Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down- regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia

Blood

Volumn 96, Issue 2, 2000, Pages 393-397

  Kitada, Shinichi ^b   Zapata, Juan M ^b   Andreeff, Michael ^b   Reed, John C ^a  

^a BURNHAM INSTITUTE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

7 HYDROXYSTAUROSPORINE; CASPASE INHIBITOR; FLAVOPIRIDOL; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE INHIBITOR; STAUROSPORINE DERIVATIVE;

APOPTOSIS; ARTICLE; B CELL LEUKEMIA; CELL CULTURE; CELL KILLING; CHRONIC LYMPHATIC LEUKEMIA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0034661538     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.2.393.014k47_393_397     Document Type: Article

References (35)

1. Kipps T. Chronic lymphocytic leukemia. Curr Opin Hematol. 1997;4:268-276.
2. Reed J. Chronic lymphocytic leukemia: a disease of disregulated programmed cell death. Clin Immunol Newslett. 1998;17:125-140.
3. Hanada M, Delia D. Aiello A, Stadtmauer E, Reed J. Bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia. Blood. 1993;82:1820-1828.
4. Robertson LE, Plunkett W, McConnell K, Keating MJ, McDonnell TJ. Bcl-2 expression in chronic lymphocytic leukemia and its correlation with the induction of apoptosis and clinical outcome. Leukemia. 1996;10:456-459.
5. Pepper C, Bentley P, Hoy T. Regulation of clinical chemoresistance by bcl-2 and bax oncoproteins in B-cell chronic lymphocytic leukemia. Br J Haematol. 1996;95:513-517.
6. Christodoulopoulos G, Fotouhi N, Krajewski S, Reed JC, Alaouli-Jamili M, Panasci L. Relationship between nitrogen mustard drug resistance in B-cell chronic lymphocytic leukemia (B-CLL) and protein expression of Bcl-2, Bax, Bcl-X, and p53. Cancer Lett. 1997;121:59-67.
7. Pepper C, Hoy T, Bentley P. Elevated Bcl-2/Bax are a consistent feature of apoptosis resistance in B-cell chronic lymphocytic leukemia and are correlated with in vivo chemoresistance. Leuk Lymphoma. 1998;28:355-361.
8. Pepper C, Hoy T, Bentley D. Bcl-2/Bax ratios in chronic lymphocytic leukemia and their correlation with in vitro apoptosis and clinical resistance. Br J Oncol. 1998;76:935-938.
9. Kitada S, Andersen J, Akar S, et al. Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with in vitro and in vivo chemoresponses. Blood. 1998;91:3379-3389.
10. O'Brien S, del Giglio A, Keating M. Advances in the biology and treatment of B-cell chronic lymphocytic leukemia. Blood. 1995;85:307-318.
11. Byrd J. Rai K, Sausville E, Grever M. Old and new therapies in chronic lymphocytic leukemia: now is the time for a reassessment of therapeutic goals. Semin Oncol. 1998;25:65-74.
12. Arguello F, Alexander M, Sterry JA, et al. Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppression, and has potent antitumor activity in vivo against human leukemia and lymphoma xenografts. Blood. 1998; 91:2482-2490.
13. Seynaeve CM, Kazanietz MG, Blumberg PM, Sausville EA, Worland PJ. Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analogue. Mol Pharmacol. 1994;45:1207-1214.
14. Cheson BD, Bennett JM, Grever M, et al. National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood. 1996;87:4990-4997.
15. Krajewski S, Zapata JM, Reed JC. Detection of multiple antigens on Western blots. Anal Biochem. 1996;236:221-228.
16. Krajewski S, Bodrug S, Gascoyne R, Berean K, Krajewska M, Reed JC. Immunohistochemical analysis of Mcl-1 and Bcl-2 proteins in normal and neoplastic lymph nodes. Am J Pathol. 1994; 145:515-525.
17. Krajewski S, Krajewska M, Shabaik A, et al. Immunohistochemical analysis of in vivo patterns of Bcl-X expression. Cancer Res. 1994;54:5501-5507.
18. Krajewski S, Krajewska M, Reed JC. Immunohistochemical analysis of in vivo patterns of Bak expression, a pro-apoptotic member of the Bcl-2 protein family. Cancer Res. 1996;56:2849-2855.
19. Takayama S, Krajewski S. Krajewska M, et al. Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines. Cancer Res. 1998;58:3116-3131.
20. Ranjit G, Cheng M-F, Mackay W, Whitacre CM, Berger JS, Berger NA. Poly (adenosine diphosphoribose) polymerase in peripheral blood leukocytes from normal donors and patients with malignancies. Clin Cancer Res. 1995;1:223-234.
21. Lazebnik YA, Kaufman SH, Desnoyers S, Poirier GG, Earnshaw WC. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature. 1994;371:346-347.
22. Reed J. Bcl-2 family proteins. Oncogene. 1998; 17:3225-3236.
23. Kroemer G. The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nat Med. 1997;8: 614-620.
24. Reed JC. Bcl-2: prevention of apoptosis as a mechanism of drug resistance. Hematol Oncol Clin North Am. 1995;9:451-474.
25. Reed JC. Molecular biology of chronic lymphocylic leukemia: implications for therapy. Semin Hematol. 1998;35:3-13.
26. Reed JC. Cytochrome C: can't live with it; can't live without it. Cell. 1997;91:559-562.
27. Takayama S, Bimston DN, Matsuzawa S, et al. BAG-1 modulates the chaperone activity of Hsp70/Hsc70. EMBO J. 1997;16:4887-4096.
28. Jäättelä M, Wissing D, Kokholm K, Kallunki T, Egeblad M. Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases. EMBO J. 1998;17:6124-6134.
29. Kullmann M, Schneikert J, Moll J, et al. RAP46 is a negative regulator of glucocorticoid receptor action and hormone induced apoptosis. J Biol Chem. 1998;273:14620-14625.
30. Liu R, Takayama S, Zheng Y, et al. Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells. J Biol Chem. 1998;273:16985-16992.
31. Deveraux QL, Takahashi R, Salvesen GS, Reed JC. X-linked IAP is a direct inhibitor of cell death proteases. Nature. 1997;388:300-304.
32. Deveraux Q, Reed J. IAP family proteins: suppressors of apoptosis. Genes Dev. 1999;13:239-252.
33. Reed JC. A day in the life of the Bcl-2 protein: does the turnover rate of Bcl-2 serve as a biological clock for cellular lifespan regulation? Leuk Res. 1996;20:109-111.
34. Kozopas KM, Yang T, Buchan HL, Zhou P, Craig R. Mcl-1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to Bcl-2. Proc Natl Acad Sci U S A. 1993;90:3516-3520.
35. Takayama S, Sato T, Krajewski S, et al. Cloning and functional analysis of BAG-1: a novel Bcl-2 binding protein with anti-cell death activity. Cell. 1995;80:279-284.