메뉴 건너뛰기




Volumn 244, Issue 1, 1998, Pages 54-60

Inhibitors of transcription, proteasome inhibitors, and DNA-damaging drugs differentially affect feedback of p53 degradation

Author keywords

DNA damage; Mdm 2; p53; Proteasome; Protein stabilization

Indexed keywords

DNA; PROTEASOME; PROTEIN P53;

EID: 0032505719     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.1998.4193     Document Type: Article
Times cited : (49)

References (43)
  • 1
    • 0021616838 scopus 로고
    • UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells
    • Maltzman, W., and Czyzyk, L. (1984). UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells. Mol. Cell. Biol. 4, 1689-1694.
    • (1984) Mol. Cell. Biol. , vol.4 , pp. 1689-1694
    • Maltzman, W.1    Czyzyk, L.2
  • 2
  • 4
    • 0027500246 scopus 로고
    • Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents
    • Fritsche, M., Haessler, C., and Brandner, G. (1993). Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents. Oncogene 8, 307-318.
    • (1993) Oncogene , vol.8 , pp. 307-318
    • Fritsche, M.1    Haessler, C.2    Brandner, G.3
  • 6
    • 0028110809 scopus 로고
    • Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status
    • Graeber, T. G., Peterson, J. F., Tsai, M., Monica, K., Fornace, A. J., Jr., and Giaccia, A. J. (1994). Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status. Mol. Cell. Biol. 14, 6264-6277.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 6264-6277
    • Graeber, T.G.1    Peterson, J.F.2    Tsai, M.3    Monica, K.4    Fornace A.J., Jr.5    Giaccia, A.J.6
  • 8
    • 0029964158 scopus 로고    scopus 로고
    • A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage
    • Linke, S. P., Clarkin, K. C., DiLeonardo, A., Tsou, A., and Wahl, G. M. (1996). A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage. Genes Dev. 10, 934-947.
    • (1996) Genes Dev. , vol.10 , pp. 934-947
    • Linke, S.P.1    Clarkin, K.C.2    DiLeonardo, A.3    Tsou, A.4    Wahl, G.M.5
  • 10
  • 12
    • 0025639158 scopus 로고
    • The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
    • Scheffner, M., Werness, B. A., Huibregtse, J. M., Levine, A. J., and Howley, P. M. (1990). The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63, 1129-1136.
    • (1990) Cell , vol.63 , pp. 1129-1136
    • Scheffner, M.1    Werness, B.A.2    Huibregtse, J.M.3    Levine, A.J.4    Howley, P.M.5
  • 13
    • 0027358723 scopus 로고
    • The HPV16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
    • Scheffner, M., Huibregtse, J. M., Vierstra, R. D., and Howley, P. M. (1993). The HPV16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell 75, 495-505.
    • (1993) Cell , vol.75 , pp. 495-505
    • Scheffner, M.1    Huibregtse, J.M.2    Vierstra, R.D.3    Howley, P.M.4
  • 14
    • 0028205667 scopus 로고
    • Accumulation of p53 in a mutant cell line defective in the ubiquitin pathway
    • Chowdary, D. R., Dermody, J. J., Jha, K. K., and Ozer, H. L. (1994). Accumulation of p53 in a mutant cell line defective in the ubiquitin pathway. Mol. Cell. Biol. 14, 1997-2003.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 1997-2003
    • Chowdary, D.R.1    Dermody, J.J.2    Jha, K.K.3    Ozer, H.L.4
  • 15
    • 0028018268 scopus 로고
    • The ubiquitin-proteasome proteolytic pathway
    • Ciechanover, A. (1994). The ubiquitin-proteasome proteolytic pathway. Cell 79, 13-21.
    • (1994) Cell , vol.79 , pp. 13-21
    • Ciechanover, A.1
  • 16
    • 0029952441 scopus 로고    scopus 로고
    • In vivo ubiquitination and proteasome-mediated degradation of p53
    • Maki, C. G., Huibregtse, J. M., and Howley, P. M. (1996). In vivo ubiquitination and proteasome-mediated degradation of p53. Cancer Res. 56, 2649-2654.
    • (1996) Cancer Res. , vol.56 , pp. 2649-2654
    • Maki, C.G.1    Huibregtse, J.M.2    Howley, P.M.3
  • 18
    • 0031014946 scopus 로고    scopus 로고
    • Proteolytic cleavage of human p53 by calpain: A potential regulator of protein stability
    • Kubbutat, M. H., and Vousden, K. H. (1997). Proteolytic cleavage of human p53 by calpain: A potential regulator of protein stability. Mol. Cell. Biol. 17, 460-468.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 460-468
    • Kubbutat, M.H.1    Vousden, K.H.2
  • 19
    • 0030878952 scopus 로고    scopus 로고
    • Geldanamycin-stimulated destabolization of mutated p53 is mediated by the proteasome in vivo
    • Whitesell, L., Sutphin, P., An, W. G., Schulte, T., Blagosklonny, M. V., and Neckers, L. (1997). Geldanamycin-stimulated destabolization of mutated p53 is mediated by the proteasome in vivo. Oncogene 14, 2809-2816.
    • (1997) Oncogene , vol.14 , pp. 2809-2816
    • Whitesell, L.1    Sutphin, P.2    An, W.G.3    Schulte, T.4    Blagosklonny, M.V.5    Neckers, L.6
  • 20
    • 0026649648 scopus 로고
    • The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated trans-activation
    • Momand, J., Zambetti, G. P., Olson, D. C., George, D., and Levine, A. J. (1992). The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated trans-activation. Cell 69, 1237-1245.
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Olson, D.C.3    George, D.4    Levine, A.J.5
  • 21
    • 0030905284 scopus 로고    scopus 로고
    • Mdm2 promotes the rapid degradation of p53
    • Haupt, Y., Maya, R., Kazaz, A., and Oren, M. (1997). Mdm2 promotes the rapid degradation of p53. Nature 387, 296-299.
    • (1997) Nature , vol.387 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3    Oren, M.4
  • 22
    • 0030965946 scopus 로고    scopus 로고
    • Regulation of p53 stability by Mdm2
    • Kubbutat, M. H. G., Jones, S. N., and Vousden, K. H. (1997). Regulation of p53 stability by Mdm2. Nature 387, 299-303.
    • (1997) Nature , vol.387 , pp. 299-303
    • Kubbutat, M.H.G.1    Jones, S.N.2    Vousden, K.H.3
  • 24
    • 0030667702 scopus 로고    scopus 로고
    • DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
    • Shieh, S. Y., Ikeda, M., Taya, Y., and Prives, C. (1997). DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell 91, 325-334.
    • (1997) Cell , vol.91 , pp. 325-334
    • Shieh, S.Y.1    Ikeda, M.2    Taya, Y.3    Prives, C.4
  • 25
    • 0030665146 scopus 로고    scopus 로고
    • Mdm-2 phosphorylation by DNA-dependent protein kinase prevents interaction with p53
    • Mayo, L. D., Turchi, J. J., and Berberich, S. J. (1997). Mdm-2 phosphorylation by DNA-dependent protein kinase prevents interaction with p53. Cancer Res. 57, 5013-5016.
    • (1997) Cancer Res. , vol.57 , pp. 5013-5016
    • Mayo, L.D.1    Turchi, J.J.2    Berberich, S.J.3
  • 26
    • 0029145215 scopus 로고
    • Geldanamycin selectively destabilizes and conformationally alters mutated p53
    • Blagosklonny, M. V., Toretskey, J., and Neckers, L. M. (1995). Geldanamycin selectively destabilizes and conformationally alters mutated p53. Oncogene 11, 933-939.
    • (1995) Oncogene , vol.11 , pp. 933-939
    • Blagosklonny, M.V.1    Toretskey, J.2    Neckers, L.M.3
  • 28
    • 0344347168 scopus 로고    scopus 로고
    • Loss of p53 function precedes tubulin mutations in the development of paclitaxel (PTX) resistance
    • Giannakakou, P., Blagosklonny, M. V., and Fojo, T. (1998). Loss of p53 function precedes tubulin mutations in the development of paclitaxel (PTX) resistance. Proc. Am. Assoc. Cancer Res. 89, 1305.
    • (1998) Proc. Am. Assoc. Cancer Res. , vol.89 , pp. 1305
    • Giannakakou, P.1    Blagosklonny, M.V.2    Fojo, T.3
  • 29
    • 0030094571 scopus 로고    scopus 로고
    • P53 and chemosensitivity
    • Wu, G. S., and El-Deiry, W. S. (1996). p53 and chemosensitivity. Nat. Med. 2, 255-256.
    • (1996) Nat. Med. , vol.2 , pp. 255-256
    • Wu, G.S.1    El-Deiry, W.S.2
  • 31
    • 0027407260 scopus 로고
    • Wild-type p53 adopts a "mutant"-like conformation when bound to DNA
    • Halazonetis, T. D., Davis, L. J., and Kandil, A. N. (1993). Wild-type p53 adopts a "mutant"-like conformation when bound to DNA. EMBO J. 12, 1021-1028.
    • (1993) EMBO J. , vol.12 , pp. 1021-1028
    • Halazonetis, T.D.1    Davis, L.J.2    Kandil, A.N.3
  • 32
    • 0025214277 scopus 로고
    • Evidence for allosteric variants of wild-type p53, a tumour suppressor protein
    • Cook, A. C., and Milner, J. (1990). Evidence for allosteric variants of wild-type p53, a tumour suppressor protein. Br. J. Cancer 61, 548-552.
    • (1990) Br. J. Cancer , vol.61 , pp. 548-552
    • Cook, A.C.1    Milner, J.2
  • 33
    • 0025248598 scopus 로고
    • Activating mutations in p53 produce a common conformational effect, a monoclonal antibody specific for the mutant form
    • Gannon, J. V., Greaves, R., Iggo, R., and Lane, D. P. (1990). Activating mutations in p53 produce a common conformational effect, a monoclonal antibody specific for the mutant form. EMBO J. 9, 1595-1602.
    • (1990) EMBO J. , vol.9 , pp. 1595-1602
    • Gannon, J.V.1    Greaves, R.2    Iggo, R.3    Lane, D.P.4
  • 34
    • 12644271905 scopus 로고    scopus 로고
    • Wild-type p53 is not sufficient for serum starvation-induced apoptosis in cancer cells but accelerates apoptosis in sensitive cells
    • Blagosklonny, M. V., Wu, G. S., Somasundaram, K., and El-Deiry, W. S. (1997). Wild-type p53 is not sufficient for serum starvation-induced apoptosis in cancer cells but accelerates apoptosis in sensitive cells. Int. J. Oncol. 11, 1165-1170.
    • (1997) Int. J. Oncol. , vol.11 , pp. 1165-1170
    • Blagosklonny, M.V.1    Wu, G.S.2    Somasundaram, K.3    El-Deiry, W.S.4
  • 35
    • 0028303752 scopus 로고
    • Several hydrophobic amino acids in the p53 amino terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein
    • Lin, J. Y., Chen, J. D., Elenbaas, B., and Levine, A. J. (1994). Several hydrophobic amino acids in the p53 amino terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein. Genes Dev. 8, 1235-1246.
    • (1994) Genes Dev. , vol.8 , pp. 1235-1246
    • Lin, J.Y.1    Chen, J.D.2    Elenbaas, B.3    Levine, A.J.4
  • 36
    • 0029092356 scopus 로고
    • Induction of apoptosis in HeLa cells by trans-activation-deficient p53
    • Haupt, Y., Rowan, S., Shaulian, E., Vousden, K. H., and Oren, M. (1995). Induction of apoptosis in HeLa cells by trans-activation-deficient p53. Genes Dev. 9, 2170-2183.
    • (1995) Genes Dev. , vol.9 , pp. 2170-2183
    • Haupt, Y.1    Rowan, S.2    Shaulian, E.3    Vousden, K.H.4    Oren, M.5
  • 37
    • 0027185055 scopus 로고
    • Targeting and degradation of p53 by E6 of human papillomavirus type 16 is preferential for the 1620+ p53 conformation
    • Medcalf, E. A., and Milner, J. (1993). Targeting and degradation of p53 by E6 of human papillomavirus type 16 is preferential for the 1620+ p53 conformation. Oncogene 8, 2847-2851.
    • (1993) Oncogene , vol.8 , pp. 2847-2851
    • Medcalf, E.A.1    Milner, J.2
  • 38
    • 0030865104 scopus 로고    scopus 로고
    • Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute Anticancer Drug Screen and correlations with growth-inhibitory potency of 123 anticancer agents
    • O'Connor, P. M., Jackman, J., Bae, I., Myers, T. G., Fan, S., Mutoh, M., Scudiero, D. A., Monks, A., Sausville, E. A., Weinstein, J. N., Friend, S., Fornace, A. J. J., and Kohn, K. W. (1997). Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute Anticancer Drug Screen and correlations with growth-inhibitory potency of 123 anticancer agents. Cancer Res. 57, 4285-4301.
    • (1997) Cancer Res. , vol.57 , pp. 4285-4301
    • O'Connor, P.M.1    Jackman, J.2    Bae, I.3    Myers, T.G.4    Fan, S.5    Mutoh, M.6    Scudiero, D.A.7    Monks, A.8    Sausville, E.A.9    Weinstein, J.N.10    Friend, S.11    Fornace, A.J.J.12    Kohn, K.W.13
  • 39
    • 0030705168 scopus 로고    scopus 로고
    • Loss of function and p53 stabilization
    • Blagosklonny, M. V. (1997). Loss of function and p53 stabilization. Oncogene 15, 1889-1893.
    • (1997) Oncogene , vol.15 , pp. 1889-1893
    • Blagosklonny, M.V.1
  • 40
    • 0032539741 scopus 로고    scopus 로고
    • Like p53, the proliferation-associated protein p120 accumulates in human cancer cells following exposure to anticancer drugs
    • Blagosklonny, M. V., Iglesias, A., Zhan, Z., and Fojo, T. (1998). Like p53, the proliferation-associated protein p120 accumulates in human cancer cells following exposure to anticancer drugs. Biochem. Biophys. Res. Comm. 244, 368-373.
    • (1998) Biochem. Biophys. Res. Comm. , vol.244 , pp. 368-373
    • Blagosklonny, M.V.1    Iglesias, A.2    Zhan, Z.3    Fojo, T.4
  • 42
    • 0030825813 scopus 로고    scopus 로고
    • P53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding
    • Midgley, C. A., and Lane, D. P. (1997). p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding. Oncogene 15, 1179-1189.
    • (1997) Oncogene , vol.15 , pp. 1179-1189
    • Midgley, C.A.1    Lane, D.P.2
  • 43
    • 12644291915 scopus 로고    scopus 로고
    • Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: Evidence for the involvement of RNA perturbation
    • Pritchard, D. M., Watson, A. J., Potten, C. S., Jackman, A. L., and Hickman, J. A. (1997). Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: Evidence for the involvement of RNA perturbation. Proc. Natl. Acad. Sci. USA 94, 1795-1799.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 1795-1799
    • Pritchard, D.M.1    Watson, A.J.2    Potten, C.S.3    Jackman, A.L.4    Hickman, J.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.