. Cell Growth Differ., 7: 1087-1094, 1996.
-
(1996)
Cell Growth Differ.
, vol.7
, pp. 1087-1094
-
-
Ibrado, A.M.1
Huang, Y.2
Fang, G.3
Bhalla, K.4
-
36
-
-
0034654517
-
The role of Apaf-1, caspase-9, and bid proteins in etoposide- or paclitaxel-induced mitochondrial events during apoptosis
-
Perkins, C. L., Fang, G., Kim, C. N., and Bhalla, K. N. The role of Apaf-1, caspase-9, and bid proteins in etoposide- or paclitaxel-induced mitochondrial events during apoptosis. Cancer Res., 60: 1645-1653, 2000.
-
(2000)
Cancer Res.
, vol.60
, pp. 1645-1653
-
-
Perkins, C.L.1
Fang, G.2
Kim, C.N.3
Bhalla, K.N.4
-
37
-
-
0036565885
-
Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative (BMS 247550)- and Apo-2L/TRAIL-induced apoptosis
-
Guo, F., Nimmanapalli, R., Paranawithana, S., Wittman, S., Griffin, D., Bali, P., O'Bryan, E., Fumero, C., Wang, H. G., and Bhalla, K. Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative (BMS 247550)- and Apo-2L/TRAIL-induced apoptosis. Blood, 99: 3419-3426, 2002.
-
(2002)
Blood
, vol.99
, pp. 3419-3426
-
-
Guo, F.1
Nimmanapalli, R.2
Paranawithana, S.3
Wittman, S.4
Griffin, D.5
Bali, P.6
O'Bryan, E.7
Fumero, C.8
Wang, H.G.9
Bhalla, K.10
-
38
-
-
18544386724
-
Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction
-
Hegde, R., Srinivasula, S., Zhang, Z., Wassell, R., Mukattash, R., Cilenti, L., DuBois, G., Lazebnik, Y., Zervos, A., Fernandes-Alnemri, T., and Alnemri, E. S. Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction. J. Biol. Chem., 277: 432-438, 2002.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 432-438
-
-
Hegde, R.1
Srinivasula, S.2
Zhang, Z.3
Wassell, R.4
Mukattash, R.5
Cilenti, L.6
DuBois, G.7
Lazebnik, Y.8
Zervos, A.9
Fernandes-Alnemri, T.10
Alnemri, E.S.11
-
39
-
-
85008486060
-
Pretreatment with paclitaxel enhances Apo-2 ligand/tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of prostate cancer cells by inducing death receptors 4 and 5 protein levels
-
Ramadevi, N., Perkins, C., Orlando, M., Nguyen, D., O'Bryan, E., and Bhalla, K. Pretreatment with paclitaxel enhances Apo-2 ligand/tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of prostate cancer cells by inducing death receptors 4 and 5 protein levels. Cancer Res., 6: 766-770, 2001.
-
(2001)
Cancer Res.
, vol.6
, pp. 766-770
-
-
Ramadevi, N.1
Perkins, C.2
Orlando, M.3
Nguyen, D.4
O'Bryan, E.5
Bhalla, K.6
-
40
-
-
0035266132
-
Geldanamycin and its analogue 17-allylamino-17-demethoxygeldanamycin (17-AAG) lowers Bcr-Abl level and induces apoptosis and differentiation of Bcr-Abl-positive human leukemic blasts
-
Ramadevi, N., O'Bryan, E., and Bhalla, K. Geldanamycin and its analogue 17-allylamino-17-demethoxygeldanamycin (17-AAG) lowers Bcr-Abl level and induces apoptosis and differentiation of Bcr-Abl-positive human leukemic blasts. Cancer Res., 61: 1799-1804, 2001.
-
(2001)
Cancer Res.
, vol.61
, pp. 1799-1804
-
-
Ramadevi, N.1
O'Bryan, E.2
Bhalla, K.3
-
41
-
-
0035890085
-
The expanding role of mitochondria in apoptosis
-
Wang, X. The expanding role of mitochondria in apoptosis. Genes Dev., 15: 2922-2933, 2001.
-
(2001)
Genes Dev.
, vol.15
, pp. 2922-2933
-
-
Wang, X.1
-
42
-
-
0035487184
-
Effect of the proteasome inhibitor ALLaL on cisplatin sensitivity in human ovarian tumor cells
-
Yunmbam, M. K., Li, Q. Q., Mimnaugh, E. G., Kayastha, G. L., Yu, J. J., Jones, L. N., Neckers, L., and Reed, E. Effect of the proteasome inhibitor ALLaL on cisplatin sensitivity in human ovarian tumor cells. Int. J. Oncol., 19: 741-748, 2001.
-
(2001)
Int. J. Oncol.
, vol.19
, pp. 741-748
-
-
Yunmbam, M.K.1
Li, Q.Q.2
Mimnaugh, E.G.3
Kayastha, G.L.4
Yu, J.J.5
Jones, L.N.6
Neckers, L.7
Reed, E.8
-
43
-
-
0040932434
-
The novel cyclin-dependent kinase inhibitor flavopiridol downregulates Bcl-2 and induces growth arrest and apoptosis in chronic B-cell leukemia lines
-
Konig, A., Schwartz, G. K., Mohammad, R. M., Al-Katib, A., and Gabrilove, J. L. The novel cyclin-dependent kinase inhibitor flavopiridol downregulates Bcl-2 and induces growth arrest and apoptosis in chronic B-cell leukemia lines. Blood, 90: 4307-4312, 1997.
-
(1997)
Blood
, vol.90
, pp. 4307-4312
-
-
Konig, A.1
Schwartz, G.K.2
Mohammad, R.M.3
Al-Katib, A.4
Gabrilove, J.L.5
-
44
-
-
0034644659
-
Bcl-2 independence of flavopiridol-induced apoptosis. Mitochondrial depolarization in the absence of cytochrome c release
-
Achenbach, T. V., Muller, R., and Slater, E. P. Bcl-2 independence of flavopiridol-induced apoptosis. Mitochondrial depolarization in the absence of cytochrome c release. J. Biol. Chem., 275: 32089-32097, 2000.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 32089-32097
-
-
Achenbach, T.V.1
Muller, R.2
Slater, E.P.3
-
45
-
-
0033258543
-
Pleiotropic cell-division defects and apoptosis induced by interference with survivin function
-
Li, F., Ackermann, E. J., Bennett, C. F., Rothermel, A. L., Plescia, J., Tognin, S., Villa, A., Marchisio, P. C., and Altieri, D. C. Pleiotropic cell-division defects and apoptosis induced by interference with survivin function. Nat. Cell Biol., 1: 461-466, 1999.
-
(1999)
Nat. Cell Biol.
, vol.1
, pp. 461-466
-
-
Li, F.1
Ackermann, E.J.2
Bennett, C.F.3
Rothermel, A.L.4
Plescia, J.5
Tognin, S.6
Villa, A.7
Marchisio, P.C.8
Altieri, D.C.9
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