Down-regulation of cyclin D1 by transcriptional repression in MCF-7 human breast carcinoma cells induced by flavopiridol

Cancer Research

Volumn 59, Issue 18, 1999, Pages 4634-4641

  Carlson, Brad ^a   Lahusen, Tyler ^a   Singh, Sheo ^a   Loaiza Perez, Andrea ^a   Worland, Peter J ^c   Pestell, Richard ^b   Albanese, Chris ^b   Sausville, Edward A ^a   Senderowicz, Adrian M ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b ALBERT EINSTEIN CANCER CENTER   (United States)

^c GPC Biotech Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; CYCLIN D2; CYCLIN D3; CYCLIN DEPENDENT KINASE; CYCLIN E; CYCLOHEXIMIDE; FLAVOPIRIDOL; ISOENZYME; LUCIFERASE; MESSENGER RNA; RETINOBLASTOMA PROTEIN;

ARTICLE; BREAST CARCINOMA; CELL LEVEL; CELL STRAIN MCF 7; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG MECHANISM; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MITOSIS INHIBITION; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; REPORTER GENE; TRANSCRIPTION REGULATION;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CDC2-CDC28 KINASES; CELL CYCLE; CYCLIN D1; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASES; FEMALE; FLAVONOIDS; G1 PHASE; GENE EXPRESSION REGULATION, NEOPLASTIC; HALF-LIFE; HUMANS; KINETICS; PIPERIDINES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; RNA, MESSENGER; S PHASE; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0033568521     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (84)

1. Morgan, D. O. Cyclin-dependent kinases: engines, clocks, and microprocessors. Annu. Rev. Cell Dev. Biol., 13: 261-291, 1997.
2. Rickert, P., Seghezzi, W., Shanahan, F., Cho, H., and Lees, E. Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II. Oncogene, 12: 2631-2640, 1996.
3. Wei, P., Garber, M. E., Fang, S. M., Fischer, W. H., and Jones, K. A. A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA. Cell, 92: 451-462, 1998.
4. 1/S transition. Cancer Surv., 29: 7-23, 1997.
5. Weinberg, R. A. The retinoblastoma protein and cell cycle control. Cell, 81: 323-330, 1995.
6. Dyson, N. The regulation of E2F by pRB-family proteins. Genes Dev., 12: 2245-2262, 1998.
7. 1 progression-related events. Exp. Cell Res., 236: 173-180, 1997.
8. 1 progression. Oncogene, 9: 2663-2674, 1994.
9. Lovec, H., Sewing, A., Lucibello, F. C., Muller, R., and Moroy, T. Oncogenic activity of cyclin D1 revealed through cooperation with Ha-ras: link between cell cycle control and malignant transformation. Oncogene, 9: 323-326, 1994.
10. Nakagawa, H., Wang, T. C., Zukerberg, L., Odze, R., Togawa, K., May, G. H., Wilson, J., and Rustgi, A. K. The targeting of the cyclin D1 oncogene by an Epstein-Barr virus promoter in transgenic mice causes dysplasia in the tongue, esophagus and forestomach. Oncogene, 14: 1185-1190, 1997.
11. 2-terminal kinase, p38/Mpk2, serum response factor, or c-Jun. J. Biol. Chem., 273: 16739-16747, 1998.
12. Hinds, P. W., Dowdy, S. F., Eaton, E. N., Arnold, A., and Weinberg, R. A. Function of a human cyclin gene as an oncogene. Proc. Natl. Acad. Sci. USA, 91: 709-713, 1994.
13. Robles, A. I., Rodriguez-Puebla, M. L., Glick, A. B., Trempus, C., Hansen, L., Sicinski, P., Tennant, R. W., Weinberg, R. A., Yuspa, S. H., and Conti, C. J. Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo. Genes Dev., 12: 2469-2474, 1998.
14. Wang, T. C., Cardiff, R. D., Zukerberg, L., Lees, E., Arnold, A., and Schmidt, E. V. Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice. Nature (Lond.), 369: 669-671, 1994.
15. Pagano, M., Theodoras, A. M., Tam, S. W., and Draetta, G. F. Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts. Genes Dev., 8: 1627-1639, 1994.
16. Zhou, P., Jiang, W., Weghorst, C. M., and Weinstein, I. B. Overexpression of cyclin Dl enhances gene amplification, Cancer Res., 56: 36-39, 1996.
17. Xiong, Y., Connolly, T., Futcher, B., and Beach, D. Human D-type cyclin. Cell, 65: 691-699, 1991.
18. 1 cyclin (Cln) function in yeast. Cell, 66: 1197-1206, 1991.
19. Motokura, T., Bloom, T., Kim, H. G., Juppner, H., Ruderman, J. V., Kronenberg, H. M., and Arnold, A. A novel cyclin encoded by a bcl1-linked candidate oncogene. Nature (Lond.), 350: 512-515, 1991.
20. Withers, D. A., Harvey, R. C., Faust, J. B., Melnyk, O., Carey, K., and Meeker, T. C. Characterization of a candidate bcl-1 gene. Mol. Cell. Biol., 11: 4846-4853, 1991.
21. Raffeld, M., and Jaffe, E. S. bcl-1. t(11;14), and mantle cell-derived lymphomas. Blood, 78: 259-263, 1991.
22. Xu, J., Gimenez-Conti, I. B., Cunningham, J. E., Collet, A. M., Luna, M. A., Lanfranchi, H. E., Spitz, M. R., and Conti, C. J. Alterations of p53, cyclin D1, Rb, and H-ras in human oral carcinomas related to tobacco use. Cancer (Phila.), 83: 204-212, 1998.
23. 1a,b) invasive breast carcinomas. Cancer Res., 57: 1259-1263, 1997.
24. Weinstat-Saslow, D., Merino, M. J., Manrow, R. E., Lawrence, J. A., Bluth, R. F., Wittenbel, K. D., Simpson, J. F., Page, D. L., and Steeg, P. S. Overexpression of cyclin D mRNA distinguishes invasive and in situ breast carcinomas from non-malignant lesions. Nat Med., 1: 1257-1260, 1995.
25. Somers, K. D., Cartwright, S. L., and Schechter, G. L. Amplification of the int-2 gene in human head and neck squamous cell carcinomas. Oncogene, 5: 915-920, 1990.
26. Theillet, C., Adnane, J., Szepetowski, P., Simon, M. P., Jeanteur, P., Birnbaum, D., and Gaudray, P. BCL-1 participates in the 11q13 amplification found in breast cancer. Oncogene, 5: 147-149, 1990.
27. 1 restriction point regulation in Rb-deficient fibroblasts. Mol. Cell. Biol., 16: 2402-2407, 1996.
28. 1 regulation in human head and neck cancer. Cancer Res., 55: 949-956, 1995.
29. Betticher, D. C., Heighway, J., Hasleton, P. S., Altermatt, H. J., Ryder, W. D., Cerny, T., and Thatcher, N. Prognostic significance of CCND1 (cyclin D1) overexpression in primary resected non-small-cell lung cancer. Br. J. Cancer, 73: 294-300, 1996.
30. CDKN2B genes in certain B cell non-Hodgkin's lymphomas. Functional studies in a cell line (Granta 519). Leukemia (Baltimore), 11: 64-72, 1997.
31. Kitagawa, Y., Ueda, M., Ando, N., Shinozawa, Y., Shimizu, N., and Abe, O. Significance of int-2/hst-1 coamplification as a prognostic factor in patients with esophageal squamous carcinoma. Cancer Res., 51: 1504-1508, 1991.
32. Nishida, N., Fukuda, Y., Komeda, T., Kita, R., Sando, T., Furukawa, M., Amenomori, M., Shibagaki, I., Nakao, K., Ikenaga, M., and Ishizaki, K. Amplification and overexpression of the cyclin D1 gene in aggressive human hepatocellular carcinoma. Cancer Res., 54: 3107-3110, 1994.
33. Sausville, E. A., and Senderowicz, A. M. Chemical cyclin-dependent kinase inhibitors: therapeutic implications. In, J. S. Gutkind (ed.), Signal Transduction, Cell cycle and their Inhibitors, Vol. (in press). Totowa, NJ: The Humana Press Inc., 1999.
34. Kaur, G., Stetler-Stevenson, M., Sebers, S., Worland, P., Sedlacek, H., Myers, C., Czech, J., Naik, R., and Sausville, E. Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275. J. Natl. Cancer Inst., 84: 1736-1740, 1992.
35. 1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells. Cancer Res., 56: 2973-2978, 1996.
36. Carlson, B., Pearlstein, R., Naik, R., Sedlacek, H., Sausville, E., and Worland, P. Inhibition of CDK2, CDK4 and CDK7 by flavopiridol and structural analogs. Proc. Am. Assoc. Cancer Res., Abstract 424, 1996.
37. Losiewicz, M. D., Carlson, B. A., Kaur, G., Sausville, E. A., and Worland, P. J. Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275. Biochem. Biophys. Res. Commun., 201: 589-595, 1994.
38. De Azevedo, W. F., Jr, Mueller-Dieckmann, H. J., Schulze-Gahmen, U., Worland, P. J., Sausville, E., and Kim, S. H. Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase. Proc. Natl. Acad. Sci. USA, 93: 2735-2740, 1996.
39. ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions. J. Biol. Chem., 270: 23589-23597, 1995.
40. Chaidarun, S. S., and Alexander, J. M. A tumor-specific truncated estrogen receptor splice variant enhances estrogen-stimulated gene expression. Mol. Endocrinol., 12: 1355-1366, 1998.
41. Kitagawa, M., Higashi, H., Jung, H. K., Suzuki-Takahashi, I., Ikeda, M., Tamai, K., Kato, J., Segawa, K., Yoshida, E., Nishimura, S., and Taya, Y. The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. EMBO J., 15: 7060-7069, 1996.
42. Davis, L., Kuehl, W., and Battey, J. Basic Methods in Molecular Biology, Ed. 2, pp. 350-354. Norwalk, CT: Appleton & Lange, 1994.
43. Patel, V., Senderowicz, A. M., Pinto, D., Igishi, T., Raffeld, M., Quintanilla-Martinez, L., Ensley, J. F., Sausville, E. A., and Silvio Gutkind, J. Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis. J. Clin. Invest., 102: 1674-1681, 1998.
44. Pines, J. The cell cycle kinases. Semin. Cancer Biol., 5: 305-313, 1994.
45. 1 cyclin-dependent kinase activity during growth arrest of human breast carcinoma cells by prostaglandin A2. Mol. Cell. Biol., 16: 762-770, 1996.
46. Worland, P. J., Kaur, G., Stetler-Stevenson, M., Sebers, S., Sartor, O., and Sausville, E. A. Alteration of the phosphorylation state of p34cdc2 kinase by the flavone L86-8275 in breast carcinoma cells. Correlation with decreased H1 kinase activity. Biochem. Pharmacol., 46: 1831-1840, 1993.
47. 1 cyclins. Stem Cells (Dayton), 12 (Suppl. I): 47-57, 1994.
48. Choi, Y. H., Lee, S. J., Nguyen, P., Jang, J. S., Lee, J., Wu, M. L., Takano, E., Maki, M., Henkart, P. A., and Trepel, J. B. Regulation of cyclin D1 by calpain protease. J. Biol. Chem., 272: 28479-28484, 1997.
49. Rosenwald, I. B., Kaspar, R., Rousseau, D., Gehrke, L., Leboulch, P., Chen, J. J., Schmidt, E. V., Sonenberg, N., and London, I. M. Eukaryotic translation initiation factor 4E regulates expression of cyclin D1 at transcriptional and post-transcriptional levels. J. Biol. Chem., 270: 21176-21180, 1995.
50. 1 cyclins. Cell, 71: 323-334, 1992.
51. Pelosio, P., Barbareschi, M., Bonoldi, E., Marchetti, A., Verderio, P., Caffo, O., Bevilacqua, P., Boracchi, P., Buttitta, F., Barbazza, R., Dalla Palma, P., and Gasparini, G. Clinical significance of cyclin D1 expression in patients with node-positive breast carcinoma treated with adjuvant therapy. Ann. Oncol., 7: 695-703, 1996.
52. kip1 and degree of malignancy in human breast and colorectal cancers. Proc. Natl. Acad. Sci. USA, 94: 6380-6385, 1997.
53. Bartkova, J., Lukas, J., Strauss, M., and Bartek, J. Cyclin D1 oncoprotein aberrantly accumulates in malignancies of diverse histogenesis. Oncogene, 10: 775-778, 1995.
54. 1 to complete the cell cycle. Proc. Natl. Acad. Sci. USA, 91: 8022-8026, 1994.
55. Sherr, C. J. Cancer cell cycles. Science (Washington DC), 274: 1672-1677, 1996.
56. Bartkova, J., Lukas, J., Strauss, M., and Bartek, J. Cell cycle-related variation and tissue-restricted expression of human cyclin D1 protein. J. Pathol., 772: 237-245, 1994.
57. INK4/MTS1 tumour suppressor gene product. EMBO J., 14: 503-511, 1995.
58. 1 control in retinoblastoma gene-deficient cells independently of cdk4 activity. Mol. Cell Biol., 15: 2600-2611, 1995.
59. Pusch, O., Soucek, T., Wawra, E., Hengstschlager-Ottnad, E., Bemaschek, G., and Hengstschlager, M. Specific transformation abolishes cyclin D1 fluctuation throughout the cell cycle. FEBS Lett., 385: 143-148, 1996.
60. Juan, G., Gong, J., Traganos, F., and Darzynkiewicz, Z. Unscheduled expression of cyclins D1 and D3 in human tumour cell lines. Cell Proliferation, 29: 259-266, 1996.
61. King, R. W., Deshaies, R. J., Peters, J. M., and Kirschner, M. W. How proteolysis drives the cell cycle. Science (Washington DC), 274: 1652-1659, 1996.
62. Sherr, C. J. D-type cyclins. Trends Biochem. Sci., 20: 187-190, 1995.
63. Diehl, J. A., Cheng, M., Roussel, M. F., and Sherr, C. J. Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization. Genes Dev., 12: 3499-3511, 1998.
64. Lavoie, J. N., L'Allemain, G., Brunet, A., Muller, R., and Pouyssegur, J. Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway. J. Biol. Chem., 271: 20608-20616, 1996.
65. Watanabe, G., Howe, A., Lee, R. J., Albanese, C., Shu, I. W., Karnezis, A. N., Zon. L., Kyriakis, J., Rundell, K., and Pestell, R. G. Induction of cyclin D1 by simian virus 40 small tumor antigen. Proc. Natl. Acad. Sci. USA, 93: 12861-12866, 1996.
66. Watanabe, G., Lee, R. J., Albanese, C., Rainey, W. E., Batlle, D., and Pestell, R. G. Angiotensin II activation of cyclin D1-dependent kinase activity. J. Biol. Chem., 271: 22570-22577, 1996.
67. Westwick, J. K., Lambert, Q. T., Clark, G. J., Symons, M., Van Aelst, L., Pestell, R. G., and Der, C. J. Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways. Mol. Cell. Biol., 17: 1324-1335, 1997.
68. Lee, R. J., Albanese, C., Stenger, R., Watanabe, G., Inghirami, G., Haines, G. K., Penar, P., Webster, M., Muller, W. J., Brugge, J., Davis, R., and Pestell., R. G. pp60v-src induction of cyclin D1 requires collaborative interactions between the ERK, p38 and Jun kinase pathways: a role for CREB and ATF-2 in pp60v-src signaling in breast cancer cells. J. Biol. Chem., 274, 7341-7350, 1999.
69. Brown, J. R., Nigh, E., Lee, R. J., Ye, H., Thompson, M. A., Saudou, F., Pestell, R. G., and Greenberg, M. E. Fos family members induce cell cycle entry by activating cyclin Dl. Mol. Cell. Biol., 18: 5609-5619, 1998.
70. Watanabe, G., Albanese, C., Lee, R. J., Reutens, A., Vairo, G., Henglein, B., and Pestell, R. G. Inhibition of cyclin D1 kinase activity is associated with E2F-mediated inhibition of cyclin D1 promoter activity through E2F and Spl. Mol. Cell. Biol., 18: 3212-3222, 1998.
71. Muise-Helmericks, R. C., Grimes, H. L., Bellacosa, A., Malstrom, S. E., Tsichlis, P. N., and Rosen, N. Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-kinase/Akt-dependent pathway. J. Biol. Chem., 273: 29864-29872, 1998.
72. Grana, X., De Luca, A., Sang, N., Fu, Y., Claudio, P. P., Rosenblalt, J., Morgan, D. O., and Giordano, A. PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in film. Proc. Natl. Acad. Sci. USA, 91: 3834-3838, 1994.
73. Gold, M. O., and Rice, A. P. Targeting of CDK8 to a promoter-proximal RNA element demonstrates catalysis-dependent activation of gene expression. Nucleic Acids Res., 26: 3784-3788, 1998.
74. Jeoung, D. I., Tang, B., and Sonenberg, M. Effects of tumor necrosis factor-α on antimitogenicity and cell cycle-related proteins in MCF-7 cells. J. Biol. Chem., 270: 18367-18373, 1995.
75. Watts, C. K,. Brady, A., Sarcevic, B., deFazio, A., Musgrove, E. A., and Sutherland, R. L. Antiestrogen inhibition of cell cycle progression in breast cancer cells in associated with inhibition of cyclin-dependent kinase activity and decreased retinoblastoma protein phosphorylation. Mol. Endocrinol., 9: 1804-1813, 1995.
76. Zhou, Q., Stetler-Stevenson, M., and Steeg, P. S. Inhibition of cyclin D expression in human breast carcinoma cells by relinoids in vitro, Oncogene, 15: 107-115, 1997.
77. 1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability, J Biol Chem., 273: 14424-14429, 1998.
78. Winston, J. T., and Pledger, W. J. Growth factor regulation of cyclin D1 mRNA expression through protein synthesis-dependent and -independent mechanisms, Mol Biol Cell, 4: 1133-1144, 1993.
79. Brooks, A. R., Shiffman, D., Chan, C. S., Brooks, E. E., and Milner, P. G. Functional analysis of the human cyclin D2 and cyclin D3 promoters, J Biol Chem., 271-9090-9099, 1996.
80. 1/S transition and high abundance in quiescent tissues suggest a dual role in proliferation and differentiation. Oncogene, 17: 1027-1037, 1998.
81. Neuman, E., Ladha, M. H., Lin, N., Upton, T. M., Miller, S. J., DiRenzo, J., Pestell, R. G., Hinds, P. W., Dowdy, S. F., Brown, M., and Ewen, M. E. Cyclin D1 stimulation of estrogen receptor transcriptional activity independent of cdk4. Mol. Cell. Biol., 17: 5338-5347, 1997.
82. Zwijsen, R. M., Wientjens, E., Klompmaker, R., van der Sman, J., Bernards, R., and Michalides, R. J. CDK-independent activation of estrogen receptor by cyclin D1. Cell, 88: 405-415, 1997.
83. Zimmet, J. M., Ladd, D., Jackson, C. W., Stenberg, P. E., and Ravid, K. A role for cyclin D3 in the endomitotic cell cycle. Mol. Cell. Biol., 17: 7248-7259, 1997.
84. Meyyappan, M., Wong, H., Hull, C., and Riabowol, K. T Increased expression of cyclin D2 during multiple states of growth arrest in primary and established cells. Mol. Cell. Biol., 18: 3163-3172, 1998.