메뉴 건너뛰기




Volumn 3, Issue 7, 2004, Pages 873-875

Gene profiling and the cyclin-dependent kinase inhibitor flavopiridol: What's in a name?

Author keywords

[No Author keywords available]

Indexed keywords

7 HYDROXYSTAUROSPORINE; BCR ABL PROTEIN; CYCLIN D1; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; CYTOTOXIC AGENT; FLAVOPIRIDOL; IMATINIB; N [5 (5 TERT BUTYL 2 OXAZOLYLMETHYLTHIO) 2 THIAZOLYL]ISONIPECOTAMIDE; ROSCOVITINE; UNCLASSIFIED DRUG;

EID: 4444331760     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (15)

References (29)
  • 2
    • 0242708738 scopus 로고    scopus 로고
    • Small-molecule cyclin-dependent kinase modulators
    • Senderowicz AM. Small-molecule cyclin-dependent kinase modulators. Oncogene 2003;22:6609-20.
    • (2003) Oncogene , vol.22 , pp. 6609-6620
    • Senderowicz, A.M.1
  • 3
    • 0032055497 scopus 로고    scopus 로고
    • Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppression, and has potent antitumor activity in vivo against human leukemia and lymphoma xenografts
    • Arguello F, Alexander M, Sterry JA, et al. Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppression, and has potent antitumor activity in vivo against human leukemia and lymphoma xenografts. Blood 1998;91:2482-90.
    • (1998) Blood , vol.91 , pp. 2482-2490
    • Arguello, F.1    Alexander, M.2    Sterry, J.A.3
  • 4
    • 0032804733 scopus 로고    scopus 로고
    • Sequential dependent enhancement of caspase activation and apoptosis by flavopiridol on paclitaxel-treated human gastric and breast cancer cells
    • Motwani M, Delohery TM, Schwartz GK. Sequential dependent enhancement of caspase activation and apoptosis by flavopiridol on paclitaxel-treated human gastric and breast cancer cells. Clin Cancer Res 1999;5:1876-83.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 1876-1883
    • Motwani, M.1    Delohery, T.M.2    Schwartz, G.K.3
  • 5
    • 0036259143 scopus 로고    scopus 로고
    • Synergistic induction of apoptosis in human myeloid leukemia cells by phorbol 12-myristate 13-acetate and flavopiridol proceeds via activation of both the intrinsic and tumor necrosis factor-mediated extrinsic cell death pathways
    • Cartee L, Smith R, Dai Y, et al. Synergistic induction of apoptosis in human myeloid leukemia cells by phorbol 12-myristate 13-acetate and flavopiridol proceeds via activation of both the intrinsic and tumor necrosis factor-mediated extrinsic cell death pathways. Mol Pharmacol 2002;61: 1313-21.
    • (2002) Mol. Pharmacol. , vol.61 , pp. 1313-1321
    • Cartee, L.1    Smith, R.2    Dai, Y.3
  • 6
    • 0033375469 scopus 로고    scopus 로고
    • Flavopiridol: The first cyclin-dependent kinase inhibitor in human clinical trials
    • Senderowicz AM. Flavopiridol: the first cyclin-dependent kinase inhibitor in human clinical trials. Invest New Drugs 1999;17:313-20.
    • (1999) Invest. New Drugs , vol.17 , pp. 313-320
    • Senderowicz, A.M.1
  • 7
    • 0038473927 scopus 로고    scopus 로고
    • Flavopiridol in untreated or relapsed mantle-cell lymphoma: Results of a phase II study of the National Cancer Institute of Canada Clinical Trials Group
    • National Cancer Institute of Canada Clinical Trials Group
    • Kouroukis CT, Belch A, Crump M, et al. National Cancer Institute of Canada Clinical Trials Group. Flavopiridol in untreated or relapsed mantle-cell lymphoma: results of a phase II study of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 2003;21:1740-5.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 1740-1745
    • Kouroukis, C.T.1    Belch, A.2    Crump, M.3
  • 8
    • 0035871444 scopus 로고    scopus 로고
    • Phase I trial of 72-hour continuous infusion UCN-01 in patients with refractory neoplasms
    • Sausville EA, Arbuck SG, Messmann R, et al. Phase I trial of 72-hour continuous infusion UCN-01 in patients with refractory neoplasms. J Clin Oncol 2001;19:2319-33.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 2319-2333
    • Sausville, E.A.1    Arbuck, S.G.2    Messmann, R.3
  • 9
    • 2442541492 scopus 로고    scopus 로고
    • A phase I and pharmacokinetic (PK) trial of CYC202, a novel oral cyclin-dependent kinase inhibitor, in patients (pts) with advanced solid tumors
    • Pierga J-Y, Faiver S, Vera K, et al. A phase I and pharmacokinetic (PK) trial of CYC202, a novel oral cyclin-dependent kinase inhibitor, in patients (pts) with advanced solid tumors. Proc Am Soc Clin Oncol 2003;22:840.
    • (2003) Proc. Am. Soc. Clin. Oncol. , vol.22 , pp. 840
    • Pierga, J.-Y.1    Faiver, S.2    Vera, K.3
  • 10
    • 1642405155 scopus 로고    scopus 로고
    • A phase I study to determine the safety and pharmacokinetics of BMS-387032 with a 24-hr infusion given every three weeks in patients with metastatic refractory solid tumors
    • Shapiro G, Lewis N, Bai B, et al. A phase I study to determine the safety and pharmacokinetics of BMS-387032 with a 24-hr infusion given every three weeks in patients with metastatic refractory solid tumors. Proc Am Soc Clin Oncol 2003;22:799.
    • (2003) Proc. Am. Soc. Clin. Oncol. , vol.22 , pp. 799
    • Shapiro, G.1    Lewis, N.2    Bai, B.3
  • 11
    • 0026425587 scopus 로고
    • Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor models
    • Akinaga S, Gomi K, Morimoto M, Tamaoki T, Okabe M. Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor models. Cancer Res 1991;51:4888-92.
    • (1991) Cancer Res. , vol.51 , pp. 4888-4892
    • Akinaga, S.1    Gomi, K.2    Morimoto, M.3    Tamaoki, T.4    Okabe, M.5
  • 12
    • 0030615323 scopus 로고    scopus 로고
    • G1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated human epidermoid carcinoma A431 cells
    • Akiyama T, Yoshida T, Tsujita T, et al. G1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated human epidermoid carcinoma A431 cells. Cancer Res 1997;57:1495-501.
    • (1997) Cancer Res. , vol.57 , pp. 1495-1501
    • Akiyama, T.1    Yoshida, T.2    Tsujita, T.3
  • 13
    • 2242421834 scopus 로고    scopus 로고
    • Structural basis for Chk1 inhibition by UCN-01
    • Zhao B, Bower MJ, McDevitt PJ, et al. Structural basis for Chk1 inhibition by UCN-01. J Biol Chem 2002;277:46609-15.
    • (2002) J. Biol. Chem. , vol.277 , pp. 46609-46615
    • Zhao, B.1    Bower, M.J.2    McDevitt, P.J.3
  • 14
    • 0037034928 scopus 로고    scopus 로고
    • Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine)
    • Sato S, Fujita N, Tsuruo T. Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine). Oncogene 2002; 21:1727-38.
    • (2002) Oncogene , vol.21 , pp. 1727-1738
    • Sato, S.1    Fujita, N.2    Tsuruo, T.3
  • 15
    • 0036101635 scopus 로고    scopus 로고
    • Flavopiridol inhibits vascular endothelial growth factor production induced by hypoxia or picolinic acid in human neuroblastoma
    • Rapella A, Negrioli A, Melillo G, Pastorino S, Varesio L, Bosco MC. Flavopiridol inhibits vascular endothelial growth factor production induced by hypoxia or picolinic acid in human neuroblastoma. J Cancer 2002;99: 658-64.
    • (2002) J. Cancer , vol.99 , pp. 658-664
    • Rapella, A.1    Negrioli, A.2    Melillo, G.3    Pastorino, S.4    Varesio, L.5    Bosco, M.C.6
  • 16
    • 0034665961 scopus 로고    scopus 로고
    • Flavopiridol inhibits P-TEFb and blocks HIV-1 replication
    • Chao SH, Fujinaga K, Marion JE, et al. Flavopiridol inhibits P-TEFb and blocks HIV-1 replication. J Biol Chem 2000;275:28345-8.
    • (2000) J. Biol. Chem. , vol.275 , pp. 28345-28348
    • Chao, S.H.1    Fujinaga, K.2    Marion, J.E.3
  • 17
    • 0034661538 scopus 로고    scopus 로고
    • Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate anti-apoptosis proteins in B-cell chronic lymphocytic leukemia
    • Kitada S, Zapata JM, Andreeff M, Reed JC. Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate anti-apoptosis proteins in B-cell chronic lymphocytic leukemia. Blood 2000; 96:393-7.
    • (2000) Blood , vol.96 , pp. 393-397
    • Kitada, S.1    Zapata, J.M.2    Andreeff, M.3    Reed, J.C.4
  • 18
    • 0036850211 scopus 로고    scopus 로고
    • The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in multiple myeloma cells through transcriptional repression and down-regulation of Mcl-1
    • Gojo I, Zhang B, Fenton RG. The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in multiple myeloma cells through transcriptional repression and down-regulation of Mcl-1. Clin Cancer Res 2002;8: 3527-38.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 3527-3538
    • Gojo, I.1    Zhang, B.2    Fenton, R.G.3
  • 19
    • 1342308338 scopus 로고    scopus 로고
    • Evidence of a functional role for p21WAF1/CIP1 down-regulation in synergistic antileukemic interactions between the histone deacetylase inhibitor sodium butyrate and flavopiridol
    • Rosato RR, Almenara JA, Yu C, Grant S. Evidence of a functional role for p21WAF1/CIP1 down-regulation in synergistic antileukemic interactions between the histone deacetylase inhibitor sodium butyrate and flavopiridol. Mol Pharmacol 2004;65:571-81.
    • (2004) Mol. Pharmacol. , vol.65 , pp. 571-581
    • Rosato, R.R.1    Almenara, J.A.2    Yu, C.3    Grant, S.4
  • 21
    • 0037228959 scopus 로고    scopus 로고
    • Suppression of survivin phosphorylation on Thr34 by flavopiridol enhances tumor cell apoptosis
    • Wall NR, O'Connor DS, Plescia J, Pommier Y, Altieri DC. Suppression of survivin phosphorylation on Thr34 by flavopiridol enhances tumor cell apoptosis. Cancer Res 2003;63:230-5.
    • (2003) Cancer Res. , vol.63 , pp. 230-235
    • Wall, N.R.1    O'Connor, D.S.2    Plescia, J.3    Pommier, Y.4    Altieri, D.C.5
  • 22
    • 0033568521 scopus 로고    scopus 로고
    • Down-regulation of cyclin D1 by transcriptional repression in MCF-7 human breast carcinoma cells induced by flavopiridol
    • Carlson B, Lahusen T, Singh S, et al. Down-regulation of cyclin D1 by transcriptional repression in MCF-7 human breast carcinoma cells induced by flavopiridol. Cancer Res 1999;59:4634-41.
    • (1999) Cancer Res. , vol.59 , pp. 4634-4641
    • Carlson, B.1    Lahusen, T.2    Singh, S.3
  • 23
    • 1042278138 scopus 로고    scopus 로고
    • Flavopiridol inhibits NF-κB activation induced by various carcinogens and inflammatory agents through inhibition of Iκ Bα kinase and p65 phosphorylation: Abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9
    • Takada Y, Aggarwal BB. Flavopiridol inhibits NF-κB activation induced by various carcinogens and inflammatory agents through inhibition of IκBα kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9. J Biol Chem 2004; 279:4750-9.
    • (2004) J. Biol. Chem. , vol.279 , pp. 4750-4759
    • Takada, Y.1    Aggarwal, B.B.2
  • 24
    • 0142121411 scopus 로고    scopus 로고
    • Imatinib mesylate (STI-571 Glivec, Gleevec) is an active agent for gastrointestinal stromal tumours, but does not yield responses in other soft-tissue sarcomas that are unselected for a molecular target
    • Results from an EORTC Soft Tissue and Bone Sarcoma Group phase II study
    • Verweij J, van Oosterom A, Blay JY, et al. Imatinib mesylate (STI-571 Glivec, Gleevec) is an active agent for gastrointestinal stromal tumours, but does not yield responses in other soft-tissue sarcomas that are unselected for a molecular target. Results from an EORTC Soft Tissue and Bone Sarcoma Group phase II study. Eur J Cancer 2003;39:2006-11.
    • (2003) Eur. J. Cancer , vol.39 , pp. 2006-2011
    • Verweij, J.1    van Oosterom, A.2    Blay, J.Y.3
  • 25
    • 4444263072 scopus 로고    scopus 로고
    • Transcriptional signature of flavopiridol-induced tumor cell death
    • Lu X, Burgan WE, Cerra MA, et al. Transcriptional signature of flavopiridol-induced tumor cell death. Mol Cancer Ther 2004;3:861-72.
    • (2004) Mol. Cancer Ther. , vol.3 , pp. 861-872
    • Lu, X.1    Burgan, W.E.2    Cerra, M.A.3
  • 26
    • 1842856885 scopus 로고    scopus 로고
    • ERK signaling: Duration, duration, duration
    • Stork PJ. ERK signaling: duration, duration, duration. Cell Cycle 2002; 1:315-7.
    • (2002) Cell Cycle , vol.1 , pp. 315-317
    • Stork, P.J.1
  • 27
    • 0037446980 scopus 로고    scopus 로고
    • The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process
    • Yu C, Rahmani M, Dai Y, et al. The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process. Cancer Res 2003;63:1822-33.
    • (2003) Cancer Res. , vol.63 , pp. 1822-1833
    • Yu, C.1    Rahmani, M.2    Dai, Y.3
  • 28
    • 0242468166 scopus 로고    scopus 로고
    • Proteasome inhibitors potentiate leukemic cell apoptosis induced by the cyclin-dependent kinase inhibitor flavopiridol through a SAPK/JNK- and NF-κB-dependent process
    • Dai Y, Rahmani M, Grant S. Proteasome inhibitors potentiate leukemic cell apoptosis induced by the cyclin-dependent kinase inhibitor flavopiridol through a SAPK/JNK- and NF-κB-dependent process. Oncogene 2003;22: 7108-22.
    • (2003) Oncogene , vol.22 , pp. 7108-7122
    • Dai, Y.1    Rahmani, M.2    Grant, S.3
  • 29
    • 0028216322 scopus 로고
    • Cloning mammalian genes by expression selection of genetic suppressor elements: Association of kinesin with drug resistance and cell immortalization
    • Gudkov AV, Kazarov AR, Thimmapaya R, Axenovich SA, Mazo IA, Roninson IB. Cloning mammalian genes by expression selection of genetic suppressor elements: association of kinesin with drug resistance and cell immortalization. Proc Natl Acad Sci USA 1994; 91:3744-8.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 3744-3748
    • Gudkov, A.V.1    Kazarov, A.R.2    Thimmapaya, R.3    Axenovich, S.A.4    Mazo, I.A.5    Roninson, I.B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.