P-TEFb, a cyclin-dependent kinase controlling elongation by RNA polymerase II

Molecular and Cellular Biology

Volumn 20, Issue 8, 2000, Pages 2629-2634

  Price, David H ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; ELONGATION FACTOR; MESSENGER RNA; RNA POLYMERASE II; TRANSACTIVATOR PROTEIN;

DROSOPHILA; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; LONG TERMINAL REPEAT; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RNA PROCESSING; RNA TRANSCRIPTION; SACCHAROMYCES CEREVISIAE; SHORT SURVEY; T LYMPHOCYTE ACTIVATION; TRANSACTIVATION; TRANSCRIPTION REGULATION; VIRUS REPLICATION;

AMINO ACID SEQUENCE; ANIMALS; GENE PRODUCTS, TAT; HUMANS; MOLECULAR SEQUENCE DATA; POSITIVE TRANSCRIPTIONAL ELONGATION FACTOR B; PROTEIN-SERINE-THREONINE KINASES; RNA POLYMERASE II; TRANSCRIPTION, GENETIC;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; SACCHAROMYCES CEREVISIAE;

EID: 0034111019     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.8.2629-2634.2000     Document Type: Short Survey

References (86)

1. Archambault, J., G. Pan, G. K. Dahmus, M. Cartier, N. F. Marshall, S. Zhang, M. E. Dahmus, and J. Greenblatt. 1998. FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO. J. Biol. Chem. 273: 27593-27601.
2. Bentley, D. 1999. Coupling RNA polymerase II transcription with pre-mRNA processing. Curr. Opin. Cell Biol. 11:347-351.
3. Bentley, D. L. 1995. Regulation of transcriptional elongation by RNA polymerase II. Curr. Opin. Genet. Dev. 5:210-216.
4. Bieniasz, P. D., T. A. Grdina, H. P. Bogerd, and B. R. Cullen. 1998. Recruitment of a protein complex containing Tat and cyclin T1 to TAR governs the species specificity of HIV-1 Tat. EMBO J. 17:7056-7065.
5. Bieniasz, P. D., T. A. Grdina, H. P. Bogerd, and B. R. Cullen. 1999. Analysis of the effect of natural sequence variation in Tat and in cyclin T on the formation and RNA binding properties of Tat-cyclin T complexes. J. Virol. 73:5777-5786.
6. Bieniasz, P. D., T. A. Grdina, H. P. Bogerd, and B. R. Cullen. 1999. Highly divergent lentiviral Tat proteins activate viral gene expression by a common mechanism. Mol. Cell. Biol. 19:4592-4599.
7. Bieniasz, P. D., T. A. Grdina, H. P. Bogerd, and B. R. Cullen. 1999. Recruitment of cyclin T1/P-TEFb to an HIV type 1 long terminal repeat promoter proximal RNA target is both necessary and sufficient for full activation of transcription. Proc. Natl. Acad. Sci. USA 96:7791-7796.
8. Blau, J., H. Xiao, S. McCracken, P. O'Hare, J. Greenblatt, and D. Bentley. 1996. Three functional classes of transcriptional activation domains. Mol. Cell. Biol. 16:2044-2055.
9. Carroll, R., B. M. Peterlin, and D. Derse. 1992. Inhibition of human immunodeficiency virus type 1 Tat activity by coexpression of heterologous trans activators. J. Virol. 66:2000-2007.
10. Chen, D., and Q. Zhou. 1999. Tat activates human immunodeficiency virus type 1 transcriptional elongation independent of TFIIH kinase. Mol. Cell. Biol. 19:2863-2871.
11. Cho, H., T. K. Kim, H. Mancebo, W. S. Lane, O. Flores, and D. Reinberg. 1999. A protein phosphatase functions to recycle RNA polymerase II. Genes Dev. 13:1540-1552.
12. Chodosh, L. A., A. Fire, M. Samuels, and P. A. Sharp. 1989. 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole inhibits transcription elongation by RNA polymerase II in vitro. J. Biol. Chem. 264:2250-2257.
13. Chun, R. F., and K. T. Jeang. 1996. Requirements for RNA polymerase II carboxyl-terminal domain for transcription of human retroviruses, human T-cell lymphotrophic virus, and HIV-1. J. Biol. Chem. 271:27888-27894.
14. Collart, M. A., N. Tourkine, D. Belin, P. Vassalli, P. Jeanteur, and J.-M. Blanchard. 1991. c-fos gene transcription in murine macrophages is modulated by a calcium-dependent block to elongation in intron 1, Mol. Cell. Biol. 11:2826-2831.
15. Cujec, T. P., H. Okamoto, K. Fujinaga, J. Meyer, H. Chamberlin, D. O. Morgan, B. M. Peterlin. 1997. The HIV transactivator TAT hinds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase II. Genes Dev. 11:2645-2657.
16. Dahmus, M. E. 1996. Phosphorylation of mammalian RNA polymerase II. Methods Enzymol. 273:185-193.
17. Edwards, M. C., C. Wong, and S. J. Elledge. 1998. Human cyclin K, a novel RNA polymerase II-associated cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. Mol. Cell. Biol. 18:4291-4300.
18. Egyhazi, E., A. Ossoinak, A. Pigon, C. Holmgren, J. M. Lee, and A. L. Greenleaf. 1996. Phosphorylation dependence of the initiation of productive transcription of Balbiani ring 2 genes in living cells. Chromosoma 104:422-433.
19. Flores, O., G. Lee, J. Kessler, M. Miller, W. Schlief, J. Tomassini, and D. Hazuda. 1999. Host-cell positive transcription elongation factor b kinase activity is essential and limiting for HIV type 1 replication. Proc. Natl. Acad. Sci. USA 96:7208-7213.
20. Fu, T. J., J. Peng, D. H. Price, and O. Flores. 1999. Cyclin K functions as a Cdk9 regulatory subunit and participates in RNA polymerase II transcription. J. Biol. Chem. 274:34527-34530.
21. Kujinaga, K., T. P. Cujec, J. Peng, J. Garriga, D. H. Price, X. Grana, and B. M. Peterlin. 1998. The ability of positive transcription elongation factor B to transactivate human immunodeficiency virus transcription depends on a functional kinase domain, cyclin T1, and Tat. J. Virol. 72:7154-7159.
22. Garber, M. E., and K. A. Jones. 1999. HIV-1 Tat: coping with negative elongation factors. Curr. Opin. Immunol. 11:460-465.
23. Garber, M. E., P. Wei, V. N. KewalRamani, T. P. Mayall, C. H. Herrmann, A. P. Rice, D. R. Littman, and K. A. Jones. 1998. The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein. Genes Dev. 12:3512-3527.
24. Garcia-Martinez, L. F., G. Mavankal, J. M. Neveu, W. S. Lane, D. Ivanov, and R. B. Gaynor. 1997. Purification of a Tat-associatcd kinase reveals a TFIIH complex that modulates HIV-1 transcription. EMBO J. 16:2836-2850.
25. Garriga, J., X. Mayol, and X. Grana. 1996. The CDC2-related kinase PITALRE is the catalytic subunit of active multimeric protein complexes. Biochem. J. 319:293-298.
26. Garriga, J., J. Peng, M. Parreno, D. H. Price, E. E. Henderson, and X. Grana. 1998. Upregulation of cyclin T1/ CDK9 complexes during T cell activation. Oncogene 17:3093-3102.
27. Garriga, J., E. Segura, X. Mayol, C. Grubmeyer, and X. Grana. 1996. Phosphorylation site specificity of the CDC2-related kinase PITALRE. Biochem. J. 320:983-989.
28. Gold, M. O., and A. P. Rice. 1498. Targeting of CDK8 to a promoter-proximal RNA element demonstrates catalysis-dependent activation of gene expression. Nucleic Acids Res. 26:3784-3788.
29. Gold, M. O., X. Yang, C. H. Herrmann, and A. P. Rice. 1998. PITALRE, the catalytic subunit of TAK, is required for human immunodeficiency virus Tat transactivation in vivo. J. Virol. 72:4448-4453.
30. Grana, X., A. De Luca, N. Sang, Y. Fu, P. P. Claudio, J. Rosenblatt, D. O. Morgan, and A. Giordano. 1994. PITALRE, a nuclear CDC2-rclated protein kinase that phosphorylates the retinoblastoma protein in vitro. Proc. Natl. Acad. Sci. USA 91:3834-3838.
31. Herrmann, C. H., R. G. Carroll, P. Wei, K. A. Jones, and A. P. Rice. 1998. Tat-associated kinase. TAK, activity is regulated by distinct mechanisms in peripheral blood lymphocytes and promonocytic cell lines. J. Virol. 72:9881-9888.
32. Herrmann, C. H., and A. P. Rice. 1993. Specific interaction of the human immunodeficiency virus Tat proteins with a cellular protein kinase. Virology 197:601-608.
33. Herrmann, C. H., and A. P. Rice. 1995. Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor. J. Virol. 69:1612-1620.
34. Ho, C. K., and S. Shuman. 1999. Distinct roles for CTD Ser-2 and Ser-5 phosphorylation in the recruitment and allosteric activation of mammalian mRNA capping enzyme. Mol. Cell 3:405-411.
35. Isel, C., and J. Karn. 1999. Direct evidence that HIV-1 Tat stimulates RNA polymerase II carboxyl-terminal domain hyperphosphorylation during transcriptional elongation. J. Mol. Biol. 290:929-941.
36. Kanazawa, S., T. Okamoto, and B. M. Peterlin. 1999. Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection. Immunity 12:61-70.
37. Kao, S.-Y., A. F. Calman, P. A. Luciw, and E. M. Peterlin. 1987. Antitermination of transcription within the long terminal repeat of HIV by the tat gene product. Nature 330:489-493.
38. Karn, J. 1999. Tackling Tat. J. Mol. Biol. 293:235-254.
39. Keen, N. J., M. J. Churcher, and J. Karn. 1997. Transfer of Tat and release of TAR RNA during the activation of the human immunodeficiency virus type-1 transcription elongation complex. EMBO J. 10-3272.
40. Kephart, D. D., N. F. Marshall, and D. H. Price. 1992. Stability of Drosophila RNA polymerase II elongation complexes in vitro. Mol. Cell. Biol. 12:2067-2077.
41. Laspia, M. F., P. Wendel, and M. B. Mathews. 1993. HIV-1 Tat overcomes inefficient transcriptional elongation in vitro. J. Mol. Biol. 232:732-746.
42. Lee, J. M., and A. L. Greenleaf. 1997. Modulation of RNA polymerase II elongation efficiency by C-terminal heptapeptide repeat domain kinase I. J. Biol. Chem. 272:10990-10993.
43. Lis, J. T., P. Mason, J. Peng, D. H. Price, and J. Werner. P-TEFb kinase recruitment and function at heat shock loci. Genes Dev., in press.
44. Liu, M., Z. Xie, and D. H. Price. 1998. A human RNA polymerase II transcription termination factor is a SWI2/SNF2 family member. J. Biol. Chem. 273:25541-25544.
45. Madore, S. J., and B. R. Cullen. 1993. Genetic analysis of the cofactor requirement for human immunodeficiency virus type 1 Tat function. J. Virol. 67:3703-3711.
46. Majello, B., C. Napolitano, and L. Lania. 1998. Recruitment of the TATA-binding protein to the HIV-1 promoter is a limiting step for Tat transactivation. AIDS 12:1957-1964.
47. Majello, B., G. Napolitano, A. Giordano, and L. Lania. 1999. Transcriptional regulation by targeted recruitment of cyclin-dependent CDK9 kinase in vivo. Oncogene 18:4598-4605.
48. Mancebo, H. S., G. Lee, J. Flygare, J. Tomassini, P. Luu, Y. Zhu, J. Peng, C. Blau, D. Hazuda, D. H. Price, and O. Flores. 1997. P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro. Genes Dev. 11:2633-2644.
49. Marciniak, R. A., and P. A. Sharp. 1991. HIV-1 Tat protein promotes formation of more-processive elongation complexes. EMBO J. 10:4189-4196.
50. Marshall, N. F., G. K. Dahmus, and M. E. Dahmus. 1998. Regulation of carboxyl-terminal domain phosphatase by HIV-1 Tat protein. J. Biol. Chem. 273:31726-31730.
51. Marshall, N. F., J. Peng, Z. Xie, and D. H. Price. 1996. Control of RNA polymerase II elongation potential by a novel carboxyl-terminal domain kinase. J. Biol. Chem. 271:27176-27183.
52. Marshall, N. F., and D. H. Price. 1992. Control of formation of two distinct classes of RNA polymerase H elongation complexes. Mol. Cell. Biol. 12: 2078-2090.
53. Marshall, N. F., and D. H. Price. 1995. Purification of P-TEFb, a transcription factor required for the transition into productive elongation. J. Biol. Chem. 270:12335-12338.
54. Minvielle-Sebastia, L., and W. Keller. 1999. mRNA polyadenylation and its coupling to other RNA processing reactions and to transcription. Curr. Opin. Cell Biol. 11:352-357.
55. Napolitano, G., P. Licciardo, P. Gallo, B. Majello, A. Giordano, L. Lania. 1999. The CDK9-associated cyclins T1 and T2 exert opposite effects on HIV-1 Tat activity. AIDS 13:1453-1459.
56. Parada, C. A., and R. G. Roeder. 1996. Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain. Nature 384:375-378.
57. Pendergrast, P. S., and N. Hernandez. 1997. RNA-targeted activators, but not DNA-targeted activators, repress the synthesis of short transcripts at the human immunodeficiency virus type 1 long terminal repeat. J. Virol. 71:910-917.
58. Peng, J., M. Liu, J. Marion, Y. Zhu, and D. H. Price. 1998. RNA polymerase II elongation control. Cold Spring Harbor Symp. Quant. Biol. 63:365-370.
59. Peng, J., N. F. Marshall, and D. H. Price. 1998. Identification of a cyclin subunit required for the function of Drosophila P-TEFb. J. Biol. Chem. 273:13855-13860.
60. Peng, J., Y. Zhu, J. T. Milton, and D. H. Price. 1998. Identification of multiple cyclin subunits of human P-TEFb. Genes Dev. 12:755-762.
61. Ping, Y. H., and T. M. Rana. 1999. Tat-associated kinase (P-TEFb): a component of transcription preinitiation and elongation complexes. J. Biol. Chem. 274:7399-7404.
62. Rana, T. M., and K. T. Jeang. 1999. Biochemical and functional interactions between HIV-1 Tat protein and TAR RNA. Arch. Biochem. Biophys. 365: 175-185.
63. Reines, D., J. W. Conaway, and R. C. Conaway. 1996. The RNA polymerase II general elongation factors. Trends Biochem. Sci. 21:351-355.
64. Reines, D., R. C. Conaway, and J. W. Conaway. 1999. Mechanism and regulation of transcriptional elongation by RNA polymerase II. Curr. Opin. Cell Biol. 11:342-346.
65. Sehgal, P. B., J. E. Darnell, and I. Tamm. 1976. The inhibition by DRB (5,6,-dichloro-1-β-D-ribofuranosylbenzimidazołe) of hnRNA and mRNA production in HeLa cells. Cell 9:473-480.
66. Shilatifard, A. 1998. Factors regulating the transcriptional elongation activity of RNA polymerase II. FASEB J. 12:1437-1446.
67. Tamm, I., T. Kikuchi, J. E. Darnell, and M. Salditt-Georgeieff. 1980. Short capped hnRNA precursor chains in HeLa cells: continued synthesis in the presence of 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole. Biochemistry 19:2743-2748.
68. Taube, R., K. Fujinaga, D. Irwin, J. Wimmer, M. Geyer, and B. M. Peterlin. 2000. Interactions between equine cyclin T1, Tat, and TAR are disrupted by a leucine-to-valine substitution found in human cyclin T1. J. Virol. 74:892-898.
69. Taube, R., K. Fujinaga, J. Wimmer, M. Barborie, and B. M. Peterlin. 1999. Tat transactivation: a model for the regulation of eukaryotic transcriptional elongation. Virology 264:245-253.
70. Toohey, M. G., and K. A. Jones. 1989. In vitro formation of short RNA polymerase II transcripts that terminate within the HIV-1 and HIV-2 promoter-proximal downstream regions. Genes Dev. 3:265-282.
71. Wada, T., T. Takagi, Y. Yamaguchi, A. Ferdous, T. Imai, S. Hirose, S. Sugimoto. K. Yano, G. A. Hartzog, F. Winston, S. Buratowski, and H. Handa. 1998. DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs. Genes Dev. 12:343-356.
72. Wada, T., T. Takagi, Y. Yamaguchi, D. Watanabe, and H. Handa. 1998. Evidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro. EMBO J. 17:7395-7403.
73. Wei, P., M. E. Garber, S. M. Fang, W. H. Fischer, and K. A. Jones. 1998. A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA. Cell 92:451-462.
74. Wen, Y., and A. J. Shatkin. 1999. Transcription elongation factor hSPT5 stimulates mRNA capping. Genes Dev. 13:1774-1779.
75. Wimmer, J., K. Fujinaga, R. Taube, T. P. Cujec, Y. Zhu, J. Peng, D. H. Price, and B. M. Peterlin. 1999. Interactions between Tat and TAR and human immunodeficiency virus replication are facilitated by human cyclin T1 but not cyclins T2a or T2b. Virology 255:182-189.
76. Wu-Baer, F., W. S. Lane, and R. B. Gaynor. 1998. Role of the human homolog of the yeast transcription factor SPT5 in HIV-1 Tat-activation. J. Mol. Biol. 277:179-197.
77. Xie, Z., and D. H. Price. 1996. Purification of an RNA polymerase II transcript release factor from Drosophila. J. Biol. Chem. 271:11043-11046.
78. Xie, Z., and D. H. Price. 1997. Drosophila factor 2, an RNA polymerase II transcript release factor, has DNA-dependent ATPase activity. J. Biol. Chem. 272:31902-31907.
79. Yamaguchi, Y., T. Takagi, T. Wada, K. Yano, A. Furuya, S. Sugimoto, J. Hasegawa, and H. Handa. 1999. NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation. Cell 97:41-51.
80. Yamaguchi, Y., T. Wada, D. Watanabe, T. Takagi, J. Hasegawa, and H. Handa. 1999. Structure and function of the human transcription elongation factor DSIF. J. Biol. Chem. 274:8085-8092.
81. Yang, X. Z., M. O. Gold, D. N. Tang, D. E. Lewis, E. Aguilarcordova, A. P. Rice, and C. H. Herrmann. 1997. TAK. an HIV TAT-associated kinase, is a memher of the cyclin-dependent family of protein kinases and is induced by activation of peripheral blood lymphocytes and differentiation of promonocytic cell lines. Proc. Natl. Acad. Sci. USA 94:12331-12336.
82. Yankulov, K., and D. Bentley. 1998. Transcriptional control: Tat cofactors and transcriptional elongation. Curr. Biol. 8:R447-R449.
83. Zandomeni, R., B. Mittleman, D. Bunick, S. Ackerman, and R. Weinmann. 1982. Mechanism of action of dichloro-beta-D-ribofuranosylbenzimidazole: effect on in vitro transcription. Proc. Natl. Acad. Sci. USA 79:3167-3170.
84. Zawel, L., K. P. Kumar, and D. Reinberg. 1995. Recycling of the general transcription factors during RNA polymerase II transcription. Genes Dev. 9:1479-1490.
85. Zhou, Q., D. Chen, E. Pierstorff, and K. Luo. 1998. Transcription elongation factor P-TEFb mediates Tat activation of HIV-1 transcription at multiple stages. EMBO J. 17:3681-3691.
86. Zhu, Y., T. Pe'ery, J. Peng, Y. Ramanathan, N. F. Marshall, T. Marshall, B. Amendt, M. B. Mathews, and D. H. Price. 1997. Transcription elongation factor P-TEFb is required for HIV-1 tat transactivation in vitro. Genes Dev. 11:2622-2632.